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SLC7A1 Gene Record

  • Summary
  • Interactions
  • Claims
  • SLC7A1 6541 Druggable Genome

    Alternate Names:

    6541
    SOLUTE CARRIER FAMILY 7 MEMBER 1
    SLC7A1
    ATRC1
    CAT-1
    ERR
    HCAT1
    REC1L
    104615
    11057
    ENSG00000139514
    OTTHUMG00000016658
    891
    High affinity cationic amino acid transporter 1
    P30825
    HIGH-AFFINITY CATIONIC AMINO ACID TRANSPORTER-1 (CAT-1) (CAT1) (SYSTEM Y+ BASIC AMINO ACID TRANSPORTER) (ECOTROPIC RETROVIRAL LEUKEMIA RECEPTOR HOMOLOG) (ERR) (ECOTROPIC RETROVIRUS RECEPTOR HOMOLOG). [SOURCE:UNIPROT/SWISSPROT;ACC:P30825]
    BE0000212

    Gene Info:

    GuideToPharmacology Gene Category Name SLC7 family
    GuideToPharmacology Gene Category ID 169
    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME

    Publications:

    Rotmann et al., 2004, Protein kinase C activation promotes the internalization of the human cationic amino acid transporter hCAT-1. A new regulatory mechanism for hCAT-1 activity., J. Biol. Chem.
    Yeramian et al., 2006, Macrophages require distinct arginine catabolism and transport systems for proliferation and for activation., Eur. J. Immunol.
    Kaneko S et al., 2007, Ornithine transport via cationic amino acid transporter-1 is involved in ornithine cytotoxicity in retinal pigment epithelial cells., Invest Ophthalmol Vis Sci
    Cérec et al., 2007, Multiple pathways for cationic amino acid transport in rat seminiferous tubule cells., Biol. Reprod.
    Lopez et al., 2007, A feedback transcriptional mechanism controls the level of the arginine/lysine transporter cat-1 during amino acid starvation., Biochem. J.
    Nicholson et al., 1998, Increased Cat3-mediated cationic amino acid transport functionally compensates in Cat1 knockout cell lines., J. Biol. Chem.
    Fernandez et al., 2003, Transcriptional control of the arginine/lysine transporter, cat-1, by physiological stress., J. Biol. Chem.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Rotmann et al., 2007, Activation of classical protein kinase C decreases transport via systems y+ and y+L., Am. J. Physiol., Cell Physiol.
    Vásquez et al., 2007, D-glucose stimulation of L-arginine transport and nitric oxide synthesis results from activation of mitogen-activated protein kinases p42/44 and Smad2 requiring functional type II TGF-beta receptors in human umbilical vein endothelium., J. Cell. Physiol.
    Rotoli et al., 2007, Alveolar macrophages from normal subjects lack the NOS-related system y+ for arginine transport., Am. J. Respir. Cell Mol. Biol.
    Yang et al., 2007, Identification of a novel polymorphism in the 3'UTR of the L-arginine transporter gene SLC7A1: contribution to hypertension and endothelial dysfunction., Circulation
  • LYSINE   SLC7A1

    Interaction Score: 16.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17042743 9614060 14523001 17139284 17016423


    Sources:
    DrugBank

  • ARGININE   SLC7A1

    Interaction Score: 11.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17329401 17427197 17363779 17325243 17065601


    Sources:
    DrugBank

  • ORNITHINE   SLC7A1

    Interaction Score: 8.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15491978 16703566 17197568 17065601


    Sources:
    DrugBank

  • Ensembl: ENSG00000139514

    • Version: 101_38

    Alternate Names:
    SLC7A1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000139514

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000139514 Ensembl Gene Id
    SLC7A1 Display Id
    HIGH-AFFINITY CATIONIC AMINO ACID TRANSPORTER-1 (CAT-1) (CAT1) (SYSTEM Y+ BASIC AMINO ACID TRANSPORTER) (ECOTROPIC RETROVIRAL LEUKEMIA RECEPTOR HOMOLOG) (ERR) (ECOTROPIC RETROVIRUS RECEPTOR HOMOLOG). [SOURCE:UNIPROT/SWISSPROT;ACC:P30825] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 6541

    • Version: 29-September-2020

    Alternate Names:
    11057 HUGO Gene ID
    11057 HUGO Gene Symbol
    solute carrier family 7 member 1 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name SLC7 family
    GuideToPharmacology Gene Category ID 169

    Gene Categories:
    TRANSPORTER

    Publications:

  • DrugBank: BE0000212

    • Version: 5.1.7

    Alternate Names:
    SLC7A1 DrugBank Gene Name
    P30825 UniProt Accession
    6541 Entrez Gene Id

    Gene Info:

    Publications:
    Rotmann et al., 2007, Activation of classical protein kinase C decreases transport via systems y+ and y+L., Am. J. Physiol., Cell Physiol.
    Vásquez et al., 2007, D-glucose stimulation of L-arginine transport and nitric oxide synthesis results from activation of mitogen-activated protein kinases p42/44 and Smad2 requiring functional type II TGF-beta receptors in human umbilical vein endothelium., J. Cell. Physiol.
    Rotoli et al., 2007, Alveolar macrophages from normal subjects lack the NOS-related system y+ for arginine transport., Am. J. Respir. Cell Mol. Biol.

  • Pharos: SLC7A1

    • Version: 03-September-2020

    Alternate Names:
    High affinity cationic amino acid transporter 1 Gene Name
    P30825 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

  • GO: SLC7A1

    • Version: 05-September-2020

    Alternate Names:
    ATRC1 GO Gene Synonym
    ERR GO Gene Synonym
    REC1L GO Gene Synonym

    Gene Info:

    Gene Categories:
    EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21