DGIdb - SLC7A1 Gene Record

SLC7A1 6541 Druggable Genome

Alternate Names:

6541
SOLUTE CARRIER FAMILY 7 MEMBER 1
SLC7A1
ATRC1
CAT-1
ERR
HCAT1
REC1L
104615
11057
ENSG00000139514
OTTHUMG00000016658
891
High affinity cationic amino acid transporter 1
P30825
HIGH-AFFINITY CATIONIC AMINO ACID TRANSPORTER-1 (CAT-1) (CAT1) (SYSTEM Y+ BASIC AMINO ACID TRANSPORTER) (ECOTROPIC RETROVIRAL LEUKEMIA RECEPTOR HOMOLOG) (ERR) (ECOTROPIC RETROVIRUS RECEPTOR HOMOLOG). [SOURCE:UNIPROT/SWISSPROT;ACC:P30825]
BE0000212

Gene Info:

GuideToPharmacology Gene Category Name	SLC7 family
GuideToPharmacology Gene Category ID	169
Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

TRANSPORTER
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Rotmann et al., 2004, Protein kinase C activation promotes the internalization of the human cationic amino acid transporter hCAT-1. A new regulatory mechanism for hCAT-1 activity., J. Biol. Chem.
Yeramian et al., 2006, Macrophages require distinct arginine catabolism and transport systems for proliferation and for activation., Eur. J. Immunol.
Kaneko S et al., 2007, Ornithine transport via cationic amino acid transporter-1 is involved in ornithine cytotoxicity in retinal pigment epithelial cells., Invest Ophthalmol Vis Sci
Cérec et al., 2007, Multiple pathways for cationic amino acid transport in rat seminiferous tubule cells., Biol. Reprod.
Lopez et al., 2007, A feedback transcriptional mechanism controls the level of the arginine/lysine transporter cat-1 during amino acid starvation., Biochem. J.
Nicholson et al., 1998, Increased Cat3-mediated cationic amino acid transport functionally compensates in Cat1 knockout cell lines., J. Biol. Chem.
Fernandez et al., 2003, Transcriptional control of the arginine/lysine transporter, cat-1, by physiological stress., J. Biol. Chem.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Rotmann et al., 2007, Activation of classical protein kinase C decreases transport via systems y+ and y+L., Am. J. Physiol., Cell Physiol.
Vásquez et al., 2007, D-glucose stimulation of L-arginine transport and nitric oxide synthesis results from activation of mitogen-activated protein kinases p42/44 and Smad2 requiring functional type II TGF-beta receptors in human umbilical vein endothelium., J. Cell. Physiol.
Rotoli et al., 2007, Alveolar macrophages from normal subjects lack the NOS-related system y+ for arginine transport., Am. J. Respir. Cell Mol. Biol.
Yang et al., 2007, Identification of a novel polymorphism in the 3'UTR of the L-arginine transporter gene SLC7A1: contribution to hypertension and endothelial dysfunction., Circulation

LYSINE SLC7A1

Interaction Score: 16.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17042743 9614060 14523001 17139284 17016423

Sources:
DrugBank
ARGININE SLC7A1

Interaction Score: 11.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17329401 17427197 17363779 17325243 17065601

Sources:
DrugBank
ORNITHINE SLC7A1

Interaction Score: 8.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15491978 16703566 17197568 17065601

Sources:
DrugBank

Ensembl: ENSG00000139514
- Version: 101_38
Alternate Names:

SLC7A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000139514

Version: 26-July-2011

Alternate Names:

ENSG00000139514 Ensembl Gene Id

SLC7A1 Display Id

HIGH-AFFINITY CATIONIC AMINO ACID TRANSPORTER-1 (CAT-1) (CAT1) (SYSTEM Y+ BASIC AMINO ACID TRANSPORTER) (ECOTROPIC RETROVIRAL LEUKEMIA RECEPTOR HOMOLOG) (ERR) (ECOTROPIC RETROVIRUS RECEPTOR HOMOLOG). [SOURCE:UNIPROT/SWISSPROT;ACC:P30825] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

GuideToPharmacology: 6541
- Version: 29-September-2020
Alternate Names:

11057 HUGO Gene ID

11057 HUGO Gene Symbol

solute carrier family 7 member 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name SLC7 family

GuideToPharmacology Gene Category ID 169

Gene Categories:

TRANSPORTER

Publications:

DrugBank: BE0000212

Version: 5.1.7

Alternate Names:

SLC7A1 DrugBank Gene Name

P30825 UniProt Accession

6541 Entrez Gene Id

Gene Info:

Publications:

Rotmann et al., 2007, Activation of classical protein kinase C decreases transport via systems y+ and y+L., Am. J. Physiol., Cell Physiol.

Vásquez et al., 2007, D-glucose stimulation of L-arginine transport and nitric oxide synthesis results from activation of mitogen-activated protein kinases p42/44 and Smad2 requiring functional type II TGF-beta receptors in human umbilical vein endothelium., J. Cell. Physiol.

Rotoli et al., 2007, Alveolar macrophages from normal subjects lack the NOS-related system y+ for arginine transport., Am. J. Respir. Cell Mol. Biol.

Pharos: SLC7A1
- Version: 03-September-2020
Alternate Names:

High affinity cationic amino acid transporter 1 Gene Name

P30825 UniProt ID

Gene Info:

Gene Categories:

TRANSPORTER

Publications:
GO: SLC7A1
- Version: 05-September-2020
Alternate Names:

ATRC1 GO Gene Synonym

ERR GO Gene Synonym

REC1L GO Gene Synonym

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

ENSG00000139514	Ensembl Gene Id
SLC7A1	Display Id
HIGH-AFFINITY CATIONIC AMINO ACID TRANSPORTER-1 (CAT-1) (CAT1) (SYSTEM Y+ BASIC AMINO ACID TRANSPORTER) (ECOTROPIC RETROVIRAL LEUKEMIA RECEPTOR HOMOLOG) (ERR) (ECOTROPIC RETROVIRUS RECEPTOR HOMOLOG). [SOURCE:UNIPROT/SWISSPROT;ACC:P30825]	Description

11057	HUGO Gene ID
11057	HUGO Gene Symbol
solute carrier family 7 member 1	HUGO Gene Name

SLC7A1	DrugBank Gene Name
P30825	UniProt Accession
6541	Entrez Gene Id

High affinity cationic amino acid transporter 1	Gene Name
P30825	UniProt ID

SLC7A1 Gene Record

SLC7A1 6541 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

LYSINE SLC7A1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17042743 9614060 14523001 17139284 17016423

Sources: DrugBank

ARGININE SLC7A1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17329401 17427197 17363779 17325243 17065601

Sources: DrugBank

ORNITHINE SLC7A1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15491978 16703566 17197568 17065601

Sources: DrugBank

Ensembl: ENSG00000139514

Alternate Names: SLC7A1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000139514

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

GuideToPharmacology: 6541

Alternate Names: 11057 HUGO Gene ID 11057 HUGO Gene Symbol solute carrier family 7 member 1 HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name SLC7 family GuideToPharmacology Gene Category ID 169

Gene Categories: TRANSPORTER

Publications:

DrugBank: BE0000212

Alternate Names: SLC7A1 DrugBank Gene Name P30825 UniProt Accession 6541 Entrez Gene Id

Gene Info:

Pharos: SLC7A1

Alternate Names: High affinity cationic amino acid transporter 1 Gene Name P30825 UniProt ID

Gene Info:

Gene Categories: TRANSPORTER

Publications:

GO: SLC7A1

Alternate Names: ATRC1 GO Gene Synonym ERR GO Gene Synonym REC1L GO Gene Synonym

Gene Info:

Gene Categories: EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
17042743 9614060 14523001 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17329401 17427197 17363779 17325243 17065601

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
15491978 16703566 17197568 17065601

Sources:
DrugBank

Alternate Names:

SLC7A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

11057 HUGO Gene ID

11057 HUGO Gene Symbol

solute carrier family 7 member 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name SLC7 family

GuideToPharmacology Gene Category ID 169

Gene Categories:

TRANSPORTER

Alternate Names:

SLC7A1 DrugBank Gene Name

P30825 UniProt Accession

6541 Entrez Gene Id

Alternate Names:

High affinity cationic amino acid transporter 1 Gene Name

P30825 UniProt ID

Gene Categories:

TRANSPORTER

Alternate Names:

ATRC1 GO Gene Synonym

ERR GO Gene Synonym

REC1L GO Gene Synonym

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE