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SLC47A2 Gene Record

  • Summary
  • Interactions
  • Claims
  • SLC47A2 146802 Druggable Genome

    Alternate Names:

    146802
    SOLUTE CARRIER FAMILY 47 MEMBER 2
    SLC47A2
    MATE2
    MATE2-B
    MATE2-K
    MATE2K
    609833
    26439
    ENSG00000180638
    OTTHUMG00000059464
    Q86VL8
    PA162403847
    Multidrug and toxin extrusion protein 2

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    DRUGGABLE GENOME

    Publications:

    Pedersen AJT et al., 2018, The Pharmacogenetics of Metformin in Women with Polycystic Ovary Syndrome: A Randomized Trial., Basic Clin Pharmacol Toxicol
    Christensen MMH et al., 2015, Steady-state pharmacokinetics of metformin is independent of the OCT1 genotype in healthy volunteers., Eur J Clin Pharmacol
    Todd JN et al., 2014, An update on the pharmacogenomics of metformin: progress, problems and potential., Pharmacogenomics
    Chung JY et al., 2013, Functional characterization of MATE2-K genetic variants and their effects on metformin pharmacokinetics., Pharmacogenet Genomics
    Yoon H et al., 2013, Influences of organic cation transporter polymorphisms on the population pharmacokinetics of metformin in healthy subjects., AAPS J
    Stocker SL et al., 2013, The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin., Clin Pharmacol Ther
    Gong L et al., 2012, Metformin pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
    Choi JH et al., 2011, A common 5'-UTR variant in MATE2-K is associated with poor response to metformin., Clin Pharmacol Ther
  • METFORMIN   SLC47A2

    Interaction Score: 7.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28834135 25939711 24624919 23652408 23417334 23267855 22722338 21956618


    Sources:
    PharmGKB

  • RUCAPARIB   SLC47A2

    Interaction Score: 0.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000180638

    • Version: 101_38

    Alternate Names:
    SLC47A2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: SLC47A2

    • Version: 18-August-2020

    Alternate Names:
    PA162403847 PharmGKB ID

    Gene Info:

    Publications:
    Yoon H et al., 2013, Influences of organic cation transporter polymorphisms on the population pharmacokinetics of metformin in healthy subjects., AAPS J
    Stocker SL et al., 2013, The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin., Clin Pharmacol Ther
    Pedersen AJT et al., 2018, The Pharmacogenetics of Metformin in Women with Polycystic Ovary Syndrome: A Randomized Trial., Basic Clin Pharmacol Toxicol

  • HingoraniCasas: ENSG00000180638

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000180638 Gene Symbol
    SLC47A2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Tempus: SLC47A2

    • Version: 11-November-2018

    Alternate Names:
    SLC47A2 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Pharos: SLC47A2

    • Version: 01-February-2022

    Alternate Names:
    Multidrug and toxin extrusion protein 2 Gene Name
    Q86VL8 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21