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SLC47A1 Gene Record

  • Summary
  • Interactions
  • Claims
  • SLC47A1 55244 Druggable Genome

    Alternate Names:

    55244
    SOLUTE CARRIER FAMILY 47 MEMBER 1
    SLC47A1
    MATE1
    609832
    25588
    ENSG00000142494
    OTTHUMG00000059466
    Q96FL8
    PA162403808
    T39676
    Multidrug and toxin extrusion protein 1

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME

    Publications:

    Pedersen AJT et al., 2018, The Pharmacogenetics of Metformin in Women with Polycystic Ovary Syndrome: A Randomized Trial., Basic Clin Pharmacol Toxicol
    He R et al., 2015, SLC47A1 gene rs2289669 G>A variants enhance the glucose-lowering effect of metformin via delaying its excretion in Chinese type 2 diabetes patients., Diabetes Res Clin Pract
    Todd JN et al., 2014, An update on the pharmacogenomics of metformin: progress, problems and potential., Pharmacogenomics
    Christensen MM et al., 2013, A gene-gene interaction between polymorphisms in the OCT2 and MATE1 genes influences the renal clearance of metformin., Pharmacogenet Genomics
    Stocker SL et al., 2013, The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin., Clin Pharmacol Ther
    Tkáč I et al., 2013, Pharmacogenomic association between a variant in SLC47A1 gene and therapeutic response to metformin in type 2 diabetes., Diabetes Obes Metab
    Gong L et al., 2012, Metformin pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
  • METFORMIN   SLC47A1

    Interaction Score: 7.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28834135 26004431 24624919 23873119 23267855 22882994 22722338


    Sources:
    PharmGKB TTD

  • RUCAPARIB   SLC47A1

    Interaction Score: 0.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000142494

    • Version: 101_38

    Alternate Names:
    SLC47A1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: SLC47A1

    • Version: 18-August-2020

    Alternate Names:
    PA162403808 PharmGKB ID

    Gene Info:

    Publications:
    Stocker SL et al., 2013, The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin., Clin Pharmacol Ther
    Christensen MM et al., 2013, A gene-gene interaction between polymorphisms in the OCT2 and MATE1 genes influences the renal clearance of metformin., Pharmacogenet Genomics
    Pedersen AJT et al., 2018, The Pharmacogenetics of Metformin in Women with Polycystic Ovary Syndrome: A Randomized Trial., Basic Clin Pharmacol Toxicol

  • HingoraniCasas: ENSG00000142494

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000142494 Gene Symbol
    SLC47A1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: SLC47A1

    • Version: 01-February-2022

    Alternate Names:
    MATE1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • TTD: Solute carrier family 47 member 1

    • Version: 2020.06.01

    Alternate Names:
    SLC47A1 TTD Gene Abbreviation
    T39676 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: SLC47A1

    • Version: 01-February-2022

    Alternate Names:
    Multidrug and toxin extrusion protein 1 Gene Name
    Q96FL8 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21