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SLC46A1 Gene Record

  • Summary
  • Interactions
  • Claims
  • SLC46A1 113235 Druggable Genome

    Alternate Names:

    113235
    SOLUTE CARRIER FAMILY 46 MEMBER 1
    SLC46A1
    G21
    HCP1
    PCFT
    611672
    30521
    ENSG00000076351
    OTTHUMG00000179415
    Q96NT5
    Proton-coupled folate transporter
    NP_542400.2
    PA162403775
    T19229
    MGC9564

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    CELL SURFACE
    DRUGGABLE GENOME

    Publications:

    Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics
    Wang L et al., 2011, Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase., J Med Chem
    Wang L et al., 2015, 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors., J Med Chem
  • PEMETREXED   SLC46A1

    Interaction Score: 6.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21879757 26317331


    Sources:
    DTC

  • METHOTREXATE   SLC46A1

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21317831


    Sources:
    PharmGKB TTD

  • Ensembl: ENSG00000076351

    • Version: 101_38

    Alternate Names:
    SLC46A1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000076351

    • Version: 26-July-2011

    Alternate Names:
    NP_542400.2 Display Id
    ENSG00000076351 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: SLC46A1

    • Version: 18-August-2020

    Alternate Names:
    PA162403775 PharmGKB ID

    Gene Info:

    Publications:
    Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics

  • DTC: SLC46A1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Wang L et al., 2015, 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors., J Med Chem
    Wang L et al., 2011, Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase., J Med Chem

  • HumanProteinAtlas: SLC46A1

    • Version: 19.3

    Alternate Names:
    ENSG00000076351 Ensembl Gene ID
    HCP1 Human Protein Atlas Gene Synonym
    MGC9564 Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

  • GO: SLC46A1

    • Version: 01-February-2022

    Alternate Names:
    HCP1 GO Gene Synonym
    PCFT GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE

    Publications:

  • TTD: Proton-coupled folate transporter

    • Version: 2020.06.01

    Alternate Names:
    SLC46A1 TTD Gene Abbreviation
    T19229 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: SLC46A1

    • Version: 01-February-2022

    Alternate Names:
    Proton-coupled folate transporter Gene Name
    Q96NT5 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21