DGIdb - SLC46A1 Gene Record

SLC46A1 113235 Druggable Genome

Alternate Names:

113235
SOLUTE CARRIER FAMILY 46 MEMBER 1
SLC46A1
G21
HCP1
PCFT
611672
30521
ENSG00000076351
OTTHUMG00000179415
Q96NT5
1213
Proton-coupled folate transporter
NP_542400.2
PA162403775
T19229
MGC9564

Gene Info:

GuideToPharmacology Gene Category Name	SLC46 family of folate transporters
GuideToPharmacology Gene Category ID	235
Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

TRANSPORTER
CELL SURFACE
DRUGGABLE GENOME

Publications:

Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics
Wang L et al., 2015, 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors., J Med Chem
Wang L et al., 2011, Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase., J Med Chem

PEMETREXED SLC46A1

Interaction Score: 3.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26317331 21879757

Sources:
DTC
SULFASALAZINE SLC46A1

Interaction Score: 0.49

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
METHOTREXATE SLC46A1

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21317831

Sources:
PharmGKB TTD
INDOMETHACIN SLC46A1

Interaction Score: 0.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology

Ensembl: ENSG00000076351
- Version: 101_38
Alternate Names:

SLC46A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000076351
- Version: 26-July-2011
Alternate Names:

NP_542400.2 Display Id

ENSG00000076351 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
GuideToPharmacology: 113235
- Version: 29-September-2020
Alternate Names:

30521 HUGO Gene ID

30521 HUGO Gene Symbol

solute carrier family 46 member 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name SLC46 family of folate transporters

GuideToPharmacology Gene Category ID 235

Gene Categories:

TRANSPORTER

Publications:
PharmGKB: SLC46A1
- Version: 18-August-2020
Alternate Names:

PA162403775 PharmGKB ID

Gene Info:

Publications:

Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics

DTC: SLC46A1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Wang L et al., 2015, 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors., J Med Chem

Wang L et al., 2011, Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase., J Med Chem

HumanProteinAtlas: SLC46A1
- Version: 19.3
Alternate Names:

ENSG00000076351 Ensembl Gene ID

HCP1 Human Protein Atlas Gene Synonym

MGC9564 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

TRANSPORTER

Publications:
Pharos: SLC46A1
- Version: 03-September-2020
Alternate Names:

Proton-coupled folate transporter Gene Name

Q96NT5 UniProt ID

Gene Info:

Gene Categories:

TRANSPORTER

Publications:
GO: SLC46A1
- Version: 05-September-2020
Alternate Names:

HCP1 GO Gene Synonym

PCFT GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE

Publications:
TTD: Proton-coupled folate transporter
- Version: 2020.06.01
Alternate Names:

SLC46A1 TTD Gene Abbreviation

T19229 TTD Target ID

Gene Info:

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

30521	HUGO Gene ID
30521	HUGO Gene Symbol
solute carrier family 46 member 1	HUGO Gene Name

ENSG00000076351	Ensembl Gene ID
HCP1	Human Protein Atlas Gene Synonym
MGC9564	Human Protein Atlas Gene Synonym

SLC46A1 Gene Record

SLC46A1 113235 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

PEMETREXED SLC46A1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26317331 21879757

Sources: DTC

SULFASALAZINE SLC46A1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

METHOTREXATE SLC46A1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21317831

Sources: PharmGKB TTD

INDOMETHACIN SLC46A1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: GuideToPharmacology

Ensembl: ENSG00000076351

Alternate Names: SLC46A1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000076351

Alternate Names: NP_542400.2 Display Id ENSG00000076351 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

GuideToPharmacology: 113235

Alternate Names: 30521 HUGO Gene ID 30521 HUGO Gene Symbol solute carrier family 46 member 1 HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name SLC46 family of folate transporters GuideToPharmacology Gene Category ID 235

Gene Categories: TRANSPORTER

Publications:

PharmGKB: SLC46A1

Alternate Names: PA162403775 PharmGKB ID

Gene Info:

Publications: Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics

DTC: SLC46A1

Alternate Names:

Gene Info:

HumanProteinAtlas: SLC46A1

Alternate Names: ENSG00000076351 Ensembl Gene ID HCP1 Human Protein Atlas Gene Synonym MGC9564 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories: TRANSPORTER

Publications:

Pharos: SLC46A1

Alternate Names: Proton-coupled folate transporter Gene Name Q96NT5 UniProt ID

Gene Info:

Gene Categories: TRANSPORTER

Publications:

GO: SLC46A1

Alternate Names: HCP1 GO Gene Synonym PCFT GO Gene Synonym

Gene Info:

Gene Categories: CELL SURFACE

Publications:

TTD: Proton-coupled folate transporter

Alternate Names: SLC46A1 TTD Gene Abbreviation T19229 TTD Target ID

Gene Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
26317331 21879757

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
21317831

Sources:
PharmGKB TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology

Alternate Names:

SLC46A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

NP_542400.2 Display Id

ENSG00000076351 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

30521 HUGO Gene ID

30521 HUGO Gene Symbol

solute carrier family 46 member 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name SLC46 family of folate transporters

GuideToPharmacology Gene Category ID 235

Gene Categories:

TRANSPORTER

Alternate Names:

PA162403775 PharmGKB ID

Publications:

Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics

Alternate Names:

ENSG00000076351 Ensembl Gene ID

HCP1 Human Protein Atlas Gene Synonym

MGC9564 Human Protein Atlas Gene Synonym

Gene Categories:

TRANSPORTER

Alternate Names:

Proton-coupled folate transporter Gene Name

Q96NT5 UniProt ID

Gene Categories:

TRANSPORTER

Alternate Names:

HCP1 GO Gene Synonym

PCFT GO Gene Synonym

Gene Categories:

CELL SURFACE

Alternate Names:

SLC46A1 TTD Gene Abbreviation

T19229 TTD Target ID