DGIdb - SLC46A1 Gene Record

SLC46A1 113235 Druggable Genome

Alternate Names:

113235
SOLUTE CARRIER FAMILY 46 MEMBER 1
SLC46A1
G21
HCP1
PCFT
611672
30521
ENSG00000076351
OTTHUMG00000179415
Q96NT5
Proton-coupled folate transporter
NP_542400.2
PA162403775
T19229
MGC9564

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

TRANSPORTER
CELL SURFACE
DRUGGABLE GENOME

Publications:

Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics
Wang L et al., 2011, Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase., J Med Chem
Wang L et al., 2015, 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors., J Med Chem

PEMETREXED SLC46A1

Interaction Score: 6.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21879757 26317331

Sources:
DTC
METHOTREXATE SLC46A1

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21317831

Sources:
PharmGKB TTD

Ensembl: ENSG00000076351
- Version: 101_38
Alternate Names:

SLC46A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000076351
- Version: 26-July-2011
Alternate Names:

NP_542400.2 Display Id

ENSG00000076351 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
PharmGKB: SLC46A1
- Version: 18-August-2020
Alternate Names:

PA162403775 PharmGKB ID

Gene Info:

Publications:

Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics

DTC: SLC46A1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Wang L et al., 2015, 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors., J Med Chem

Wang L et al., 2011, Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase., J Med Chem

HumanProteinAtlas: SLC46A1
- Version: 19.3
Alternate Names:

ENSG00000076351 Ensembl Gene ID

HCP1 Human Protein Atlas Gene Synonym

MGC9564 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

TRANSPORTER

Publications:
GO: SLC46A1
- Version: 01-February-2022
Alternate Names:

HCP1 GO Gene Synonym

PCFT GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE

Publications:
TTD: Proton-coupled folate transporter
- Version: 2020.06.01
Alternate Names:

SLC46A1 TTD Gene Abbreviation

T19229 TTD Target ID

Gene Info:

Publications:
Pharos: SLC46A1
- Version: 01-February-2022
Alternate Names:

Proton-coupled folate transporter Gene Name

Q96NT5 UniProt ID

Gene Info:

Gene Categories:

TRANSPORTER

Publications:

ENSG00000076351	Ensembl Gene ID
HCP1	Human Protein Atlas Gene Synonym
MGC9564	Human Protein Atlas Gene Synonym

SLC46A1	TTD Gene Abbreviation
T19229	TTD Target ID

SLC46A1 Gene Record

SLC46A1 113235 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

PEMETREXED SLC46A1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21879757 26317331

Sources: DTC

METHOTREXATE SLC46A1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21317831

Sources: PharmGKB TTD

Ensembl: ENSG00000076351

Alternate Names: SLC46A1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000076351

Alternate Names: NP_542400.2 Display Id ENSG00000076351 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

PharmGKB: SLC46A1

Alternate Names: PA162403775 PharmGKB ID

Gene Info:

Publications: Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics

DTC: SLC46A1

Alternate Names:

Gene Info:

HumanProteinAtlas: SLC46A1

Alternate Names: ENSG00000076351 Ensembl Gene ID HCP1 Human Protein Atlas Gene Synonym MGC9564 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories: TRANSPORTER

Publications:

GO: SLC46A1

Alternate Names: HCP1 GO Gene Synonym PCFT GO Gene Synonym

Gene Info:

Gene Categories: CELL SURFACE

Publications:

TTD: Proton-coupled folate transporter

Alternate Names: SLC46A1 TTD Gene Abbreviation T19229 TTD Target ID

Gene Info:

Publications:

Pharos: SLC46A1

Alternate Names: Proton-coupled folate transporter Gene Name Q96NT5 UniProt ID

Gene Info:

Gene Categories: TRANSPORTER

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
21879757 26317331

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21317831

Sources:
PharmGKB TTD

Alternate Names:

SLC46A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

NP_542400.2 Display Id

ENSG00000076351 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PA162403775 PharmGKB ID

Publications:

Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics

Alternate Names:

ENSG00000076351 Ensembl Gene ID

HCP1 Human Protein Atlas Gene Synonym

MGC9564 Human Protein Atlas Gene Synonym

Gene Categories:

TRANSPORTER

Alternate Names:

HCP1 GO Gene Synonym

PCFT GO Gene Synonym

Gene Categories:

CELL SURFACE

Alternate Names:

SLC46A1 TTD Gene Abbreviation

T19229 TTD Target ID

Alternate Names:

Proton-coupled folate transporter Gene Name

Q96NT5 UniProt ID

Gene Categories:

TRANSPORTER