DGIdb - SLC2A4 Gene Record

SLC2A4 6517 Druggable Genome

Alternate Names:

6517
SOLUTE CARRIER FAMILY 2 MEMBER 4
SLC2A4
GLUT4
138190
11009
ENSG00000181856
OTTHUMG00000102181
878
P14672
Glucose transporter 4
SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER, MEMBER 4 (GLUCOSE TRANSPORTER TYPE 4, INSULIN-RESPONSIVE). [SOURCE:UNIPROT/SWISSPROT;ACC:P14672]
Glucose transporter type 4
T67658
Solute carrier family 2, facilitated glucose transporter member 4

Gene Info:

GuideToPharmacology Gene Category Name	Class I transporters
GuideToPharmacology Gene Category ID	165
Target Class	Transporters
Target Subclass	TC:2.A.1.1.80
Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

TRANSPORTER
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Lira et al., 2007, Nitric oxide increases GLUT4 expression and regulates AMPK signaling in skeletal muscle., Am. J. Physiol. Endocrinol. Metab.
Kondapaka et al., 2004, 7-hydroxystaurosporine (UCN-01) inhibition of Akt Thr308 but not Ser473 phosphorylation: a basis for decreased insulin-stimulated glucose transport., Clin. Cancer Res.
Somwar et al., 2001, Differential effects of phosphatidylinositol 3-kinase inhibition on intracellular signals regulating GLUT4 translocation and glucose transport., J. Biol. Chem.
Bose et al., Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c., Nature
Semiz et al., 2003, Conventional kinesin KIF5B mediates insulin-stimulated GLUT4 movements on microtubules., EMBO J.
Yan et al., 2008, [Induction of insulin resistance induced by PI-3K inhibitor in porcine granulosa cells]., Zhonghua Fu Chan Ke Za Zhi
Furuta et al., 2002, Troglitazone improves GLUT4 expression in adipose tissue in an animal model of obese type 2 diabetes mellitus., Diabetes Res. Clin. Pract.
Schmitz et al., 1994, Effects of glipizide on glucose metabolism and muscle content of the insulin-regulatable glucose transporter (GLUT 4) and glycogen synthase activity during hyperglycaemia in type 2 diabetic patients., Acta Diabetol
Egert et al., 1999, Contribution of alpha-adrenergic and beta-adrenergic stimulation to ischemia-induced glucose transporter (GLUT) 4 and GLUT1 translocation in the isolated perfused rat heart., Circ. Res.
Ros-Baro et al., 2001, Lipid rafts are required for GLUT4 internalization in adipose cells., Proc. Natl. Acad. Sci. U.S.A.
Young et al., 2002, Effects of rearing temperature on sympathoadrenal activity in young adult rats., Am. J. Physiol. Regul. Integr. Comp. Physiol.
Ohtake et al., 1995, Myocardial glucose metabolism in noninsulin-dependent diabetes mellitus patients evaluated by FDG-PET., J. Nucl. Med.
McFalls et al., Myocardial glucose uptake after dobutamine stress in chronic hibernating swine myocardium., J Nucl Cardiol
Song et al., Soluble dietary fibre improves insulin sensitivity by increasing muscle GLUT-4 content in stroke-prone spontaneously hypertensive rats., Clin. Exp. Pharmacol. Physiol.
Vettor et al., 2000, Substrate competition and insulin action in animal models., Int. J. Obes. Relat. Metab. Disord.
Long et al., 1996, Regulation of GLUT4 gene expression by arachidonic acid. Evidence for multiple pathways, one of which requires oxidation to prostaglandin E2., J. Biol. Chem.
Sajan et al., 2002, Sorbitol activates atypical protein kinase C and GLUT4 glucose transporter translocation/glucose transport through proline-rich tyrosine kinase-2, the extracellular signal-regulated kinase pathway and phospholipase D., Biochem. J.
Shimoyama et al., 2006, Gliclazide protects 3T3L1 adipocytes against insulin resistance induced by hydrogen peroxide with restoration of GLUT4 translocation., Metab. Clin. Exp.
Jacob et al., 1996, Effects of trandolapril and verapamil on glucose transport in insulin-resistant rat skeletal muscle., Metab. Clin. Exp.
Goto et al., 1997, Effect of triiodothyronine on glucose transport in rat adipocytes., Life Sci.
Chen et al., 2002, Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport., J. Biol. Chem.
Huang et al., 2005, Disruption of microtubules ablates the specificity of insulin signaling to GLUT4 translocation in 3T3-L1 adipocytes., J. Biol. Chem.
Hawkins et al., 1997, The tissue concentration of UDP-N-acetylglucosamine modulates the stimulatory effect of insulin on skeletal muscle glucose uptake., J. Biol. Chem.
Nomura et al., 2008, Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells., Biol. Pharm. Bull.
Hellwig et al., 1991, Differentiation of erythrocyte-(GLUT1), liver-(GLUT2), and adipocyte-type (GLUT4) glucose transporters by binding of the inhibitory ligands cytochalasin B, forskolin, dipyridamole, and isobutylmethylxanthine., Mol. Pharmacol.
Tarn et al., 2006, Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms., Cancer Res.
Ledwig et al., 2002, Early acarbose treatment ameliorates resistance of insulin-regulated GLUT4 trafficking in obese Zucker rats., Eur. J. Pharmacol.
Sato et al., 2008, Testosterone and DHEA activate the glucose metabolism-related signaling pathway in skeletal muscle., Am. J. Physiol. Endocrinol. Metab.
Hruz et al., 2002, Indinavir induces acute and reversible peripheral insulin resistance in rats., Diabetes
Maor et al., 1999, The insulin-sensitive glucose transporter (GLUT4) is involved in early bone growth in control and diabetic mice, but is regulated through the insulin-like growth factor I receptor., Endocrinology
Dombrowski et al., 1998, Selective impairment in GLUT4 translocation to transverse tubules in skeletal muscle of streptozotocin-induced diabetic rats., Diabetes
Pedersen et al., 1990, Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM., Diabetes
Date et al., 2005, Expression of constitutively stable hybrid hypoxia-inducible factor-1alpha protects cultured rat cardiomyocytes against simulated ischemia-reperfusion injury., Am. J. Physiol., Cell Physiol.
Ordóñez et al., 2007, Insulin sensitivity in streptozotocin-induced diabetic rats treated with different doses of 17beta-oestradiol or progesterone., Exp. Physiol.
Lekli et al., 2008, Protective mechanisms of resveratrol against ischemia-reperfusion-induced damage in hearts obtained from Zucker obese rats: the role of GLUT-4 and endothelin., Am. J. Physiol. Heart Circ. Physiol.
James et al., 2004, Neomycin prevents the wortmannin inhibition of insulin-stimulated Glut4 translocation and glucose transport in 3T3-L1 adipocytes., J. Biol. Chem.
Heiser et al., 2006, Effects of different antipsychotics and the antidepressant mirtazapine on glucose transporter mRNA levels in human blood cells., J Psychiatr Res
Robinson et al., 1993, Pre-exposure to glucosamine induces insulin resistance of glucose transport and glycogen synthesis in isolated rat skeletal muscles. Study of mechanisms in muscle and in rat-1 fibroblasts overexpressing the human insulin receptor., Diabetes
Noguchi et al., 1998, Insulin resistance in cancer patients is associated with enhanced tumor necrosis factor-alpha expression in skeletal muscle., Biochem. Biophys. Res. Commun.
Stephens et al., 1997, Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction., J. Biol. Chem.
Abe et al., 2001, Postnatal development of glucose transporter proteins in bovine skeletal muscle and adipose tissue., J. Vet. Med. Sci.
Cao et al., 2007, Green tea polyphenol extract regulates the expression of genes involved in glucose uptake and insulin signaling in rats fed a high fructose diet., J. Agric. Food Chem.
Müller et al., 1993, The sulfonylurea drug, glimepiride, stimulates glucose transport, glucose transporter translocation, and dephosphorylation in insulin-resistant rat adipocytes in vitro., Diabetes
Kahn et al., 1991, Decreased in vivo glucose uptake but normal expression of GLUT1 and GLUT4 in skeletal muscle of diabetic rats., J. Clin. Invest.
Barros et al., 2006, Muscle GLUT4 regulation by estrogen receptors ERbeta and ERalpha., Proc. Natl. Acad. Sci. U.S.A.
Bouzakri et al., 2007, MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance., J. Biol. Chem.
D'Alessandris et al., 2007, C-reactive protein induces phosphorylation of insulin receptor substrate-1 on Ser307 and Ser 612 in L6 myocytes, thereby impairing the insulin signalling pathway that promotes glucose transport., Diabetologia
Fernández-Veledo et al., 2006, Ceramide mediates TNF-alpha-induced insulin resistance on GLUT4 gene expression in brown adipocytes., Arch. Physiol. Biochem.
Thorell et al., 1999, Surgery-induced insulin resistance in human patients: relation to glucose transport and utilization., Am. J. Physiol.
Miura et al., 2003, Regulatory sequence elements of mouse GLUT4 gene expression in adipose tissues., Biochem. Biophys. Res. Commun.
Wu et al., 2004, Green tea supplementation ameliorates insulin resistance and increases glucose transporter IV content in a fructose-fed rat model., Eur J Nutr
Watson et al., 2001, Transmembrane domain length determines intracellular membrane compartment localization of syntaxins 3, 4, and 5., Am. J. Physiol., Cell Physiol.
Anai et al., 1998, Different subcellular distribution and regulation of expression of insulin receptor substrate (IRS)-3 from those of IRS-1 and IRS-2., J. Biol. Chem.
Das, 1999, GLUT-4, tumour necrosis factor, essential fatty acids and daf-genes and their role in glucose homeostasis, insulin resistance, non-insulin dependent diabetes mellitus, and longevity., J Assoc Physicians India
Liu et al., 2007, Myricetin, a naturally occurring flavonol, ameliorates insulin resistance induced by a high-fructose diet in rats., Life Sci.
Pedersen et al., 1991, High fat feeding causes insulin resistance and a marked decrease in the expression of glucose transporters (Glut 4) in fat cells of rats., Endocrinology
Kaburagi et al., 1999, The mechanism of insulin-induced signal transduction mediated by the insulin receptor substrate family., Endocr. J.
Garvey et al., 1991, Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity., J. Clin. Invest.
Gaster et al., 2001, GLUT4 is reduced in slow muscle fibers of type 2 diabetic patients: is insulin resistance in type 2 diabetes a slow, type 1 fiber disease?, Diabetes
Hernandez et al., 2004, Rosiglitazone ameliorates insulin resistance in brown adipocytes of Wistar rats by impairing TNF-alpha induction of p38 and p42/p44 mitogen-activated protein kinases., Diabetologia
Kim et al., 1999, Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle., Diabetes
Torrance et al., 1997, Effects of thyroid hormone on GLUT4 glucose transporter gene expression and NIDDM in rats., Endocrinology
Garvey et al., 1998, Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance., J. Clin. Invest.
Tejero et al., 2004, Quantitative genetic analysis of glucose transporter 4 mRNA levels in baboon adipose., Obes. Res.
Bader et al., 1992, Normal insulin receptor tyrosine kinase activity and glucose transporter (GLUT 4) levels in the skeletal muscle of hyperinsulinaemic hypertensive rats., Diabetologia
Kono-Sugita et al., 1996, Insulin-induced GLUT4 recycling in rat adipose cells by a pathway insensitive to brefeldin A., Eur. J. Biochem.
Kahn et al., 1993, Suppression of GLUT4 expression in skeletal muscle of rats that are obese from high fat feeding but not from high carbohydrate feeding or genetic obesity., Endocrinology
Etgen et al., 1997, Exercise training reverses insulin resistance in muscle by enhanced recruitment of GLUT-4 to the cell surface., Am. J. Physiol.
Hirshman et al., 1995, Pioglitazone treatment for 7 days failed to correct the defect in glucose transport and glucose transporter translocation in obese Zucker rat (fa/fa) skeletal muscle plasma membranes., Biochem. Biophys. Res. Commun.
Buse et al., 1997, Increased activity of the hexosamine synthesis pathway in muscles of insulin-resistant ob/ob mice., Am. J. Physiol.
Deng et al., 2007, Impairment of cardiac insulin signaling and myocardial contractile performance in high-cholesterol/fructose-fed rats., Am. J. Physiol. Heart Circ. Physiol.
Ricort et al., 1994, Parallel changes in Glut 4 and Rab4 movements in two insulin-resistant states., FEBS Lett.
de Carvalho Papa et al., 2002, GLUT4 protein is differently modulated during development of obesity in monosodium glutamate-treated mice., Life Sci.
Park et al., 2007, The depletion of cellular mitochondrial DNA causes insulin resistance through the alteration of insulin receptor substrate-1 in rat myocytes., Diabetes Res. Clin. Pract.
Yoshikawa et al., Insulin resistance and the alterations of glucose transporter-4 in adipose cells from cachectic tumor-bearing rats., JPEN J Parenter Enteral Nutr
Jaquet et al., 2001, Impaired regulation of glucose transporter 4 gene expression in insulin resistance associated with in utero undernutrition., J. Clin. Endocrinol. Metab.
Shimaya et al., 1997, Insulin sensitizer YM268 ameliorates insulin resistance by normalizing the decreased content of GLUT4 in adipose tissue of obese Zucker rats., Eur. J. Endocrinol.
Seraphim et al., 2007, Age related obesity-induced shortening of GLUT4 mRNA poly(A) tail length in rat gastrocnemius skeletal muscle., Mol. Cell. Endocrinol.
Kozka et al., 1991, Chronic treatment with insulin selectively down-regulates cell-surface GLUT4 glucose transporters in 3T3-L1 adipocytes., J. Biol. Chem.
Paternostro et al., 1995, Decreased GLUT-4 mRNA content and insulin-sensitive deoxyglucose uptake show insulin resistance in the hypertensive rat heart., Cardiovasc. Res.
Thamotharan et al., 2003, Aberrant insulin-induced GLUT4 translocation predicts glucose intolerance in the offspring of a diabetic mother., Am. J. Physiol. Endocrinol. Metab.
Ivy, 2004, Muscle insulin resistance amended with exercise training: role of GLUT4 expression., Med Sci Sports Exerc
Maier et al., 2000, Long-term insulin treatment of 3T3-L1 adipocytes results in mis-targeting of GLUT4: implications for insulin-stimulated glucose transport., Diabetologia
Carvalho et al., 2000, Insulin resistance in fat cells from obese Zucker rats--evidence for an impaired activation and translocation of protein kinase B and glucose transporter 4., Mol. Cell. Biochem.
James et al., 2001, Skeletal muscle of stroke-prone spontaneously hypertensive rats exhibits reduced insulin-stimulated glucose transport and elevated levels of caveolin and flotillin., Diabetes
Thompson et al., 1996, Insulin regulation of multiple ribonucleic acid species in human skeletal muscle in insulin-sensitive and insulin-resistant subjects., J. Clin. Endocrinol. Metab.
Seböková et al., 1995, Decreased glucose transporter protein (GLUT4) in skeletal muscle of hypertriglyceridaemic insulin-resistant rat., Physiol Res
Livingstone et al., 1995, Hypothalamic GLUT 4 expression: a glucose- and insulin-sensing mechanism?, Mol. Cell. Endocrinol.
Weinstein et al., 1993, Effects of thiazolidinediones on glucocorticoid-induced insulin resistance and GLUT4 glucose transporter expression in rat skeletal muscle., Metab. Clin. Exp.
Das, 2005, A defect in the activity of Delta6 and Delta5 desaturases may be a factor predisposing to the development of insulin resistance syndrome., Prostaglandins Leukot. Essent. Fatty Acids
Brichard et al., 1992, Vanadate treatment markedly increases glucose utilization in muscle of insulin-resistant fa/fa rats without modifying glucose transporter expression., Endocrinology
Baron et al., 1995, Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle. Implications for glucose toxicity., J. Clin. Invest.
Krook et al., 2004, Sending the signal: molecular mechanisms regulating glucose uptake., Med Sci Sports Exerc
Bähr et al., 1995, Direct stimulation of myocardial glucose transport and glucose transporter-1 (GLUT1) and GLUT4 protein expression by the sulfonylurea glimepiride., Endocrinology
Foran et al., 1999, Protein kinase B stimulates the translocation of GLUT4 but not GLUT1 or transferrin receptors in 3T3-L1 adipocytes by a pathway involving SNAP-23, synaptobrevin-2, and/or cellubrevin., J. Biol. Chem.
Qin et al., 2007, Voluntary running improves in vivo insulin resistance in high-salt diet fed rats., Exp. Biol. Med. (Maywood)
Vahsen et al., 2006, Altered GLUT4 translocation in skeletal muscle of 12/15-lipoxygenase knockout mice., Horm. Metab. Res.
Cusin et al., 1990, Hyperinsulinemia increases the amount of GLUT4 mRNA in white adipose tissue and decreases that of muscles: a clue for increased fat depot and insulin resistance., Endocrinology
Uphues et al., 1995, Failure of insulin-regulated recruitment of the glucose transporter GLUT4 in cardiac muscle of obese Zucker rats is associated with alterations of small-molecular-mass GTP-binding proteins., Biochem. J.
Fernández-Veledo et al., 2006, Liver X receptor agonists ameliorate TNFalpha-induced insulin resistance in murine brown adipocytes by downregulating protein tyrosine phosphatase-1B gene expression., Diabetologia
Hansen et al., 1998, A high fat diet impairs stimulation of glucose transport in muscle. Functional evaluation of potential mechanisms., J. Biol. Chem.
Matthaei et al., 1993, In vivo metformin treatment ameliorates insulin resistance: evidence for potentiation of insulin-induced translocation and increased functional activity of glucose transporters in obese (fa/fa) Zucker rat adipocytes., Endocrinology
Strobel et al., 2005, Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes., Biochem. J.
Haber et al., 1992, Role of glucose transporters in glucocorticoid-induced insulin resistance. GLUT4 isoform in rat skeletal muscle is not decreased by dexamethasone., Diabetes
Sato et al., 1997, Plasma membrane content of insulin-regulated glucose transporter in skeletal muscle of the male Otsuka Long-Evans Tokushima Fatty rat, a model of non-insulin-dependent diabetes mellitus., FEBS Lett.
Katayama et al., 1997, Glucose intolerance in spontaneously hypertensive and Wistar-Kyoto rats: enhanced gene expression and synthesis of skeletal muscle glucose transporter 4., Hypertens. Res.
Cohen, 2008, Obesity in men: the hypogonadal-estrogen receptor relationship and its effect on glucose homeostasis., Med. Hypotheses
Storz et al., 1999, Cross-talk mechanisms in the development of insulin resistance of skeletal muscle cells palmitate rather than tumour necrosis factor inhibits insulin-dependent protein kinase B (PKB)/Akt stimulation and glucose uptake., Eur. J. Biochem.
Smith et al., 1997, Growth hormone-induced insulin resistance: role of the insulin receptor, IRS-1, GLUT-1, and GLUT-4., Am. J. Physiol.
Didyk et al., 1994, Effect of immobilization on glucose transporter expression in rat hindlimb muscles., Metab. Clin. Exp.
Maier et al., 2000, v- and t-SNARE protein expression in models of insulin resistance: normalization of glycemia by rosiglitazone treatment corrects overexpression of cellubrevin, vesicle-associated membrane protein-2, and syntaxin 4 in skeletal muscle of Zucker diabetic fatty rats., Diabetes
Koster et al., 2003, HIV protease inhibitors acutely impair glucose-stimulated insulin release., Diabetes
Zanquetta et al., 2003, Calorie restriction reduces pinealectomy-induced insulin resistance by improving GLUT4 gene expression and its translocation to the plasma membrane., J. Pineal Res.
Jensterle et al., 2008, Impact of metformin and rosiglitazone treatment on glucose transporter 4 mRNA expression in women with polycystic ovary syndrome., Eur. J. Endocrinol.
Ferreras et al., 1994, Early decrease in GLUT4 protein levels in brown adipose tissue of New Zealand obese mice., Int. J. Obes. Relat. Metab. Disord.
Schalin-Jäntti et al., 1994, Effect of insulin on GLUT-4 mRNA and protein concentrations in skeletal muscle of patients with NIDDM and their first-degree relatives., Diabetologia
Yoshikawa et al., 1999, Inhibition of IRS-1 phosphorylation and the alterations of GLUT4 in isolated adipocytes from cachectic tumor-bearing rats., Biochem. Biophys. Res. Commun.
Florholmen et al., 2006, Leukaemia inhibitory factor stimulates glucose transport in isolated cardiomyocytes and induces insulin resistance after chronic exposure., Diabetologia
Dalen et al., 2003, Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha., J. Biol. Chem.
Li et al., 2000, Reduced glucose uptake precedes insulin signaling defects in adipocytes from heterozygous GLUT4 knockout mice., FASEB J.
Vargas et al., 2004, Abnormal subcellular distribution of GLUT4 protein in obese and insulin-treated diabetic female dogs., Braz. J. Med. Biol. Res.
Tsao et al., 1996, Enhanced insulin action due to targeted GLUT4 overexpression exclusively in muscle., Diabetes
Cheng et al., 2004, In vitro and in vivo prevention of HIV protease inhibitor-induced insulin resistance by a novel small molecule insulin receptor activator., J. Cell. Biochem.
Brozinick et al., 1994, Glucose uptake and GLUT-4 protein distribution in skeletal muscle of the obese Zucker rat., Am. J. Physiol.
Friedman et al., 1991, Muscle insulin resistance in uremic humans: glucose transport, glucose transporters, and insulin receptors., Am. J. Physiol.
Rett et al., 1996, Insulin-induced glucose transporter (GLUT1 and GLUT4) translocation in cardiac muscle tissue is mimicked by bradykinin., Diabetes
Marshall et al., 1999, GLUT-1 or GLUT-4 transgenes in obese mice improve glucose tolerance but do not prevent insulin resistance., Am. J. Physiol.
Nishimura et al., 1994, Staurosporine inhibits phorbol 12-myristate 13-acetate- and insulin-stimulated translocation of GLUT1 and GLUT4 glucose transporters in rat adipose cells., Biochem. J.
Smith et al., 1993, Genistein inhibits insulin-stimulated glucose transport and decreases immunocytochemical labeling of GLUT4 carboxyl-terminus without affecting translocation of GLUT4 in isolated rat adipocytes: additional evidence of GLUT4 activation by insulin., Arch. Biochem. Biophys.
Ikonomov et al., 2002, Requirement for PIKfyve enzymatic activity in acute and long-term insulin cellular effects., Endocrinology
Fliegner et al., 2008, Up-regulation of PPARgamma in myocardial infarction., Eur. J. Heart Fail.
Kern et al., 1993, Increased muscle glucose uptake in response to chronic glyburide treatment is not related to changes in glucose transporter (GLUT4) protein., Int. J. Biochem.
Lapointe et al., 2005, Effects of the vasopeptidase inhibitor omapatrilat on peri- and postmyocardial infarction in Zucker lean rats., Can J Cardiol

INSULIN SLC2A4

Interaction Score: 2.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8349045 7884509 9918825 8995390 11714021 17616136 8243832 2040701 16423895 17227768 17279354 16754199 10198313 14637133 15083319 11401844 9792680 10778531 17976658 1855475 12054114 1999488 11375332 15365619 10334307 12490950 9048628 9616209 15536229 1324860 8665891 8419118 9176187 7695642 9227455 17400720 8013658 12175706 17462778 9406133 11443199 9437239 17709177 2050674 7585807 12540375 15235327 11079746 10839189 11522683 8636261 8789319 7796936 8412752 15850715 1612011 8675649 15235328 11916910 7750476 10497159 9421368 17959846 16823721 2249650 7575448 17072583 9748297 8391425 15469417 1587399 9175878 9453263 17825496 10542046 9227454 7968595 10871200 12829635 12932196 18322300 7866477 8063042 10080958 16489447 12970362 10834933 15264018 8522056 15258906 18366935 8048627 1858877 8529803 9950801

Sources:
NCI
OMAPATRILAT SLC2A4

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15776120

Sources:
NCI
SORBITOL SLC2A4

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11879194

Sources:
NCI
PSYLLIUM SEED HUSKS SLC2A4

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10696527

Sources:
NCI
NYSTATIN SLC2A4

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11593015

Sources:
NCI
FLUDEOXYGLUCOSE-F18 SLC2A4

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7884509 12900743

Sources:
NCI
SOYBEAN OIL SLC2A4

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10997602

Sources:
NCI
NEOMYCIN SLC2A4

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15024008

Sources:
NCI
ETOPOSIDE PHOSPHATE SLC2A4

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15496478

Sources:
NCI
ACARBOSE SLC2A4

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12065205

Sources:
NCI
PENICILLAMINE SLC2A4

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17666490

Sources:
NCI
GLIPIZIDE SLC2A4

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8043894

Sources:
NCI
URIDINE SLC2A4

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9030547

Sources:
NCI
INDINAVIR SLC2A4

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11916910

Sources:
NCI
IRBESARTAN SLC2A4

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18162196

Sources:
NCI
PHENTOLAMINE SLC2A4

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10381893

Sources:
NCI
WORTMANNIN SLC2A4

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11598141 12490950 12743033 18366935

Sources:
NCI
CLOFIBRATE SLC2A4

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8557642

Sources:
NCI
GLUFOSFAMIDE SLC2A4

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name Glufosfamide

PMIDs:
None found

Sources:
TdgClinicalTrial
UCN-01 SLC2A4

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15534092

Sources:
NCI
MIRTAZAPINE SLC2A4

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16002093

Sources:
NCI
GLYBURIDE SLC2A4

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8224371

Sources:
NCI
STREPTOZOCIN SLC2A4

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10098523 9421368 2354749

Sources:
NCI
ACETYLCYSTEINE SLC2A4

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16713429

Sources:
NCI
PRASTERONE SLC2A4

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18349113

Sources:
NCI
EPIGALOCATECHIN GALLATE SLC2A4

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18591783

Sources:
NCI
LIOTHYRONINE SODIUM SLC2A4

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9217278

Sources:
NCI
EPINEPHRINE SLC2A4

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12376414

Sources:
NCI
ESTRADIOL SLC2A4

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17068109

Sources:
NCI
TROGLITAZONE SLC2A4

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11947963

Sources:
NCI
CHEMBL35482 SLC2A4

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11978788

Sources:
NCI
HEPARIN SLC2A4

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10997602

Sources:
NCI
INDOMETHACIN SLC2A4

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8557642

Sources:
NCI
COLCHICINE SLC2A4

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16239226

Sources:
NCI
VERAPAMIL SLC2A4

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8622594

Sources:
NCI
STAUROSPORINE SLC2A4

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8068015

Sources:
NCI
DIPYRIDAMOLE SLC2A4

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1716731

Sources:
NCI
GENISTEIN SLC2A4

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8424658

Sources:
NCI
RESVERATROL SLC2A4

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18065527

Sources:
NCI
IMATINIB SLC2A4

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16707477

Sources:
NCI
CURCUMIN SLC2A4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12446602

Sources:
NCI
PROGESTERONE SLC2A4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17068109

Sources:
NCI
HALOPERIDOL SLC2A4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16002093

Sources:
NCI
DEXAMETHASONE SLC2A4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1587399

Sources:
NCI

Ensembl: ENSG00000181856
- Version: 101_38
Alternate Names:

SLC2A4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000181856

Version: 26-July-2011

Alternate Names:

SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER, MEMBER 4 (GLUCOSE TRANSPORTER TYPE 4, INSULIN-RESPONSIVE). [SOURCE:UNIPROT/SWISSPROT;ACC:P14672] Description

ENSG00000181856 Ensembl Gene Id

SLC2A4 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P14672
- Version: January-2014
Alternate Names:

SLC2A4 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:2.A.1.1.80

Publications:
GuideToPharmacology: 6517
- Version: 29-September-2020
Alternate Names:

11009 HUGO Gene ID

11009 HUGO Gene Symbol

solute carrier family 2 member 4 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Class I transporters

GuideToPharmacology Gene Category ID 165

Gene Categories:

TRANSPORTER

Publications:

NCI: SLC2A4

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Furuta et al., 2002, Troglitazone improves GLUT4 expression in adipose tissue in an animal model of obese type 2 diabetes mellitus., Diabetes Res. Clin. Pract.

Song et al., Soluble dietary fibre improves insulin sensitivity by increasing muscle GLUT-4 content in stroke-prone spontaneously hypertensive rats., Clin. Exp. Pharmacol. Physiol.

Chen et al., 2002, Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport., J. Biol. Chem.

HingoraniCasas: ENSG00000181856
- Version: 31-May-2017
Alternate Names:

ENSG00000181856 Gene Symbol

SLC2A4 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: SLC2A4
- Version: 19.3
Alternate Names:

ENSG00000181856 Ensembl Gene ID

GLUT4 Human Protein Atlas Gene Synonym

Solute carrier family 2 member 4 Human Protein Atlas Gene Description

Gene Info:

Gene Categories:

TRANSPORTER

Publications:
Pharos: SLC2A4
- Version: 03-September-2020
Alternate Names:

Solute carrier family 2, facilitated glucose transporter member 4 Gene Name

P14672 UniProt ID

Gene Info:

Gene Categories:

TRANSPORTER

Publications:
GO: SLC2A4
- Version: 05-September-2020
Alternate Names:

GLUT4 GO Gene Synonym

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
TTD: Glucose transporter type 4
- Version: 2020.06.01
Alternate Names:

SLC2A4 TTD Gene Abbreviation

T67658 TTD Target ID

Gene Info:

Publications:

SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER, MEMBER 4 (GLUCOSE TRANSPORTER TYPE 4, INSULIN-RESPONSIVE). [SOURCE:UNIPROT/SWISSPROT;ACC:P14672]	Description
ENSG00000181856	Ensembl Gene Id
SLC2A4	Display Id

11009	HUGO Gene ID
11009	HUGO Gene Symbol
solute carrier family 2 member 4	HUGO Gene Name

Solute carrier family 2, facilitated glucose transporter member 4	Gene Name
P14672	UniProt ID

SLC2A4 Gene Record

SLC2A4 6517 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15776120

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11879194

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10696527

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11593015

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7884509 12900743

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10997602

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15024008

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15496478

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12065205

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17666490

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8043894

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9030547

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11916910

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18162196

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10381893

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11598141 12490950 12743033 18366935

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8557642

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Novel Target Trial Name Glufosfamide

PMIDs: None found

Interaction Types & Directionality:

n/a

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15776120

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11879194

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10696527

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11593015

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7884509 12900743

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10997602

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15024008

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15496478

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12065205

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17666490

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8043894

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9030547

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11916910

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18162196

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10381893

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11598141 12490950 12743033 18366935

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8557642

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name Glufosfamide

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
15534092

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16002093

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8224371

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10098523 9421368 2354749

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16713429

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18349113

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18591783

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9217278