DGIdb - SLC2A4 Gene Record

TdgClinicalTrial: P14672
- Version: January-2014
Alternate Names:

SLC2A4 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:2.A.1.1.80

Publications:
GuideToPharmacology: 6517
- Version: 29-September-2020
Alternate Names:

11009 HUGO Gene ID

11009 HUGO Gene Symbol

solute carrier family 2 member 4 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Class I transporters

GuideToPharmacology Gene Category ID 165

Gene Categories:

TRANSPORTER

Publications:

NCI: SLC2A4

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Furuta et al., 2002, Troglitazone improves GLUT4 expression in adipose tissue in an animal model of obese type 2 diabetes mellitus., Diabetes Res. Clin. Pract.

Song et al., Soluble dietary fibre improves insulin sensitivity by increasing muscle GLUT-4 content in stroke-prone spontaneously hypertensive rats., Clin. Exp. Pharmacol. Physiol.

Chen et al., 2002, Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport., J. Biol. Chem.

HingoraniCasas: ENSG00000181856
- Version: 31-May-2017
Alternate Names:

ENSG00000181856 Gene Symbol

SLC2A4 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: SLC2A4
- Version: 19.3
Alternate Names:

ENSG00000181856 Ensembl Gene ID

GLUT4 Human Protein Atlas Gene Synonym

Solute carrier family 2 member 4 Human Protein Atlas Gene Description

Gene Info:

Gene Categories:

TRANSPORTER

Publications:
Pharos: SLC2A4
- Version: 03-September-2020
Alternate Names:

Solute carrier family 2, facilitated glucose transporter member 4 Gene Name

P14672 UniProt ID

Gene Info:

Gene Categories:

TRANSPORTER

Publications:
GO: SLC2A4
- Version: 05-September-2020
Alternate Names:

GLUT4 GO Gene Synonym

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
TTD: Glucose transporter type 4
- Version: 2020.06.01
Alternate Names:

SLC2A4 TTD Gene Abbreviation

T67658 TTD Target ID

Gene Info:

Publications:

GuideToPharmacology Gene Category Name	Class I transporters
GuideToPharmacology Gene Category ID	165
Target Class	Transporters
Target Subclass	TC:2.A.1.1.80
Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER, MEMBER 4 (GLUCOSE TRANSPORTER TYPE 4, INSULIN-RESPONSIVE). [SOURCE:UNIPROT/SWISSPROT;ACC:P14672]	Description
ENSG00000181856	Ensembl Gene Id
SLC2A4	Display Id

11009	HUGO Gene ID
11009	HUGO Gene Symbol
solute carrier family 2 member 4	HUGO Gene Name

ENSG00000181856	Ensembl Gene ID
GLUT4	Human Protein Atlas Gene Synonym
Solute carrier family 2 member 4	Human Protein Atlas Gene Description

Solute carrier family 2, facilitated glucose transporter member 4	Gene Name
P14672	UniProt ID

TRANSPORTER
CELL SURFACE
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Novel drug target	Novel Target
Trial Name	Glufosfamide

SLC2A4 Gene Record

SLC2A4 6517 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Novel Target Trial Name Glufosfamide

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Lira et al., 2007, Nitric oxide increases GLUT4 expression and regulates AMPK signaling in skeletal muscle., Am. J. Physiol. Endocrinol. Metab.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Kondapaka et al., 2004, 7-hydroxystaurosporine (UCN-01) inhibition of Akt Thr308 but not Ser473 phosphorylation: a basis for decreased insulin-stimulated glucose transport., Clin. Cancer Res.

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Furuta et al., 2002, Troglitazone improves GLUT4 expression in adipose tissue in an animal model of obese type 2 diabetes mellitus., Diabetes Res. Clin. Pract.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Schmitz et al., 1994, Effects of glipizide on glucose metabolism and muscle content of the insulin-regulatable glucose transporter (GLUT 4) and glycogen synthase activity during hyperglycaemia in type 2 diabetic patients., Acta Diabetol

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Egert et al., 1999, Contribution of alpha-adrenergic and beta-adrenergic stimulation to ischemia-induced glucose transporter (GLUT) 4 and GLUT1 translocation in the isolated perfused rat heart., Circ. Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Ros-Baro et al., 2001, Lipid rafts are required for GLUT4 internalization in adipose cells., Proc. Natl. Acad. Sci. U.S.A.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Young et al., 2002, Effects of rearing temperature on sympathoadrenal activity in young adult rats., Am. J. Physiol. Regul. Integr. Comp. Physiol.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Ohtake et al., 1995, Myocardial glucose metabolism in noninsulin-dependent diabetes mellitus patients evaluated by FDG-PET., J. Nucl. Med. McFalls et al., Myocardial glucose uptake after dobutamine stress in chronic hibernating swine myocardium., J Nucl Cardiol

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Song et al., Soluble dietary fibre improves insulin sensitivity by increasing muscle GLUT-4 content in stroke-prone spontaneously hypertensive rats., Clin. Exp. Pharmacol. Physiol.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Vettor et al., 2000, Substrate competition and insulin action in animal models., Int. J. Obes. Relat. Metab. Disord.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Long et al., 1996, Regulation of GLUT4 gene expression by arachidonic acid. Evidence for multiple pathways, one of which requires oxidation to prostaglandin E2., J. Biol. Chem.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Sajan et al., 2002, Sorbitol activates atypical protein kinase C and GLUT4 glucose transporter translocation/glucose transport through proline-rich tyrosine kinase-2, the extracellular signal-regulated kinase pathway and phospholipase D., Biochem. J.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Shimoyama et al., 2006, Gliclazide protects 3T3L1 adipocytes against insulin resistance induced by hydrogen peroxide with restoration of GLUT4 translocation., Metab. Clin. Exp.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Jacob et al., 1996, Effects of trandolapril and verapamil on glucose transport in insulin-resistant rat skeletal muscle., Metab. Clin. Exp.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Goto et al., 1997, Effect of triiodothyronine on glucose transport in rat adipocytes., Life Sci.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Chen et al., 2002, Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport., J. Biol. Chem.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Huang et al., 2005, Disruption of microtubules ablates the specificity of insulin signaling to GLUT4 translocation in 3T3-L1 adipocytes., J. Biol. Chem.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Hawkins et al., 1997, The tissue concentration of UDP-N-acetylglucosamine modulates the stimulatory effect of insulin on skeletal muscle glucose uptake., J. Biol. Chem.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Nomura et al., 2008, Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells., Biol. Pharm. Bull.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Hellwig et al., 1991, Differentiation of erythrocyte-(GLUT1), liver-(GLUT2), and adipocyte-type (GLUT4) glucose transporters by binding of the inhibitory ligands cytochalasin B, forskolin, dipyridamole, and isobutylmethylxanthine., Mol. Pharmacol.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Tarn et al., 2006, Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms., Cancer Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Ledwig et al., 2002, Early acarbose treatment ameliorates resistance of insulin-regulated GLUT4 trafficking in obese Zucker rats., Eur. J. Pharmacol.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Sato et al., 2008, Testosterone and DHEA activate the glucose metabolism-related signaling pathway in skeletal muscle., Am. J. Physiol. Endocrinol. Metab.

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name Glufosfamide

Interaction Types & Directionality:

n/a

Publications:

Lira et al., 2007, Nitric oxide increases GLUT4 expression and regulates AMPK signaling in skeletal muscle., Am. J. Physiol. Endocrinol. Metab.

Interaction Types & Directionality:

n/a

Publications:

Kondapaka et al., 2004, 7-hydroxystaurosporine (UCN-01) inhibition of Akt Thr308 but not Ser473 phosphorylation: a basis for decreased insulin-stimulated glucose transport., Clin. Cancer Res.

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

Furuta et al., 2002, Troglitazone improves GLUT4 expression in adipose tissue in an animal model of obese type 2 diabetes mellitus., Diabetes Res. Clin. Pract.

Interaction Types & Directionality:

n/a

Publications:

Schmitz et al., 1994, Effects of glipizide on glucose metabolism and muscle content of the insulin-regulatable glucose transporter (GLUT 4) and glycogen synthase activity during hyperglycaemia in type 2 diabetic patients., Acta Diabetol

Interaction Types & Directionality:

n/a

Publications:

Egert et al., 1999, Contribution of alpha-adrenergic and beta-adrenergic stimulation to ischemia-induced glucose transporter (GLUT) 4 and GLUT1 translocation in the isolated perfused rat heart., Circ. Res.

Interaction Types & Directionality:

n/a

Publications:

Ros-Baro et al., 2001, Lipid rafts are required for GLUT4 internalization in adipose cells., Proc. Natl. Acad. Sci. U.S.A.

Interaction Types & Directionality:

n/a

Publications:

Young et al., 2002, Effects of rearing temperature on sympathoadrenal activity in young adult rats., Am. J. Physiol. Regul. Integr. Comp. Physiol.

Interaction Types & Directionality:

n/a

Publications:

Ohtake et al., 1995, Myocardial glucose metabolism in noninsulin-dependent diabetes mellitus patients evaluated by FDG-PET., J. Nucl. Med.

McFalls et al., Myocardial glucose uptake after dobutamine stress in chronic hibernating swine myocardium., J Nucl Cardiol

Interaction Types & Directionality:

n/a

Publications:

Song et al., Soluble dietary fibre improves insulin sensitivity by increasing muscle GLUT-4 content in stroke-prone spontaneously hypertensive rats., Clin. Exp. Pharmacol. Physiol.

Interaction Types & Directionality:

n/a

Publications:

Vettor et al., 2000, Substrate competition and insulin action in animal models., Int. J. Obes. Relat. Metab. Disord.

Interaction Types & Directionality:

n/a

Publications:

Long et al., 1996, Regulation of GLUT4 gene expression by arachidonic acid. Evidence for multiple pathways, one of which requires oxidation to prostaglandin E2., J. Biol. Chem.

Interaction Types & Directionality:

n/a

Publications:

Sajan et al., 2002, Sorbitol activates atypical protein kinase C and GLUT4 glucose transporter translocation/glucose transport through proline-rich tyrosine kinase-2, the extracellular signal-regulated kinase pathway and phospholipase D., Biochem. J.

Interaction Types & Directionality:

n/a

Publications:

Shimoyama et al., 2006, Gliclazide protects 3T3L1 adipocytes against insulin resistance induced by hydrogen peroxide with restoration of GLUT4 translocation., Metab. Clin. Exp.

Interaction Types & Directionality:

n/a

Publications:

Jacob et al., 1996, Effects of trandolapril and verapamil on glucose transport in insulin-resistant rat skeletal muscle., Metab. Clin. Exp.

Interaction Types & Directionality:

n/a

Publications:

Goto et al., 1997, Effect of triiodothyronine on glucose transport in rat adipocytes., Life Sci.

Interaction Types & Directionality:

n/a

Publications:

Chen et al., 2002, Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport., J. Biol. Chem.

Interaction Types & Directionality:

n/a

Publications:

Huang et al., 2005, Disruption of microtubules ablates the specificity of insulin signaling to GLUT4 translocation in 3T3-L1 adipocytes., J. Biol. Chem.

Interaction Types & Directionality:

n/a

Publications:

Hawkins et al., 1997, The tissue concentration of UDP-N-acetylglucosamine modulates the stimulatory effect of insulin on skeletal muscle glucose uptake., J. Biol. Chem.

Interaction Types & Directionality:

n/a

Publications:

Nomura et al., 2008, Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells., Biol. Pharm. Bull.

Interaction Types & Directionality:

n/a

Publications:

Hellwig et al., 1991, Differentiation of erythrocyte-(GLUT1), liver-(GLUT2), and adipocyte-type (GLUT4) glucose transporters by binding of the inhibitory ligands cytochalasin B, forskolin, dipyridamole, and isobutylmethylxanthine., Mol. Pharmacol.

Interaction Types & Directionality:

n/a

Publications:

Tarn et al., 2006, Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms., Cancer Res.

Interaction Types & Directionality:

n/a

Publications:

Ledwig et al., 2002, Early acarbose treatment ameliorates resistance of insulin-regulated GLUT4 trafficking in obese Zucker rats., Eur. J. Pharmacol.

Interaction Types & Directionality:

n/a

Publications:

Sato et al., 2008, Testosterone and DHEA activate the glucose metabolism-related signaling pathway in skeletal muscle., Am. J. Physiol. Endocrinol. Metab.

Interaction Types & Directionality:

n/a

Publications:

Hruz et al., 2002, Indinavir induces acute and reversible peripheral insulin resistance in rats., Diabetes

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

Date et al., 2005, Expression of constitutively stable hybrid hypoxia-inducible factor-1alpha protects cultured rat cardiomyocytes against simulated ischemia-reperfusion injury., Am. J. Physiol., Cell Physiol.

Interaction Types & Directionality:

n/a

Publications:

Ordóñez et al., 2007, Insulin sensitivity in streptozotocin-induced diabetic rats treated with different doses of 17beta-oestradiol or progesterone., Exp. Physiol.

Interaction Types & Directionality:

n/a

Publications:

Lekli et al., 2008, Protective mechanisms of resveratrol against ischemia-reperfusion-induced damage in hearts obtained from Zucker obese rats: the role of GLUT-4 and endothelin., Am. J. Physiol. Heart Circ. Physiol.

Interaction Types & Directionality:

n/a

Publications:

James et al., 2004, Neomycin prevents the wortmannin inhibition of insulin-stimulated Glut4 translocation and glucose transport in 3T3-L1 adipocytes., J. Biol. Chem.

Interaction Types & Directionality:

n/a

Publications:

Vettor et al., 2000, Substrate competition and insulin action in animal models., Int. J. Obes. Relat. Metab. Disord.

Interaction Types & Directionality:

n/a

Publications:

Heiser et al., 2006, Effects of different antipsychotics and the antidepressant mirtazapine on glucose transporter mRNA levels in human blood cells., J Psychiatr Res

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

Ordóñez et al., 2007, Insulin sensitivity in streptozotocin-induced diabetic rats treated with different doses of 17beta-oestradiol or progesterone., Exp. Physiol.

Interaction Types & Directionality:

n/a

Publications:

Nishimura et al., 1994, Staurosporine inhibits phorbol 12-myristate 13-acetate- and insulin-stimulated translocation of GLUT1 and GLUT4 glucose transporters in rat adipose cells., Biochem. J.