DGIdb - SLC2A1 Gene Record

SLC2A1 6513 Druggable Genome

Alternate Names:

6513
SOLUTE CARRIER FAMILY 2 MEMBER 1
SLC2A1
CSE
DYT17
DYT18
DYT9
EIG12
GLUT
GLUT-1
GLUT1
GLUT1DS
HTLVR
PED
SDCHCN
138140
11005
ENSG00000117394
OTTHUMG00000007657
P11166
SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER, MEMBER 1 (GLUCOSE TRANSPORTER TYPE 1, ERYTHROCYTE/BRAIN) (HEPG2 GLUCOSE TRANSPORTER). [SOURCE:UNIPROT/SWISSPROT;ACC:P11166]
Solute carrier family 2, facilitated glucose transporter member 1

Gene Info:

Target Class	Transporters
Target Subclass	TC:2.A.1.1.28
Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

TRANSPORTER
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Naftalin et al., 2004, Piracetam and TRH analogues antagonise inhibition by barbiturates, diazepam, melatonin and galanin of human erythrocyte D-glucose transport., Br. J. Pharmacol.
Stuart et al., 2007, Overexpression of GLUT5 in diabetic muscle is reversed by pioglitazone., Diabetes Care
Vera et al., 1996, Genistein is a natural inhibitor of hexose and dehydroascorbic acid transport through the glucose transporter, GLUT1., J. Biol. Chem.
Hahn et al., 1999, Placental glucose transporter expression is regulated by glucocorticoids., J. Clin. Endocrinol. Metab.
Shapira R et al., 2013, Multifunctional cyclic D,L-α-peptide architectures stimulate non-insulin dependent glucose uptake in skeletal muscle cells and protect them against oxidative stress., J Med Chem
Medina et al., 2004, Differential regulation of glucose transporter expression by estrogen and progesterone in Ishikawa endometrial cancer cells., J. Endocrinol.
Asano et al., 1991, Expression of the GLUT1 glucose transporter increases thymidine uptake in Chinese hamster ovary cells at low glucose concentrations., Cancer Res.
Wong et al., 2005, The effects of phenytoin and its metabolite 5-(4-hydroxyphenyl)-5-phenylhydantoin on cellular glucose transport., Life Sci.
Kramer et al., 2001, Insulin-sensitizing effect of rosiglitazone (BRL-49653) by regulation of glucose transporters in muscle and fat of Zucker rats., Metab. Clin. Exp.
Dominguez et al., 1996, Studies of renal injury. I. Gentamicin toxicity and expression of basolateral transporters., Am. J. Physiol.

THIOCTIC ACID SLC2A1

Interaction Score: 11.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23984871

Sources:
DTC
THYMIDINE SLC2A1

Interaction Score: 2.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1868466

Sources:
NCI
PIOGLITAZONE SLC2A1

Interaction Score: 0.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17251278

Sources:
NCI
GLUFOSFAMIDE SLC2A1

Interaction Score: 0.7

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Glufosfamide

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
GENTAMICIN SLC2A1

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8779884

Sources:
NCI
ROSIGLITAZONE SLC2A1

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11699047

Sources:
NCI
TRIAMCINOLONE SLC2A1

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10199793

Sources:
NCI
DIAZEPAM SLC2A1

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15148255

Sources:
NCI
PHENYTOIN SLC2A1

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15698863

Sources:
NCI
GENISTEIN SLC2A1

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8621505

Sources:
NCI
PROGESTERONE SLC2A1

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15350188

Sources:
NCI

Ensembl: ENSG00000117394
- Version: 101_38
Alternate Names:

SLC2A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000117394

Version: 26-July-2011

Alternate Names:

SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER, MEMBER 1 (GLUCOSE TRANSPORTER TYPE 1, ERYTHROCYTE/BRAIN) (HEPG2 GLUCOSE TRANSPORTER). [SOURCE:UNIPROT/SWISSPROT;ACC:P11166] Description

SLC2A1 Display Id

ENSG00000117394 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P11166
- Version: January-2014
Alternate Names:

SLC2A1 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:2.A.1.1.28

Publications:

NCI: SLC2A1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Naftalin et al., 2004, Piracetam and TRH analogues antagonise inhibition by barbiturates, diazepam, melatonin and galanin of human erythrocyte D-glucose transport., Br. J. Pharmacol.

Medina et al., 2004, Differential regulation of glucose transporter expression by estrogen and progesterone in Ishikawa endometrial cancer cells., J. Endocrinol.

Dominguez et al., 1996, Studies of renal injury. I. Gentamicin toxicity and expression of basolateral transporters., Am. J. Physiol.

DTC: SLC2A1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Shapira R et al., 2013, Multifunctional cyclic D,L-α-peptide architectures stimulate non-insulin dependent glucose uptake in skeletal muscle cells and protect them against oxidative stress., J Med Chem

HingoraniCasas: ENSG00000117394
- Version: 31-May-2017
Alternate Names:

ENSG00000117394 Gene Symbol

SLC2A1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: SLC2A1
- Version: 19.3
Alternate Names:

P11166 UniProt ID

ENSG00000117394 Ensembl Gene ID

CSE Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

TRANSPORTER

Publications:
GO: SLC2A1
- Version: 01-February-2022
Alternate Names:

GLUT1 GO Gene Synonym

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
Pharos: SLC2A1
- Version: 01-February-2022
Alternate Names:

Solute carrier family 2, facilitated glucose transporter member 1 Gene Name

P11166 UniProt ID

Gene Info:

Gene Categories:

TRANSPORTER

Publications:

SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER, MEMBER 1 (GLUCOSE TRANSPORTER TYPE 1, ERYTHROCYTE/BRAIN) (HEPG2 GLUCOSE TRANSPORTER). [SOURCE:UNIPROT/SWISSPROT;ACC:P11166]	Description
SLC2A1	Display Id
ENSG00000117394	Ensembl Gene Id

P11166	UniProt ID
ENSG00000117394	Ensembl Gene ID
CSE	Human Protein Atlas Gene Synonym

Solute carrier family 2, facilitated glucose transporter member 1	Gene Name
P11166	UniProt ID

Trial Name	Glufosfamide
Novel drug target	Novel Target

SLC2A1 Gene Record

SLC2A1 6513 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23984871

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1868466

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17251278

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Glufosfamide Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8779884

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11699047

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10199793

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15148255

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15698863

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8621505

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15350188

Sources: NCI

Ensembl: ENSG00000117394

Alternate Names: SLC2A1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000117394

Alternate Names: SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER, MEMBER 1 (GLUCOSE TRANSPORTER TYPE 1, ERYTHROCYTE/BRAIN) (HEPG2 GLUCOSE TRANSPORTER). [SOURCE:UNIPROT/SWISSPROT;ACC:P11166] Description SLC2A1 Display Id ENSG00000117394 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P11166

Alternate Names: SLC2A1 Gene Symbol

Gene Info: Target Class Transporters Target Subclass TC:2.A.1.1.28

Publications:

NCI: SLC2A1

Alternate Names:

Gene Info:

DTC: SLC2A1

Alternate Names:

Gene Info:

Publications: Shapira R et al., 2013, Multifunctional cyclic D,L-α-peptide architectures stimulate non-insulin dependent glucose uptake in skeletal muscle cells and protect them against oxidative stress., J Med Chem

HingoraniCasas: ENSG00000117394

Alternate Names: ENSG00000117394 Gene Symbol SLC2A1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

HumanProteinAtlas: SLC2A1

Alternate Names: P11166 UniProt ID ENSG00000117394 Ensembl Gene ID CSE Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories: TRANSPORTER

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
23984871

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
1868466

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17251278

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Glufosfamide

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
8779884

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11699047

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10199793

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15148255

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15698863

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8621505

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15350188

Sources:
NCI

Alternate Names:

SLC2A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER, MEMBER 1 (GLUCOSE TRANSPORTER TYPE 1, ERYTHROCYTE/BRAIN) (HEPG2 GLUCOSE TRANSPORTER). [SOURCE:UNIPROT/SWISSPROT;ACC:P11166] Description

SLC2A1 Display Id

ENSG00000117394 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

SLC2A1 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:2.A.1.1.28

Publications:

Shapira R et al., 2013, Multifunctional cyclic D,L-α-peptide architectures stimulate non-insulin dependent glucose uptake in skeletal muscle cells and protect them against oxidative stress., J Med Chem

Alternate Names:

ENSG00000117394 Gene Symbol

SLC2A1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

P11166 UniProt ID

ENSG00000117394 Ensembl Gene ID

CSE Human Protein Atlas Gene Synonym

Gene Categories:

TRANSPORTER

Alternate Names:

GLUT1 GO Gene Synonym

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Alternate Names:

Solute carrier family 2, facilitated glucose transporter member 1 Gene Name

P11166 UniProt ID

Gene Categories:

TRANSPORTER