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SLC28A1 Gene Record

  • Summary
  • Interactions
  • Claims
  • SLC28A1 9154 Druggable Genome

    Alternate Names:

    9154
    SOLUTE CARRIER FAMILY 28 MEMBER 1
    SLC28A1
    CNT1
    HCNT1
    606207
    11001
    ENSG00000156222
    OTTHUMG00000148668
    PA387
    1114
    Sodium/nucleoside cotransporter 1
    O00337

    Gene Info:

    GuideToPharmacology Gene Category Name SLC28 family
    GuideToPharmacology Gene Category ID 215
    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME

    Publications:

    Soo RA et al., 2009, Distribution of gemcitabine pathway genotypes in ethnic Asians and their association with outcome in non-small cell lung cancer patients., Lung Cancer
    Alvarellos ML et al., 2014, PharmGKB summary: gemcitabine pathway., Pharmacogenet Genomics
    Innocenti F et al., 2019, An initial genetic analysis of gemcitabine-induced high-grade neutropenia in pancreatic cancer patients in CALGB 80303 (Alliance)., Pharmacogenet Genomics
    Lepist EI et al., 2013, Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1., Drug Metab Dispos
    Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics
    Crawford et al., 1998, Stable expression of a recombinant sodium-dependent, pyrimidine-selective nucleoside transporter (CNT1) in a transport-deficient mouse leukemia cell line., Biochem. Cell Biol.
    Loewen et al., 1999, Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2., J. Biol. Chem.
  • URIDINE   SLC28A1

    Interaction Score: 5.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10455109 23388705


    Sources:
    NCI DTC

  • THYMIDINE   SLC28A1

    Interaction Score: 3.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10353719


    Sources:
    NCI

  • ADENOSINE   SLC28A1

    Interaction Score: 2.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23388705


    Sources:
    DTC

  • ZIDOVUDINE   SLC28A1

    Interaction Score: 0.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22960662


    Sources:
    PharmGKB

  • GEMCITABINE   SLC28A1

    Interaction Score: 0.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18538445 25162786 30889042


    Sources:
    PharmGKB

  • Ensembl: ENSG00000156222

    • Version: 101_38

    Alternate Names:
    SLC28A1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • GuideToPharmacology: 9154

    • Version: 29-September-2020

    Alternate Names:
    11001 HUGO Gene ID
    11001 HUGO Gene Symbol
    solute carrier family 28 member 1 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name SLC28 family
    GuideToPharmacology Gene Category ID 215

    Gene Categories:
    TRANSPORTER

    Publications:

  • PharmGKB: SLC28A1

    • Version: 18-August-2020

    Alternate Names:
    PA387 PharmGKB ID

    Gene Info:

    Publications:
    Visscher H et al., 2013, Validation of variants in SLC28A3 and UGT1A6 as genetic markers predictive of anthracycline-induced cardiotoxicity in children., Pediatr Blood Cancer
    Visscher H et al., 2012, Pharmacogenomic prediction of anthracycline-induced cardiotoxicity in children., J Clin Oncol
    Soo RA et al., 2009, Distribution of gemcitabine pathway genotypes in ethnic Asians and their association with outcome in non-small cell lung cancer patients., Lung Cancer

  • NCI: SLC28A1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Crawford et al., 1998, Stable expression of a recombinant sodium-dependent, pyrimidine-selective nucleoside transporter (CNT1) in a transport-deficient mouse leukemia cell line., Biochem. Cell Biol.
    Fernández-Veledo et al., 2004, Up-regulation of the high-affinity pyrimidine-preferring nucleoside transporter concentrative nucleoside transporter 1 by tumor necrosis factor-alpha and interleukin-6 in liver parenchymal cells., J. Hepatol.
    Loewen et al., 1999, Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2., J. Biol. Chem.

  • DTC: SLC28A1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Lepist EI et al., 2013, Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1., Drug Metab Dispos

  • HingoraniCasas: ENSG00000156222

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000156222 Gene Symbol
    SLC28A1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: SLC28A1

    • Version: 05-September-2020

    Alternate Names:
    CNT1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21