DGIdb - SLC28A1 Gene Record

SLC28A1 9154 Druggable Genome

Alternate Names:

9154
SOLUTE CARRIER FAMILY 28 MEMBER 1
SLC28A1
CNT1
HCNT1
606207
11001
ENSG00000156222
OTTHUMG00000148668
PA387
solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
1114
Sodium/nucleoside cotransporter 1
O00337
solute carrier family 28 (concentrative nucleoside transporter), member 1
S28A1_HUMAN
URCTU

Gene Info:

Has Variant Annotation	true
Is VIP	false
GuideToPharmacology Gene Category Name	SLC28 family
GuideToPharmacology Gene Category ID	215
GuideToPharmacology Gene Type	transporter
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

TRANSPORTER
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Innocenti F et al., 2019, An initial genetic analysis of gemcitabine-induced high-grade neutropenia in pancreatic cancer patients in CALGB 80303 (Alliance)., Pharmacogenet Genomics
Alvarellos ML et al., 2014, PharmGKB summary: gemcitabine pathway., Pharmacogenet Genomics
Soo RA et al., 2009, Distribution of gemcitabine pathway genotypes in ethnic Asians and their association with outcome in non-small cell lung cancer patients., Lung Cancer
Lepist EI et al., 2013, Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1., Drug Metab Dispos
Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics
Crawford et al., 1998, Stable expression of a recombinant sodium-dependent, pyrimidine-selective nucleoside transporter (CNT1) in a transport-deficient mouse leukemia cell line., Biochem. Cell Biol.
Loewen et al., 1999, Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2., J. Biol. Chem.

GEMCITABINE SLC28A1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Innocenti F et al., 2019, An initial genetic analysis of gemcitabine-induced high-grade neutropenia in pancreatic cancer patients in CALGB 80303 (Alliance)., Pharmacogenet Genomics

Alvarellos ML et al., 2014, PharmGKB summary: gemcitabine pathway., Pharmacogenet Genomics

Soo RA et al., 2009, Distribution of gemcitabine pathway genotypes in ethnic Asians and their association with outcome in non-small cell lung cancer patients., Lung Cancer

ADENOSINE SLC28A1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Lepist EI et al., 2013, Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1., Drug Metab Dispos

ZIDOVUDINE SLC28A1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics

THYMIDINE SLC28A1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Crawford et al., 1998, Stable expression of a recombinant sodium-dependent, pyrimidine-selective nucleoside transporter (CNT1) in a transport-deficient mouse leukemia cell line., Biochem. Cell Biol.

URIDINE SLC28A1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Loewen et al., 1999, Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2., J. Biol. Chem.

Lepist EI et al., 2013, Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1., Drug Metab Dispos

Ensembl: ENSG00000156222
- Version: 101_38
Alternate Names:

SLC28A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
GuideToPharmacologyGenes: 1114
- Version: 4-March-2015
Alternate Names:

solute carrier family 28 (concentrative nucleoside transporter), member 1 HUGO Gene Name

11001 HUGO Gene ID

SLC28A1 Gene Symbol

Gene Info:

GuideToPharmacology Gene Category Name SLC28 family

GuideToPharmacology Gene Category ID 215

GuideToPharmacology Gene Type transporter

Gene Categories:

TRANSPORTER

Publications:

PharmGKB: SLC28A1

Version: 18-August-2020

Alternate Names:

PA387 PharmGKB ID

Gene Info:

Publications:

Visscher H et al., 2012, Pharmacogenomic prediction of anthracycline-induced cardiotoxicity in children., J Clin Oncol

Visscher H et al., 2013, Validation of variants in SLC28A3 and UGT1A6 as genetic markers predictive of anthracycline-induced cardiotoxicity in children., Pediatr Blood Cancer

Soo RA et al., 2009, Distribution of gemcitabine pathway genotypes in ethnic Asians and their association with outcome in non-small cell lung cancer patients., Lung Cancer

NCI: SLC28A1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Crawford et al., 1998, Stable expression of a recombinant sodium-dependent, pyrimidine-selective nucleoside transporter (CNT1) in a transport-deficient mouse leukemia cell line., Biochem. Cell Biol.

Fernández-Veledo et al., 2004, Up-regulation of the high-affinity pyrimidine-preferring nucleoside transporter concentrative nucleoside transporter 1 by tumor necrosis factor-alpha and interleukin-6 in liver parenchymal cells., J. Hepatol.

Loewen et al., 1999, Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2., J. Biol. Chem.

DTC: SLC28A1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Lepist EI et al., 2013, Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1., Drug Metab Dispos

HingoraniCasas: ENSG00000156222
- Version: 31-May-2017
Alternate Names:

ENSG00000156222 Gene Symbol

SLC28A1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: SLC28A1
- Version: 05-September-2020
Alternate Names:

CNT1 GO Gene Synonym

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications: