DGIdb - SLC28A1 Gene Record

SLC28A1 9154 Druggable Genome

Alternate Names:

9154
SOLUTE CARRIER FAMILY 28 MEMBER 1
SLC28A1
CNT1
HCNT1
606207
11001
ENSG00000156222
OTTHUMG00000148668
PA387
1114
Sodium/nucleoside cotransporter 1
O00337

Gene Info:

GuideToPharmacology Gene Category Name	SLC28 family
GuideToPharmacology Gene Category ID	215
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

TRANSPORTER
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Soo RA et al., 2009, Distribution of gemcitabine pathway genotypes in ethnic Asians and their association with outcome in non-small cell lung cancer patients., Lung Cancer
Alvarellos ML et al., 2014, PharmGKB summary: gemcitabine pathway., Pharmacogenet Genomics
Innocenti F et al., 2019, An initial genetic analysis of gemcitabine-induced high-grade neutropenia in pancreatic cancer patients in CALGB 80303 (Alliance)., Pharmacogenet Genomics
Lepist EI et al., 2013, Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1., Drug Metab Dispos
Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics
Crawford et al., 1998, Stable expression of a recombinant sodium-dependent, pyrimidine-selective nucleoside transporter (CNT1) in a transport-deficient mouse leukemia cell line., Biochem. Cell Biol.
Loewen et al., 1999, Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2., J. Biol. Chem.

URIDINE SLC28A1

Interaction Score: 5.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10455109 23388705

Sources:
NCI DTC
THYMIDINE SLC28A1

Interaction Score: 3.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10353719

Sources:
NCI
ADENOSINE SLC28A1

Interaction Score: 2.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23388705

Sources:
DTC
ZIDOVUDINE SLC28A1

Interaction Score: 0.71

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22960662

Sources:
PharmGKB
GEMCITABINE SLC28A1

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18538445 25162786 30889042

Sources:
PharmGKB

Ensembl: ENSG00000156222
- Version: 101_38
Alternate Names:

SLC28A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
GuideToPharmacology: 9154
- Version: 29-September-2020
Alternate Names:

11001 HUGO Gene ID

11001 HUGO Gene Symbol

solute carrier family 28 member 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name SLC28 family

GuideToPharmacology Gene Category ID 215

Gene Categories:

TRANSPORTER

Publications:

PharmGKB: SLC28A1

Version: 18-August-2020

Alternate Names:

PA387 PharmGKB ID

Gene Info:

Publications:

Visscher H et al., 2013, Validation of variants in SLC28A3 and UGT1A6 as genetic markers predictive of anthracycline-induced cardiotoxicity in children., Pediatr Blood Cancer

Visscher H et al., 2012, Pharmacogenomic prediction of anthracycline-induced cardiotoxicity in children., J Clin Oncol

Soo RA et al., 2009, Distribution of gemcitabine pathway genotypes in ethnic Asians and their association with outcome in non-small cell lung cancer patients., Lung Cancer

NCI: SLC28A1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Crawford et al., 1998, Stable expression of a recombinant sodium-dependent, pyrimidine-selective nucleoside transporter (CNT1) in a transport-deficient mouse leukemia cell line., Biochem. Cell Biol.

Fernández-Veledo et al., 2004, Up-regulation of the high-affinity pyrimidine-preferring nucleoside transporter concentrative nucleoside transporter 1 by tumor necrosis factor-alpha and interleukin-6 in liver parenchymal cells., J. Hepatol.

Loewen et al., 1999, Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2., J. Biol. Chem.

DTC: SLC28A1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Lepist EI et al., 2013, Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1., Drug Metab Dispos

HingoraniCasas: ENSG00000156222
- Version: 31-May-2017
Alternate Names:

ENSG00000156222 Gene Symbol

SLC28A1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: SLC28A1
- Version: 05-September-2020
Alternate Names:

CNT1 GO Gene Synonym

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

11001	HUGO Gene ID
11001	HUGO Gene Symbol
solute carrier family 28 member 1	HUGO Gene Name

SLC28A1 Gene Record

SLC28A1 9154 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

URIDINE SLC28A1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10455109 23388705

Sources: NCI DTC

THYMIDINE SLC28A1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10353719

Sources: NCI

ADENOSINE SLC28A1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23388705

Sources: DTC

ZIDOVUDINE SLC28A1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22960662

Sources: PharmGKB

GEMCITABINE SLC28A1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18538445 25162786 30889042

Sources: PharmGKB

Ensembl: ENSG00000156222

Alternate Names: SLC28A1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

GuideToPharmacology: 9154

Alternate Names: 11001 HUGO Gene ID 11001 HUGO Gene Symbol solute carrier family 28 member 1 HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name SLC28 family GuideToPharmacology Gene Category ID 215

Gene Categories: TRANSPORTER

Publications:

PharmGKB: SLC28A1

Alternate Names: PA387 PharmGKB ID

Gene Info:

NCI: SLC28A1

Alternate Names:

Gene Info:

DTC: SLC28A1

Alternate Names:

Gene Info:

Publications: Lepist EI et al., 2013, Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1., Drug Metab Dispos

HingoraniCasas: ENSG00000156222

Alternate Names: ENSG00000156222 Gene Symbol SLC28A1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

GO: SLC28A1

Alternate Names: CNT1 GO Gene Synonym

Gene Info:

Gene Categories: EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
10455109 23388705

Sources:
NCI DTC

Interaction Types & Directionality:

n/a

PMIDs:
10353719

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23388705

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22960662

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
18538445 25162786 30889042

Sources:
PharmGKB

Alternate Names:

SLC28A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

11001 HUGO Gene ID

11001 HUGO Gene Symbol

solute carrier family 28 member 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name SLC28 family

GuideToPharmacology Gene Category ID 215

Gene Categories:

TRANSPORTER

Alternate Names:

PA387 PharmGKB ID

Publications:

Lepist EI et al., 2013, Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1., Drug Metab Dispos

Alternate Names:

ENSG00000156222 Gene Symbol

SLC28A1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CNT1 GO Gene Synonym

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE