DGIdb - SLC22A8 Gene Record

SLC22A8 9376 Druggable Genome

Alternate Names:

9376
SOLUTE CARRIER FAMILY 22 MEMBER 8
SLC22A8
OAT3
607581
10972
ENSG00000149452
OTTHUMG00000167768
Q8TCC7
S22A8_HUMAN
PA389
BE0003645
1027
Organic anion transporter 3
hOAT3
SOLUTE CARRIER FAMILY 22 MEMBER 8 [SOURCE:REFSEQ_PEPTIDE;ACC:NP_004245]
T70680

Gene Info:

Target Subclass	SLC
Target Subclass	SLC22
Target Main Class	Transporters
Transmembrane Helix Count	9
Target Subclass	MFS
Target Class	Transporters
Target Subclass	TC:2.A.1.19.34
Human Readable Name	DRUGGABLE GENOME
GuideToPharmacology Gene Category Name	Organic anion transporters (OATs)
GuideToPharmacology Gene Category ID	198
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

TRANSPORTER
DRUGGABLE GENOME

Publications:

Takeda et al., 2002, Characterization of methotrexate transport and its drug interactions with human organic anion transporters., J. Pharmacol. Exp. Ther.
Sweet et al., 2003, Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient., Am. J. Physiol. Renal Physiol.
Kusuhara et al., 1999, Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain., J. Biol. Chem.
Jung et al., 2001, Characterization of ochratoxin A transport by human organic anion transporters., Life Sci.
Takeda et al., 2001, Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters., Eur. J. Pharmacol.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Wolman AT et al., 2013, Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics., Drug Metab Dispos
Takeda et al., 2002, Interaction of human organic anion transporters with various cephalosporin antibiotics., Eur. J. Pharmacol.
Yee SW et al., 2013, Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8)., J Pharm Sci
Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics
Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics
Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics
Varma MV et al., 2015, Quantitative Rationalization of Gemfibrozil Drug Interactions: Consideration of Transporters-Enzyme Interplay and the Role of Circulating Metabolite Gemfibrozil 1-O-β-Glucuronide., Drug Metab Dispos

BENZYLPENICILLIN SLC22A8

Interaction Score: 4.73

Interaction Types & Directionality:

inhibitor (inhibitory)

substrate

Interaction Info:

PMIDs:
12130730 23344796

Sources:
DTC DrugBank
PROBENECID SLC22A8

Interaction Score: 4.62

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Solute carrier family 22 member 8 inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
12130730 12488248 10224140 11669456 11426832 10592235 23344796

Sources:
TEND DTC TdgClinicalTrial TTD DrugBank ChemblInteractions
OXACILLIN SLC22A8

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23344796

Sources:
DTC
DICLOXACILLIN SLC22A8

Interaction Score: 1.78

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23344796

Sources:
DTC
CEFOTAXIME SLC22A8

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11909604 23649425

Sources:
PharmGKB DrugBank
PRATOSARTAN SLC22A8

Interaction Score: 0.89

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Solute carrier family 22 member 8 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GEMFIBROZIL SLC22A8

Interaction Score: 0.55

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
25941268

Sources:
DrugBank
CEFACLOR SLC22A8

Interaction Score: 0.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23344796

Sources:
DTC
FLUORESCEIN SLC22A8

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CEFTRIAXONE SLC22A8

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11909604

Sources:
DrugBank
AVATROMBOPAG SLC22A8

Interaction Score: 0.39

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
CEPHALOTHIN SLC22A8

Interaction Score: 0.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology
ZIDOVUDINE SLC22A8

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22960662

Sources:
PharmGKB
RUCAPARIB SLC22A8

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
METHOTREXATE SLC22A8

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25502615 21317831

Sources:
PharmGKB
PRAVASTATIN SLC22A8

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000149452
- Version: 101_38
Alternate Names:

SLC22A8 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000149452
- Version: 26-July-2011
Alternate Names:

SLC22A8 Display Id

SOLUTE CARRIER FAMILY 22 MEMBER 8 [SOURCE:REFSEQ_PEPTIDE;ACC:NP_004245] Description

ENSG00000149452 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TEND: Q8TCC7
- Version: 01-August-2011
Alternate Names:

SLC22A8 Gene Symbol

S22A8_HUMAN Uniprot Id

Q8TCC7 Uniprot Accession

Gene Info:

Target Subclass SLC

Target Subclass SLC22

Target Main Class Transporters

Publications:
TdgClinicalTrial: Q8TCC7
- Version: January-2014
Alternate Names:

SLC22A8 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:2.A.1.19.34

Publications:
GuideToPharmacology: 9376
- Version: 29-September-2020
Alternate Names:

10972 HUGO Gene ID

10972 HUGO Gene Symbol

solute carrier family 22 member 8 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Organic anion transporters (OATs)

GuideToPharmacology Gene Category ID 198

Gene Categories:

TRANSPORTER

Publications:

PharmGKB: SLC22A8

Version: 18-August-2020

Alternate Names:

PA389 PharmGKB ID

Gene Info:

Publications:

Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics

Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics

Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics

DrugBank: BE0003645

Version: 5.1.7

Alternate Names:

SLC22A8 DrugBank Gene Name

Q8TCC7 UniProt Accession

9376 Entrez Gene Id

Gene Info:

Publications:

Takeda et al., 2002, Interaction of human organic anion transporters with various cephalosporin antibiotics., Eur. J. Pharmacol.

Takeda et al., 2002, Characterization of methotrexate transport and its drug interactions with human organic anion transporters., J. Pharmacol. Exp. Ther.

Sweet et al., 2003, Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient., Am. J. Physiol. Renal Physiol.

DTC: SLC22A8
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Wolman AT et al., 2013, Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics., Drug Metab Dispos
ChemblInteractions: OAT3
- Version: chembl_23
Alternate Names:

OAT3 GENE_SYMBOL

SLC22A8 GENE_SYMBOL

Solute carrier family 22 member 8 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000149452
- Version: 31-May-2017
Alternate Names:

ENSG00000149452 Gene Symbol

SLC22A8 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Solute carrier family 22 member 8
- Version: 2020.06.01
Alternate Names:

SLC22A8 TTD Gene Abbreviation

T70680 TTD Target ID

Gene Info:

Publications:

Mechanism of Interaction	Solute carrier family 22 member 8 inhibitor
Direct Interaction	yes
Trial Name	-

Direct Interaction?	False
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

SLC22A8	Display Id
SOLUTE CARRIER FAMILY 22 MEMBER 8 [SOURCE:REFSEQ_PEPTIDE;ACC:NP_004245]	Description
ENSG00000149452	Ensembl Gene Id

SLC22A8	Gene Symbol
S22A8_HUMAN	Uniprot Id
Q8TCC7	Uniprot Accession

10972	HUGO Gene ID
10972	HUGO Gene Symbol
solute carrier family 22 member 8	HUGO Gene Name

SLC22A8	DrugBank Gene Name
Q8TCC7	UniProt Accession
9376	Entrez Gene Id

OAT3	GENE_SYMBOL
SLC22A8	GENE_SYMBOL
Solute carrier family 22 member 8	UNIPROT

inhibitor (inhibitory)
substrate

SLC22A8 Gene Record

SLC22A8 9376 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory) substrate

Interaction Info:

PMIDs: 12130730 23344796

Sources: DTC DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Solute carrier family 22 member 8 inhibitor Direct Interaction yes Trial Name -

PMIDs: 12130730 12488248 10224140 11669456 11426832 10592235 23344796

Sources: TEND DTC TdgClinicalTrial TTD DrugBank ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23344796

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23344796

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11909604 23649425

Sources: PharmGKB DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Solute carrier family 22 member 8 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 25941268

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23344796

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11909604

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22960662

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25502615 21317831

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Ensembl: ENSG00000149452

Alternate Names: SLC22A8 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000149452

Alternate Names: SLC22A8 Display Id SOLUTE CARRIER FAMILY 22 MEMBER 8 [SOURCE:REFSEQ_PEPTIDE;ACC:NP_004245] Description ENSG00000149452 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TEND: Q8TCC7

Interaction Types & Directionality:

inhibitor (inhibitory)

substrate

PMIDs:
12130730 23344796

Sources:
DTC DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Solute carrier family 22 member 8 inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
12130730 12488248 10224140 11669456 11426832 10592235 23344796

Sources:
TEND DTC TdgClinicalTrial TTD DrugBank ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
23344796

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23344796

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
11909604 23649425

Sources:
PharmGKB DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Solute carrier family 22 member 8 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
25941268

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
23344796

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
11909604

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
22960662

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25502615 21317831

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

SLC22A8 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

SLC22A8 Display Id

SOLUTE CARRIER FAMILY 22 MEMBER 8 [SOURCE:REFSEQ_PEPTIDE;ACC:NP_004245] Description

ENSG00000149452 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

SLC22A8 Gene Symbol

S22A8_HUMAN Uniprot Id

Q8TCC7 Uniprot Accession

Gene Info:

Target Subclass SLC

Target Subclass SLC22

Target Main Class Transporters

Alternate Names:

SLC22A8 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:2.A.1.19.34

Alternate Names:

10972 HUGO Gene ID

10972 HUGO Gene Symbol

solute carrier family 22 member 8 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Organic anion transporters (OATs)

GuideToPharmacology Gene Category ID 198

Gene Categories:

TRANSPORTER

Alternate Names:

PA389 PharmGKB ID

Publications:

Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics

Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics

Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics

Alternate Names:

SLC22A8 DrugBank Gene Name

Q8TCC7 UniProt Accession

9376 Entrez Gene Id

Publications:

Wolman AT et al., 2013, Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics., Drug Metab Dispos

Alternate Names:

OAT3 GENE_SYMBOL

SLC22A8 GENE_SYMBOL

Solute carrier family 22 member 8 UNIPROT

Alternate Names:

ENSG00000149452 Gene Symbol

SLC22A8 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

SLC22A8 TTD Gene Abbreviation

T70680 TTD Target ID