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SLC22A8 Gene Record

  • Summary
  • Interactions
  • Claims
  • SLC22A8 9376 Druggable Genome

    Alternate Names:

    9376
    SOLUTE CARRIER FAMILY 22 MEMBER 8
    SLC22A8
    OAT3
    607581
    10972
    ENSG00000149452
    OTTHUMG00000167768
    Q8TCC7
    S22A8_HUMAN
    PA389
    BE0003645
    1027
    Organic anion transporter 3
    hOAT3
    SOLUTE CARRIER FAMILY 22 MEMBER 8 [SOURCE:REFSEQ_PEPTIDE;ACC:NP_004245]
    T70680

    Gene Info:

    Target Subclass SLC
    Target Subclass SLC22
    Target Main Class Transporters
    Transmembrane Helix Count 9
    Target Subclass MFS
    Target Class Transporters
    Target Subclass TC:2.A.1.19.34
    Human Readable Name DRUGGABLE GENOME
    GuideToPharmacology Gene Category Name Organic anion transporters (OATs)
    GuideToPharmacology Gene Category ID 198
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    DRUGGABLE GENOME

    Publications:

    Takeda et al., 2002, Characterization of methotrexate transport and its drug interactions with human organic anion transporters., J. Pharmacol. Exp. Ther.
    Sweet et al., 2003, Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient., Am. J. Physiol. Renal Physiol.
    Kusuhara et al., 1999, Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain., J. Biol. Chem.
    Jung et al., 2001, Characterization of ochratoxin A transport by human organic anion transporters., Life Sci.
    Takeda et al., 2001, Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters., Eur. J. Pharmacol.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Wolman AT et al., 2013, Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics., Drug Metab Dispos
    Takeda et al., 2002, Interaction of human organic anion transporters with various cephalosporin antibiotics., Eur. J. Pharmacol.
    Yee SW et al., 2013, Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8)., J Pharm Sci
    Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics
    Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics
    Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics
    Varma MV et al., 2015, Quantitative Rationalization of Gemfibrozil Drug Interactions: Consideration of Transporters-Enzyme Interplay and the Role of Circulating Metabolite Gemfibrozil 1-O-β-Glucuronide., Drug Metab Dispos
  • BENZYLPENICILLIN   SLC22A8

    Interaction Score: 4.73

    Interaction Types & Directionality:
    inhibitor (inhibitory)
    substrate

    Interaction Info:

    PMIDs:
    12130730 23344796


    Sources:
    DTC DrugBank

  • PROBENECID   SLC22A8

    Interaction Score: 4.62

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Solute carrier family 22 member 8 inhibitor
    Direct Interaction yes
    Trial Name -

    PMIDs:
    12130730 12488248 10224140 11669456 11426832 10592235 23344796


    Sources:
    TEND DTC TdgClinicalTrial TTD DrugBank ChemblInteractions

  • OXACILLIN   SLC22A8

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23344796


    Sources:
    DTC

  • DICLOXACILLIN   SLC22A8

    Interaction Score: 1.78

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23344796


    Sources:
    DTC

  • CEFOTAXIME   SLC22A8

    Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11909604 23649425


    Sources:
    PharmGKB DrugBank

  • PRATOSARTAN   SLC22A8

    Interaction Score: 0.89

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Solute carrier family 22 member 8 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GEMFIBROZIL   SLC22A8

    Interaction Score: 0.55

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    25941268


    Sources:
    DrugBank

  • CEFACLOR   SLC22A8

    Interaction Score: 0.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23344796


    Sources:
    DTC

  • FLUORESCEIN   SLC22A8

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CEFTRIAXONE   SLC22A8

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11909604


    Sources:
    DrugBank

  • AVATROMBOPAG   SLC22A8

    Interaction Score: 0.39

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • CEPHALOTHIN   SLC22A8

    Interaction Score: 0.36

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ZIDOVUDINE   SLC22A8

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22960662


    Sources:
    PharmGKB

  • RUCAPARIB   SLC22A8

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • METHOTREXATE   SLC22A8

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25502615 21317831


    Sources:
    PharmGKB

  • PRAVASTATIN   SLC22A8

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000149452

    • Version: 101_38

    Alternate Names:
    SLC22A8 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000149452

    • Version: 26-July-2011

    Alternate Names:
    SLC22A8 Display Id
    SOLUTE CARRIER FAMILY 22 MEMBER 8 [SOURCE:REFSEQ_PEPTIDE;ACC:NP_004245] Description
    ENSG00000149452 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TEND: Q8TCC7

    • Version: 01-August-2011

    Alternate Names:
    SLC22A8 Gene Symbol
    S22A8_HUMAN Uniprot Id
    Q8TCC7 Uniprot Accession

    Gene Info:
    Target Subclass SLC
    Target Subclass SLC22
    Target Main Class Transporters

    Publications:

  • TdgClinicalTrial: Q8TCC7

    • Version: January-2014

    Alternate Names:
    SLC22A8 Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass TC:2.A.1.19.34

    Publications:

  • GuideToPharmacology: 9376

    • Version: 29-September-2020

    Alternate Names:
    10972 HUGO Gene ID
    10972 HUGO Gene Symbol
    solute carrier family 22 member 8 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Organic anion transporters (OATs)
    GuideToPharmacology Gene Category ID 198

    Gene Categories:
    TRANSPORTER

    Publications:

  • PharmGKB: SLC22A8

    • Version: 18-August-2020

    Alternate Names:
    PA389 PharmGKB ID

    Gene Info:

    Publications:
    Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics
    Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics
    Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics

  • DrugBank: BE0003645

    • Version: 5.1.7

    Alternate Names:
    SLC22A8 DrugBank Gene Name
    Q8TCC7 UniProt Accession
    9376 Entrez Gene Id

    Gene Info:

    Publications:
    Takeda et al., 2002, Interaction of human organic anion transporters with various cephalosporin antibiotics., Eur. J. Pharmacol.
    Takeda et al., 2002, Characterization of methotrexate transport and its drug interactions with human organic anion transporters., J. Pharmacol. Exp. Ther.
    Sweet et al., 2003, Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient., Am. J. Physiol. Renal Physiol.

  • DTC: SLC22A8

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Wolman AT et al., 2013, Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics., Drug Metab Dispos

  • ChemblInteractions: OAT3

    • Version: chembl_23

    Alternate Names:
    OAT3 GENE_SYMBOL
    SLC22A8 GENE_SYMBOL
    Solute carrier family 22 member 8 UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000149452

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000149452 Gene Symbol
    SLC22A8 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Solute carrier family 22 member 8

    • Version: 2020.06.01

    Alternate Names:
    SLC22A8 TTD Gene Abbreviation
    T70680 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21