DGIdb - SLC22A8 Gene Record

SLC22A8 9376 Druggable Genome

Alternate Names:

9376
SOLUTE CARRIER FAMILY 22 MEMBER 8
SLC22A8
OAT3
607581
10972
ENSG00000149452
OTTHUMG00000167768
Q8TCC7
S22A8_HUMAN
PA389
Organic anion transporter 3
hOAT3
SOLUTE CARRIER FAMILY 22 MEMBER 8 [SOURCE:REFSEQ_PEPTIDE;ACC:NP_004245]
T70680

Gene Info:

Target Subclass	SLC
Target Subclass	SLC22
Target Main Class	Transporters
Transmembrane Helix Count	9
Target Subclass	MFS
Target Class	Transporters
Target Subclass	TC:2.A.1.19.34
Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Takeda et al., 2002, Characterization of methotrexate transport and its drug interactions with human organic anion transporters., J. Pharmacol. Exp. Ther.
Sweet et al., 2003, Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient., Am. J. Physiol. Renal Physiol.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Jung et al., 2001, Characterization of ochratoxin A transport by human organic anion transporters., Life Sci.
Takeda et al., 2001, Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters., Eur. J. Pharmacol.
Kusuhara et al., 1999, Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain., J. Biol. Chem.
Wolman AT et al., 2013, Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics., Drug Metab Dispos
Yee SW et al., 2013, Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8)., J Pharm Sci
Takeda et al., 2002, Interaction of human organic anion transporters with various cephalosporin antibiotics., Eur. J. Pharmacol.
Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics
Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics
Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics

BENZYLPENICILLIN SLC22A8

Interaction Score: 15.46

Interaction Types & Directionality:

inhibitor (inhibitory)

substrate

Interaction Info:

PMIDs:
12130730 23344796

Sources:
DTC
OXACILLIN SLC22A8

Interaction Score: 10.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23344796

Sources:
DTC
PROBENECID SLC22A8

Interaction Score: 8.83

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Solute carrier family 22 member 8 inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
12130730 12488248 10592235 11669456 11426832 10224140 23344796

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND TTD
CEFOTAXIME SLC22A8

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23649425 11909604

Sources:
PharmGKB
DICLOXACILLIN SLC22A8

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23344796

Sources:
DTC
PRATOSARTAN SLC22A8

Interaction Score: 1.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Solute carrier family 22 member 8 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CEFACLOR SLC22A8

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23344796

Sources:
DTC
FLUORESCEIN SLC22A8

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ZIDOVUDINE SLC22A8

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22960662

Sources:
PharmGKB
RUCAPARIB SLC22A8

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
PRAVASTATIN SLC22A8

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
METHOTREXATE SLC22A8

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25502615 21317831

Sources:
PharmGKB

Ensembl: ENSG00000149452
- Version: 101_38
Alternate Names:

SLC22A8 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000149452
- Version: 26-July-2011
Alternate Names:

SLC22A8 Display Id

SOLUTE CARRIER FAMILY 22 MEMBER 8 [SOURCE:REFSEQ_PEPTIDE;ACC:NP_004245] Description

ENSG00000149452 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TEND: Q8TCC7
- Version: 01-August-2011
Alternate Names:

SLC22A8 Gene Symbol

S22A8_HUMAN Uniprot Id

Q8TCC7 Uniprot Accession

Gene Info:

Target Subclass SLC

Target Subclass SLC22

Target Main Class Transporters

Publications:
TdgClinicalTrial: Q8TCC7
- Version: January-2014
Alternate Names:

SLC22A8 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:2.A.1.19.34

Publications:

PharmGKB: SLC22A8

Version: 18-August-2020

Alternate Names:

PA389 PharmGKB ID

Gene Info:

Publications:

Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics

Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics

Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics

DTC: SLC22A8
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Wolman AT et al., 2013, Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics., Drug Metab Dispos
ChemblInteractions: OAT3
- Version: chembl_23
Alternate Names:

OAT3 GENE_SYMBOL

SLC22A8 GENE_SYMBOL

Solute carrier family 22 member 8 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000149452
- Version: 31-May-2017
Alternate Names:

ENSG00000149452 Gene Symbol

SLC22A8 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Solute carrier family 22 member 8
- Version: 2020.06.01
Alternate Names:

SLC22A8 TTD Gene Abbreviation

T70680 TTD Target ID

Gene Info:

Publications:

Mechanism of Interaction	Solute carrier family 22 member 8 inhibitor
Direct Interaction	yes
Trial Name	-

SLC22A8	Display Id
SOLUTE CARRIER FAMILY 22 MEMBER 8 [SOURCE:REFSEQ_PEPTIDE;ACC:NP_004245]	Description
ENSG00000149452	Ensembl Gene Id

SLC22A8	Gene Symbol
S22A8_HUMAN	Uniprot Id
Q8TCC7	Uniprot Accession

OAT3	GENE_SYMBOL
SLC22A8	GENE_SYMBOL
Solute carrier family 22 member 8	UNIPROT

inhibitor (inhibitory)
substrate

SLC22A8 Gene Record

SLC22A8 9376 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory) substrate

Interaction Info:

PMIDs: 12130730 23344796

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23344796

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Solute carrier family 22 member 8 inhibitor Direct Interaction yes Trial Name -

PMIDs: 12130730 12488248 10592235 11669456 11426832 10224140 23344796

Sources: DTC TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23649425 11909604

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23344796

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Solute carrier family 22 member 8 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23344796

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22960662

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25502615 21317831

Sources: PharmGKB

Ensembl: ENSG00000149452

Alternate Names: SLC22A8 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000149452

Alternate Names: SLC22A8 Display Id SOLUTE CARRIER FAMILY 22 MEMBER 8 [SOURCE:REFSEQ_PEPTIDE;ACC:NP_004245] Description ENSG00000149452 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TEND: Q8TCC7

Alternate Names: SLC22A8 Gene Symbol S22A8_HUMAN Uniprot Id Q8TCC7 Uniprot Accession

Gene Info: Target Subclass SLC Target Subclass SLC22 Target Main Class Transporters

Publications:

TdgClinicalTrial: Q8TCC7

Alternate Names: SLC22A8 Gene Symbol

Gene Info: Target Class Transporters Target Subclass TC:2.A.1.19.34

Publications:

PharmGKB: SLC22A8

Alternate Names: PA389 PharmGKB ID

Gene Info:

Publications: Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics

DTC: SLC22A8

Alternate Names:

Gene Info:

Publications: Wolman AT et al., 2013, Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics., Drug Metab Dispos

ChemblInteractions: OAT3

Interaction Types & Directionality:

inhibitor (inhibitory)

substrate

PMIDs:
12130730 23344796

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23344796

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Solute carrier family 22 member 8 inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
12130730 12488248 10592235 11669456 11426832 10224140 23344796

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
23649425 11909604

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23344796

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Solute carrier family 22 member 8 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
23344796

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
22960662

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25502615 21317831

Sources:
PharmGKB

Alternate Names:

SLC22A8 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

SLC22A8 Display Id

SOLUTE CARRIER FAMILY 22 MEMBER 8 [SOURCE:REFSEQ_PEPTIDE;ACC:NP_004245] Description

ENSG00000149452 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

SLC22A8 Gene Symbol

S22A8_HUMAN Uniprot Id

Q8TCC7 Uniprot Accession

Gene Info:

Target Subclass SLC

Target Subclass SLC22

Target Main Class Transporters

Alternate Names:

SLC22A8 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:2.A.1.19.34

Alternate Names:

PA389 PharmGKB ID

Publications:

Ghodke Y et al., 2012, PharmGKB summary: zidovudine pathway., Pharmacogenet Genomics

Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics

Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics

Publications:

Wolman AT et al., 2013, Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics., Drug Metab Dispos

Alternate Names:

OAT3 GENE_SYMBOL

SLC22A8 GENE_SYMBOL

Solute carrier family 22 member 8 UNIPROT

Alternate Names:

ENSG00000149452 Gene Symbol

SLC22A8 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

SLC22A8 TTD Gene Abbreviation

T70680 TTD Target ID