DGIdb - SLC22A1 Gene Record

SLC22A1 6580 Druggable Genome

Alternate Names:

6580
SOLUTE CARRIER FAMILY 22 MEMBER 1
SLC22A1
HOCT1
OCT1
oct1_cds
602607
10963
ENSG00000175003
OTTHUMG00000015947
PA329
1019
O15245
Organic cation transporter 1
SOLUTE CARRIER FAMILY 22 MEMBER 1 ISOFORM A [SOURCE:REFSEQ_PEPTIDE;ACC:NP_003048]

Gene Info:

GuideToPharmacology Gene Category Name	Organic cation transporters (OCT)
GuideToPharmacology Gene Category ID	196
Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

TRANSPORTER
KINASE
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Takeuchi K et al., 2011, Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent., Drug Metab Dispos
Shu Y et al., 2008, Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics., Clin Pharmacol Ther
Sundelin E et al., 2017, Genetic Polymorphisms in Organic Cation Transporter 1 Attenuates Hepatic Metformin Exposure in Humans., Clin Pharmacol Ther
Becker ML et al., 2010, Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response., Pharmacogenet Genomics
Pedersen AJT et al., 2018, The Pharmacogenetics of Metformin in Women with Polycystic Ovary Syndrome: A Randomized Trial., Basic Clin Pharmacol Toxicol
Chien HC et al., 2016, Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1-Transfected Human Embryonic Kidney 293 Cells., Drug Metab Dispos
Tarasova L et al., 2012, Association of genetic variation in the organic cation transporters OCT1, OCT2 and multidrug and toxin extrusion 1 transporter protein genes with the gastrointestinal side effects and lower BMI in metformin-treated type 2 diabetes patients., Pharmacogenet Genomics
Tzvetkov MV et al., 2009, The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin., Clin Pharmacol Ther
Todd JN et al., 2014, An update on the pharmacogenomics of metformin: progress, problems and potential., Pharmacogenomics
Shikata E et al., 2007, Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin., J Hum Genet
Christensen MM et al., 2011, The pharmacogenetics of metformin and its impact on plasma metformin steady-state levels and glycosylated hemoglobin A1c., Pharmacogenet Genomics
Dorosz J et al., 2010, Membrane interactions of novicidin, a novel antimicrobial peptide: phosphatidylglycerol promotes bilayer insertion., J Phys Chem B
Santoro AB et al., 2018, Influence of pharmacogenetic polymorphisms and demographic variables on metformin pharmacokinetics in an admixed Brazilian cohort., Br J Clin Pharmacol
Gong L et al., 2012, Metformin pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
Becker ML et al., 2009, Genetic variation in the organic cation transporter 1 is associated with metformin response in patients with diabetes mellitus., Pharmacogenomics J
Dujic T et al., 2017, Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin: A Metgen Meta-Analysis., Clin Pharmacol Ther
Clark RE et al., 2008, Pharmacologic markers and predictors of responses to imatinib therapy in patients with chronic myeloid leukemia., Leuk Lymphoma
Ravegnini G et al., 2019, An exploratory study by DMET array identifies a germline signature associated with imatinib response in gastrointestinal stromal tumor., Pharmacogenomics J
Cargnin S et al., 2018, Impact of SLC22A1 and CYP3A5 genotypes on imatinib response in chronic myeloid leukemia: A systematic review and meta-analysis., Pharmacol Res
Verboom MC et al., 2019, Genetic polymorphisms in ABCG2 and CYP1A2 are associated with imatinib dose reduction in patients treated for gastrointestinal stromal tumors., Pharmacogenomics J
Qiu HB et al., 2018, Imatinib-induced ophthalmological side-effects in GIST patients are associated with the variations of EGFR, SLC22A1, SLC22A5 and ABCB1., Pharmacogenomics J
Giannoudis A et al., 2013, The hOCT1 SNPs M420del and M408V alter imatinib uptake and M420del modifies clinical outcome in imatinib-treated chronic myeloid leukemia., Blood
Di Paolo A et al., 2014, The c.480C>G polymorphism of hOCT1 influences imatinib clearance in patients affected by chronic myeloid leukemia., Pharmacogenomics J
Kim DH et al., 2009, Clinical relevance of a pharmacogenetic approach using multiple candidate genes to predict response and resistance to imatinib therapy in chronic myeloid leukemia., Clin Cancer Res
Matthaei J et al., 2019, OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil., Clin Pharmacol Ther
Tzvetkov MV et al., 2011, Genetically polymorphic OCT1: another piece in the puzzle of the variable pharmacokinetics and pharmacodynamics of the opioidergic drug tramadol., Clin Pharmacol Ther
Shen CH et al., 2016, Specific OCT1 and ABCG2 polymorphisms are associated with Lamotrigine concentrations in Chinese patients with epilepsy., Epilepsy Res
Tzvetkov MV et al., 2012, Effects of OCT1 polymorphisms on the cellular uptake, plasma concentrations and efficacy of the 5-HT(3) antagonists tropisetron and ondansetron., Pharmacogenomics J
Herraez E et al., 2013, Expression of SLC22A1 variants may affect the response of hepatocellular carcinoma and cholangiocarcinoma to sorafenib., Hepatology
Tzvetkov MV et al., 2013, Morphine is a substrate of the organic cation transporter OCT1 and polymorphisms in OCT1 gene affect morphine pharmacokinetics after codeine administration., Biochem Pharmacol

TETRYLAMMONIUM SLC22A1

Interaction Score: 2.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21422191

Sources:
DTC
CHLOROGUANIDE SLC22A1

Interaction Score: 1.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29882324

Sources:
PharmGKB
METFORMIN SLC22A1

Interaction Score: 1.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17609683 28380657 19898263 28834135 26700958 22735389 19536068 24624919 17111267 21989078 20690652 29352482 22722338 19381165 27859023

Sources:
PharmGKB
ELTROMBOPAG SLC22A1

Interaction Score: 1.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21422191

Sources:
DTC
TROPISETRON SLC22A1

Interaction Score: 0.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20921968

Sources:
PharmGKB
IMATINIB SLC22A1

Interaction Score: 0.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18398725 30237583 29427770 30713339 28762371 23223357 24589908 19584153

Sources:
PharmGKB
SELEGILINE SLC22A1

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
AMANTADINE SLC22A1

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CLONIDINE SLC22A1

Interaction Score: 0.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology
TRAMADOL SLC22A1

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21562485

Sources:
PharmGKB
MORPHINE SLC22A1

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23835420

Sources:
PharmGKB
LAMOTRIGINE SLC22A1

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27610747

Sources:
PharmGKB
LAMIVUDINE SLC22A1

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
LEVODOPA SLC22A1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
SORAFENIB SLC22A1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23532667

Sources:
PharmGKB

Ensembl: ENSG00000175003
- Version: 101_38
Alternate Names:

SLC22A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000175003
- Version: 26-July-2011
Alternate Names:

ENSG00000175003 Ensembl Gene Id

SOLUTE CARRIER FAMILY 22 MEMBER 1 ISOFORM A [SOURCE:REFSEQ_PEPTIDE;ACC:NP_003048] Description

SLC22A1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
GuideToPharmacology: 6580
- Version: 29-September-2020
Alternate Names:

10963 HUGO Gene ID

10963 HUGO Gene Symbol

solute carrier family 22 member 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Organic cation transporters (OCT)

GuideToPharmacology Gene Category ID 196

Gene Categories:

TRANSPORTER

Publications:

PharmGKB: SLC22A1

Version: 18-August-2020

Alternate Names:

PA329 PharmGKB ID

Gene Info:

Publications:

Matthaei J et al., 2019, OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil., Clin Pharmacol Ther

Shen CH et al., 2016, Specific OCT1 and ABCG2 polymorphisms are associated with Lamotrigine concentrations in Chinese patients with epilepsy., Epilepsy Res

Herraez E et al., 2013, Expression of SLC22A1 variants may affect the response of hepatocellular carcinoma and cholangiocarcinoma to sorafenib., Hepatology

DTC: SLC22A1
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Takeuchi K et al., 2011, Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent., Drug Metab Dispos
HingoraniCasas: ENSG00000175003
- Version: 31-May-2017
Alternate Names:

ENSG00000175003 Gene Symbol

SLC22A1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: SLC22A1
- Version: 03-September-2020
Alternate Names:

Solute carrier family 22 member 1 Gene Name

O15245 UniProt ID

Gene Info:

Gene Categories:

TRANSPORTER, KINASE

Publications:
GO: SLC22A1
- Version: 05-September-2020
Alternate Names:

OCT1 GO Gene Synonym

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

Direct Interaction?	False
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

ENSG00000175003	Ensembl Gene Id
SOLUTE CARRIER FAMILY 22 MEMBER 1 ISOFORM A [SOURCE:REFSEQ_PEPTIDE;ACC:NP_003048]	Description
SLC22A1	Display Id

10963	HUGO Gene ID
10963	HUGO Gene Symbol
solute carrier family 22 member 1	HUGO Gene Name

SLC22A1 Gene Record

SLC22A1 6580 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21422191

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29882324

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17609683 28380657 19898263 28834135 26700958 22735389 19536068 24624919 17111267 21989078 20690652 29352482 22722338 19381165 27859023

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21422191

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20921968

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18398725 30237583 29427770 30713339 28762371 23223357 24589908 19584153

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21562485

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23835420

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27610747

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23532667

Sources: PharmGKB

Ensembl: ENSG00000175003

Alternate Names: SLC22A1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000175003

Alternate Names: ENSG00000175003 Ensembl Gene Id SOLUTE CARRIER FAMILY 22 MEMBER 1 ISOFORM A [SOURCE:REFSEQ_PEPTIDE;ACC:NP_003048] Description SLC22A1 Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

GuideToPharmacology: 6580

Alternate Names: 10963 HUGO Gene ID 10963 HUGO Gene Symbol solute carrier family 22 member 1 HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name Organic cation transporters (OCT) GuideToPharmacology Gene Category ID 196

Gene Categories: TRANSPORTER

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
21422191

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
29882324

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17609683 28380657 19898263 28834135 26700958 22735389 19536068 24624919 17111267 21989078 20690652 29352482 22722338 19381165 27859023

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21422191

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20921968

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
18398725 30237583 29427770 30713339 28762371 23223357 24589908 19584153

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
21562485

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23835420

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27610747

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23532667

Sources:
PharmGKB

Alternate Names:

SLC22A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000175003 Ensembl Gene Id

SOLUTE CARRIER FAMILY 22 MEMBER 1 ISOFORM A [SOURCE:REFSEQ_PEPTIDE;ACC:NP_003048] Description

SLC22A1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

10963 HUGO Gene ID

10963 HUGO Gene Symbol

solute carrier family 22 member 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Organic cation transporters (OCT)

GuideToPharmacology Gene Category ID 196

Gene Categories:

TRANSPORTER

Alternate Names:

PA329 PharmGKB ID

Publications:

Takeuchi K et al., 2011, Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent., Drug Metab Dispos

Alternate Names:

ENSG00000175003 Gene Symbol

SLC22A1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

Solute carrier family 22 member 1 Gene Name

O15245 UniProt ID

Gene Categories:

TRANSPORTER, KINASE

Alternate Names:

OCT1 GO Gene Synonym

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE