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SLC19A1 Gene Record

  • Summary
  • Interactions
  • Claims
  • SLC19A1 6573 Druggable Genome

    Alternate Names:

    6573
    SOLUTE CARRIER FAMILY 19 MEMBER 1
    SLC19A1
    CHMD
    FOLT
    IFC1
    REFC
    RFC1
    600424
    10937
    ENSG00000173638
    OTTHUMG00000090397
    P41440
    PA327
    T35465
    IFC-1
    MEGAF
    RFC
    RFT-1
    hRFC
    hSLC19A1
    FLOT1
    Folate transporter 1

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME

    Publications:

    Wang L et al., 2011, Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase., J Med Chem
    Whetstine JR et al., 2001, Single nucleotide polymorphisms in the human reduced folate carrier: characterization of a high-frequency G/A variant at position 80 and transport properties of the His(27) and Arg(27) carriers., Clin Cancer Res
    Hou Z et al., 2005, Localization of a substrate binding domain of the human reduced folate carrier to transmembrane domain 11 by radioaffinity labeling and cysteine-substituted accessibility methods., J Biol Chem
    Chung et al., 2006, XRCC1 R399Q polymorphism is associated with response to platinum-based neoadjuvant chemotherapy in bulky cervical cancer., Gynecol. Oncol.
    Corrigan A et al., 2014, Pharmacogenetics of pemetrexed combination therapy in lung cancer: pathway analysis reveals novel toxicity associations., Pharmacogenomics J
    Adjei AA et al., 2010, Phase II trial of pemetrexed plus bevacizumab for second-line therapy of patients with advanced non-small-cell lung cancer: NCCTG and SWOG study N0426., J Clin Oncol
    Goldman ID et al., 2002, Molecular, biochemical, and cellular pharmacology of pemetrexed., Semin Oncol
    Ravegnini G et al., 2019, An exploratory study by DMET array identifies a germline signature associated with imatinib response in gastrointestinal stromal tumor., Pharmacogenomics J
  • TALOTREXIN   SLC19A1

    Interaction Score: 3.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21879757


    Sources:
    DTC

  • RALTITREXED   SLC19A1

    Interaction Score: 3.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21879757 11705857


    Sources:
    DTC PharmGKB

  • PEMETREXED   SLC19A1

    Interaction Score: 2.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21879757 24732178 19841321 12571805


    Sources:
    DTC PharmGKB

  • LOMETREXOL   SLC19A1

    Interaction Score: 2.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21879757


    Sources:
    DTC

  • LEUCOVORIN   SLC19A1

    Interaction Score: 0.8

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16115875 21879757


    Sources:
    DTC PharmGKB

  • IMATINIB   SLC19A1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30237583


    Sources:
    PharmGKB

  • CARBOPLATIN   SLC19A1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16875718


    Sources:
    PharmGKB

  • FLUOROURACIL   SLC19A1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16875718


    Sources:
    PharmGKB

  • IRINOTECAN   SLC19A1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CISPLATIN   SLC19A1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16875718


    Sources:
    PharmGKB

  • METHOTREXATE   SLC19A1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Ensembl: ENSG00000173638

    • Version: 101_38

    Alternate Names:
    SLC19A1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: SLC19A1

    • Version: 18-August-2020

    Alternate Names:
    PA327 PharmGKB ID

    Gene Info:

    Publications:
    Chung et al., 2006, XRCC1 R399Q polymorphism is associated with response to platinum-based neoadjuvant chemotherapy in bulky cervical cancer., Gynecol. Oncol.
    Pérez-Ramírez C et al., 2019, Pharmacogenetics of platinum-based chemotherapy: impact of DNA repair and folate metabolism gene polymorphisms on prognosis of non-small cell lung cancer patients., Pharmacogenomics J
    Hou Z et al., 2005, Localization of a substrate binding domain of the human reduced folate carrier to transmembrane domain 11 by radioaffinity labeling and cysteine-substituted accessibility methods., J Biol Chem

  • DTC: SLC19A1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Wang L et al., 2011, Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase., J Med Chem

  • HingoraniCasas: ENSG00000173638

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000173638 Gene Symbol
    SLC19A1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: SLC19A1

    • Version: 01-February-2022

    Alternate Names:
    FLOT1 GO Gene Synonym
    RFC1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • TTD: Solute carrier family 19 member 1

    • Version: 2020.06.01

    Alternate Names:
    SLC19A1 TTD Gene Abbreviation
    T35465 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: SLC19A1

    • Version: 01-February-2022

    Alternate Names:
    Folate transporter 1 Gene Name
    P41440 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21