DGIdb - SLC15A1 Gene Record

SLC15A1 6564 Druggable Genome

Alternate Names:

6564
SOLUTE CARRIER FAMILY 15 MEMBER 1
SLC15A1
HPECT1
HPEPT1
PEPT1
600544
10920
ENSG00000088386
OTTHUMG00000017255
P46059
984
Peptide transporter 1
OLIGOPEPTIDE TRANSPORTER, SMALL INTESTINE ISOFORM (PEPTIDE TRANSPORTER 1) (INTESTINAL H(+)/PEPTIDE COTRANSPORTER) (SOLUTE CARRIER FAMILY 15, MEMBER 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P46059]
BE0001018
PA323

Gene Info:

GuideToPharmacology Gene Category Name	SLC15 family of peptide transporters
GuideToPharmacology Gene Category ID	187
Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

TRANSPORTER
DRUGGABLE GENOME

Publications:

Luckner et al., 2005, Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1., Eur J Pharm Biopharm
Poirier A et al., 2012, Role of the intestinal peptide transporter PEPT1 in oseltamivir absorption: in vitro and in vivo studies., Drug Metab Dispos
Phan et al., 2003, Intra- and interindividual variabilities of valacyclovir oral bioavailability and effect of coadministration of an hPEPT1 inhibitor., Antimicrob. Agents Chemother.
Biegel et al., 2005, Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1., J. Med. Chem.
Omkvist DH et al., 2011, Affinity and translocation relationships via hPEPT1 of H-X aa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs., Eur J Pharm Biopharm

PENICILLIN V SLC15A1

Interaction Score: 11.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15974593

Sources:
DrugBank
GLYCYLSARCOSINE SLC15A1

Interaction Score: 11.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22584254

Sources:
DTC
BENZYLPENICILLIN SLC15A1

Interaction Score: 3.79

Interaction Types & Directionality:

inhibitor (inhibitory)

substrate

Interaction Info:

PMIDs:
15567297

Sources:
DrugBank
OXACILLIN SLC15A1

Interaction Score: 3.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15567297

Sources:
DrugBank
ACYCLOVIR SLC15A1

Interaction Score: 2.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12821497

Sources:
NCI
CEFOTAXIME SLC15A1

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15567297

Sources:
DrugBank
DEXIBUPROFEN SLC15A1

Interaction Score: 0.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21147219

Sources:
DrugBank
AMPICILLIN SLC15A1

Interaction Score: 0.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15567297

Sources:
DrugBank
CEFTRIAXONE SLC15A1

Interaction Score: 0.71

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15567297

Sources:
DrugBank
FLUVASTATIN SLC15A1

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000088386
- Version: 101_38
Alternate Names:

SLC15A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000088386

Version: 26-July-2011

Alternate Names:

OLIGOPEPTIDE TRANSPORTER, SMALL INTESTINE ISOFORM (PEPTIDE TRANSPORTER 1) (INTESTINAL H(+)/PEPTIDE COTRANSPORTER) (SOLUTE CARRIER FAMILY 15, MEMBER 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P46059] Description

SLC15A1 Display Id

ENSG00000088386 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

GuideToPharmacology: 6564
- Version: 29-September-2020
Alternate Names:

10920 HUGO Gene ID

10920 HUGO Gene Symbol

solute carrier family 15 member 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name SLC15 family of peptide transporters

GuideToPharmacology Gene Category ID 187

Gene Categories:

TRANSPORTER

Publications:

DrugBank: BE0001018

Version: 5.1.7

Alternate Names:

SLC15A1 DrugBank Gene Name

P46059 UniProt Accession

6564 Entrez Gene Id

Gene Info:

Publications:

Luckner et al., 2005, Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1., Eur J Pharm Biopharm

Omkvist DH et al., 2011, Affinity and translocation relationships via hPEPT1 of H-X aa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs., Eur J Pharm Biopharm

Biegel et al., 2005, Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1., J. Med. Chem.

NCI: SLC15A1
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Phan et al., 2003, Intra- and interindividual variabilities of valacyclovir oral bioavailability and effect of coadministration of an hPEPT1 inhibitor., Antimicrob. Agents Chemother.
DTC: SLC15A1
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Poirier A et al., 2012, Role of the intestinal peptide transporter PEPT1 in oseltamivir absorption: in vitro and in vivo studies., Drug Metab Dispos
HingoraniCasas: ENSG00000088386
- Version: 31-May-2017
Alternate Names:

ENSG00000088386 Gene Symbol

SLC15A1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
PharmGKB: SLC15A1
- Version: 18-August-2020
Alternate Names:

PA323 PharmGKB ID

Gene Info:

Publications:

OLIGOPEPTIDE TRANSPORTER, SMALL INTESTINE ISOFORM (PEPTIDE TRANSPORTER 1) (INTESTINAL H(+)/PEPTIDE COTRANSPORTER) (SOLUTE CARRIER FAMILY 15, MEMBER 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P46059]	Description
SLC15A1	Display Id
ENSG00000088386	Ensembl Gene Id

10920	HUGO Gene ID
10920	HUGO Gene Symbol
solute carrier family 15 member 1	HUGO Gene Name

SLC15A1	DrugBank Gene Name
P46059	UniProt Accession
6564	Entrez Gene Id

inhibitor (inhibitory)
substrate

SLC15A1 Gene Record

SLC15A1 6564 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15974593

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22584254

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory) substrate

Interaction Info:

PMIDs: 15567297

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15567297

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12821497

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15567297

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21147219

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15567297

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15567297

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Ensembl: ENSG00000088386

Alternate Names: SLC15A1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000088386

Alternate Names: OLIGOPEPTIDE TRANSPORTER, SMALL INTESTINE ISOFORM (PEPTIDE TRANSPORTER 1) (INTESTINAL H(+)/PEPTIDE COTRANSPORTER) (SOLUTE CARRIER FAMILY 15, MEMBER 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P46059] Description SLC15A1 Display Id ENSG00000088386 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

GuideToPharmacology: 6564

Alternate Names: 10920 HUGO Gene ID 10920 HUGO Gene Symbol solute carrier family 15 member 1 HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name SLC15 family of peptide transporters GuideToPharmacology Gene Category ID 187

Gene Categories: TRANSPORTER

Publications:

DrugBank: BE0001018

Alternate Names: SLC15A1 DrugBank Gene Name P46059 UniProt Accession 6564 Entrez Gene Id

Gene Info:

NCI: SLC15A1

Alternate Names:

Gene Info:

Publications: Phan et al., 2003, Intra- and interindividual variabilities of valacyclovir oral bioavailability and effect of coadministration of an hPEPT1 inhibitor., Antimicrob. Agents Chemother.

DTC: SLC15A1

Alternate Names:

Gene Info:

Publications: Poirier A et al., 2012, Role of the intestinal peptide transporter PEPT1 in oseltamivir absorption: in vitro and in vivo studies., Drug Metab Dispos

HingoraniCasas: ENSG00000088386

Alternate Names: ENSG00000088386 Gene Symbol SLC15A1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

PharmGKB: SLC15A1

Alternate Names: PA323 PharmGKB ID

Gene Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
15974593

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
22584254

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

substrate

PMIDs:
15567297

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
15567297

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
12821497

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15567297

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
21147219

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
15567297

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
15567297

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

SLC15A1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

OLIGOPEPTIDE TRANSPORTER, SMALL INTESTINE ISOFORM (PEPTIDE TRANSPORTER 1) (INTESTINAL H(+)/PEPTIDE COTRANSPORTER) (SOLUTE CARRIER FAMILY 15, MEMBER 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P46059] Description

SLC15A1 Display Id

ENSG00000088386 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

10920 HUGO Gene ID

10920 HUGO Gene Symbol

solute carrier family 15 member 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name SLC15 family of peptide transporters

GuideToPharmacology Gene Category ID 187

Gene Categories:

TRANSPORTER

Alternate Names:

SLC15A1 DrugBank Gene Name

P46059 UniProt Accession

6564 Entrez Gene Id

Publications:

Phan et al., 2003, Intra- and interindividual variabilities of valacyclovir oral bioavailability and effect of coadministration of an hPEPT1 inhibitor., Antimicrob. Agents Chemother.

Publications:

Poirier A et al., 2012, Role of the intestinal peptide transporter PEPT1 in oseltamivir absorption: in vitro and in vivo studies., Drug Metab Dispos

Alternate Names:

ENSG00000088386 Gene Symbol

SLC15A1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PA323 PharmGKB ID