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SLC12A3 Gene Record

  • Summary
  • Interactions
  • Claims
  • SLC12A3 6559 Druggable Genome

    Alternate Names:

    6559
    SOLUTE CARRIER FAMILY 12 MEMBER 3
    SLC12A3
    NCC
    NCCT
    TSC
    600968
    10912
    ENSG00000070915
    OTTHUMG00000133284
    P55017
    NA-CL SYMPORTER
    THIAZIDE-SENSITIVE SODIUM-CHLORIDE COTRANSPORTER
    S12A3_HUMAN
    Na-Cl cotransporter
    PA321
    SOLUTE CARRIER FAMILY 12, MEMBER 3 (THIAZIDE-SENSITIVE SODIUM-CHLORIDE COTRANSPORTER) (NA-CL SYMPORTER). [SOURCE:UNIPROT/SWISSPROT;ACC:P55017]
    T84886

    Gene Info:

    Target Class Transporters
    Target Subclass TC:2.A.30.4.2
    Interpro Name Thiazide-sensitive Na-K-Cl co-transporter
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Short Name NaCl_cotranspt
    Interpro Acc IPR002948
    Interpro Type Domain
    Interpro Name Amino acid permease domain
    Human Readable Name TRANSPORTER
    Interpro Acc IPR004841
    Interpro Short Name AA-permease_dom
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Family
    Target Main Class Transporters
    Target Subclass SLC
    Transmembrane Helix Count 12
    Target Subclass APC
    Target Subclass SLC12
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    DRUGGABLE GENOME

    Publications:

    Abuladze et al., 1998, Peripheral blood mononuclear cells express mutated NCCT mRNA in Gitelman's syndrome: evidence for abnormal thiazide-sensitive NaCl cotransport., J. Am. Soc. Nephrol.
    Ran et al., 2005, [A case of Gitelman's syndrome presenting with severe hypocalcaemia and hypokalemic periodic paralysis]., Sichuan Da Xue Xue Bao Yi Xue Ban
    Barry et al., 1997, Expression of the sodium-chloride cotransporter in osteoblast-like cells: effect of thiazide diuretics., Am. J. Physiol.
    Kurschat et al., 2003, [Gitelman's syndrome: an important differential diagnosis of hypokalemia]., Dtsch. Med. Wochenschr.
    Turner et al., 2005, WNK1 kinase polymorphism and blood pressure response to a thiazide diuretic., Hypertension
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Monroy et al., 2000, Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: a new model for ions and diuretics interaction., Am. J. Physiol. Renal Physiol.
    Thakker, Molecular pathology of renal chloride channels in Dent's disease and Bartter's syndrome., Exp. Nephrol.
    Reinalter et al., 2004, Pharmacotyping of hypokalaemic salt-losing tubular disorders., Acta Physiol. Scand.
    Wilson et al., 2003, Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4., Proc. Natl. Acad. Sci. U.S.A.
    Schmidt et al., 2001, Clinical, biochemical and molecular genetic data in five children with Gitelman's syndrome., Horm. Metab. Res.
    Maki et al., 2004, Four novel mutations in the thiazide-sensitive Na-Cl co-transporter gene in Japanese patients with Gitelman's syndrome., Nephrol. Dial. Transplant.
    Li et al., 2007, Function and regulation of epithelial sodium transporters in the kidney of a salt-sensitive hypertensive rat model., J. Hypertens.
    Smith, 2010, Thiazide diuretics., N. Engl. J. Med.
    Hasannejad et al., 2004, Interactions of human organic anion transporters with diuretics., J. Pharmacol. Exp. Ther.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Ellison, 2003, The thiazide-sensitive na-cl cotransporter and human disease: reemergence of an old player., J. Am. Soc. Nephrol.
    Blanchard A et al., 2019, Resistance to Insulin in Patients with Gitelman Syndrome and a Subtle Intermediate Phenotype in Heterozygous Carriers: A Cross-Sectional Study., J Am Soc Nephrol
    Ko et al., 2009, Molecular physiology of the thiazide-sensitive sodium-chloride cotransporter., Curr. Opin. Nephrol. Hypertens.
    Gamba, 2009, The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs., Am. J. Physiol. Renal Physiol.
    Duarte et al., 2010, Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics., Expert Rev Cardiovasc Ther
    Vormfelde SV et al., 2012, The genetics of loop diuretic effects., Pharmacogenomics J
    Vormfelde et al., 2007, Genetic variation in the renal sodium transporters NKCC2, NCC, and ENaC in relation to the effects of loop diuretic drugs., Clin. Pharmacol. Ther.
    Vallon et al., 2008, Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics., Am. J. Physiol. Renal Physiol.
    Frindt et al., 2002, Epithelial Na channels and short-term renal response to salt deprivation., Am. J. Physiol. Renal Physiol.
    Tamargo J et al., 2014, Diuretics in the treatment of hypertension. Part 1: thiazide and thiazide-like diuretics., Expert Opin Pharmacother
    Ma F et al., 2013, Indapamide lowers blood pressure by increasing production of epoxyeicosatrienoic acids in the kidney., Mol Pharmacol
  • POLYTHIAZIDE   SLC12A3

    Interaction Score: 27.48

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor
    Direct Interaction yes
    Trial Name -

    PMIDs:
    12217863 10894798 11752352 19474192


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • QUINETHAZONE   SLC12A3

    Interaction Score: 24.04

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

    PMIDs:
    12538756 19636250 19474192 20528637


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • BENDROFLUMETHIAZIDE   SLC12A3

    Interaction Score: 12.02

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

    PMIDs:
    10894798 11752352 18216144


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • BENZTHIAZIDE   SLC12A3

    Interaction Score: 6.01

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor
    Direct Interaction yes
    Novel drug target Established target

    PMIDs:
    17016423 17139284 12538756 31285285


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • METOLAZONE   SLC12A3

    Interaction Score: 5.72

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

    PMIDs:
    11752352


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • CHLOROTHIAZIDE   SLC12A3

    Interaction Score: 4.58

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor
    Direct Interaction yes
    Trial Name -

    PMIDs:
    11014932 15283765 12515852 11456284 15069170


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • INDAPAMIDE   SLC12A3

    Interaction Score: 3.43

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor
    Direct Interaction yes

    PMIDs:
    20528637 24444254 23729436


    Sources:
    ChemblInteractions

  • CHLOROTHIAZIDE SODIUM   SLC12A3

    Interaction Score: 3.43

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TRICHLORMETHIAZIDE   SLC12A3

    Interaction Score: 2.86

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor
    Direct Interaction yes

    PMIDs:
    11752352 17414671 20187262 14610216


    Sources:
    ChemblInteractions

  • METHYCLOTHIAZIDE   SLC12A3

    Interaction Score: 1.14

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • HYDROFLUMETHIAZIDE   SLC12A3

    Interaction Score: 1.14

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DIAZOXIDE   SLC12A3

    Interaction Score: 1.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • HYDROCHLOROTHIAZIDE   SLC12A3

    Interaction Score: 0.95

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor
    Direct Interaction yes
    Trial Name Amturnide

    PMIDs:
    9596079 16078592 9038817 12772080 16172412 11752352 10894798


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • TORSEMIDE   SLC12A3

    Interaction Score: 0.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20877298 17460608


    Sources:
    PharmGKB

  • FUROSEMIDE   SLC12A3

    Interaction Score: 0.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20877298 17460608


    Sources:
    PharmGKB

  • CYCLOTHIAZIDE   SLC12A3

    Interaction Score: 0.86

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BUMETANIDE   SLC12A3

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20877298 17460608


    Sources:
    PharmGKB

  • CHLORTHALIDONE   SLC12A3

    Interaction Score: 0.57

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000070915

    • Version: 101_38

    Alternate Names:
    SLC12A3 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000070915

    • Version: 26-July-2011

    Alternate Names:
    SOLUTE CARRIER FAMILY 12, MEMBER 3 (THIAZIDE-SENSITIVE SODIUM-CHLORIDE COTRANSPORTER) (NA-CL SYMPORTER). [SOURCE:UNIPROT/SWISSPROT;ACC:P55017] Description
    ENSG00000070915 Ensembl Gene Id
    SLC12A3 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P55017

    • Version: January-2014

    Alternate Names:
    SLC12A3 Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass TC:2.A.30.4.2

    Publications:

  • TEND: P55017

    • Version: 01-August-2011

    Alternate Names:
    S12A3_HUMAN Uniprot Id
    P55017 Uniprot Accession
    SLC12A3 Gene Symbol

    Gene Info:
    Target Main Class Transporters
    Target Subclass SLC
    Transmembrane Helix Count 12

    Publications:

  • HopkinsGroom: P55017

    • Version: 11-September-2012

    Alternate Names:
    P55017 Uniprot Accession
    S12A3_HUMAN Uniprot Id
    6559 Entrez Gene Id

    Gene Info:
    Interpro Name Thiazide-sensitive Na-K-Cl co-transporter
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot

    Gene Categories:
    TRANSPORTER, DRUGGABLE GENOME

    Publications:

  • PharmGKB: SLC12A3

    • Version: 18-August-2020

    Alternate Names:
    PA321 PharmGKB ID

    Gene Info:

    Publications:
    Thorn CF et al., 2013, PharmGKB summary: Diuretics pathway, pharmacodynamics., Pharmacogenet Genomics
    Matayoshi T et al., 2004, The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics., Hypertens Res
    Vormfelde SV et al., 2012, The genetics of loop diuretic effects., Pharmacogenomics J

  • HingoraniCasas: ENSG00000070915

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000070915 Gene Symbol
    SLC12A3 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: NCC

    • Version: chembl_23

    Alternate Names:
    TSC GENE_SYMBOL
    SLC12A3 GENE_SYMBOL
    Solute carrier family 12 member 3 UNIPROT

    Gene Info:

    Publications:

  • TTD: Solute carrier family 12 member 3

    • Version: 2020.06.01

    Alternate Names:
    SLC12A3 TTD Gene Abbreviation
    T84886 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21