DGIdb - SLC12A3 Gene Record

SLC12A3 6559 Druggable Genome

Alternate Names:

6559
SOLUTE CARRIER FAMILY 12 MEMBER 3
SLC12A3
NCC
NCCT
TSC
600968
10912
ENSG00000070915
OTTHUMG00000133284
P55017
NA-CL SYMPORTER
THIAZIDE-SENSITIVE SODIUM-CHLORIDE COTRANSPORTER
S12A3_HUMAN
Na-Cl cotransporter
PA321
SOLUTE CARRIER FAMILY 12, MEMBER 3 (THIAZIDE-SENSITIVE SODIUM-CHLORIDE COTRANSPORTER) (NA-CL SYMPORTER). [SOURCE:UNIPROT/SWISSPROT;ACC:P55017]
T84886

Gene Info:

Target Class	Transporters
Target Subclass	TC:2.A.30.4.2
Interpro Name	Thiazide-sensitive Na-K-Cl co-transporter
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Interpro Short Name	NaCl_cotranspt
Interpro Acc	IPR002948
Interpro Type	Domain
Interpro Name	Amino acid permease domain
Human Readable Name	TRANSPORTER
Interpro Acc	IPR004841
Interpro Short Name	AA-permease_dom
Uniprot Evidence	1: Evidence at protein level
Interpro Type	Family
Target Main Class	Transporters
Target Subclass	SLC
Transmembrane Helix Count	12
Target Subclass	APC
Target Subclass	SLC12
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

TRANSPORTER
DRUGGABLE GENOME

Publications:

Abuladze et al., 1998, Peripheral blood mononuclear cells express mutated NCCT mRNA in Gitelman's syndrome: evidence for abnormal thiazide-sensitive NaCl cotransport., J. Am. Soc. Nephrol.
Ran et al., 2005, [A case of Gitelman's syndrome presenting with severe hypocalcaemia and hypokalemic periodic paralysis]., Sichuan Da Xue Xue Bao Yi Xue Ban
Barry et al., 1997, Expression of the sodium-chloride cotransporter in osteoblast-like cells: effect of thiazide diuretics., Am. J. Physiol.
Kurschat et al., 2003, [Gitelman's syndrome: an important differential diagnosis of hypokalemia]., Dtsch. Med. Wochenschr.
Turner et al., 2005, WNK1 kinase polymorphism and blood pressure response to a thiazide diuretic., Hypertension
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Monroy et al., 2000, Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: a new model for ions and diuretics interaction., Am. J. Physiol. Renal Physiol.
Thakker, Molecular pathology of renal chloride channels in Dent's disease and Bartter's syndrome., Exp. Nephrol.
Reinalter et al., 2004, Pharmacotyping of hypokalaemic salt-losing tubular disorders., Acta Physiol. Scand.
Wilson et al., 2003, Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4., Proc. Natl. Acad. Sci. U.S.A.
Schmidt et al., 2001, Clinical, biochemical and molecular genetic data in five children with Gitelman's syndrome., Horm. Metab. Res.
Maki et al., 2004, Four novel mutations in the thiazide-sensitive Na-Cl co-transporter gene in Japanese patients with Gitelman's syndrome., Nephrol. Dial. Transplant.
Li et al., 2007, Function and regulation of epithelial sodium transporters in the kidney of a salt-sensitive hypertensive rat model., J. Hypertens.
Smith, 2010, Thiazide diuretics., N. Engl. J. Med.
Hasannejad et al., 2004, Interactions of human organic anion transporters with diuretics., J. Pharmacol. Exp. Ther.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Ellison, 2003, The thiazide-sensitive na-cl cotransporter and human disease: reemergence of an old player., J. Am. Soc. Nephrol.
Blanchard A et al., 2019, Resistance to Insulin in Patients with Gitelman Syndrome and a Subtle Intermediate Phenotype in Heterozygous Carriers: A Cross-Sectional Study., J Am Soc Nephrol
Ko et al., 2009, Molecular physiology of the thiazide-sensitive sodium-chloride cotransporter., Curr. Opin. Nephrol. Hypertens.
Gamba, 2009, The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs., Am. J. Physiol. Renal Physiol.
Duarte et al., 2010, Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics., Expert Rev Cardiovasc Ther
Vormfelde SV et al., 2012, The genetics of loop diuretic effects., Pharmacogenomics J
Vormfelde et al., 2007, Genetic variation in the renal sodium transporters NKCC2, NCC, and ENaC in relation to the effects of loop diuretic drugs., Clin. Pharmacol. Ther.
Vallon et al., 2008, Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics., Am. J. Physiol. Renal Physiol.
Frindt et al., 2002, Epithelial Na channels and short-term renal response to salt deprivation., Am. J. Physiol. Renal Physiol.
Tamargo J et al., 2014, Diuretics in the treatment of hypertension. Part 1: thiazide and thiazide-like diuretics., Expert Opin Pharmacother
Ma F et al., 2013, Indapamide lowers blood pressure by increasing production of epoxyeicosatrienoic acids in the kidney., Mol Pharmacol

POLYTHIAZIDE SLC12A3

Interaction Score: 27.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
12217863 10894798 11752352 19474192

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
QUINETHAZONE SLC12A3

Interaction Score: 24.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

PMIDs:
12538756 19636250 19474192 20528637

Sources:
TdgClinicalTrial ChemblInteractions TEND
BENDROFLUMETHIAZIDE SLC12A3

Interaction Score: 12.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

PMIDs:
10894798 11752352 18216144

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
BENZTHIAZIDE SLC12A3

Interaction Score: 6.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

Novel drug target Established target

PMIDs:
17016423 17139284 12538756 31285285

Sources:
TdgClinicalTrial ChemblInteractions TEND
METOLAZONE SLC12A3

Interaction Score: 5.72

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

PMIDs:
11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
CHLOROTHIAZIDE SLC12A3

Interaction Score: 4.58

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
11014932 15283765 12515852 11456284 15069170

Sources:
TdgClinicalTrial ChemblInteractions TEND
INDAPAMIDE SLC12A3

Interaction Score: 3.43

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

PMIDs:
20528637 24444254 23729436

Sources:
ChemblInteractions
CHLOROTHIAZIDE SODIUM SLC12A3

Interaction Score: 3.43

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TRICHLORMETHIAZIDE SLC12A3

Interaction Score: 2.86

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

PMIDs:
11752352 17414671 20187262 14610216

Sources:
ChemblInteractions
METHYCLOTHIAZIDE SLC12A3

Interaction Score: 1.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HYDROFLUMETHIAZIDE SLC12A3

Interaction Score: 1.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIAZOXIDE SLC12A3

Interaction Score: 1.06

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND
HYDROCHLOROTHIAZIDE SLC12A3

Interaction Score: 0.95

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

Trial Name Amturnide

PMIDs:
9596079 16078592 9038817 12772080 16172412 11752352 10894798

Sources:
TdgClinicalTrial ChemblInteractions TEND
TORSEMIDE SLC12A3

Interaction Score: 0.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20877298 17460608

Sources:
PharmGKB
FUROSEMIDE SLC12A3

Interaction Score: 0.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20877298 17460608

Sources:
PharmGKB
CYCLOTHIAZIDE SLC12A3

Interaction Score: 0.86

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BUMETANIDE SLC12A3

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20877298 17460608

Sources:
PharmGKB
CHLORTHALIDONE SLC12A3

Interaction Score: 0.57

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000070915
- Version: 101_38
Alternate Names:

SLC12A3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000070915

Version: 26-July-2011

Alternate Names:

SOLUTE CARRIER FAMILY 12, MEMBER 3 (THIAZIDE-SENSITIVE SODIUM-CHLORIDE COTRANSPORTER) (NA-CL SYMPORTER). [SOURCE:UNIPROT/SWISSPROT;ACC:P55017] Description

ENSG00000070915 Ensembl Gene Id

SLC12A3 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P55017
- Version: January-2014
Alternate Names:

SLC12A3 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:2.A.30.4.2

Publications:
TEND: P55017
- Version: 01-August-2011
Alternate Names:

S12A3_HUMAN Uniprot Id

P55017 Uniprot Accession

SLC12A3 Gene Symbol

Gene Info:

Target Main Class Transporters

Target Subclass SLC

Transmembrane Helix Count 12

Publications:
HopkinsGroom: P55017
- Version: 11-September-2012
Alternate Names:

P55017 Uniprot Accession

S12A3_HUMAN Uniprot Id

6559 Entrez Gene Id

Gene Info:

Interpro Name Thiazide-sensitive Na-K-Cl co-transporter

Human Readable Name DRUGGABLE GENOME

Uniprot Status Swiss-Prot

Gene Categories:

TRANSPORTER, DRUGGABLE GENOME

Publications:

PharmGKB: SLC12A3

Version: 18-August-2020

Alternate Names:

PA321 PharmGKB ID

Gene Info:

Publications:

Thorn CF et al., 2013, PharmGKB summary: Diuretics pathway, pharmacodynamics., Pharmacogenet Genomics

Matayoshi T et al., 2004, The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics., Hypertens Res

Vormfelde SV et al., 2012, The genetics of loop diuretic effects., Pharmacogenomics J

HingoraniCasas: ENSG00000070915
- Version: 31-May-2017
Alternate Names:

ENSG00000070915 Gene Symbol

SLC12A3 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: NCC
- Version: chembl_23
Alternate Names:

TSC GENE_SYMBOL

SLC12A3 GENE_SYMBOL

Solute carrier family 12 member 3 UNIPROT

Gene Info:

Publications:
TTD: Solute carrier family 12 member 3
- Version: 2020.06.01
Alternate Names:

SLC12A3 TTD Gene Abbreviation

T84886 TTD Target ID

Gene Info:

Publications:

Mechanism of Interaction	Thiazide-sensitive sodium-chloride cotransporter inhibitor
Direct Interaction	yes
Trial Name	-

Trial Name	-
Novel drug target	Established target
Mechanism of Interaction	Thiazide-sensitive sodium-chloride cotransporter inhibitor

SOLUTE CARRIER FAMILY 12, MEMBER 3 (THIAZIDE-SENSITIVE SODIUM-CHLORIDE COTRANSPORTER) (NA-CL SYMPORTER). [SOURCE:UNIPROT/SWISSPROT;ACC:P55017]	Description
ENSG00000070915	Ensembl Gene Id
SLC12A3	Display Id

S12A3_HUMAN	Uniprot Id
P55017	Uniprot Accession
SLC12A3	Gene Symbol

TSC	GENE_SYMBOL
SLC12A3	GENE_SYMBOL
Solute carrier family 12 member 3	UNIPROT

SLC12A3 Gene Record

SLC12A3 6559 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor Direct Interaction yes Trial Name -

PMIDs: 12217863 10894798 11752352 19474192

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

PMIDs: 12538756 19636250 19474192 20528637

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

PMIDs: 10894798 11752352 18216144

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor Direct Interaction yes Novel drug target Established target

PMIDs: 17016423 17139284 12538756 31285285

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

PMIDs: 11752352

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor Direct Interaction yes Trial Name -

PMIDs: 11014932 15283765 12515852 11456284 15069170

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor Direct Interaction yes

PMIDs: 20528637 24444254 23729436

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor Direct Interaction yes

PMIDs: 11752352 17414671 20187262 14610216

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor Direct Interaction yes Trial Name Amturnide

PMIDs: 9596079 16078592 9038817 12772080 16172412 11752352 10894798

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20877298 17460608

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20877298 17460608

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20877298 17460608

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000070915

Alternate Names: SLC12A3 Ensembl Gene Name

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
12217863 10894798 11752352 19474192

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

PMIDs:
12538756 19636250 19474192 20528637

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

PMIDs:
10894798 11752352 18216144

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

Novel drug target Established target

PMIDs:
17016423 17139284 12538756 31285285

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

PMIDs:
11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
11014932 15283765 12515852 11456284 15069170

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

PMIDs:
20528637 24444254 23729436

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

PMIDs:
11752352 17414671 20187262 14610216

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

Trial Name Amturnide

PMIDs:
9596079 16078592 9038817 12772080 16172412 11752352 10894798

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
20877298 17460608

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20877298 17460608

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
20877298 17460608

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

SLC12A3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

SOLUTE CARRIER FAMILY 12, MEMBER 3 (THIAZIDE-SENSITIVE SODIUM-CHLORIDE COTRANSPORTER) (NA-CL SYMPORTER). [SOURCE:UNIPROT/SWISSPROT;ACC:P55017] Description

ENSG00000070915 Ensembl Gene Id

SLC12A3 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

SLC12A3 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:2.A.30.4.2

Alternate Names:

S12A3_HUMAN Uniprot Id

P55017 Uniprot Accession

SLC12A3 Gene Symbol

Gene Info:

Target Main Class Transporters

Target Subclass SLC

Transmembrane Helix Count 12

Alternate Names:

P55017 Uniprot Accession

S12A3_HUMAN Uniprot Id

6559 Entrez Gene Id

Gene Info:

Interpro Name Thiazide-sensitive Na-K-Cl co-transporter

Human Readable Name DRUGGABLE GENOME

Uniprot Status Swiss-Prot