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SIRT2 Gene Record

  • Summary
  • Interactions
  • Claims
  • SIRT2 22933 Druggable Genome

    Alternate Names:

    22933
    SIRTUIN 2
    SIRT2
    SIR2
    SIR2L
    SIR2L2
    604480
    10886
    ENSG00000068903
    Q8IXJ6
    PA35786
    NAD-dependent deacetylase sirtuin-2
    T83904
    NAD-dependent protein deacetylase sirtuin-2

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    TUMOR SUPPRESSOR
    KINASE
    TRANSCRIPTION FACTOR BINDING
    DRUGGABLE GENOME
    ENZYME
    TRANSCRIPTION FACTOR

    Publications:

    Huber K et al., 2010, Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins)., J Med Chem
    Trapp J et al., 2006, Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition., J Med Chem
    Tatum PR et al., 2014, Identification of novel SIRT2-selective inhibitors using a click chemistry approach., Bioorg Med Chem Lett
    Xin S et al., 2020, Polymorphisms of NF-κB pathway genes influence adverse drug reactions of gefitinib in NSCLC patients., Pharmacogenomics J
    McCarthy AR et al., 2012, Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins., Bioorg Med Chem
  • PAULLONE   SIRT2

    Interaction Score: 15.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17149860


    Sources:
    DTC

  • CHEMBL589270   SIRT2

    Interaction Score: 15.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24675380


    Sources:
    DTC

  • CHEMBL1794051   SIRT2

    Interaction Score: 15.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20030343


    Sources:
    DTC

  • CHEMBL595354   SIRT2

    Interaction Score: 7.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22304848


    Sources:
    DTC

  • SALERMIDE   SIRT2

    Interaction Score: 3.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BISINDOLYLMALEIMIDE IX   SIRT2

    Interaction Score: 2.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17149860 20030343


    Sources:
    DTC

  • TRICHOSTATIN   SIRT2

    Interaction Score: 1.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17149860 20030343


    Sources:
    DTC

  • GEFITINIB   SIRT2

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31664190


    Sources:
    PharmGKB

  • Ensembl: ENSG00000068903

    • Version: 101_38

    Alternate Names:
    SIRT2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: SIRT2

    • Version: 18-August-2020

    Alternate Names:
    PA35786 PharmGKB ID

    Gene Info:

    Publications:
    Xin S et al., 2020, Polymorphisms of NF-κB pathway genes influence adverse drug reactions of gefitinib in NSCLC patients., Pharmacogenomics J

  • DTC: SIRT2

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Huber K et al., 2010, Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins)., J Med Chem
    Trapp J et al., 2006, Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition., J Med Chem
    McCarthy AR et al., 2012, Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins., Bioorg Med Chem

  • HingoraniCasas: ENSG00000068903

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000068903 Gene Symbol
    SIRT2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: SIRT2

    • Version: 01-February-2022

    Alternate Names:
    SIR2L GO Gene Synonym
    SIR2L2 GO Gene Synonym

    Gene Info:

    Gene Categories:
    TUMOR SUPPRESSOR, TRANSCRIPTION FACTOR BINDING

    Publications:

  • TTD: NAD-dependent deacetylase sirtuin-2

    • Version: 2020.06.01

    Alternate Names:
    SIRT2 TTD Gene Abbreviation
    T83904 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: SIRT2

    • Version: 01-February-2022

    Alternate Names:
    NAD-dependent protein deacetylase sirtuin-2 Gene Name
    Q8IXJ6 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, ENZYME, TRANSCRIPTION FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21