DGIdb - SIRT2 Gene Record

SIRT2 22933 Druggable Genome

Alternate Names:

22933
SIRTUIN 2
SIRT2
SIR2
SIR2L
SIR2L2
604480
10886
ENSG00000068903
Q8IXJ6
2708
PA35786
NAD-dependent deacetylase sirtuin-2
T83904
NM_012237
NP_036369
NAD-dependent protein deacetylase sirtuin-2

Gene Info:

Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	3.5.1.- Histone deacetylases (HDACs)
GuideToPharmacology Gene Category ID	848

(4 More Sources)

Gene Categories: Category Details

TUMOR SUPPRESSOR
KINASE
TRANSCRIPTION FACTOR BINDING
DRUGGABLE GENOME
ENZYME
TRANSCRIPTION FACTOR

Publications:

Huber K et al., 2010, Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins)., J Med Chem
Trapp J et al., 2006, Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition., J Med Chem
Tatum PR et al., 2014, Identification of novel SIRT2-selective inhibitors using a click chemistry approach., Bioorg Med Chem Lett
Xin S et al., 2020, Polymorphisms of NF-κB pathway genes influence adverse drug reactions of gefitinib in NSCLC patients., Pharmacogenomics J
McCarthy AR et al., 2012, Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins., Bioorg Med Chem

PAULLONE SIRT2

Interaction Score: 15.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17149860

Sources:
DTC
CHEMBL589270 SIRT2

Interaction Score: 15.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24675380

Sources:
DTC
CHEMBL595354 SIRT2

Interaction Score: 7.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22304848

Sources:
DTC
CHEMBL1794051 SIRT2

Interaction Score: 7.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20030343

Sources:
DTC
SALERMIDE SIRT2

Interaction Score: 3.99

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BISINDOLYLMALEIMIDE IX SIRT2

Interaction Score: 2.99

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17149860 20030343

Sources:
DTC
TRICHOSTATIN SIRT2

Interaction Score: 1.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17149860 20030343

Sources:
DTC
GEFITINIB SIRT2

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31664190

Sources:
PharmGKB

Ensembl: ENSG00000068903
- Version: 101_38
Alternate Names:

SIRT2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
GuideToPharmacology: 22933
- Version: 29-September-2020
Alternate Names:

10886 HUGO Gene ID

10886 HUGO Gene Symbol

sirtuin 2 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name 3.5.1.- Histone deacetylases (HDACs)

GuideToPharmacology Gene Category ID 848

Gene Categories:

ENZYME

Publications:
PharmGKB: SIRT2
- Version: 18-August-2020
Alternate Names:

PA35786 PharmGKB ID

Gene Info:

Publications:

Xin S et al., 2020, Polymorphisms of NF-κB pathway genes influence adverse drug reactions of gefitinib in NSCLC patients., Pharmacogenomics J

DTC: SIRT2

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Huber K et al., 2010, Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins)., J Med Chem

Trapp J et al., 2006, Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition., J Med Chem

McCarthy AR et al., 2012, Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins., Bioorg Med Chem

HingoraniCasas: ENSG00000068903
- Version: 31-May-2017
Alternate Names:

ENSG00000068903 Gene Symbol

SIRT2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: NAD-dependent deacetylase sirtuin-2
- Version: 2020.06.01
Alternate Names:

SIRT2 TTD Gene Abbreviation

T83904 TTD Target ID

Gene Info:

Publications:
GO: SIRT2
- Version: 01-May-2021
Alternate Names:

SIR2L GO Gene Synonym

SIR2L2 GO Gene Synonym

Gene Info:

Gene Categories:

TUMOR SUPPRESSOR, TRANSCRIPTION FACTOR BINDING

Publications:
Pharos: SIRT2
- Version: 01-May-2021
Alternate Names:

NAD-dependent protein deacetylase sirtuin-2 Gene Name

Q8IXJ6 UniProt ID

Gene Info:

Gene Categories:

KINASE, ENZYME, TRANSCRIPTION FACTOR

Publications:

10886	HUGO Gene ID
10886	HUGO Gene Symbol
sirtuin 2	HUGO Gene Name

NAD-dependent protein deacetylase sirtuin-2	Gene Name
Q8IXJ6	UniProt ID

SIRT2	TTD Gene Abbreviation
T83904	TTD Target ID

SIRT2 Gene Record

SIRT2 22933 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17149860

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24675380

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22304848

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20030343

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17149860 20030343

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17149860 20030343

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 31664190

Sources: PharmGKB

Ensembl: ENSG00000068903

Alternate Names: SIRT2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

GuideToPharmacology: 22933

Alternate Names: 10886 HUGO Gene ID 10886 HUGO Gene Symbol sirtuin 2 HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name 3.5.1.- Histone deacetylases (HDACs) GuideToPharmacology Gene Category ID 848

Gene Categories: ENZYME

Publications:

PharmGKB: SIRT2

Alternate Names: PA35786 PharmGKB ID

Gene Info:

Publications: Xin S et al., 2020, Polymorphisms of NF-κB pathway genes influence adverse drug reactions of gefitinib in NSCLC patients., Pharmacogenomics J

DTC: SIRT2

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000068903

Alternate Names: ENSG00000068903 Gene Symbol SIRT2 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

TTD: NAD-dependent deacetylase sirtuin-2

Alternate Names: SIRT2 TTD Gene Abbreviation T83904 TTD Target ID

Gene Info:

Publications:

GO: SIRT2

Alternate Names: SIR2L GO Gene Synonym SIR2L2 GO Gene Synonym

Gene Info:

Gene Categories: TUMOR SUPPRESSOR, TRANSCRIPTION FACTOR BINDING

Publications:

Pharos: SIRT2

Alternate Names: NAD-dependent protein deacetylase sirtuin-2 Gene Name Q8IXJ6 UniProt ID

Gene Info:

Gene Categories: KINASE, ENZYME, TRANSCRIPTION FACTOR

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
17149860

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24675380

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22304848

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20030343

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17149860 20030343

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17149860 20030343

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
31664190

Sources:
PharmGKB

Alternate Names:

SIRT2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

10886 HUGO Gene ID

10886 HUGO Gene Symbol

sirtuin 2 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name 3.5.1.- Histone deacetylases (HDACs)

GuideToPharmacology Gene Category ID 848

Gene Categories:

ENZYME

Alternate Names:

PA35786 PharmGKB ID

Publications:

Xin S et al., 2020, Polymorphisms of NF-κB pathway genes influence adverse drug reactions of gefitinib in NSCLC patients., Pharmacogenomics J

Alternate Names:

ENSG00000068903 Gene Symbol

SIRT2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

SIRT2 TTD Gene Abbreviation

T83904 TTD Target ID

Alternate Names:

SIR2L GO Gene Synonym

SIR2L2 GO Gene Synonym

Gene Categories:

TUMOR SUPPRESSOR, TRANSCRIPTION FACTOR BINDING

Alternate Names:

NAD-dependent protein deacetylase sirtuin-2 Gene Name

Q8IXJ6 UniProt ID

Gene Categories:

KINASE, ENZYME, TRANSCRIPTION FACTOR