DGIdb - SIRT1 Gene Record

SIRT1 23411 Druggable Genome

Alternate Names:

23411
SIRTUIN 1
SIRT1
SIR2
SIR2L1
SIR2alpha
604479
14929
ENSG00000096717
OTTHUMG00000018340
Q96EB6
NAD-DEPENDENT DEACETYLASE SIRTUIN-1
T14731
NAD-dependent protein deacetylase sirtuin-1

Gene Info:

Target Class	Enzymes
Target Subclass	EC:3.5.1.-
Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

KINASE
DRUGGABLE GENOME
ENZYME
TRANSCRIPTION FACTOR

Publications:

Dao TT et al., 2012, Terpenylated coumarins as SIRT1 activators isolated from Ailanthus altissima., J Nat Prod
Ota H et al., 2013, trans-Resveratrol in Gnetum gnemon protects against oxidative-stress-induced endothelial senescence., J Nat Prod
Milne et al., 2007, Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes., Nature
Wu J et al., 2013, Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate., J Med Chem
Hubbard BP et al., 2013, Evidence for a common mechanism of SIRT1 regulation by allosteric activators., Science
Lakshminarasimhan M et al., 2013, Sirt1 activation by resveratrol is substrate sequence-selective., Aging (Albany NY)
Ma LY et al., 2015, New SIRT1 activator from alkaline hydrolysate of total saponins in the stems-leaves of Panax ginseng., Bioorg Med Chem Lett
Rotili D et al., 2012, Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells., J Med Chem
García J et al., 2011, Epigenetic profiling of the antitumor natural product psammaplin A and its analogues., Bioorg Med Chem
Matsuya Y et al., 2013, Search for a novel SIRT1 activator: structural modification of SRT1720 and biological evaluation., Bioorg Med Chem Lett
McCarthy AR et al., 2012, Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins., Bioorg Med Chem
Heltweg B et al., 2006, Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes., Cancer Res
Li Y et al., 2015, A FRET-based assay for screening SIRT6 modulators., Eur J Med Chem
Yang JL et al., 2014, Dammarane triterpenes as potential SIRT1 activators from the leaves of Panax ginseng., J Nat Prod

ALTISSIMACOUMARIN E SIRT1

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22799262

Sources:
DTC
CHEMBL403308 SIRT1

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18046409

Sources:
DTC
SIRTINOL SIRT1

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23189967

Sources:
DTC
ALTISSIMACOUMARIN F SIRT1

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22799262

Sources:
DTC
ALTISSIMACOUMARIN D SIRT1

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22799262

Sources:
DTC
CHEMBL255683 SIRT1

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26420067

Sources:
DTC
CHEMBL254156 SIRT1

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18046409

Sources:
DTC
CHEMBL372375 SIRT1

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23189967

Sources:
DTC
CHEMBL200762 SIRT1

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23189967

Sources:
DTC
GISENOSIDE RK1 SIRT1

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26420067

Sources:
DTC
GINSENOSIDE RH1 SIRT1

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26420067

Sources:
DTC
ALTISSIMACOUMARIN C SIRT1

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22799262

Sources:
DTC
CHEMBL257991 SIRT1

Interaction Score: 3.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23876989 18046409

Sources:
DTC
CHEMBL595354 SIRT1

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22304848

Sources:
DTC
CHEMBL1436543 SIRT1

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22304848

Sources:
DTC
CHEMBL398412 SIRT1

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24968750

Sources:
DTC
NIACINAMIDE SIRT1

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25884115

Sources:
DTC
SALERMIDE SIRT1

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL375563 SIRT1

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26420067

Sources:
DTC
CAMBINOL SIRT1

Interaction Score: 0.86

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
16618762

Sources:
TTD
PSAMMAPLIN A SIRT1

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21215647

Sources:
DTC
RESVERATROL SIRT1

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23859249 18046409 23316803 23471411 23524286

Sources:
DTC
SURAMIN SIRT1

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21215647

Sources:
DTC
LAPACHONE SIRT1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

Ensembl: ENSG00000096717
- Version: 101_38
Alternate Names:

SIRT1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q96EB6
- Version: January-2014
Alternate Names:

SIRT1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.5.1.-

Publications:

DTC: SIRT1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Ma LY et al., 2015, New SIRT1 activator from alkaline hydrolysate of total saponins in the stems-leaves of Panax ginseng., Bioorg Med Chem Lett

Li Y et al., 2015, A FRET-based assay for screening SIRT6 modulators., Eur J Med Chem

Yang JL et al., 2014, Dammarane triterpenes as potential SIRT1 activators from the leaves of Panax ginseng., J Nat Prod

HingoraniCasas: ENSG00000096717
- Version: 31-May-2017
Alternate Names:

ENSG00000096717 Gene Symbol

SIRT1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: NAD-dependent deacetylase sirtuin-1
- Version: 2020.06.01
Alternate Names:

SIRT1 TTD Gene Abbreviation

T14731 TTD Target ID

Gene Info:

Publications:
Pharos: SIRT1
- Version: 01-February-2022
Alternate Names:

NAD-dependent protein deacetylase sirtuin-1 Gene Name

Q96EB6 UniProt ID

Gene Info:

Gene Categories:

KINASE, ENZYME, TRANSCRIPTION FACTOR

Publications:

NAD-dependent protein deacetylase sirtuin-1	Gene Name
Q96EB6	UniProt ID

SIRT1 Gene Record

SIRT1 23411 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22799262

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18046409

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23189967

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22799262

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22799262

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26420067

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18046409

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23189967

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23189967

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26420067

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26420067

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22799262

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23876989 18046409

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22304848

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22304848

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24968750

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25884115

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
22799262

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18046409

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23189967

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22799262

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22799262

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
26420067

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18046409

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23189967

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23189967

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
26420067

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
26420067

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22799262

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23876989 18046409

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22304848

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22304848

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24968750

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25884115

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
26420067

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
16618762

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
21215647

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23859249 18046409 23316803 23471411 23524286

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21215647

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Alternate Names:

SIRT1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

SIRT1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.5.1.-

Alternate Names:

ENSG00000096717 Gene Symbol

SIRT1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

SIRT1 TTD Gene Abbreviation

T14731 TTD Target ID

Alternate Names:

NAD-dependent protein deacetylase sirtuin-1 Gene Name

Q96EB6 UniProt ID