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SHMT1 Gene Record

  • Summary
  • Interactions
  • Claims
  • SHMT1 6470

    Alternate Names:

    6470
    SERINE HYDROXYMETHYLTRANSFERASE 1
    SHMT1
    CSHMT
    SHMT
    182144
    10850
    ENSG00000176974
    OTTHUMG00000059094
    PA35753
    BE0000331
    P34896
    Serine hydroxymethyltransferase, cytosolic

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (0 More Sources)

    Gene Categories: Category Details

    ENZYME

    Publications:

    Budai B et al., 2012, Impact of SHMT1 polymorphism on the clinical outcome of patients with metastatic colorectal cancer treated with first-line FOLFIRI+bevacizumab., Pharmacogenet Genomics
    Stamp LK et al., 2010, Polymorphisms within the folate pathway predict folate concentrations but are not associated with disease activity in rheumatoid arthritis patients on methotrexate., Pharmacogenet Genomics
    James HM et al., 2008, Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis., J Rheumatol
    de Jonge R et al., 2005, Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia., Blood
    Dorababu P et al., 2012, Genetic variants of thiopurine and folate metabolic pathways determine 6-MP-mediated hematological toxicity in childhood ALL., Pharmacogenomics
    Huang L et al., 2008, Polymorphisms in folate-related genes: association with side effects of high-dose methotrexate in childhood acute lymphoblastic leukemia., Leukemia
    Rao et al., 2000, The role of Glu74 and Tyr82 in the reaction catalyzed by sheep liver cytosolic serine hydroxymethyltransferase., Eur. J. Biochem.
    Heil et al., 2001, Is mutated serine hydroxymethyltransferase (SHMT) involved in the etiology of neural tube defects?, Mol. Genet. Metab.
    Li et al., 2003, Investigating the regulation of one-carbon metabolism in Arabidopsis thaliana., Plant Cell Physiol.
    Ravanel et al., 2001, Tetrahydrofolate biosynthesis in plants: molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thaliana., Proc. Natl. Acad. Sci. U.S.A.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Scarsdale et al., 2000, Crystal structure at 2.4 A resolution of E. coli serine hydroxymethyltransferase in complex with glycine substrate and 5-formyl tetrahydrofolate., J. Mol. Biol.
    Rajinikanth et al., 2007, The glycine decarboxylase complex multienzyme family in Populus., J. Exp. Bot.
    Nijhout et al., 2006, In silico experimentation with a model of hepatic mitochondrial folate metabolism., Theor Biol Med Model
    Gagnon et al., 2006, Stage specific gene expression and cellular localization of two isoforms of the serine hydroxymethyltransferase in the protozoan parasite Leishmania., Mol. Biochem. Parasitol.
    Chang et al., 2007, Serine hydroxymethyltransferase isoforms are differentially inhibited by leucovorin: characterization and comparison of recombinant zebrafish serine hydroxymethyltransferases., Drug Metab. Dispos.
    Vatsyayan et al., 2007, Molecular cloning and biochemical characterization of Leishmania donovani serine hydroxymethyltransferase., Protein Expr. Purif.
    Lin et al., 1996, Mimosine targets serine hydroxymethyltransferase., J. Biol. Chem.
    Conti et al., 2002, Inhibition of MCP-1 and MIP-2 transcription and translation by mimosine in muscle tissue infected with the parasite Trichinella spiralis., Mol. Cell. Biochem.
    Perry et al., 2005, Mimosine attenuates serine hydroxymethyltransferase transcription by chelating zinc. Implications for inhibition of DNA replication., J. Biol. Chem.
    Oppenheim et al., 2000, Mimosine is a cell-specific antagonist of folate metabolism., J. Biol. Chem.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Trakatellis et al., 1994, Effect of combination of deoxypyridoxine with known anti-proliferative or immunosuppressive agents on lymphocyte serine hydroxymethyltransferase., Postgrad Med J
    Bourguignon et al., 1988, Resolution and characterization of the glycine-cleavage reaction in pea leaf mitochondria. Properties of the forward reaction catalysed by glycine decarboxylase and serine hydroxymethyltransferase., Biochem. J.
    Jagath et al., 1997, The role of His-134, -147, and -150 residues in subunit assembly, cofactor binding, and catalysis of sheep liver cytosolic serine hydroxymethyltransferase., J. Biol. Chem.
  • CHEMBL1236268   SHMT1

    Interaction Score: 22.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • MIMOSINE   SHMT1

    Interaction Score: 9.47

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    8576220 11936838 15531579 10766749


    Sources:
    DrugBank

  • TETRAHYDROFOLATE   SHMT1

    Interaction Score: 3.61

    Interaction Types & Directionality:
    cofactor (activating)

    Interaction Info:

    PMIDs:
    10998057 11386852 12668769 11752472 10592235 10656824


    Sources:
    DrugBank

  • GLYCINE   SHMT1

    Interaction Score: 1.03

    Interaction Types & Directionality:
    product of

    Interaction Info:

    PMIDs:
    17355947 17150100 16876889 17664250 17142057


    Sources:
    DrugBank

  • PYRIDOXAL PHOSPHATE   SHMT1

    Interaction Score: 0.55

    Interaction Types & Directionality:
    cofactor (activating)

    Interaction Info:

    PMIDs:
    7526359 3143355 10592235 9305893


    Sources:
    DrugBank

  • LEUCOVORIN   SHMT1

    Interaction Score: 0.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22044939


    Sources:
    PharmGKB

  • METHOTREXATE   SHMT1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20386493 18322994 15797993 22838948 18368069


    Sources:
    PharmGKB

  • BEVACIZUMAB   SHMT1

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22044939


    Sources:
    PharmGKB

  • IRINOTECAN   SHMT1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22044939


    Sources:
    PharmGKB

  • FLUOROURACIL   SHMT1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22044939


    Sources:
    PharmGKB

  • Ensembl: ENSG00000176974

    • Version: 101_38

    Alternate Names:
    SHMT1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: SHMT1

    • Version: 18-August-2020

    Alternate Names:
    PA35753 PharmGKB ID

    Gene Info:

    Publications:
    Stamp LK et al., 2010, Polymorphisms within the folate pathway predict folate concentrations but are not associated with disease activity in rheumatoid arthritis patients on methotrexate., Pharmacogenet Genomics
    James HM et al., 2008, Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis., J Rheumatol
    de Jonge R et al., 2005, Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia., Blood

  • DrugBank: BE0000331

    • Version: 5.1.7

    Alternate Names:
    SHMT1 DrugBank Gene Name
    P34896 UniProt Accession
    6470 Entrez Gene Id

    Gene Info:

    Publications:
    Trakatellis et al., 1994, Effect of combination of deoxypyridoxine with known anti-proliferative or immunosuppressive agents on lymphocyte serine hydroxymethyltransferase., Postgrad Med J
    Bourguignon et al., 1988, Resolution and characterization of the glycine-cleavage reaction in pea leaf mitochondria. Properties of the forward reaction catalysed by glycine decarboxylase and serine hydroxymethyltransferase., Biochem. J.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

  • Pharos: SHMT1

    • Version: 03-September-2020

    Alternate Names:
    Serine hydroxymethyltransferase, cytosolic Gene Name
    P34896 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21