DGIdb - SHMT1 Gene Record

SHMT1 6470

Alternate Names:

6470
SERINE HYDROXYMETHYLTRANSFERASE 1
SHMT1
CSHMT
SHMT
182144
10850
ENSG00000176974
OTTHUMG00000059094
PA35753
BE0000331
P34896
Serine hydroxymethyltransferase, cytosolic

Gene Info:

Gene Biotype	PROTEIN_CODING

(0 More Sources)

Gene Categories: Category Details

ENZYME

Publications:

Budai B et al., 2012, Impact of SHMT1 polymorphism on the clinical outcome of patients with metastatic colorectal cancer treated with first-line FOLFIRI+bevacizumab., Pharmacogenet Genomics
Stamp LK et al., 2010, Polymorphisms within the folate pathway predict folate concentrations but are not associated with disease activity in rheumatoid arthritis patients on methotrexate., Pharmacogenet Genomics
James HM et al., 2008, Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis., J Rheumatol
de Jonge R et al., 2005, Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia., Blood
Dorababu P et al., 2012, Genetic variants of thiopurine and folate metabolic pathways determine 6-MP-mediated hematological toxicity in childhood ALL., Pharmacogenomics
Huang L et al., 2008, Polymorphisms in folate-related genes: association with side effects of high-dose methotrexate in childhood acute lymphoblastic leukemia., Leukemia
Rao et al., 2000, The role of Glu74 and Tyr82 in the reaction catalyzed by sheep liver cytosolic serine hydroxymethyltransferase., Eur. J. Biochem.
Heil et al., 2001, Is mutated serine hydroxymethyltransferase (SHMT) involved in the etiology of neural tube defects?, Mol. Genet. Metab.
Li et al., 2003, Investigating the regulation of one-carbon metabolism in Arabidopsis thaliana., Plant Cell Physiol.
Ravanel et al., 2001, Tetrahydrofolate biosynthesis in plants: molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thaliana., Proc. Natl. Acad. Sci. U.S.A.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Scarsdale et al., 2000, Crystal structure at 2.4 A resolution of E. coli serine hydroxymethyltransferase in complex with glycine substrate and 5-formyl tetrahydrofolate., J. Mol. Biol.
Rajinikanth et al., 2007, The glycine decarboxylase complex multienzyme family in Populus., J. Exp. Bot.
Nijhout et al., 2006, In silico experimentation with a model of hepatic mitochondrial folate metabolism., Theor Biol Med Model
Gagnon et al., 2006, Stage specific gene expression and cellular localization of two isoforms of the serine hydroxymethyltransferase in the protozoan parasite Leishmania., Mol. Biochem. Parasitol.
Chang et al., 2007, Serine hydroxymethyltransferase isoforms are differentially inhibited by leucovorin: characterization and comparison of recombinant zebrafish serine hydroxymethyltransferases., Drug Metab. Dispos.
Vatsyayan et al., 2007, Molecular cloning and biochemical characterization of Leishmania donovani serine hydroxymethyltransferase., Protein Expr. Purif.
Lin et al., 1996, Mimosine targets serine hydroxymethyltransferase., J. Biol. Chem.
Conti et al., 2002, Inhibition of MCP-1 and MIP-2 transcription and translation by mimosine in muscle tissue infected with the parasite Trichinella spiralis., Mol. Cell. Biochem.
Perry et al., 2005, Mimosine attenuates serine hydroxymethyltransferase transcription by chelating zinc. Implications for inhibition of DNA replication., J. Biol. Chem.
Oppenheim et al., 2000, Mimosine is a cell-specific antagonist of folate metabolism., J. Biol. Chem.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Trakatellis et al., 1994, Effect of combination of deoxypyridoxine with known anti-proliferative or immunosuppressive agents on lymphocyte serine hydroxymethyltransferase., Postgrad Med J
Bourguignon et al., 1988, Resolution and characterization of the glycine-cleavage reaction in pea leaf mitochondria. Properties of the forward reaction catalysed by glycine decarboxylase and serine hydroxymethyltransferase., Biochem. J.
Jagath et al., 1997, The role of His-134, -147, and -150 residues in subunit assembly, cofactor binding, and catalysis of sheep liver cytosolic serine hydroxymethyltransferase., J. Biol. Chem.

CHEMBL1236268 SHMT1

Interaction Score: 22.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
MIMOSINE SHMT1

Interaction Score: 9.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
8576220 11936838 15531579 10766749

Sources:
DrugBank
TETRAHYDROFOLATE SHMT1

Interaction Score: 3.61

Interaction Types & Directionality:

cofactor (activating)

Interaction Info:

PMIDs:
10998057 11386852 12668769 11752472 10592235 10656824

Sources:
DrugBank
GLYCINE SHMT1

Interaction Score: 1.03

Interaction Types & Directionality:

product of

Interaction Info:

PMIDs:
17355947 17150100 16876889 17664250 17142057

Sources:
DrugBank
PYRIDOXAL PHOSPHATE SHMT1

Interaction Score: 0.55

Interaction Types & Directionality:

cofactor (activating)

Interaction Info:

PMIDs:
7526359 3143355 10592235 9305893

Sources:
DrugBank
LEUCOVORIN SHMT1

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22044939

Sources:
PharmGKB
METHOTREXATE SHMT1

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20386493 18322994 15797993 22838948 18368069

Sources:
PharmGKB
BEVACIZUMAB SHMT1

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22044939

Sources:
PharmGKB
IRINOTECAN SHMT1

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22044939

Sources:
PharmGKB
FLUOROURACIL SHMT1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22044939

Sources:
PharmGKB

Ensembl: ENSG00000176974
- Version: 101_38
Alternate Names:

SHMT1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: SHMT1

Version: 18-August-2020

Alternate Names:

PA35753 PharmGKB ID

Gene Info:

Publications:

Stamp LK et al., 2010, Polymorphisms within the folate pathway predict folate concentrations but are not associated with disease activity in rheumatoid arthritis patients on methotrexate., Pharmacogenet Genomics

James HM et al., 2008, Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis., J Rheumatol

de Jonge R et al., 2005, Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia., Blood

DrugBank: BE0000331

Version: 5.1.7

Alternate Names:

SHMT1 DrugBank Gene Name

P34896 UniProt Accession

6470 Entrez Gene Id

Gene Info:

Publications:

Trakatellis et al., 1994, Effect of combination of deoxypyridoxine with known anti-proliferative or immunosuppressive agents on lymphocyte serine hydroxymethyltransferase., Postgrad Med J

Bourguignon et al., 1988, Resolution and characterization of the glycine-cleavage reaction in pea leaf mitochondria. Properties of the forward reaction catalysed by glycine decarboxylase and serine hydroxymethyltransferase., Biochem. J.

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Pharos: SHMT1
- Version: 03-September-2020
Alternate Names:

Serine hydroxymethyltransferase, cytosolic Gene Name

P34896 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

SHMT1	DrugBank Gene Name
P34896	UniProt Accession
6470	Entrez Gene Id

Serine hydroxymethyltransferase, cytosolic	Gene Name
P34896	UniProt ID

SHMT1 Gene Record

SHMT1 6470

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 8576220 11936838 15531579 10766749

Sources: DrugBank

Interaction Types & Directionality: cofactor (activating)

Interaction Info:

PMIDs: 10998057 11386852 12668769 11752472 10592235 10656824

Sources: DrugBank

Interaction Types & Directionality: product of

Interaction Info:

PMIDs: 17355947 17150100 16876889 17664250 17142057

Sources: DrugBank

Interaction Types & Directionality: cofactor (activating)

Interaction Info:

PMIDs: 7526359 3143355 10592235 9305893

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22044939

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20386493 18322994 15797993 22838948 18368069

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22044939

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22044939

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22044939

Sources: PharmGKB

Ensembl: ENSG00000176974

Alternate Names: SHMT1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: SHMT1

Alternate Names: PA35753 PharmGKB ID

Gene Info:

DrugBank: BE0000331

Alternate Names: SHMT1 DrugBank Gene Name P34896 UniProt Accession 6470 Entrez Gene Id

Gene Info:

Pharos: SHMT1

Alternate Names: Serine hydroxymethyltransferase, cytosolic Gene Name P34896 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
8576220 11936838 15531579 10766749

Sources:
DrugBank

Interaction Types & Directionality:

cofactor (activating)

PMIDs:
10998057 11386852 12668769 11752472 10592235 10656824

Sources:
DrugBank

Interaction Types & Directionality:

product of

PMIDs:
17355947 17150100 16876889 17664250 17142057

Sources:
DrugBank

Interaction Types & Directionality:

cofactor (activating)

PMIDs:
7526359 3143355 10592235 9305893

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
22044939

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20386493 18322994 15797993 22838948 18368069

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22044939

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22044939

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22044939

Sources:
PharmGKB

Alternate Names:

SHMT1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PA35753 PharmGKB ID

Alternate Names:

SHMT1 DrugBank Gene Name

P34896 UniProt Accession

6470 Entrez Gene Id

Alternate Names:

Serine hydroxymethyltransferase, cytosolic Gene Name

P34896 UniProt ID

Gene Categories:

ENZYME