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SFTPA1 Gene Record

  • Summary
  • Interactions
  • Claims
  • SFTPA1 653509 Druggable Genome

    Alternate Names:

    653509
    SURFACTANT PROTEIN A1
    SFTPA1
    COLEC4
    PSAP
    PSP-A
    PSPA
    SFTP1
    SFTPA1B
    SP-A
    SP-A1
    SPA
    SPA1
    178630
    10798
    ENSG00000122852
    OTTHUMG00000018565
    Superoxide anion
    T26327
    SP-A1 beta
    SP-A1 delta
    SP-A1 epsilon
    SP-A1 gamma
    ILD1

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (0 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Dhar et al., 1997, Interleukin-1 alpha upregulates the expression of surfactant protein-A in rabbit lung explants., Biol. Neonate
    Kumar et al., 1998, Differential regulation of SP-A1 and SP-A2 genes by cAMP, glucocorticoids, and insulin., Am. J. Physiol.
    Dulkerian et al., 1996, Regulation of surfactant protein D in human fetal lung., Am. J. Respir. Cell Mol. Biol.
    Asabe et al., 1996, Maternal dexamethasone treatment enhances the expression of surfactant apoprotein A in the hypoplastic lung of rabbit fetuses induced by oligohydramnios., J. Pediatr. Surg.
    Chroneos et al., 1995, Differential regulation of the mannose and SP-A receptors on macrophages., Am. J. Physiol.
    O'Reilly et al., 1988, Differential effects of glucocorticoid on expression of surfactant proteins in a human lung adenocarcinoma cell line., Biochim. Biophys. Acta
    Liley et al., 1988, Glucocorticoids both stimulate and inhibit production of pulmonary surfactant protein A in fetal human lung., Proc. Natl. Acad. Sci. U.S.A.
    O'Reilly et al., 1989, Glucocorticoids regulate surfactant protein synthesis in a pulmonary adenocarcinoma cell line., Am. J. Physiol.
    Schellhase et al., 1991, Effects of maternal dexamethasone on expression of SP-A, SP-B, and SP-C in the fetal rat lung., Am. J. Respir. Cell Mol. Biol.
    Ohashi et al., 1991, Effect of dexamethasone on pulmonary surfactant metabolism in hyperoxia-treated rat lungs., Pediatr. Res.
    Mouhieddine-Gueddiche et al., 2003, Dexamethasone potentiates keratinocyte growth factor-stimulated SP-A and SP-B gene expression in alveolar epithelial cells., Pediatr. Res.
    Nakamura et al., 2000, Mechanical strain and dexamethasone selectively increase surfactant protein C and tropoelastin gene expression., Am. J. Physiol. Lung Cell Mol. Physiol.
    Baritussio et al., 2001, Amiodarone inhibits lung degradation of SP-A and perturbs the distribution of lysosomal enzymes., Am. J. Physiol. Lung Cell Mol. Physiol.
    Van Iwaarden et al., 1994, Binding of surfactant protein A to the lipid A moiety of bacterial lipopolysaccharides., Biochem. J.
    Pison et al., 1992, Specific binding of surfactant apoprotein SP-A to rat alveolar macrophages., Am. J. Physiol.
    George et al., 1998, Mechanism of all trans-retinoic acid and glucocorticoid regulation of surfactant protein mRNA., Am. J. Physiol.
    Khalak et al., 1999, Antagonistic effects of pyrrolidine dithiocarbamate and N-acetyl-L-cysteine on surfactant protein A and B mRNAs., Exp. Lung Res.
    Weikert et al., 2000, Surfactant protein A enhances mycobacterial killing by rat macrophages through a nitric oxide-dependent pathway., Am. J. Physiol. Lung Cell Mol. Physiol.
  • ANAKINRA   SFTPA1

    Interaction Score: 1.93

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8996657


    Sources:
    NCI

  • BCG VACCINE   SFTPA1

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10926544


    Sources:
    NCI

  • DEXAMETHASONE   SFTPA1

    Interaction Score: 1.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9486201 8969273 8906664 8572233 3382698 3194412 2610267 2015097 2014154 12538780 10781428


    Sources:
    NCI

  • ACETYLCYSTEINE   SFTPA1

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10533675


    Sources:
    NCI

  • ALBUMIN HUMAN   SFTPA1

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1314502


    Sources:
    NCI

  • AMIODARONE   SFTPA1

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11597911


    Sources:
    NCI

  • HEPARIN   SFTPA1

    Interaction Score: 0.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7980398


    Sources:
    NCI

  • HYDROCORTISONE   SFTPA1

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9575874


    Sources:
    NCI

  • Ensembl: ENSG00000122852

    • Version: 101_38

    Alternate Names:
    SFTPA1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • NCI: SFTPA1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Khalak et al., 1999, Antagonistic effects of pyrrolidine dithiocarbamate and N-acetyl-L-cysteine on surfactant protein A and B mRNAs., Exp. Lung Res.
    Bogue et al., 1996, Retinoic acid increases surfactant protein mRNA in fetal rat lung in culture., Am. J. Physiol.
    O'Reilly et al., 1988, Differential effects of glucocorticoid on expression of surfactant proteins in a human lung adenocarcinoma cell line., Biochim. Biophys. Acta

  • HingoraniCasas: ENSG00000122852

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000122852 Gene Symbol
    SFTPA1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Superoxide anion

    • Version: 2020.06.01

    Alternate Names:
    SPA TTD Gene Abbreviation
    T26327 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21