DGIdb - SFTPA1 Gene Record

SFTPA1 653509 Druggable Genome

Alternate Names:

653509
SURFACTANT PROTEIN A1
SFTPA1
COLEC4
PSAP
PSP-A
PSPA
SFTP1
SFTPA1B
SP-A
SP-A1
SPA
SPA1
178630
10798
ENSG00000122852
OTTHUMG00000018565
BE0004481
Q8IWL2
Superoxide anion
T26327

Gene Info:

Gene Biotype	PROTEIN_CODING

(1 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Dhar et al., 1997, Interleukin-1 alpha upregulates the expression of surfactant protein-A in rabbit lung explants., Biol. Neonate
Kumar et al., 1998, Differential regulation of SP-A1 and SP-A2 genes by cAMP, glucocorticoids, and insulin., Am. J. Physiol.
Schellhase et al., 1991, Effects of maternal dexamethasone on expression of SP-A, SP-B, and SP-C in the fetal rat lung., Am. J. Respir. Cell Mol. Biol.
Nakamura et al., 2000, Mechanical strain and dexamethasone selectively increase surfactant protein C and tropoelastin gene expression., Am. J. Physiol. Lung Cell Mol. Physiol.
Dulkerian et al., 1996, Regulation of surfactant protein D in human fetal lung., Am. J. Respir. Cell Mol. Biol.
Liley et al., 1988, Glucocorticoids both stimulate and inhibit production of pulmonary surfactant protein A in fetal human lung., Proc. Natl. Acad. Sci. U.S.A.
Asabe et al., 1996, Maternal dexamethasone treatment enhances the expression of surfactant apoprotein A in the hypoplastic lung of rabbit fetuses induced by oligohydramnios., J. Pediatr. Surg.
O'Reilly et al., 1988, Differential effects of glucocorticoid on expression of surfactant proteins in a human lung adenocarcinoma cell line., Biochim. Biophys. Acta
Mouhieddine-Gueddiche et al., 2003, Dexamethasone potentiates keratinocyte growth factor-stimulated SP-A and SP-B gene expression in alveolar epithelial cells., Pediatr. Res.
O'Reilly et al., 1989, Glucocorticoids regulate surfactant protein synthesis in a pulmonary adenocarcinoma cell line., Am. J. Physiol.
Ohashi et al., 1991, Effect of dexamethasone on pulmonary surfactant metabolism in hyperoxia-treated rat lungs., Pediatr. Res.
Chroneos et al., 1995, Differential regulation of the mannose and SP-A receptors on macrophages., Am. J. Physiol.
Baritussio et al., 2001, Amiodarone inhibits lung degradation of SP-A and perturbs the distribution of lysosomal enzymes., Am. J. Physiol. Lung Cell Mol. Physiol.
Van Iwaarden et al., 1994, Binding of surfactant protein A to the lipid A moiety of bacterial lipopolysaccharides., Biochem. J.
Pison et al., 1992, Specific binding of surfactant apoprotein SP-A to rat alveolar macrophages., Am. J. Physiol.
George et al., 1998, Mechanism of all trans-retinoic acid and glucocorticoid regulation of surfactant protein mRNA., Am. J. Physiol.
Khalak et al., 1999, Antagonistic effects of pyrrolidine dithiocarbamate and N-acetyl-L-cysteine on surfactant protein A and B mRNAs., Exp. Lung Res.
Weikert et al., 2000, Surfactant protein A enhances mycobacterial killing by rat macrophages through a nitric oxide-dependent pathway., Am. J. Physiol. Lung Cell Mol. Physiol.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

ANAKINRA SFTPA1

Interaction Score: 1.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8996657

Sources:
NCI
BCG VACCINE SFTPA1

Interaction Score: 1.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10926544

Sources:
NCI
CHEMBL1234276 SFTPA1

Interaction Score: 0.97

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
DEXAMETHASONE SFTPA1

Interaction Score: 0.88

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9486201 2015097 10781428 8969273 3194412 8906664 3382698 12538780 2610267 2014154 8572233

Sources:
NCI
ALBUMIN HUMAN SFTPA1

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1314502

Sources:
NCI
ACETYLCYSTEINE SFTPA1

Interaction Score: 0.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10533675

Sources:
NCI
AMIODARONE SFTPA1

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11597911

Sources:
NCI
HYDROCORTISONE SFTPA1

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9575874

Sources:
NCI
HEPARIN SFTPA1

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7980398

Sources:
NCI

Ensembl: ENSG00000122852
- Version: 101_38
Alternate Names:

SFTPA1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
DrugBank: BE0004481
- Version: 5.1.7
Alternate Names:

SFTPA1 DrugBank Gene Name

Q8IWL2 UniProt Accession

653509 Entrez Gene Id

Gene Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

NCI: SFTPA1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Khalak et al., 1999, Antagonistic effects of pyrrolidine dithiocarbamate and N-acetyl-L-cysteine on surfactant protein A and B mRNAs., Exp. Lung Res.

Bogue et al., 1996, Retinoic acid increases surfactant protein mRNA in fetal rat lung in culture., Am. J. Physiol.

O'Reilly et al., 1988, Differential effects of glucocorticoid on expression of surfactant proteins in a human lung adenocarcinoma cell line., Biochim. Biophys. Acta

HingoraniCasas: ENSG00000122852
- Version: 31-May-2017
Alternate Names:

ENSG00000122852 Gene Symbol

SFTPA1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Superoxide anion
- Version: 2020.06.01
Alternate Names:

SPA TTD Gene Abbreviation

T26327 TTD Target ID

Gene Info:

Publications:

SFTPA1	DrugBank Gene Name
Q8IWL2	UniProt Accession
653509	Entrez Gene Id

SPA	TTD Gene Abbreviation
T26327	TTD Target ID

SFTPA1 Gene Record

SFTPA1 653509 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8996657

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10926544

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9486201 2015097 10781428 8969273 3194412 8906664 3382698 12538780 2610267 2014154 8572233

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1314502

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10533675

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11597911

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9575874

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7980398

Sources: NCI

Ensembl: ENSG00000122852

Alternate Names: SFTPA1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

DrugBank: BE0004481

Alternate Names: SFTPA1 DrugBank Gene Name Q8IWL2 UniProt Accession 653509 Entrez Gene Id

Gene Info:

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

NCI: SFTPA1

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000122852

Alternate Names: ENSG00000122852 Gene Symbol SFTPA1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

TTD: Superoxide anion

Alternate Names: SPA TTD Gene Abbreviation T26327 TTD Target ID

Gene Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
8996657

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10926544

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
9486201 2015097 10781428 8969273 3194412 8906664 3382698 12538780 2610267 2014154 8572233

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1314502

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10533675

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11597911

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9575874

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7980398

Sources:
NCI

Alternate Names:

SFTPA1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

SFTPA1 DrugBank Gene Name

Q8IWL2 UniProt Accession

653509 Entrez Gene Id

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Alternate Names:

ENSG00000122852 Gene Symbol

SFTPA1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

SPA TTD Gene Abbreviation

T26327 TTD Target ID