DGIdb - SERPINE1 Gene Record

SERPINE1 5054 Druggable Genome

Alternate Names:

5054
SERPIN FAMILY E MEMBER 1
SERPINE1
PAI
PAI-1
PAI1
PLANH1
173360
8583
ENSG00000106366
OTTHUMG00000157107
Endothelial plasminogen activator inhibitor
Serpin E1
Plasminogen activator inhibitor 1
P05121
PA261
PLASMINOGEN ACTIVATOR INHIBITOR-1 PRECURSOR (PAI-1) (ENDOTHELIAL PLASMINOGEN ACTIVATOR INHIBITOR) (PAI). [SOURCE:UNIPROT/SWISSPROT;ACC:P05121]
PAI1_HUMAN
T15556

Gene Info:

Target Class	Miscellaneous
Target Subclass	Protease_inhib_Serpin family
Human Readable Name	PROTEASE INHIBITOR
Human Readable Name	DRUGGABLE GENOME
Interpro Name	Serpin family
Uniprot Evidence	1: Evidence at protein level
Interpro Type	Family
Interpro Acc	IPR000215
Uniprot Status	Swiss-Prot
Interpro Short Name	Serpin_fam
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

PROTEASE INHIBITOR
DRUGGABLE GENOME

Publications:

Kaleelrahman et al., 2003, Role of plasminogen activator inhibitor-1 (PAI-1) levels in the diagnosis of BMT-associated hepatic veno-occlusive disease and monitoring of subsequent therapy with defibrotide (DF)., Hematology
Chadarevian et al., 2005, Effect of levothyroxine replacement therapy on coagulation and fibrinolysis in severe hypothyroidism., J. Endocrinol. Invest.
Tsai SJ et al., 2008, Plasminogen activator inhibitor-1 gene is associated with major depression and antidepressant treatment response., Pharmacogenet Genomics
Dondi et al., 2006, GnRH agonists and antagonists decrease the metastatic progression of human prostate cancer cell lines by inhibiting the plasminogen activator system., Oncol. Rep.
Gerstein et al., 2003, [Urokinase and tissue type plasminogen activators and their type-1 inhibitor (PAI-1) in gastric cancer]., Vopr Onkol
Hellgren, 2003, Hemostasis during normal pregnancy and puerperium., Semin. Thromb. Hemost.
Gamberi et al., Identification of markers of possible prognostic value in 57 giant cell tumors of bone., Oncol. Rep.
Chang et al., Cell adhesion induces the plasminogen activator inhibitor-1 gene expression through phosphatidylinositol 3-kinase/Akt activation in anchorage dependent cells., Cell Commun. Adhes.
Shetty et al., 2003, Induction of plasminogen activator inhibitor-1 by urokinase in lung epithelial cells., J. Biol. Chem.
Hamilton et al., 1993, Macrophage colony-stimulating factor and granulocyte-macrophage colony-stimulating factor stimulate the synthesis of plasminogen-activator inhibitors by human monocytes., Blood
French D et al., 2008, A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group., Blood
Pedersen et al., 1995, Plasminogen activator inhibitor type-1 determines plasmin formation in patients with ischaemic heart disease., Thromb. Haemost.
Gorlatova NV et al., 2007, Mechanism of inactivation of plasminogen activator inhibitor-1 by a small molecule inhibitor., J Biol Chem
Roos et al., 2001, Nimodipine increases fibrinolytic activity in patients with aneurysmal subarachnoid hemorrhage., Stroke
Shafiq et al., 2006, A randomized controlled clinical trial to evaluate the efficacy, safety, cost-effectiveness and effect on PAI-1 levels of the three low-molecular-weight heparins--enoxaparin, nadroparin and dalteparin. The ESCAPe-END study., Pharmacology
Katz et al., 1996, Effects of hormone replacement therapy on the circadian pattern of atherothrombotic risk factors., Am. J. Cardiol.
Rissanen et al., 2001, Weight change and blood coagulability and fibrinolysis in healthy obese women., Int. J. Obes. Relat. Metab. Disord.
Moriyama et al., 1997, Captopril reduced plasminogen activator inhibitor activity in patients with acute myocardial infarction., Jpn. Circ. J.
Bouchie et al., 2000, P2Y receptor regulation of PAI-1 expression in vascular smooth muscle cells., Arterioscler. Thromb. Vasc. Biol.
Sawathiparnich et al., 2002, Spironolactone abolishes the relationship between aldosterone and plasminogen activator inhibitor-1 in humans., J. Clin. Endocrinol. Metab.
Demirkan et al., 2006, The effect of anthracycline-based (epirubicin) adjuvant chemotherapy on plasma TAFI and PAI-1 levels in operable breast cancer., Clin. Appl. Thromb. Hemost.

TIPLASININ SERPINE1

Interaction Score: 6.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17276980

Sources:
DTC
DIAPLASININ SERPINE1

Interaction Score: 3.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PREMARIN SERPINE1

Interaction Score: 3.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8888658

Sources:
NCI
DALTEPARIN SERPINE1

Interaction Score: 3.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17057417

Sources:
NCI
ALEPLASININ SERPINE1

Interaction Score: 3.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Plasminogen activator inhibitor-1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
UROKINASE SERPINE1

Interaction Score: 3.09

Interaction Types & Directionality:

inducer (activating)

substrate

Interaction Info:

Trial Name urokinase for injection,Kinlytic

Novel drug target Established target

PMIDs:
12785198 12709915 12579271 12745435 12642587

Sources:
TdgClinicalTrial
DEFIBROTIDE SERPINE1

Interaction Score: 3.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12745658

Sources:
NCI
CETRORELIX SERPINE1

Interaction Score: 2.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16391860

Sources:
NCI
URIDINE SERPINE1

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10712415

Sources:
NCI
ORLISTAT SERPINE1

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11410822

Sources:
NCI
LEVOTHYROXINE SERPINE1

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16075920

Sources:
NCI
CAPTOPRIL SERPINE1

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9152782

Sources:
NCI
NIMODIPINE SERPINE1

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11486117

Sources:
NCI
REGRAMOSTIM SERPINE1

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8260700

Sources:
NCI
VASOPRESSIN SERPINE1

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7482412

Sources:
NCI
FLUOXETINE SERPINE1

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18794724

Sources:
PharmGKB
EPIRUBICIN SERPINE1

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16444429

Sources:
NCI
CITALOPRAM SERPINE1

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18794724

Sources:
PharmGKB
HYDROCHLOROTHIAZIDE SERPINE1

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11836266

Sources:
NCI
DEXAMETHASONE SERPINE1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18285546

Sources:
PharmGKB

Ensembl: ENSG00000106366
- Version: 101_38
Alternate Names:

SERPINE1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P05121
- Version: January-2014
Alternate Names:

SERPINE1 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Protease_inhib_Serpin family

Publications:
HopkinsGroom: P05121
- Version: 11-September-2012
Alternate Names:

5054 Entrez Gene Id

PAI1_HUMAN Uniprot Id

PLASMINOGEN ACTIVATOR INHIBITOR 1 Uniprot Protein Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Name Serpin family

Human Readable Name PROTEASE INHIBITOR

Gene Categories:

PROTEASE INHIBITOR, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000106366

Version: 26-July-2011

Alternate Names:

ENSG00000106366 Ensembl Gene Id

SERPINE1 Display Id

PLASMINOGEN ACTIVATOR INHIBITOR-1 PRECURSOR (PAI-1) (ENDOTHELIAL PLASMINOGEN ACTIVATOR INHIBITOR) (PAI). [SOURCE:UNIPROT/SWISSPROT;ACC:P05121] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: SERPINE1

Version: 18-August-2020

Alternate Names:

PA261 PharmGKB ID

Gene Info:

Publications:

Tsai SJ et al., 2008, Plasminogen activator inhibitor-1 gene is associated with major depression and antidepressant treatment response., Pharmacogenet Genomics

French D et al., 2008, A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group., Blood

NCI: SERPINE1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Kaleelrahman et al., 2003, Role of plasminogen activator inhibitor-1 (PAI-1) levels in the diagnosis of BMT-associated hepatic veno-occlusive disease and monitoring of subsequent therapy with defibrotide (DF)., Hematology

Roos et al., 2001, Nimodipine increases fibrinolytic activity in patients with aneurysmal subarachnoid hemorrhage., Stroke

Sawathiparnich et al., 2002, Spironolactone abolishes the relationship between aldosterone and plasminogen activator inhibitor-1 in humans., J. Clin. Endocrinol. Metab.

DTC: SERPINE1
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Gorlatova NV et al., 2007, Mechanism of inactivation of plasminogen activator inhibitor-1 by a small molecule inhibitor., J Biol Chem
HingoraniCasas: ENSG00000106366
- Version: 31-May-2017
Alternate Names:

ENSG00000106366 Gene Symbol

SERPINE1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: PAI1
- Version: chembl_23
Alternate Names:

PLANH1 GENE_SYMBOL

SERPINE1 GENE_SYMBOL

Plasminogen activator inhibitor 1 UNIPROT

Gene Info:

Publications:
dGene: SERPINE1
- Version: 27-Jun-2013
Alternate Names:

5054 Gene ID

PAI dGene Synonym

PAI-1 dGene Synonym

Gene Info:

Gene Categories:

PROTEASE INHIBITOR

Publications:
TTD: Endothelial plasminogen activator inhibitor
- Version: 2020.06.01
Alternate Names:

SERPINE1 TTD Gene Abbreviation

T15556 TTD Target ID

Gene Info:

Publications:

Mechanism of Interaction	Plasminogen activator inhibitor-1 inhibitor
Direct Interaction	yes

Trial Name	urokinase for injection,Kinlytic
Novel drug target	Established target

5054	Entrez Gene Id
PAI1_HUMAN	Uniprot Id
PLASMINOGEN ACTIVATOR INHIBITOR 1	Uniprot Protein Name

ENSG00000106366	Ensembl Gene Id
SERPINE1	Display Id
PLASMINOGEN ACTIVATOR INHIBITOR-1 PRECURSOR (PAI-1) (ENDOTHELIAL PLASMINOGEN ACTIVATOR INHIBITOR) (PAI). [SOURCE:UNIPROT/SWISSPROT;ACC:P05121]	Description

PLANH1	GENE_SYMBOL
SERPINE1	GENE_SYMBOL
Plasminogen activator inhibitor 1	UNIPROT

inducer (activating)
substrate

SERPINE1 Gene Record

SERPINE1 5054 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17276980

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8888658

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17057417

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Plasminogen activator inhibitor-1 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inducer (activating) substrate

Interaction Info: Trial Name urokinase for injection,Kinlytic Novel drug target Established target

PMIDs: 12785198 12709915 12579271 12745435 12642587

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12745658

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16391860

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10712415

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11410822

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16075920

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9152782

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11486117

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8260700

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7482412

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18794724

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16444429

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18794724

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
17276980

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
8888658

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17057417

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Plasminogen activator inhibitor-1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inducer (activating)

substrate

Interaction Info:

Trial Name urokinase for injection,Kinlytic

Novel drug target Established target

PMIDs:
12785198 12709915 12579271 12745435 12642587

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
12745658

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16391860

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10712415

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11410822

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16075920

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9152782

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11486117

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8260700

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7482412

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18794724

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16444429

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18794724

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
11836266

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18285546

Sources:
PharmGKB

Alternate Names:

SERPINE1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

SERPINE1 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Protease_inhib_Serpin family

Alternate Names:

5054 Entrez Gene Id

PAI1_HUMAN Uniprot Id

PLASMINOGEN ACTIVATOR INHIBITOR 1 Uniprot Protein Name

Gene Info:

Human Readable Name DRUGGABLE GENOME

Interpro Name Serpin family

Human Readable Name PROTEASE INHIBITOR

Gene Categories:

PROTEASE INHIBITOR, DRUGGABLE GENOME

Alternate Names:

ENSG00000106366 Ensembl Gene Id

SERPINE1 Display Id

PLASMINOGEN ACTIVATOR INHIBITOR-1 PRECURSOR (PAI-1) (ENDOTHELIAL PLASMINOGEN ACTIVATOR INHIBITOR) (PAI). [SOURCE:UNIPROT/SWISSPROT;ACC:P05121] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PA261 PharmGKB ID

Publications:

Gorlatova NV et al., 2007, Mechanism of inactivation of plasminogen activator inhibitor-1 by a small molecule inhibitor., J Biol Chem

Alternate Names:

ENSG00000106366 Gene Symbol

SERPINE1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PLANH1 GENE_SYMBOL

SERPINE1 GENE_SYMBOL

Plasminogen activator inhibitor 1 UNIPROT

Alternate Names:

5054 Gene ID

PAI dGene Synonym

PAI-1 dGene Synonym

Gene Categories:

PROTEASE INHIBITOR