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SERPINA5 Gene Record

  • Summary
  • Interactions
  • Claims
  • SERPINA5 5104 Druggable Genome

    Alternate Names:

    5104
    SERPIN FAMILY A MEMBER 5
    SERPINA5
    PAI-3
    PAI3
    PCI
    PCI-B
    PLANH3
    PROCI
    601841
    8723
    ENSG00000188488
    OTTHUMG00000170860
    IPSP_HUMAN
    P05154
    PLASMA SERINE PROTEASE INHIBITOR PRECURSOR (PCI) (PROTEIN C INHIBITOR) (PLASMINOGEN ACTIVATOR INHIBITOR-3) (PAI3) (ACROSOMAL SERINE PROTEASE INHIBITOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P05154]
    PLASMA SERINE PROTEASE INHIBITOR
    PA35505

    Gene Info:

    Human Readable Name PROTEASE INHIBITOR
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Family
    Interpro Acc IPR000215
    Interpro Short Name Serpin_fam
    Interpro Name Serpin family
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    PROTEASE INHIBITOR
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Björn N et al., 2020, Genes and variants in hematopoiesis-related pathways are associated with gemcitabine/carboplatin-induced thrombocytopenia., Pharmacogenomics J
    Whinna et al., 1993, Interaction of thrombin with antithrombin, heparin cofactor II, and protein C inhibitor., J. Protein Chem.
  • THROMBIN   SERPINA5

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8136018


    Sources:
    NCI

  • HEPARIN   SERPINA5

    Interaction Score: 1.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8136018


    Sources:
    NCI

  • CARBOPLATIN   SERPINA5

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31616045


    Sources:
    PharmGKB

  • GEMCITABINE   SERPINA5

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31616045


    Sources:
    PharmGKB

  • Ensembl: ENSG00000188488

    • Version: 101_38

    Alternate Names:
    SERPINA5 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P05154

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000188488 Ensembl Gene Id
    5104 Entrez Gene Id
    P05154 Uniprot Accession

    Gene Info:
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name PROTEASE INHIBITOR

    Gene Categories:
    PROTEASE INHIBITOR, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000188488

    • Version: 26-July-2011

    Alternate Names:
    SERPINA5 Display Id
    PLASMA SERINE PROTEASE INHIBITOR PRECURSOR (PCI) (PROTEIN C INHIBITOR) (PLASMINOGEN ACTIVATOR INHIBITOR-3) (PAI3) (ACROSOMAL SERINE PROTEASE INHIBITOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P05154] Description
    ENSG00000188488 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: SERPINA5

    • Version: 18-August-2020

    Alternate Names:
    PA35505 PharmGKB ID

    Gene Info:

    Publications:
    Björn N et al., 2020, Genes and variants in hematopoiesis-related pathways are associated with gemcitabine/carboplatin-induced thrombocytopenia., Pharmacogenomics J

  • NCI: SERPINA5

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Whinna et al., 1993, Interaction of thrombin with antithrombin, heparin cofactor II, and protein C inhibitor., J. Protein Chem.

  • HingoraniCasas: ENSG00000188488

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000188488 Gene Symbol
    SERPINA5 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: SERPINA5

    • Version: 01-February-2022

    Alternate Names:
    PCI GO Gene Synonym
    PLANH3 GO Gene Synonym
    PROCI GO Gene Synonym

    Gene Info:

    Gene Categories:
    EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • dGene: SERPINA5

    • Version: 27-Jun-2013

    Alternate Names:
    5104 Gene ID
    PAI-3 dGene Synonym
    PAI3 dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE INHIBITOR

    Publications:

  • Pharos: SERPINA5

    • Version: 01-February-2022

    Alternate Names:
    Plasma serine protease inhibitor Gene Name
    P05154 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21