DGIdb - SCN8A Gene Record

SCN8A 6334 Druggable Genome

Alternate Names:

6334
SODIUM VOLTAGE-GATED CHANNEL ALPHA SUBUNIT 8
SCN8A
BFIS5
CERIII
CIAT
EIEE13
MED
NaCh6
Nav1.6
PN4
600702
10596
ENSG00000196876
OTTHUMG00000169490
Q9UQD0
SODIUM CHANNEL PROTEIN TYPE VIII ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.6). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9UQD0]
SCN8A_HUMAN
SODIUM CHANNEL PROTEIN TYPE 8 SUBUNIT ALPHA
Sodium channel protein type VIII subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.6
Voltage-gated sodium channel alpha Nav1.6
T58741
DEE13
MYOCL2

Gene Info:

Initial Gene Query	Nav1.6
Counted Citations from 1950-2000	277
Target Class	Transporters
Target Subclass	TC:1.A.1.10.8
Human Readable Name	DRUGGABLE GENOME
Interpro Name	Ion transport domain
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	ION CHANNEL
Interpro Short Name	Ion_trans_dom
Interpro Type	Domain
Uniprot Status	Swiss-Prot
Interpro Acc	IPR005821
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

ION CHANNEL
DRUGGABLE GENOME

Publications:

Sage et al., 2007, Na(v)1.7 and Na(v)1.3 are the only tetrodotoxin-sensitive sodium channels expressed by the adult guinea pig enteric nervous system., J. Comp. Neurol.
Tate et al., 2005, Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin., Proc. Natl. Acad. Sci. U.S.A.

TETRODOTOXIN SCN8A

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name tetrodotoxin,Tectin, Tetrodin

PMIDs:
17663442

Sources:
TdgClinicalTrial
PROCAINE HYDROCHLORIDE SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ARTICAINE HYDROCHLORIDE SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ESLICARBAZEPINE ACETATE SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
QUINIDINE SULFATE SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ROPIVACAINE HYDROCHLORIDE SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEXILETINE HYDROCHLORIDE SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEPIVACAINE HYDROCHLORIDE SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LIDOCAINE HYDROCHLORIDE SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
HEXYLCAINE HYDROCHLORIDE SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENYTOIN SODIUM SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ETIDOCAINE HYDROCHLORIDE SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHLOROPROCAINE HYDROCHLORIDE SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENACEMIDE SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ESLICARBAZEPINE SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
EVENAMIDE SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INDECAINIDE HYDROCHLORIDE SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROPOXYCAINE HYDROCHLORIDE SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TOCAINIDE HYDROCHLORIDE SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
MERETHOXYLLINE PROCAINE SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FOSPHENYTOIN SODIUM SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
QUINIDINE GLUCONATE SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
ETHOTOIN SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
PROPARACAINE HYDROCHLORIDE SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NKTR-171 SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
QUINIDINE POLYGALACTURONATE SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
PROCAINAMIDE HYDROCHLORIDE SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TETRACAINE HYDROCHLORIDE SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DISOPYRAMIDE PHOSPHATE SCN8A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PRILOCAINE HYDROCHLORIDE SCN8A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TETRACAINE SCN8A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RUFINAMIDE SCN8A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PRILOCAINE SCN8A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BENOXINATE HYDROCHLORIDE SCN8A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MORICIZINE HYDROCHLORIDE SCN8A

Interaction Score: 0.09

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ERLOSAMIDE SCN8A

Interaction Score: 0.09

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEPHENYTOIN SCN8A

Interaction Score: 0.09

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
PROPAFENONE HYDROCHLORIDE SCN8A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
IRAMPANEL SCN8A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SAFINAMIDE SCN8A

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
PHENAZOPYRIDINE HYDROCHLORIDE SCN8A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DRONEDARONE HYDROCHLORIDE SCN8A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RILUZOLE SCN8A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DYCLONINE HYDROCHLORIDE SCN8A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LIDOCAINE SCN8A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RALFINAMIDE SCN8A

Interaction Score: 0.06

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENYTOIN SCN8A

Interaction Score: 0.06

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
15805193

Sources:
ChemblInteractions
ORPHENADRINE HYDROCHLORIDE SCN8A

Interaction Score: 0.06

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OXCARBAZEPINE SCN8A

Interaction Score: 0.06

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ORPHENADRINE CITRATE SCN8A

Interaction Score: 0.05

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ZONISAMIDE SCN8A

Interaction Score: 0.05

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LAMOTRIGINE SCN8A

Interaction Score: 0.04

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PRIMIDONE SCN8A

Interaction Score: 0.04

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
TOPIRAMATE SCN8A

Interaction Score: 0.03

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CARBAMAZEPINE SCN8A

Interaction Score: 0.02

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NERISPIRDINE SCN8A

Interaction Score: 0.02

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000196876
- Version: 101_38
Alternate Names:

SCN8A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
BaderLabGenes: SCN8A
- Version: February-2014
Alternate Names:

6334 Entrez Gene ID

Gene Info:

Initial Gene Query Nav1.6

Counted Citations from 1950-2000 277

Gene Categories:

ION CHANNEL

Publications:
HopkinsGroom: Q9UQD0
- Version: 11-September-2012
Alternate Names:

6334 Entrez Gene Id

SODIUM CHANNEL PROTEIN TYPE 8 SUBUNIT ALPHA Uniprot Protein Name

ENSG00000196876 Ensembl Gene Id

Gene Info:

Interpro Name Ion transport domain

Uniprot Evidence 1: Evidence at protein level

Human Readable Name DRUGGABLE GENOME

Gene Categories:

ION CHANNEL, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: Q9UQD0
- Version: January-2014
Alternate Names:

SCN8A Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:1.A.1.10.8

Publications:

RussLampel: ENSG00000196876

Version: 26-July-2011

Alternate Names:

ENSG00000196876 Ensembl Gene Id

SCN8A Display Id

SODIUM CHANNEL PROTEIN TYPE VIII ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.6). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9UQD0] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HingoraniCasas: ENSG00000196876
- Version: 31-May-2017
Alternate Names:

ENSG00000196876 Gene Symbol

SCN8A Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: MED
- Version: chembl_23
Alternate Names:

MED GENE_SYMBOL

SCN8A GENE_SYMBOL

Sodium channel protein type 8 subunit alpha UNIPROT

Gene Info:

Publications:
TTD: Voltage-gated sodium channel alpha Nav1.6
- Version: 2020.06.01
Alternate Names:

SCN8A TTD Gene Abbreviation

T58741 TTD Target ID

Gene Info:

Publications:
Pharos: SCN8A
- Version: 01-February-2022
Alternate Names:

Sodium channel protein type 8 subunit alpha Gene Name

Q9UQD0 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:

Novel drug target	Established target
Trial Name	tetrodotoxin,Tectin, Tetrodin

Mechanism of Interaction	Sodium channel alpha subunit blocker
Direct Interaction	yes

6334	Entrez Gene Id
SODIUM CHANNEL PROTEIN TYPE 8 SUBUNIT ALPHA	Uniprot Protein Name
ENSG00000196876	Ensembl Gene Id

MED	GENE_SYMBOL
SCN8A	GENE_SYMBOL
Sodium channel protein type 8 subunit alpha	UNIPROT

Sodium channel protein type 8 subunit alpha	Gene Name
Q9UQD0	UniProt ID

SCN8A Gene Record

SCN8A 6334 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name tetrodotoxin,Tectin, Tetrodin

PMIDs: 17663442

Sources: TdgClinicalTrial

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name tetrodotoxin,Tectin, Tetrodin

PMIDs:
17663442

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions