SCN7A Gene Record

  • SCN7A 6332 Druggable Genome

    Alternate Names:

    6332
    SODIUM VOLTAGE-GATED CHANNEL ALPHA SUBUNIT 7
    SCN7A
    NaG
    Nav2.1
    Nav2.2
    SCN6A
    182392
    10594
    ENSG00000136546
    OTTHUMG00000154078
    Sodium channel protein type VII subunit alpha
    Sodium channel protein cardiac and skeletal muscle subunit alpha
    Putative voltage-gated sodium channel subunit alpha Nax
    Sodium channel protein type 7 subunit alpha
    SCN7A_HUMAN
    Q01118
    SODIUM CHANNEL PROTEIN TYPE VII ALPHA SUBUNIT (PUTATIVE VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAX) (SODIUM CHANNEL PROTEIN, CARDIAC AND SKELETAL MUSCLE ALPHA-SUBUNIT). [SOURCE:UNIPROT/SWISSPROT;ACC:Q01118]

    Gene Info:

    Target Class Transporters
    Target Subclass TC:1.A.1.10
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Domain
    Human Readable Name ION CHANNEL
    Interpro Short Name Ion_trans_dom
    Uniprot Evidence 2: Evidence at transcript level
    Interpro Name Ion transport domain
    Uniprot Status Swiss-Prot
    Interpro Acc IPR005821
    Initial Gene Query Nax
    Counted Citations from 1950-2000 33
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    ION CHANNEL
    DRUGGABLE GENOME

    Publications:

  • QUINIDINE POLYGALACTURONATE   SCN7A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ETHOTOIN   SCN7A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • QUINIDINE GLUCONATE   SCN7A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FOSPHENYTOIN SODIUM   SCN7A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • HEXYLCAINE HYDROCHLORIDE   SCN7A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROCAINAMIDE HYDROCHLORIDE   SCN7A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • QUINIDINE SULFATE   SCN7A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PHENYTOIN SODIUM   SCN7A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INDECAINIDE HYDROCHLORIDE   SCN7A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROPOXYCAINE HYDROCHLORIDE   SCN7A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LIDOCAINE HYDROCHLORIDE   SCN7A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NKTR-171   SCN7A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TOCAINIDE HYDROCHLORIDE   SCN7A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MEXILETINE HYDROCHLORIDE   SCN7A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ESLICARBAZEPINE   SCN7A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROCAINE HYDROCHLORIDE   SCN7A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • EVENAMIDE   SCN7A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ETIDOCAINE HYDROCHLORIDE   SCN7A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PHENACEMIDE   SCN7A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MERETHOXYLLINE PROCAINE   SCN7A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ARTICAINE HYDROCHLORIDE   SCN7A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHLOROPROCAINE HYDROCHLORIDE   SCN7A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ESLICARBAZEPINE ACETATE   SCN7A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ROPIVACAINE HYDROCHLORIDE   SCN7A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TETRACAINE HYDROCHLORIDE   SCN7A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROPARACAINE HYDROCHLORIDE   SCN7A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MEPIVACAINE HYDROCHLORIDE   SCN7A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RUFINAMIDE   SCN7A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BENOXINATE HYDROCHLORIDE   SCN7A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRILOCAINE   SCN7A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRILOCAINE HYDROCHLORIDE   SCN7A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TETRACAINE   SCN7A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DISOPYRAMIDE PHOSPHATE   SCN7A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MEPHENYTOIN   SCN7A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ERLOSAMIDE   SCN7A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MORICIZINE HYDROCHLORIDE   SCN7A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • IRAMPANEL   SCN7A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROPAFENONE HYDROCHLORIDE   SCN7A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SAFINAMIDE   SCN7A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Safinamide
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • LIDOCAINE   SCN7A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DYCLONINE HYDROCHLORIDE   SCN7A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DRONEDARONE HYDROCHLORIDE   SCN7A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RILUZOLE   SCN7A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PHENAZOPYRIDINE HYDROCHLORIDE   SCN7A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RALFINAMIDE   SCN7A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • OXCARBAZEPINE   SCN7A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ORPHENADRINE HYDROCHLORIDE   SCN7A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ORPHENADRINE CITRATE   SCN7A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ZONISAMIDE   SCN7A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LAMOTRIGINE   SCN7A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRIMIDONE   SCN7A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PHENYTOIN   SCN7A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TOPIRAMATE   SCN7A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CARBAMAZEPINE   SCN7A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NERISPIRDINE   SCN7A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000136546

    • Version: 101_38

    Alternate Names:
    SCN7A Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: Q01118

    • Version: January-2014

    Alternate Names:
    SCN7A Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass TC:1.A.1.10

    Publications:

  • HopkinsGroom: Q01118

    • Version: 11-September-2012

    Alternate Names:
    SCN7A Uniprot Gene Name
    SCN7A_HUMAN Uniprot Id
    SODIUM CHANNEL PROTEIN TYPE 7 SUBUNIT ALPHA Uniprot Protein Name

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Domain
    Human Readable Name ION CHANNEL

    Gene Categories:
    ION CHANNEL, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000136546

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000136546 Ensembl Gene Id
    SCN7A Display Id
    SODIUM CHANNEL PROTEIN TYPE VII ALPHA SUBUNIT (PUTATIVE VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAX) (SODIUM CHANNEL PROTEIN, CARDIAC AND SKELETAL MUSCLE ALPHA-SUBUNIT). [SOURCE:UNIPROT/SWISSPROT;ACC:Q01118] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • BaderLabGenes: SCN7A

    • Version: February-2014

    Alternate Names:
    6332 Entrez Gene ID

    Gene Info:
    Initial Gene Query Nax
    Counted Citations from 1950-2000 33

    Gene Categories:
    ION CHANNEL

    Publications:

  • ChemblInteractions: SCN6A

    • Version: chembl_23

    Alternate Names:
    SCN6A GENE_SYMBOL
    SCN7A GENE_SYMBOL
    Sodium channel protein type 7 subunit alpha UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000136546

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000136546 Gene Symbol
    SCN7A Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • IDG: SCN7A

    • Version: 15-July-2019

    Alternate Names:
    SCN7A Gene Symbol

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications:

  • Pharos: SCN7A

    • Version: 01-February-2022

    Alternate Names:
    Sodium channel protein type 7 subunit alpha Gene Name
    Q01118 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications: