6329 |
SODIUM VOLTAGE-GATED CHANNEL ALPHA SUBUNIT 4 |
SCN4A |
CMS16 |
HOKPP2 |
HYKPP |
HYPP |
NAC1A |
Na(V)1.4 |
Nav1.4 |
SkM1 |
603967 |
10591 |
ENSG00000007314 |
OTTHUMG00000179046 |
Voltage-gated sodium channel subunit alpha Nav1.4 |
Sodium channel protein type IV subunit alpha |
Sodium channel protein skeletal muscle subunit alpha |
Sodium channel protein type 4 subunit alpha |
P35499 |
SCN4A_HUMAN |
SODIUM CHANNEL PROTEIN TYPE IV ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.4) (SODIUM CHANNEL PROTEIN, SKELETAL MUSCLE ALPHA-SUBUNIT) (SKM1). [SOURCE:UNIPROT/SWISSPROT;ACC:P35499] |
Voltage-gated sodium channel alpha Nav1.4 |
T02546 |
Target Class | Transporters |
Target Subclass | TC:1.A.1.10.4 |
Initial Gene Query | Nav1.4 |
Counted Citations from 1950-2000 | 496 |
Interpro Type | Domain |
Uniprot Status | Swiss-Prot |
Interpro Name | Ion transport domain |
Human Readable Name | DRUGGABLE GENOME |
Uniprot Evidence | 1: Evidence at protein level |
Human Readable Name | ION CHANNEL |
Interpro Short Name | Ion_trans_dom |
Interpro Acc | IPR005821 |
Transmembrane Helix Count | 24 |
Target Subclass | Voltage_gated_ion_channels |
Target Subclass | Channels |
Target Main Class | Transporters |
Target Subclass | SodiumChannels |
Gene Biotype | PROTEIN_CODING |
ION CHANNEL |
DRUGGABLE GENOME |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel protein type IV alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel protein type IV alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
inhibitor (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
Trial Name | Empatic |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel protein type IV alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Trial Name | tetrodotoxin,Tectin, Tetrodin |
Novel drug target | Established target |
inhibitor (inhibitory) |
Trial Name | propofol lingual spray |
Novel drug target | Established target |
Trial Name | propofol,Diprivan |
blocker (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel protein type IV alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
blocker (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
n/a |
Novel drug target | Established target |
Trial Name | Safinamide |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
blocker (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
blocker (inhibitory) |
Mechanism of Interaction | Sodium channel alpha subunit blocker |
Direct Interaction | yes |
SCN4A | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
SCN4A_HUMAN | Uniprot Id |
SCN4A | Gene Symbol |
6329 | Entrez Gene Id |
Transmembrane Helix Count | 24 |
Target Subclass | Voltage_gated_ion_channels |
Target Subclass | Channels |
6329 | Entrez Gene ID |
Initial Gene Query | Nav1.4 |
Counted Citations from 1950-2000 | 496 |
ION CHANNEL |
ENSG00000007314 | Ensembl Gene Id |
SODIUM CHANNEL PROTEIN TYPE IV ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.4) (SODIUM CHANNEL PROTEIN, SKELETAL MUSCLE ALPHA-SUBUNIT) (SKM1). [SOURCE:UNIPROT/SWISSPROT;ACC:P35499] | Description |
SCN4A | Display Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
SCN4A_HUMAN | Uniprot Id |
ENSG00000007314 | Ensembl Gene Id |
P35499 | Uniprot Accession |
Interpro Type | Domain |
Uniprot Status | Swiss-Prot |
Interpro Name | Ion transport domain |
ION CHANNEL, DRUGGABLE GENOME |
SCN4A | Gene Symbol |
Target Class | Transporters |
Target Subclass | TC:1.A.1.10.4 |
SCN4A | GENE_SYMBOL |
Sodium channel protein type 4 subunit alpha | UNIPROT |
SkM1 | UNIPROT |
ENSG00000007314 | Gene Symbol |
SCN4A | Ensembl Id |
DRUGGABLE GENOME |
SCN4A | TTD Gene Abbreviation |
T02546 | TTD Target ID |
Sodium channel protein type 4 subunit alpha | Gene Name |
P35499 | UniProt ID |
ION CHANNEL |