DGIdb - SCN4A Gene Record

SCN4A 6329 Druggable Genome

Alternate Names:

6329
SODIUM VOLTAGE-GATED CHANNEL ALPHA SUBUNIT 4
SCN4A
CMS16
HOKPP2
HYKPP
HYPP
NAC1A
Na(V)1.4
Nav1.4
SkM1
603967
10591
ENSG00000007314
OTTHUMG00000179046
Voltage-gated sodium channel subunit alpha Nav1.4
Sodium channel protein type IV subunit alpha
Sodium channel protein skeletal muscle subunit alpha
Sodium channel protein type 4 subunit alpha
581
NM_000334
sodium channel, voltage-gated, type IV, alpha subunit
Na<sub>v</sub>1.4
NP_000325
P35499
SCN4A_HUMAN
BE0002083
SODIUM CHANNEL PROTEIN TYPE IV ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.4) (SODIUM CHANNEL PROTEIN, SKELETAL MUSCLE ALPHA-SUBUNIT) (SKM1). [SOURCE:UNIPROT/SWISSPROT;ACC:P35499]
Voltage-gated sodium channel alpha Nav1.4
T02546

Gene Info:

GuideToPharmacology Gene Category Name	Voltage-gated sodium channels
GuideToPharmacology Gene Category ID	82
GuideToPharmacology Gene Type	vgic
Target Class	Transporters
Target Subclass	TC:1.A.1.10.4
Initial Gene Query	Nav1.4
Counted Citations from 1950-2000	496
Interpro Type	Domain
Uniprot Status	Swiss-Prot
Interpro Name	Ion transport domain
Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	ION CHANNEL
Interpro Short Name	Ion_trans_dom
Interpro Acc	IPR005821
Transmembrane Helix Count	24
Target Subclass	Voltage_gated_ion_channels
Target Subclass	Channels
Target Main Class	Transporters
Target Subclass	SodiumChannels
Gene Biotype	PROTEIN_CODING

(9 More Sources)

Gene Categories: Category Details

TRANSPORTER
ION CHANNEL
DRUGGABLE GENOME

Publications:

Haeseler et al., 2008, High-affinity blockade of voltage-operated skeletal muscle and neuronal sodium channels by halogenated propofol analogues., Br. J. Pharmacol.
Sonsalla et al., 2010, The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance., Exp. Neurol.
Leppik, 2004, Zonisamide: chemistry, mechanism of action, and pharmacokinetics., Seizure
Sobieszek et al., Zonisamide: a new antiepileptic drug., Pol J Pharmacol
Kothare et al., 2008, Zonisamide: review of pharmacology, clinical efficacy, tolerability, and safety., Expert Opin Drug Metab Toxicol
Schulze-Bonhage, 2010, Zonisamide in the treatment of epilepsy., Expert Opin Pharmacother
Janszky, 2009, [Role of zonisamid in treating epilepsy, Parkinson disorders and other neurological diseases]., Ideggyogy Sz
Zaccara et al., 2009, Long-term safety and effectiveness of zonisamide in the treatment of epilepsy: a review of the literature., Neuropsychiatr Dis Treat
Desaphy et al., 2004, Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block., J. Physiol. (Lond.)
Yang et al., 2005, An inactivation stabilizer of the Na+ channel acts as an opportunistic pore blocker modulated by external Na+., J. Gen. Physiol.
Jones et al., 2004, Acid-induced pain and its modulation in humans., J. Neurosci.
Voilley, 2004, Acid-sensing ion channels (ASICs): new targets for the analgesic effects of non-steroid anti-inflammatory drugs (NSAIDs)., Curr Drug Targets Inflamm Allergy
Leuwer M et al., 2004, An improved model for the binding of lidocaine and structurally related local anaesthetics to fast-inactivated voltage-operated sodium channels, showing evidence of cooperativity., Br J Pharmacol

PROPOFOL SCN4A

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name propofol lingual spray

Novel drug target Established target

Trial Name propofol,Diprivan

Publications:

Haeseler et al., 2008, High-affinity blockade of voltage-operated skeletal muscle and neuronal sodium channels by halogenated propofol analogues., Br. J. Pharmacol.
BENOXINATE HYDROCHLORIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
ESLICARBAZEPINE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
PROPOXYCAINE HYDROCHLORIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:
MERETHOXYLLINE PROCAINE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
TETRACAINE HYDROCHLORIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:
DYCLONINE HYDROCHLORIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:
TOPIRAMATE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:
ETIDOCAINE HYDROCHLORIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:
HEXYLCAINE HYDROCHLORIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
MEXILETINE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

Publications:
PRIMIDONE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:
TETRODOTOXIN SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Pore blocker

Publications:
PROPAFENONE HYDROCHLORIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:
MORICIZINE HYDROCHLORIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:
NKTR-171 SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:
QUINIDINE POLYGALACTURONATE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
PHENYTOIN SODIUM SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
FOSPHENYTOIN SODIUM SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:
OXCARBAZEPINE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
TOCAINIDE HYDROCHLORIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
QUINIDINE GLUCONATE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
BUPIVACAINE HYDROCHLORIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel protein type IV alpha subunit blocker

Direct Interaction yes

Publications:
PHENACEMIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
NERISPIRDINE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
PHENAZOPYRIDINE HYDROCHLORIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
INDECAINIDE HYDROCHLORIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
RUFINAMIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
PROPARACAINE HYDROCHLORIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
ORPHENADRINE HYDROCHLORIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
LIDOCAINE HYDROCHLORIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
IRAMPANEL SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
DRONEDARONE HYDROCHLORIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
MEPHENYTOIN SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
ROPIVACAINE HYDROCHLORIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
PHENYTOIN SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
RALFINAMIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
QUINIDINE SULFATE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
LAMOTRIGINE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
ERLOSAMIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
ETHOTOIN SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
LEVOBUPIVACAINE HYDROCHLORIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel protein type IV alpha subunit blocker

Direct Interaction yes

Publications:
ESLICARBAZEPINE ACETATE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:
CARBAMAZEPINE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:
RILUZOLE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
EVENAMIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
PRILOCAINE HYDROCHLORIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
CHLOROPROCAINE HYDROCHLORIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:
ORPHENADRINE CITRATE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
BUPIVACAINE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel protein type IV alpha subunit blocker

Direct Interaction yes

Publications:
DISOPYRAMIDE PHOSPHATE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
PROCAINAMIDE HYDROCHLORIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
ARTICAINE HYDROCHLORIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
PROCAINE HYDROCHLORIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
MEPIVACAINE HYDROCHLORIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
RANOLAZINE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel protein type IV alpha subunit blocker

Direct Interaction yes

Publications:
MEXILETINE HYDROCHLORIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
PRILOCAINE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
TETRACAINE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:

ZONISAMIDE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Trial Name Empatic

Publications:

Sonsalla et al., 2010, The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance., Exp. Neurol.

Leppik, 2004, Zonisamide: chemistry, mechanism of action, and pharmacokinetics., Seizure

Sobieszek et al., Zonisamide: a new antiepileptic drug., Pol J Pharmacol

FLECAINIDE SCN4A

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Desaphy et al., 2004, Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block., J. Physiol. (Lond.)

DICLOFENAC SCN4A

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Yang et al., 2005, An inactivation stabilizer of the Na+ channel acts as an opportunistic pore blocker modulated by external Na+., J. Gen. Physiol.

Jones et al., 2004, Acid-induced pain and its modulation in humans., J. Neurosci.

Voilley, 2004, Acid-sensing ion channels (ASICs): new targets for the analgesic effects of non-steroid anti-inflammatory drugs (NSAIDs)., Curr Drug Targets Inflamm Allergy

LIDOCAINE SCN4A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:

Leuwer M et al., 2004, An improved model for the binding of lidocaine and structurally related local anaesthetics to fast-inactivated voltage-operated sodium channels, showing evidence of cooperativity., Br J Pharmacol

SAFINAMIDE SCN4A

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name Safinamide

Publications:

PARACHLOROPHENOL SCN4A

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Leuwer M et al., 2004, An improved model for the binding of lidocaine and structurally related local anaesthetics to fast-inactivated voltage-operated sodium channels, showing evidence of cooperativity., Br J Pharmacol

FOSPROPOFOL SCN4A

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
VERATRIDINE SCN4A

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
ZNCCNCSSKWCRDHSRCC SCN4A

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
chembl:CHEMBL448556 SCN4A

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
LANPERISONE SCN4A

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
ZRCCNCSSKWCRDHSRCC SCN4A

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ensembl: ENSG00000007314
- Version: 101_38
Alternate Names:

SCN4A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
GuideToPharmacologyGenes: 581
- Version: 4-March-2015
Alternate Names:

sodium channel, voltage-gated, type IV, alpha subunit HUGO Gene Name

10591 HUGO Gene ID

SCN4A Gene Symbol

Gene Info:

GuideToPharmacology Gene Category Name Voltage-gated sodium channels

GuideToPharmacology Gene Category ID 82

GuideToPharmacology Gene Type vgic

Gene Categories:

TRANSPORTER, ION CHANNEL

Publications:
TEND: P35499
- Version: 01-August-2011
Alternate Names:

SCN4A_HUMAN Uniprot Id

SCN4A Gene Symbol

6329 Entrez Gene Id

Gene Info:

Transmembrane Helix Count 24

Target Subclass Voltage_gated_ion_channels

Target Subclass Channels

Publications:
BaderLabGenes: SCN4A
- Version: February-2014
Alternate Names:

6329 Entrez Gene ID

Gene Info:

Initial Gene Query Nav1.4

Counted Citations from 1950-2000 496

Gene Categories:

ION CHANNEL

Publications:

RussLampel: ENSG00000007314

Version: 26-July-2011

Alternate Names:

ENSG00000007314 Ensembl Gene Id

SODIUM CHANNEL PROTEIN TYPE IV ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.4) (SODIUM CHANNEL PROTEIN, SKELETAL MUSCLE ALPHA-SUBUNIT) (SKM1). [SOURCE:UNIPROT/SWISSPROT;ACC:P35499] Description

SCN4A Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P35499
- Version: 11-September-2012
Alternate Names:

SCN4A_HUMAN Uniprot Id

ENSG00000007314 Ensembl Gene Id

P35499 Uniprot Accession

Gene Info:

Interpro Type Domain

Uniprot Status Swiss-Prot

Interpro Name Ion transport domain

Gene Categories:

ION CHANNEL, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P35499
- Version: January-2014
Alternate Names:

SCN4A Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:1.A.1.10.4

Publications:

DrugBank: BE0002083

Version: 5.1.7

Alternate Names:

SCN4A DrugBank Gene Name

P35499 UniProt Accession

6329 Entrez Gene Id

Gene Info:

Publications:

Leuwer M et al., 2004, An improved model for the binding of lidocaine and structurally related local anaesthetics to fast-inactivated voltage-operated sodium channels, showing evidence of cooperativity., Br J Pharmacol

Haeseler et al., 2008, High-affinity blockade of voltage-operated skeletal muscle and neuronal sodium channels by halogenated propofol analogues., Br. J. Pharmacol.

Leppik, 2004, Zonisamide: chemistry, mechanism of action, and pharmacokinetics., Seizure

ChemblInteractions: SCN4A
- Version: chembl_23
Alternate Names:

SCN4A GENE_SYMBOL

Sodium channel protein type 4 subunit alpha UNIPROT

SkM1 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000007314
- Version: 31-May-2017
Alternate Names:

ENSG00000007314 Gene Symbol

SCN4A Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GuideToPharmacologyInteractions: ENSG00000007314
- Version: 20-July-2020
Alternate Names:

Na<sub>v</sub>1.4 GuideToPharmacology Name

P35499 UniProtKB ID

Gene Info:

Publications:
TTD: Voltage-gated sodium channel alpha Nav1.4
- Version: 2020.06.01
Alternate Names:

SCN4A TTD Gene Abbreviation

T02546 TTD Target ID

Gene Info:

Publications:
Pharos: SCN4A
- Version: 03-September-2020
Alternate Names:

Sodium channel protein type 4 subunit alpha Gene Name

P35499 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:

Trial Name	propofol lingual spray
Novel drug target	Established target
Trial Name	propofol,Diprivan

Mechanism of Interaction	Sodium channel alpha subunit blocker
Direct Interaction	yes

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False
Direct Interaction?	True

sodium channel, voltage-gated, type IV, alpha subunit	HUGO Gene Name
10591	HUGO Gene ID
SCN4A	Gene Symbol

ENSG00000007314	Ensembl Gene Id
SODIUM CHANNEL PROTEIN TYPE IV ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.4) (SODIUM CHANNEL PROTEIN, SKELETAL MUSCLE ALPHA-SUBUNIT) (SKM1). [SOURCE:UNIPROT/SWISSPROT;ACC:P35499]	Description
SCN4A	Display Id

SCN4A_HUMAN	Uniprot Id
ENSG00000007314	Ensembl Gene Id
P35499	Uniprot Accession

SCN4A	DrugBank Gene Name
P35499	UniProt Accession
6329	Entrez Gene Id

SCN4A	GENE_SYMBOL
Sodium channel protein type 4 subunit alpha	UNIPROT
SkM1	UNIPROT

Sodium channel protein type 4 subunit alpha	Gene Name
P35499	UniProt ID

SCN4A Gene Record

SCN4A 6329 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name propofol lingual spray Novel drug target Established target Trial Name propofol,Diprivan

Publications: Haeseler et al., 2008, High-affinity blockade of voltage-operated skeletal muscle and neuronal sodium channels by halogenated propofol analogues., Br. J. Pharmacol.

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? True

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Pore blocker

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel protein type IV alpha subunit blocker Direct Interaction yes

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name propofol lingual spray

Novel drug target Established target

Trial Name propofol,Diprivan

Publications:

Haeseler et al., 2008, High-affinity blockade of voltage-operated skeletal muscle and neuronal sodium channels by halogenated propofol analogues., Br. J. Pharmacol.

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Pore blocker

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel protein type IV alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes