DGIdb - SCN3A Gene Record

SCN3A 6328 Druggable Genome

Alternate Names:

6328
SODIUM VOLTAGE-GATED CHANNEL ALPHA SUBUNIT 3
SCN3A
NAC3
Nav1.3
182391
10590
ENSG00000153253
OTTHUMG00000044171
Q9NY46
KIAA1356
Sodium channel protein type III subunit alpha
Sodium channel protein type 3 subunit alpha
Sodium channel protein brain III subunit alpha
Voltage-gated sodium channel subtype III
Voltage-gated sodium channel subunit alpha Nav1.3
SCN3A_HUMAN
SODIUM CHANNEL PROTEIN TYPE III ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.3) (SODIUM CHANNEL PROTEIN, BRAIN III ALPHA SUBUNIT) (VOLTAGE-GATED SODIUM CHANNEL SUBTYPE III). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9NY46]
Voltage-gated sodium channel alpha Nav1.3
T76937
DEE62
EIEE62
FFEVF4

Gene Info:

Target Class	Transporters
Target Subclass	TC:1.A.1.10
Uniprot Status	Swiss-Prot
Interpro Name	Ion transport domain
Interpro Short Name	Ion_trans_dom
Interpro Type	Domain
Interpro Acc	IPR005821
Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	ION CHANNEL
Initial Gene Query	Nav1.3
Counted Citations from 1950-2000	165
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

ION CHANNEL
DRUGGABLE GENOME

Publications:

Sonsalla et al., 2010, The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance., Exp. Neurol.
Leppik, 2004, Zonisamide: chemistry, mechanism of action, and pharmacokinetics., Seizure
Sobieszek et al., Zonisamide: a new antiepileptic drug., Pol J Pharmacol
Kothare et al., 2008, Zonisamide: review of pharmacology, clinical efficacy, tolerability, and safety., Expert Opin Drug Metab Toxicol
Schulze-Bonhage, 2010, Zonisamide in the treatment of epilepsy., Expert Opin Pharmacother
Janszky, 2009, [Role of zonisamid in treating epilepsy, Parkinson disorders and other neurological diseases]., Ideggyogy Sz
Zaccara et al., 2009, Long-term safety and effectiveness of zonisamide in the treatment of epilepsy: a review of the literature., Neuropsychiatr Dis Treat
Sage et al., 2007, Na(v)1.7 and Na(v)1.3 are the only tetrodotoxin-sensitive sodium channels expressed by the adult guinea pig enteric nervous system., J. Comp. Neurol.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Lucas PT et al., 2005, An epilepsy mutation in the beta1 subunit of the voltage-gated sodium channel results in reduced channel sensitivity to phenytoin., Epilepsy Res
Tate et al., 2005, Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin., Proc. Natl. Acad. Sci. U.S.A.

ZONISAMIDE SCN3A

Interaction Score: 0.44

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Trial Name Empatic

PMIDs:
19948168 15511691 14704463 18433351 20001433 20025128 19557119

Sources:
TdgClinicalTrial ChemblInteractions
LIDOFLAZINE SCN3A

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TETRODOTOXIN SCN3A

Interaction Score: 0.24

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Trial Name tetrodotoxin,Tectin, Tetrodin

Novel drug target Established target

PMIDs:
17663442

Sources:
TdgClinicalTrial
ERLOSAMIDE SCN3A

Interaction Score: 0.18

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
10592235

Sources:
ChemblInteractions
ELPETRIGINE SCN3A

Interaction Score: 0.13

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel protein type III alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HEXYLCAINE HYDROCHLORIDE SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
EVENAMIDE SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ESLICARBAZEPINE SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
QUINIDINE POLYGALACTURONATE SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ETIDOCAINE HYDROCHLORIDE SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ETHOTOIN SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INDECAINIDE HYDROCHLORIDE SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
QUINIDINE SULFATE SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROPOXYCAINE HYDROCHLORIDE SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NKTR-171 SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROCAINE HYDROCHLORIDE SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEPIVACAINE HYDROCHLORIDE SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
LIDOCAINE HYDROCHLORIDE SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROPARACAINE HYDROCHLORIDE SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
QUINIDINE GLUCONATE SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ESLICARBAZEPINE ACETATE SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TOCAINIDE HYDROCHLORIDE SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHLOROPROCAINE HYDROCHLORIDE SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENACEMIDE SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
FOSPHENYTOIN SODIUM SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEXILETINE HYDROCHLORIDE SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
PROCAINAMIDE HYDROCHLORIDE SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
PHENYTOIN SODIUM SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
ROPIVACAINE HYDROCHLORIDE SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MERETHOXYLLINE PROCAINE SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
TETRACAINE HYDROCHLORIDE SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ARTICAINE HYDROCHLORIDE SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
PRILOCAINE SCN3A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DISOPYRAMIDE PHOSPHATE SCN3A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TETRACAINE SCN3A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
PRILOCAINE HYDROCHLORIDE SCN3A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BENOXINATE HYDROCHLORIDE SCN3A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RUFINAMIDE SCN3A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEPHENYTOIN SCN3A

Interaction Score: 0.09

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MORICIZINE HYDROCHLORIDE SCN3A

Interaction Score: 0.09

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
PHENYTOIN SCN3A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
15922564 15805193

Sources:
ChemblInteractions
PROPAFENONE HYDROCHLORIDE SCN3A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
IRAMPANEL SCN3A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
SAFINAMIDE SCN3A

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
LIDOCAINE SCN3A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENAZOPYRIDINE HYDROCHLORIDE SCN3A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RILUZOLE SCN3A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DYCLONINE HYDROCHLORIDE SCN3A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DRONEDARONE HYDROCHLORIDE SCN3A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RALFINAMIDE SCN3A

Interaction Score: 0.06

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OXCARBAZEPINE SCN3A

Interaction Score: 0.05

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ORPHENADRINE HYDROCHLORIDE SCN3A

Interaction Score: 0.05

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
ORPHENADRINE CITRATE SCN3A

Interaction Score: 0.05

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LAMOTRIGINE SCN3A

Interaction Score: 0.04

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
PRIMIDONE SCN3A

Interaction Score: 0.03

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TOPIRAMATE SCN3A

Interaction Score: 0.03

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CARBAMAZEPINE SCN3A

Interaction Score: 0.02

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NERISPIRDINE SCN3A

Interaction Score: 0.02

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000153253
- Version: 101_38
Alternate Names:

SCN3A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q9NY46
- Version: January-2014
Alternate Names:

SCN3A Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:1.A.1.10

Publications:

RussLampel: ENSG00000153253

Version: 26-July-2011

Alternate Names:

ENSG00000153253 Ensembl Gene Id

SCN3A Display Id

SODIUM CHANNEL PROTEIN TYPE III ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.3) (SODIUM CHANNEL PROTEIN, BRAIN III ALPHA SUBUNIT) (VOLTAGE-GATED SODIUM CHANNEL SUBTYPE III). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9NY46] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

BaderLabGenes: SCN3A
- Version: February-2014
Alternate Names:

6328 Entrez Gene ID

Gene Info:

Initial Gene Query Nav1.3

Counted Citations from 1950-2000 165

Gene Categories:

ION CHANNEL

Publications:
HopkinsGroom: Q9NY46
- Version: 11-September-2012
Alternate Names:

SCN3A_HUMAN Uniprot Id

ENSG00000153253 Ensembl Gene Id

SCN3A Uniprot Gene Name

Gene Info:

Uniprot Status Swiss-Prot

Interpro Name Ion transport domain

Interpro Short Name Ion_trans_dom

Gene Categories:

ION CHANNEL, DRUGGABLE GENOME

Publications:
HingoraniCasas: ENSG00000153253
- Version: 31-May-2017
Alternate Names:

ENSG00000153253 Gene Symbol

SCN3A Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: KIAA1356
- Version: chembl_23
Alternate Names:

NAC3 GENE_SYMBOL

SCN3A GENE_SYMBOL

Sodium channel protein type 3 subunit alpha UNIPROT

Gene Info:

Publications:
TTD: Voltage-gated sodium channel alpha Nav1.3
- Version: 2020.06.01
Alternate Names:

SCN3A TTD Gene Abbreviation

T76937 TTD Target ID

Gene Info:

Publications:
Pharos: SCN3A
- Version: 01-February-2022
Alternate Names:

Sodium channel protein type 3 subunit alpha Gene Name

Q9NY46 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:

Direct Interaction	yes
Mechanism of Interaction	Sodium channel alpha subunit blocker
Trial Name	Empatic

Trial Name	tetrodotoxin,Tectin, Tetrodin
Novel drug target	Established target

ENSG00000153253	Ensembl Gene Id
SCN3A	Display Id
SODIUM CHANNEL PROTEIN TYPE III ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.3) (SODIUM CHANNEL PROTEIN, BRAIN III ALPHA SUBUNIT) (VOLTAGE-GATED SODIUM CHANNEL SUBTYPE III). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9NY46]	Description

SCN3A_HUMAN	Uniprot Id
ENSG00000153253	Ensembl Gene Id
SCN3A	Uniprot Gene Name

NAC3	GENE_SYMBOL
SCN3A	GENE_SYMBOL
Sodium channel protein type 3 subunit alpha	UNIPROT

Sodium channel protein type 3 subunit alpha	Gene Name
Q9NY46	UniProt ID

blocker (inhibitory)
inhibitor (inhibitory)

SCN3A Gene Record

SCN3A 6328 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker Trial Name Empatic

PMIDs: 19948168 15511691 14704463 18433351 20001433 20025128 19557119

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Trial Name tetrodotoxin,Tectin, Tetrodin Novel drug target Established target

PMIDs: 17663442

Sources: TdgClinicalTrial

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: 10592235

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel protein type III alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Trial Name Empatic

PMIDs:
19948168 15511691 14704463 18433351 20001433 20025128 19557119

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Trial Name tetrodotoxin,Tectin, Tetrodin

Novel drug target Established target

PMIDs:
17663442

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
10592235

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel protein type III alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)