DGIdb - SCN1A Gene Record

SCN1A 6323 Druggable Genome

Alternate Names:

6323
SODIUM VOLTAGE-GATED CHANNEL ALPHA SUBUNIT 1
SCN1A
EIEE6
FEB3
FEB3A
FHM3
GEFSP2
HBSCI
NAC1
Nav1.1
SCN1
SMEI
182389
10585
ENSG00000144285
OTTHUMG00000044173
SCN1A_HUMAN
P35498
578
Na<sub>v</sub>1.1
Sodium channel protein brain I subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.1
Sodium channel protein type I subunit alpha
Sodium channel protein type 1 subunit alpha
PA301
BE0004901
NP_008851\|NP_001159435\|NP_001159436
NM_006920\|NM_001165963\|NM_001165964\|NM_001202435
SODIUM CHANNEL PROTEIN TYPE I ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.1) (SODIUM CHANNEL PROTEIN, BRAIN I ALPHA SUBUNIT). [SOURCE:UNIPROT/SWISSPROT;ACC:P35498]
BE0000141
BE0009738

Gene Info:

Initial Gene Query	Nav1.1
Counted Citations from 1950-2000	398
Target Class	Transporters
Target Subclass	TC:1.A.1.10.7
Interpro Short Name	Ion_trans_dom
Interpro Acc	IPR005821
Human Readable Name	ION CHANNEL
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Interpro Type	Domain
Interpro Name	Ion transport domain
Target Subclass	Voltage_gated_ion_channels
Target Main Class	Transporters
Target Subclass	Channels
Transmembrane Helix Count	24
Target Subclass	SodiumChannels
GuideToPharmacology Gene Category Name	Voltage-gated sodium channels
GuideToPharmacology Gene Category ID	82
Gene Biotype	PROTEIN_CODING

(10 More Sources)

Gene Categories: Category Details

ION CHANNEL
DRUGGABLE GENOME

Publications:

Haerian BS et al., 2013, SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis., Pharmacogenomics
Kumari R et al., 2011, Pharmacogenomic association study on the role of drug metabolizing, drug transporters and drug target gene polymorphisms in drug-resistant epilepsy in a north Indian population., Indian J Hum Genet
Bertok S et al., 2017, The association of SCN1A p.Thr1067Ala polymorphism with epilepsy risk and the response to antiepileptic drugs in Slovenian children and adolescents with epilepsy., Seizure
Ma CL et al., 2014, Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy., Pharmacogenomics
Ceulemans et al., 2004, "Severe myoclonic epilepsy in infancy". Relevance for the clinician of severe epilepsy starting in infancy., Acta Neurol Belg
Ceulemans et al., 2004, Severe myoclonic epilepsy in infancy: toward an optimal treatment., J. Child Neurol.
Coppola et al., 2002, Topiramate as add-on drug in severe myoclonic epilepsy in infancy: an Italian multicenter open trial., Epilepsy Res.
Korff et al., 2007, Dravet syndrome (severe myoclonic epilepsy in infancy): a retrospective study of 16 patients., J. Child Neurol.
Nieto Barrera et al., [Severe myoclonic epilepsy in infancy (Dravet's syndrome). Its nosological characteristics and therapeutic aspects]., Rev Neurol
Zaccara et al., 2009, Long-term safety and effectiveness of zonisamide in the treatment of epilepsy: a review of the literature., Neuropsychiatr Dis Treat
Schulze-Bonhage, 2010, Zonisamide in the treatment of epilepsy., Expert Opin Pharmacother
Sonsalla et al., 2010, The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance., Exp. Neurol.
Leppik, 2004, Zonisamide: chemistry, mechanism of action, and pharmacokinetics., Seizure
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Janszky, 2009, [Role of zonisamid in treating epilepsy, Parkinson disorders and other neurological diseases]., Ideggyogy Sz
Sobieszek et al., Zonisamide: a new antiepileptic drug., Pol J Pharmacol
Kothare et al., 2008, Zonisamide: review of pharmacology, clinical efficacy, tolerability, and safety., Expert Opin Drug Metab Toxicol
Tate et al., 2006, A common polymorphism in the SCN1A gene associates with phenytoin serum levels at maintenance dose., Pharmacogenet. Genomics
Tate et al., 2005, Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin., Proc. Natl. Acad. Sci. U.S.A.
Mantegazza et al., 2010, Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders., Lancet Neurol
Ragsdale et al., 1996, Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels., Proc. Natl. Acad. Sci. U.S.A.
Aizawa et al., 2010, Effects of phenazopyridine on rat bladder primary afferent activity, and comparison with lidocaine and acetaminophen., Neurourol. Urodyn.
Sage et al., 2007, Na(v)1.7 and Na(v)1.3 are the only tetrodotoxin-sensitive sodium channels expressed by the adult guinea pig enteric nervous system., J. Comp. Neurol.
Wong et al., 1986, Conformational analysis of clinically active anticonvulsant drugs., J. Med. Chem.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
McLean et al., 1988, Benzodiazepines, but not beta carbolines, limit high frequency repetitive firing of action potentials of spinal cord neurons in cell culture., J. Pharmacol. Exp. Ther.
Breckenridge et al., 2009, Evidence for a separate mechanism of toxicity for the Type I and the Type II pyrethroid insecticides., Neurotoxicology
Liu et al., 2009, Permethrin resistance and target site insensitivity in the mosquito Culex quinquefasciatus in Alabama., J. Med. Entomol.
McMahon et al., 2003, In vitro assays for repellents and deterrents for ticks: differing effects of products when tested with attractant or arrestment stimuli., Med. Vet. Entomol.
Chang et al., 2009, A novel amino acid substitution in a voltage-gated sodium channel is associated with knockdown resistance to permethrin in Aedes aegypti., Insect Biochem. Mol. Biol.
Cao et al., 2011, Mechanisms of pyrethroid insecticide-induced stimulation of calcium influx in neocortical neurons., J. Pharmacol. Exp. Ther.
Gammaitoni AR et al., 2013, Heated lidocaine/tetracaine patch for treatment of patellar tendinopathy pain., J Pain Res
Fozzard HA et al., 2011, The sodium channel as a target for local anesthetic drugs., Front Pharmacol
Zhou BT et al., 2012, Effects of SCN1A and GABA receptor genetic polymorphisms on carbamazepine tolerability and efficacy in Chinese patients with partial seizures: 2-year longitudinal clinical follow-up., CNS Neurosci Ther
Shorvon S, 2000, Oxcarbazepine: a review., Seizure
Thomas AM et al., 2018, Old Friends With New Faces: Are Sodium Channel Blockers the Future of Adjunct Pain Medication Management?, J Pain
Schmidt D et al., 2000, Oxcarbazepine for Treatment of Partial Epilepsy: A Review and Recommendations for Clinical Use., Epilepsy Behav
Daci A et al., 2015, Polymorphic Variants of SCN1A and EPHX1 Influence Plasma Carbamazepine Concentration, Metabolism and Pharmacoresistance in a Population of Kosovar Albanian Epileptic Patients., PLoS One
Schlachter K et al., 2009, A splice site variant in the sodium channel gene SCN1A confers risk of febrile seizures., Neurology
Lipkind et al., 2010, Molecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore., Mol. Pharmacol.
Zhou BT et al., 2012, Comprehensive analysis of the association of SCN1A gene polymorphisms with the retention rate of carbamazepine following monotherapy for new-onset focal seizures in the Chinese Han population., Clin Exp Pharmacol Physiol
Hung CC et al., 2012, Association of polymorphisms in EPHX1, UGT2B7, ABCB1, ABCC2, SCN1A and SCN2A genes with carbamazepine therapy optimization., Pharmacogenomics
Yang et al., 2002, Inhibition of Na(+) current by imipramine and related compounds: different binding kinetics as an inactivation stabilizer and as an open channel blocker., Mol. Pharmacol.
Ma CL et al., 2015, Association between PK/PD-involved gene polymorphisms and carbamazepine-individualized therapy., Pharmacogenomics
Rogawski et al., 2004, The neurobiology of antiepileptic drugs., Nat. Rev. Neurosci.
Yang et al., 2010, Lidocaine, carbamazepine, and imipramine have partially overlapping binding sites and additive inhibitory effect on neuronal Na+ channels., Anesthesiology
Manna I et al., 2011, A functional polymorphism in the SCN1A gene does not influence antiepileptic drug responsiveness in Italian patients with focal epilepsy., Epilepsia
Lipkind et al., 2005, Molecular modeling of local anesthetic drug binding by voltage-gated sodium channels., Mol. Pharmacol.
Jerling M, 2006, Clinical pharmacokinetics of ranolazine., Clin Pharmacokinet
Saad M et al., 2016, Ranolazine in Cardiac Arrhythmia., Clin Cardiol
Rayner-Hartley E et al., 2016, Ranolazine: A Contemporary Review., J Am Heart Assoc
Crumb WJ Jr et al., 1990, Characterization of cocaine-induced block of cardiac sodium channels., Biophys J
Wright et al., 1999, State-dependent cocaine block of sodium channel isoforms, chimeras, and channels coexpressed with the beta1 subunit., Biophys. J.
Zona C et al., 2010, Brivaracetam (ucb 34714) inhibits Na(+) current in rat cortical neurons in culture., Epilepsy Res
Visioli F et al., 2012, Molecular targets of omega 3 and conjugated linoleic Fatty acids - "micromanaging" cellular response., Front Physiol
Leung YM et al., 2013, The use of carbetapentane for spinal anesthesia and use-dependent block of sodium currents., Eur J Pharmacol
Butterworth JF 4th et al., 1990, Molecular mechanisms of local anesthesia: a review., Anesthesiology
Cantisani C et al., 2013, Topical promethazine side effects: our experience and review of the literature., Biomed Res Int
Tanaka H et al., 1992, Blockade of Na+ current by promethazine in guinea-pig ventricular myocytes., Br J Pharmacol
McCavera SJ et al., 2012, Differential state-dependent modification of inactivation-deficient Nav1.6 sodium channels by the pyrethroid insecticides S-bioallethrin, tefluthrin and deltamethrin., Neurotoxicology
Narahashi, 1996, Neuronal ion channels as the target sites of insecticides., Pharmacol. Toxicol.
Tan TW et al., 2017, Effectiveness of amylmetacresol and 2,4-dichlorobenzyl alcohol throat lozenges in patients with acute sore throat due to upper respiratory tract infection: a systematic review protocol., JBI Database System Rev Implement Rep

AMYLOCAINE SCN1A

Interaction Score: 2.27

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

PMIDs:
22053156 2157353

Sources:
DrugBank
DICHLOROBENZYL ALCOHOL SCN1A

Interaction Score: 1.51

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
28398972

Sources:
DrugBank
PRAMOXINE SCN1A

Interaction Score: 1.51

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

PMIDs:
22053156

Sources:
DrugBank
PHENAZOPYRIDINE SCN1A

Interaction Score: 1.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
8799190 20976818

Sources:
DrugBank
ETHOSUXIMIDE SCN1A

Interaction Score: 0.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23859570 21747585 28753467 25155934

Sources:
PharmGKB
PERMETHRIN SCN1A

Interaction Score: 0.76

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19766671 19960691 14651650 19171193 20881019

Sources:
DrugBank
PHENACEMIDE SCN1A

Interaction Score: 0.61

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
3959032 11752352 17139284 17016423

Sources:
TEND TdgClinicalTrial DrugBank ChemblInteractions
LEVETIRACETAM SCN1A

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23859570 21747585 28753467 25155934

Sources:
PharmGKB
PROPOXYCAINE SCN1A

Interaction Score: 0.5

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

PMIDs:
22053156

Sources:
DrugBank
BIOALLETHRIN SCN1A

Interaction Score: 0.45

Interaction Types & Directionality:

modulator

Interaction Info:

PMIDs:
22465659 8841090

Sources:
DrugBank
OXCARBAZEPINE SCN1A

Interaction Score: 0.45

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
23859570 21747585 22591328 10845729 28842369 28753467 12737829 25155934 26555147

Sources:
PharmGKB DrugBank ChemblInteractions
BRIVARACETAM SCN1A

Interaction Score: 0.38

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19914041

Sources:
DrugBank
TETRODOTOXIN SCN1A

Interaction Score: 0.34

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name tetrodotoxin,Tectin, Tetrodin

Specific Action of the Ligand Pore blocker

PMIDs:
17663442

Sources:
TdgClinicalTrial DrugBank GuideToPharmacology
CARBAMAZEPINE SCN1A

Interaction Score: 0.28

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
23859570 21747585 22591328 19289736 20643904 22292851 28753467 22188362 12391287 26314341 15208697 25155934 26555147 20526191 21561445

Sources:
PharmGKB DrugBank ChemblInteractions
RANOLAZINE SCN1A

Interaction Score: 0.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
16640453 26459200 26979079

Sources:
DrugBank
ZONISAMIDE SCN1A

Interaction Score: 0.25

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name zonisamide,Zonegran, Trerief

Trial Name OREX-003, olanzapine plus zonisamide SR

Novel drug target Established target

PMIDs:
19557119 20001433 19948168 15511691 11752352 20025128 14704463 18433351

Sources:
TEND TdgClinicalTrial DrugBank ChemblInteractions
TETRACAINE SCN1A

Interaction Score: 0.23

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
23888118 22053156

Sources:
DrugBank ChemblInteractions
CARBETAPENTANE SCN1A

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
23872380

Sources:
DrugBank
SAXITOXIN SCN1A

Interaction Score: 0.19

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Pore blocker

PMIDs:
None found

Sources:
GuideToPharmacology
VERATRIDINE SCN1A

Interaction Score: 0.19

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Activation

PMIDs:
None found

Sources:
GuideToPharmacology
CLOBAZAM SCN1A

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23859570 21747585 28753467 25155934

Sources:
PharmGKB
FISH OIL TRIGLYCERIDES SCN1A

Interaction Score: 0.15

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
22393325

Sources:
DrugBank
TOPIRAMATE SCN1A

Interaction Score: 0.15

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Trial Name topiramate controlled release,Trokesa

PMIDs:
15508261 15526956 11948006 17621480 12861512

Sources:
TEND TdgClinicalTrial DrugBank ChemblInteractions
LAMOTRIGINE SCN1A

Interaction Score: 0.15

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
23859570 21747585 28753467 16174788 25155934

Sources:
PharmGKB DrugBank ChemblInteractions
NITRAZEPAM SCN1A

Interaction Score: 0.14

Interaction Types & Directionality:

other/unknown

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2450203

Sources:
TEND TdgClinicalTrial DrugBank
PHENYTOIN SCN1A

Interaction Score: 0.14

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
17001291 15805193 20298965

Sources:
TEND PharmGKB TdgClinicalTrial DrugBank ChemblInteractions
PROMETHAZINE SCN1A

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
24350243 1327391

Sources:
DrugBank
COCAINE SCN1A

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
2155033 9876137

Sources:
DrugBank
PROPOXYCAINE HYDROCHLORIDE SCN1A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROCAINAMIDE HYDROCHLORIDE SCN1A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
QUINIDINE SULFATE SCN1A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
QUINIDINE POLYGALACTURONATE SCN1A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TETRACAINE HYDROCHLORIDE SCN1A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
EVENAMIDE SCN1A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FOSPHENYTOIN SODIUM SCN1A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ETIDOCAINE HYDROCHLORIDE SCN1A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LIDOCAINE HYDROCHLORIDE SCN1A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROPARACAINE HYDROCHLORIDE SCN1A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROCAINE HYDROCHLORIDE SCN1A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INDECAINIDE HYDROCHLORIDE SCN1A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MERETHOXYLLINE PROCAINE SCN1A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TOCAINIDE HYDROCHLORIDE SCN1A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HEXYLCAINE HYDROCHLORIDE SCN1A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEXILETINE HYDROCHLORIDE SCN1A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEPIVACAINE HYDROCHLORIDE SCN1A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
QUINIDINE GLUCONATE SCN1A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ESLICARBAZEPINE ACETATE SCN1A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
ARTICAINE HYDROCHLORIDE SCN1A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ROPIVACAINE HYDROCHLORIDE SCN1A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
CHLOROPROCAINE HYDROCHLORIDE SCN1A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENYTOIN SODIUM SCN1A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
NKTR-171 SCN1A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PRILOCAINE SCN1A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ESLICARBAZEPINE SCN1A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ETHOTOIN SCN1A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DISOPYRAMIDE PHOSPHATE SCN1A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BENOXINATE HYDROCHLORIDE SCN1A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PRILOCAINE HYDROCHLORIDE SCN1A

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ERLOSAMIDE SCN1A

Interaction Score: 0.06

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MORICIZINE HYDROCHLORIDE SCN1A

Interaction Score: 0.06

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
RUFINAMIDE SCN1A

Interaction Score: 0.06

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEPHENYTOIN SCN1A

Interaction Score: 0.06

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
IRAMPANEL SCN1A

Interaction Score: 0.05

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROPAFENONE HYDROCHLORIDE SCN1A

Interaction Score: 0.05

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SAFINAMIDE SCN1A

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
DYCLONINE HYDROCHLORIDE SCN1A

Interaction Score: 0.05

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHENAZOPYRIDINE HYDROCHLORIDE SCN1A

Interaction Score: 0.05

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DRONEDARONE HYDROCHLORIDE SCN1A

Interaction Score: 0.05

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LIDOCAINE SCN1A

Interaction Score: 0.04

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
RALFINAMIDE SCN1A

Interaction Score: 0.04

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ORPHENADRINE HYDROCHLORIDE SCN1A

Interaction Score: 0.04

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ORPHENADRINE CITRATE SCN1A

Interaction Score: 0.04

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
RILUZOLE SCN1A

Interaction Score: 0.03

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PRIMIDONE SCN1A

Interaction Score: 0.02

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NERISPIRDINE SCN1A

Interaction Score: 0.02

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000144285
- Version: 101_38
Alternate Names:

SCN1A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P35498
- Version: January-2014
Alternate Names:

SCN1A Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:1.A.1.10.7

Publications:
TEND: P35498
- Version: 01-August-2011
Alternate Names:

SCN1A Gene Symbol

SCN1A_HUMAN Uniprot Id

ENSG00000144285 Ensembl Gene Id

Gene Info:

Target Subclass Voltage_gated_ion_channels

Target Main Class Transporters

Target Subclass Channels

Publications:

RussLampel: ENSG00000144285

Version: 26-July-2011

Alternate Names:

SODIUM CHANNEL PROTEIN TYPE I ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.1) (SODIUM CHANNEL PROTEIN, BRAIN I ALPHA SUBUNIT). [SOURCE:UNIPROT/SWISSPROT;ACC:P35498] Description

ENSG00000144285 Ensembl Gene Id

SCN1A Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

BaderLabGenes: SCN1A
- Version: February-2014
Alternate Names:

6323 Entrez Gene ID

Gene Info:

Initial Gene Query Nav1.1

Counted Citations from 1950-2000 398

Gene Categories:

ION CHANNEL

Publications:
HopkinsGroom: P35498
- Version: 11-September-2012
Alternate Names:

SCN1A Uniprot Gene Name

SCN1A_HUMAN Uniprot Id

ENSG00000144285 Ensembl Gene Id

Gene Info:

Interpro Short Name Ion_trans_dom

Interpro Acc IPR005821

Human Readable Name ION CHANNEL

Gene Categories:

ION CHANNEL, DRUGGABLE GENOME

Publications:
GuideToPharmacology: 6323
- Version: 29-September-2020
Alternate Names:

10585 HUGO Gene ID

10585 HUGO Gene Symbol

sodium voltage-gated channel alpha subunit 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Voltage-gated sodium channels

GuideToPharmacology Gene Category ID 82

Gene Categories:

ION CHANNEL

Publications:

PharmGKB: SCN1A

Version: 18-August-2020

Alternate Names:

PA301 PharmGKB ID

Gene Info:

Publications:

Haerian BS et al., 2013, SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis., Pharmacogenomics

Kumari R et al., 2011, Pharmacogenomic association study on the role of drug metabolizing, drug transporters and drug target gene polymorphisms in drug-resistant epilepsy in a north Indian population., Indian J Hum Genet

Bertok S et al., 2017, The association of SCN1A p.Thr1067Ala polymorphism with epilepsy risk and the response to antiepileptic drugs in Slovenian children and adolescents with epilepsy., Seizure

DrugBank: BE0000141

Version: 5.1.7

Alternate Names:

SCN1A DrugBank Gene Name

P35498 UniProt Accession

6323 Entrez Gene Id

Gene Info:

Publications:

Zaccara et al., 2009, Long-term safety and effectiveness of zonisamide in the treatment of epilepsy: a review of the literature., Neuropsychiatr Dis Treat

Schulze-Bonhage, 2010, Zonisamide in the treatment of epilepsy., Expert Opin Pharmacother

Sonsalla et al., 2010, The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance., Exp. Neurol.

DrugBank: BE0004901

Version: 5.1.7

Alternate Names:

SCN1A DrugBank Gene Name

P35498 UniProt Accession

6323 Entrez Gene Id

Gene Info:

Publications:

Farber et al., 2002, Antiepileptic drugs and agents that inhibit voltage-gated sodium channels prevent NMDA antagonist neurotoxicity., Mol. Psychiatry

Shorvon S, 2000, Oxcarbazepine: a review., Seizure

Thomas AM et al., 2018, Old Friends With New Faces: Are Sodium Channel Blockers the Future of Adjunct Pain Medication Management?, J Pain

DrugBank: BE0009738

Version: 5.1.7

Alternate Names:

SCN1A DrugBank Gene Name

P35498 UniProt Accession

6323 Entrez Gene Id

Gene Info:

Publications:

Ceulemans et al., 2004, Severe myoclonic epilepsy in infancy: toward an optimal treatment., J. Child Neurol.

Coppola et al., 2002, Topiramate as add-on drug in severe myoclonic epilepsy in infancy: an Italian multicenter open trial., Epilepsy Res.

Nieto Barrera et al., [Severe myoclonic epilepsy in infancy (Dravet's syndrome). Its nosological characteristics and therapeutic aspects]., Rev Neurol

HingoraniCasas: ENSG00000144285
- Version: 31-May-2017
Alternate Names:

ENSG00000144285 Gene Symbol

SCN1A Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: NAC1
- Version: chembl_23
Alternate Names:

SCN1 GENE_SYMBOL

SCN1A GENE_SYMBOL

Sodium channel protein type 1 subunit alpha UNIPROT

Gene Info:

Publications:
Pharos: SCN1A
- Version: 03-September-2020
Alternate Names:

Sodium channel protein type 1 subunit alpha Gene Name

P35498 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:

Novel drug target	Established target
Trial Name	-
Mechanism of Interaction	Sodium channel alpha subunit blocker

Mechanism of Interaction	Sodium channel alpha subunit blocker
Direct Interaction	yes

Trial Name	zonisamide,Zonegran, Trerief
Trial Name	OREX-003, olanzapine plus zonisamide SR
Novel drug target	Established target

Direct Interaction?	False
Endogenous Drug?	False
Specific Action of the Ligand	Pore blocker

SCN1A	Gene Symbol
SCN1A_HUMAN	Uniprot Id
ENSG00000144285	Ensembl Gene Id

SODIUM CHANNEL PROTEIN TYPE I ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.1) (SODIUM CHANNEL PROTEIN, BRAIN I ALPHA SUBUNIT). [SOURCE:UNIPROT/SWISSPROT;ACC:P35498]	Description
ENSG00000144285	Ensembl Gene Id
SCN1A	Display Id

SCN1A	Uniprot Gene Name
SCN1A_HUMAN	Uniprot Id
ENSG00000144285	Ensembl Gene Id

10585	HUGO Gene ID
10585	HUGO Gene Symbol
sodium voltage-gated channel alpha subunit 1	HUGO Gene Name

SCN1A	DrugBank Gene Name
P35498	UniProt Accession
6323	Entrez Gene Id

SCN1	GENE_SYMBOL
SCN1A	GENE_SYMBOL
Sodium channel protein type 1 subunit alpha	UNIPROT

blocker (inhibitory)
inhibitor (inhibitory)

blocker (inhibitory)
inhibitor (inhibitory)

blocker (inhibitory)
inhibitor (inhibitory)

blocker (inhibitory)
inhibitor (inhibitory)

Sodium channel protein type 1 subunit alpha	Gene Name
P35498	UniProt ID

SCN1A Gene Record

SCN1A 6323 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info:

PMIDs: 22053156 2157353

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 28398972

Sources: DrugBank

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info:

PMIDs: 22053156

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 8799190 20976818

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23859570 21747585 28753467 25155934

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19766671 19960691 14651650 19171193 20881019

Sources: DrugBank

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name - Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs: 3959032 11752352 17139284 17016423

Sources: TEND TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23859570 21747585 28753467 25155934

Sources: PharmGKB

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info:

PMIDs: 22053156

Sources: DrugBank

Interaction Types & Directionality: modulator

Interaction Info:

PMIDs: 22465659 8841090

Sources: DrugBank

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: 23859570 21747585 22591328 10845729 28842369 28753467 12737829 25155934 26555147

Sources: PharmGKB DrugBank ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19914041

Sources: DrugBank

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Novel drug target Established target Trial Name tetrodotoxin,Tectin, Tetrodin Specific Action of the Ligand Pore blocker

PMIDs: 17663442

Sources: TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: 23859570 21747585 22591328 19289736 20643904 22292851 28753467 22188362 12391287 26314341 15208697 25155934 26555147 20526191 21561445

Sources: PharmGKB DrugBank ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 16640453 26459200 26979079

Sources: DrugBank

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name zonisamide,Zonegran, Trerief Trial Name OREX-003, olanzapine plus zonisamide SR Novel drug target Established target

PMIDs: 19557119 20001433 19948168 15511691 11752352 20025128 14704463 18433351

Sources: TEND TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs: 23888118 22053156

Sources: DrugBank ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 23872380

Sources: DrugBank

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Pore blocker

Interaction Types & Directionality:

blocker (inhibitory)

PMIDs:
22053156 2157353

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
28398972

Sources:
DrugBank

Interaction Types & Directionality:

blocker (inhibitory)

PMIDs:
22053156

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
8799190 20976818

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
23859570 21747585 28753467 25155934

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19766671 19960691 14651650 19171193 20881019

Sources:
DrugBank

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
3959032 11752352 17139284 17016423

Sources:
TEND TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
23859570 21747585 28753467 25155934

Sources:
PharmGKB

Interaction Types & Directionality:

blocker (inhibitory)

PMIDs:
22053156

Sources:
DrugBank

Interaction Types & Directionality:

modulator

PMIDs:
22465659 8841090

Sources:
DrugBank

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
23859570 21747585 22591328 10845729 28842369 28753467 12737829 25155934 26555147

Sources:
PharmGKB DrugBank ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19914041

Sources:
DrugBank

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name tetrodotoxin,Tectin, Tetrodin

Specific Action of the Ligand Pore blocker

PMIDs:
17663442

Sources:
TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
23859570 21747585 22591328 19289736 20643904 22292851 28753467 22188362 12391287 26314341 15208697 25155934 26555147 20526191 21561445

Sources:
PharmGKB DrugBank ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
16640453 26459200 26979079

Sources:
DrugBank

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name zonisamide,Zonegran, Trerief

Trial Name OREX-003, olanzapine plus zonisamide SR

Novel drug target Established target

PMIDs:
19557119 20001433 19948168 15511691 11752352 20025128 14704463 18433351

Sources:
TEND TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
23888118 22053156

Sources:
DrugBank ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
23872380

Sources:
DrugBank

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Pore blocker

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Activation

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
23859570 21747585 28753467 25155934

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
22393325

Sources:
DrugBank

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Trial Name topiramate controlled release,Trokesa

PMIDs:
15508261 15526956 11948006 17621480 12861512

Sources:
TEND TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes