DGIdb - SCN1A Gene Record

SCN1A 6323 Druggable Genome

Alternate Names:

6323
SODIUM VOLTAGE-GATED CHANNEL ALPHA SUBUNIT 1
SCN1A
EIEE6
FEB3
FEB3A
FHM3
GEFSP2
HBSCI
NAC1
Nav1.1
SCN1
SMEI
182389
10585
ENSG00000144285
OTTHUMG00000044173
SCN1A_HUMAN
P35498
578
Na<sub>v</sub>1.1
Sodium channel protein brain I subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.1
Sodium channel protein type I subunit alpha
Sodium channel protein type 1 subunit alpha
TTDS00404
SODIUM CHANNEL PROTEIN, BRAIN I SUBUNIT ALPHA
PA301
sodium channel, voltage-gated, type I, alpha subunit
BE0004901
NP_008851\|NP_001159435\|NP_001159436
NM_006920\|NM_001165963\|NM_001165964\|NM_001202435
SODIUM CHANNEL PROTEIN TYPE I ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.1) (SODIUM CHANNEL PROTEIN, BRAIN I ALPHA SUBUNIT). [SOURCE:UNIPROT/SWISSPROT;ACC:P35498]
BE0000141
BE0009738

Gene Info:

Initial Gene Query	Nav1.1
Counted Citations from 1950-2000	398
Has Variant Annotation	true
Is VIP	false
Target Class	Transporters
Target Subclass	TC:1.A.1.10.7
Interpro Short Name	Ion_trans_dom
Interpro Acc	IPR005821
Human Readable Name	ION CHANNEL
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Interpro Type	Domain
Interpro Name	Ion transport domain
Target Subclass	Voltage_gated_ion_channels
Target Main Class	Transporters
Target Subclass	Channels
Transmembrane Helix Count	24
Target Subclass	SodiumChannels
GuideToPharmacology Gene Category Name	Voltage-gated sodium channels
GuideToPharmacology Gene Category ID	82
GuideToPharmacology Gene Type	vgic
Gene Biotype	PROTEIN_CODING

(11 More Sources)

Gene Categories: Category Details

TRANSPORTER
ION CHANNEL
DRUGGABLE GENOME

Publications:

Bertok S et al., 2017, The association of SCN1A p.Thr1067Ala polymorphism with epilepsy risk and the response to antiepileptic drugs in Slovenian children and adolescents with epilepsy., Seizure
Ma CL et al., 2014, Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy., Pharmacogenomics
Haerian BS et al., 2013, SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis., Pharmacogenomics
Kumari R et al., 2011, Pharmacogenomic association study on the role of drug metabolizing, drug transporters and drug target gene polymorphisms in drug-resistant epilepsy in a north Indian population., Indian J Hum Genet
Ceulemans et al., 2004, "Severe myoclonic epilepsy in infancy". Relevance for the clinician of severe epilepsy starting in infancy., Acta Neurol Belg
Nieto Barrera et al., [Severe myoclonic epilepsy in infancy (Dravet's syndrome). Its nosological characteristics and therapeutic aspects]., Rev Neurol
Coppola et al., 2002, Topiramate as add-on drug in severe myoclonic epilepsy in infancy: an Italian multicenter open trial., Epilepsy Res.
Ceulemans et al., 2004, Severe myoclonic epilepsy in infancy: toward an optimal treatment., J. Child Neurol.
Korff et al., 2007, Dravet syndrome (severe myoclonic epilepsy in infancy): a retrospective study of 16 patients., J. Child Neurol.
Sonsalla et al., 2010, The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance., Exp. Neurol.
Leppik, 2004, Zonisamide: chemistry, mechanism of action, and pharmacokinetics., Seizure
Sobieszek et al., Zonisamide: a new antiepileptic drug., Pol J Pharmacol
Kothare et al., 2008, Zonisamide: review of pharmacology, clinical efficacy, tolerability, and safety., Expert Opin Drug Metab Toxicol
Schulze-Bonhage, 2010, Zonisamide in the treatment of epilepsy., Expert Opin Pharmacother
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Janszky, 2009, [Role of zonisamid in treating epilepsy, Parkinson disorders and other neurological diseases]., Ideggyogy Sz
Zaccara et al., 2009, Long-term safety and effectiveness of zonisamide in the treatment of epilepsy: a review of the literature., Neuropsychiatr Dis Treat
Tate et al., 2006, A common polymorphism in the SCN1A gene associates with phenytoin serum levels at maintenance dose., Pharmacogenet. Genomics
Mantegazza et al., 2010, Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders., Lancet Neurol
Tate et al., 2005, Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin., Proc. Natl. Acad. Sci. U.S.A.
Ragsdale et al., 1996, Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels., Proc. Natl. Acad. Sci. U.S.A.
Aizawa et al., 2010, Effects of phenazopyridine on rat bladder primary afferent activity, and comparison with lidocaine and acetaminophen., Neurourol. Urodyn.
Sage et al., 2007, Na(v)1.7 and Na(v)1.3 are the only tetrodotoxin-sensitive sodium channels expressed by the adult guinea pig enteric nervous system., J. Comp. Neurol.
Wong et al., 1986, Conformational analysis of clinically active anticonvulsant drugs., J. Med. Chem.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
McLean et al., 1988, Benzodiazepines, but not beta carbolines, limit high frequency repetitive firing of action potentials of spinal cord neurons in cell culture., J. Pharmacol. Exp. Ther.
Cao et al., 2011, Mechanisms of pyrethroid insecticide-induced stimulation of calcium influx in neocortical neurons., J. Pharmacol. Exp. Ther.
Breckenridge et al., 2009, Evidence for a separate mechanism of toxicity for the Type I and the Type II pyrethroid insecticides., Neurotoxicology
Liu et al., 2009, Permethrin resistance and target site insensitivity in the mosquito Culex quinquefasciatus in Alabama., J. Med. Entomol.
Chang et al., 2009, A novel amino acid substitution in a voltage-gated sodium channel is associated with knockdown resistance to permethrin in Aedes aegypti., Insect Biochem. Mol. Biol.
McMahon et al., 2003, In vitro assays for repellents and deterrents for ticks: differing effects of products when tested with attractant or arrestment stimuli., Med. Vet. Entomol.
Gammaitoni AR et al., 2013, Heated lidocaine/tetracaine patch for treatment of patellar tendinopathy pain., J Pain Res
Fozzard HA et al., 2011, The sodium channel as a target for local anesthetic drugs., Front Pharmacol
Daci A et al., 2015, Polymorphic Variants of SCN1A and EPHX1 Influence Plasma Carbamazepine Concentration, Metabolism and Pharmacoresistance in a Population of Kosovar Albanian Epileptic Patients., PLoS One
Zhou BT et al., 2012, Effects of SCN1A and GABA receptor genetic polymorphisms on carbamazepine tolerability and efficacy in Chinese patients with partial seizures: 2-year longitudinal clinical follow-up., CNS Neurosci Ther
Schmidt D et al., 2000, Oxcarbazepine for Treatment of Partial Epilepsy: A Review and Recommendations for Clinical Use., Epilepsy Behav
Thomas AM et al., 2018, Old Friends With New Faces: Are Sodium Channel Blockers the Future of Adjunct Pain Medication Management?, J Pain
Shorvon S, 2000, Oxcarbazepine: a review., Seizure
Ma CL et al., 2015, Association between PK/PD-involved gene polymorphisms and carbamazepine-individualized therapy., Pharmacogenomics
Zhou BT et al., 2012, Comprehensive analysis of the association of SCN1A gene polymorphisms with the retention rate of carbamazepine following monotherapy for new-onset focal seizures in the Chinese Han population., Clin Exp Pharmacol Physiol
Hung CC et al., 2012, Association of polymorphisms in EPHX1, UGT2B7, ABCB1, ABCC2, SCN1A and SCN2A genes with carbamazepine therapy optimization., Pharmacogenomics
Manna I et al., 2011, A functional polymorphism in the SCN1A gene does not influence antiepileptic drug responsiveness in Italian patients with focal epilepsy., Epilepsia
Schlachter K et al., 2009, A splice site variant in the sodium channel gene SCN1A confers risk of febrile seizures., Neurology
Yang et al., 2002, Inhibition of Na(+) current by imipramine and related compounds: different binding kinetics as an inactivation stabilizer and as an open channel blocker., Mol. Pharmacol.
Yang et al., 2010, Lidocaine, carbamazepine, and imipramine have partially overlapping binding sites and additive inhibitory effect on neuronal Na+ channels., Anesthesiology
Rogawski et al., 2004, The neurobiology of antiepileptic drugs., Nat. Rev. Neurosci.
Lipkind et al., 2010, Molecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore., Mol. Pharmacol.
Lipkind et al., 2005, Molecular modeling of local anesthetic drug binding by voltage-gated sodium channels., Mol. Pharmacol.
Lalevée et al., 2003, Effects of amiodarone and dronedarone on voltage-dependent sodium current in human cardiomyocytes., J. Cardiovasc. Electrophysiol.
Zona C et al., 2010, Brivaracetam (ucb 34714) inhibits Na(+) current in rat cortical neurons in culture., Epilepsy Res
Wright et al., 1999, State-dependent cocaine block of sodium channel isoforms, chimeras, and channels coexpressed with the beta1 subunit., Biophys. J.
Crumb WJ Jr et al., 1990, Characterization of cocaine-induced block of cardiac sodium channels., Biophys J
Tanaka H et al., 1992, Blockade of Na+ current by promethazine in guinea-pig ventricular myocytes., Br J Pharmacol
Cantisani C et al., 2013, Topical promethazine side effects: our experience and review of the literature., Biomed Res Int
Butterworth JF 4th et al., 1990, Molecular mechanisms of local anesthesia: a review., Anesthesiology
Visioli F et al., 2012, Molecular targets of omega 3 and conjugated linoleic Fatty acids - "micromanaging" cellular response., Front Physiol
Narahashi, 1996, Neuronal ion channels as the target sites of insecticides., Pharmacol. Toxicol.
McCavera SJ et al., 2012, Differential state-dependent modification of inactivation-deficient Nav1.6 sodium channels by the pyrethroid insecticides S-bioallethrin, tefluthrin and deltamethrin., Neurotoxicology
Rayner-Hartley E et al., 2016, Ranolazine: A Contemporary Review., J Am Heart Assoc
Jerling M, 2006, Clinical pharmacokinetics of ranolazine., Clin Pharmacokinet
Saad M et al., 2016, Ranolazine in Cardiac Arrhythmia., Clin Cardiol
Leung YM et al., 2013, The use of carbetapentane for spinal anesthesia and use-dependent block of sodium currents., Eur J Pharmacol

TETRODOTOXIN SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name tetrodotoxin,Tectin, Tetrodin

Specific Action of the Ligand Pore blocker

Publications:

Sage et al., 2007, Na(v)1.7 and Na(v)1.3 are the only tetrodotoxin-sensitive sodium channels expressed by the adult guinea pig enteric nervous system., J. Comp. Neurol.
RUFINAMIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
PRILOCAINE HYDROCHLORIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
MEPHENYTOIN SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
NKTR-171 SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
VERATRIDINE SCN1A

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Activation

Publications:
ORPHENADRINE CITRATE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:
PHENYTOIN SODIUM SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:
CHLOROPROCAINE HYDROCHLORIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
ROPIVACAINE HYDROCHLORIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:
SAXITOXIN SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Pore blocker

Publications:
DRONEDARONE HYDROCHLORIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
ARTICAINE HYDROCHLORIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
ESLICARBAZEPINE ACETATE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:
MORICIZINE HYDROCHLORIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:
LIDOCAINE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:
ORPHENADRINE HYDROCHLORIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
QUINIDINE GLUCONATE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
BENOXINATE HYDROCHLORIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
MEPIVACAINE HYDROCHLORIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
MEXILETINE HYDROCHLORIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
ERLOSAMIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
PROPAFENONE HYDROCHLORIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
PHENAZOPYRIDINE HYDROCHLORIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
PRIMIDONE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
DYCLONINE HYDROCHLORIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
HEXYLCAINE HYDROCHLORIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
TOCAINIDE HYDROCHLORIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
MERETHOXYLLINE PROCAINE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
INDECAINIDE HYDROCHLORIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
DISOPYRAMIDE PHOSPHATE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
ETHOTOIN SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
ESLICARBAZEPINE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
PROCAINE HYDROCHLORIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
RALFINAMIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
PROPARACAINE HYDROCHLORIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
NERISPIRDINE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:
LIDOCAINE HYDROCHLORIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
IRAMPANEL SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
ETIDOCAINE HYDROCHLORIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
FOSPHENYTOIN SODIUM SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
RILUZOLE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
EVENAMIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
TETRACAINE HYDROCHLORIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
PRILOCAINE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
QUINIDINE POLYGALACTURONATE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
QUINIDINE SULFATE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
PROCAINAMIDE HYDROCHLORIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:
PROPOXYCAINE HYDROCHLORIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:

TOPIRAMATE SCN1A

Interaction Types & Directionality:

inhibitor (inhibitory)

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Trial Name topiramate controlled release,Trokesa

Publications:

Ceulemans et al., 2004, "Severe myoclonic epilepsy in infancy". Relevance for the clinician of severe epilepsy starting in infancy., Acta Neurol Belg

Nieto Barrera et al., [Severe myoclonic epilepsy in infancy (Dravet's syndrome). Its nosological characteristics and therapeutic aspects]., Rev Neurol

Coppola et al., 2002, Topiramate as add-on drug in severe myoclonic epilepsy in infancy: an Italian multicenter open trial., Epilepsy Res.

ZONISAMIDE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name zonisamide,Zonegran, Trerief

Trial Name OREX-003, olanzapine plus zonisamide SR

Novel drug target Established target

Publications:

Sonsalla et al., 2010, The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance., Exp. Neurol.

Leppik, 2004, Zonisamide: chemistry, mechanism of action, and pharmacokinetics., Seizure

Sobieszek et al., Zonisamide: a new antiepileptic drug., Pol J Pharmacol

PHENYTOIN SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:

Tate et al., 2006, A common polymorphism in the SCN1A gene associates with phenytoin serum levels at maintenance dose., Pharmacogenet. Genomics

Mantegazza et al., 2010, Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders., Lancet Neurol

Tate et al., 2005, Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin., Proc. Natl. Acad. Sci. U.S.A.

PHENAZOPYRIDINE SCN1A

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Ragsdale et al., 1996, Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels., Proc. Natl. Acad. Sci. U.S.A.

Aizawa et al., 2010, Effects of phenazopyridine on rat bladder primary afferent activity, and comparison with lidocaine and acetaminophen., Neurourol. Urodyn.

PHENACEMIDE SCN1A

Interaction Types & Directionality:

inhibitor (inhibitory)

blocker (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:

Wong et al., 1986, Conformational analysis of clinically active anticonvulsant drugs., J. Med. Chem.

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

PERMETHRIN SCN1A

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Cao et al., 2011, Mechanisms of pyrethroid insecticide-induced stimulation of calcium influx in neocortical neurons., J. Pharmacol. Exp. Ther.

Breckenridge et al., 2009, Evidence for a separate mechanism of toxicity for the Type I and the Type II pyrethroid insecticides., Neurotoxicology

Liu et al., 2009, Permethrin resistance and target site insensitivity in the mosquito Culex quinquefasciatus in Alabama., J. Med. Entomol.

TETRACAINE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:

Gammaitoni AR et al., 2013, Heated lidocaine/tetracaine patch for treatment of patellar tendinopathy pain., J Pain Res

Fozzard HA et al., 2011, The sodium channel as a target for local anesthetic drugs., Front Pharmacol

OXCARBAZEPINE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:

Bertok S et al., 2017, The association of SCN1A p.Thr1067Ala polymorphism with epilepsy risk and the response to antiepileptic drugs in Slovenian children and adolescents with epilepsy., Seizure

Daci A et al., 2015, Polymorphic Variants of SCN1A and EPHX1 Influence Plasma Carbamazepine Concentration, Metabolism and Pharmacoresistance in a Population of Kosovar Albanian Epileptic Patients., PLoS One

Ma CL et al., 2014, Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy., Pharmacogenomics

CARBAMAZEPINE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:

Bertok S et al., 2017, The association of SCN1A p.Thr1067Ala polymorphism with epilepsy risk and the response to antiepileptic drugs in Slovenian children and adolescents with epilepsy., Seizure

Daci A et al., 2015, Polymorphic Variants of SCN1A and EPHX1 Influence Plasma Carbamazepine Concentration, Metabolism and Pharmacoresistance in a Population of Kosovar Albanian Epileptic Patients., PLoS One

Ma CL et al., 2015, Association between PK/PD-involved gene polymorphisms and carbamazepine-individualized therapy., Pharmacogenomics

LAMOTRIGINE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Publications:

Bertok S et al., 2017, The association of SCN1A p.Thr1067Ala polymorphism with epilepsy risk and the response to antiepileptic drugs in Slovenian children and adolescents with epilepsy., Seizure

Ma CL et al., 2014, Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy., Pharmacogenomics

Haerian BS et al., 2013, SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis., Pharmacogenomics

DRONEDARONE SCN1A

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Lalevée et al., 2003, Effects of amiodarone and dronedarone on voltage-dependent sodium current in human cardiomyocytes., J. Cardiovasc. Electrophysiol.
BRIVARACETAM SCN1A

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Zona C et al., 2010, Brivaracetam (ucb 34714) inhibits Na(+) current in rat cortical neurons in culture., Epilepsy Res

COCAINE SCN1A

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Wright et al., 1999, State-dependent cocaine block of sodium channel isoforms, chimeras, and channels coexpressed with the beta1 subunit., Biophys. J.

Crumb WJ Jr et al., 1990, Characterization of cocaine-induced block of cardiac sodium channels., Biophys J

PROMETHAZINE SCN1A

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Tanaka H et al., 1992, Blockade of Na+ current by promethazine in guinea-pig ventricular myocytes., Br J Pharmacol

Cantisani C et al., 2013, Topical promethazine side effects: our experience and review of the literature., Biomed Res Int

PROPOXYCAINE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Publications:

Fozzard HA et al., 2011, The sodium channel as a target for local anesthetic drugs., Front Pharmacol

AMYLOCAINE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Publications:

Butterworth JF 4th et al., 1990, Molecular mechanisms of local anesthesia: a review., Anesthesiology

Fozzard HA et al., 2011, The sodium channel as a target for local anesthetic drugs., Front Pharmacol

FISH OIL TRIGLYCERIDES SCN1A

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Visioli F et al., 2012, Molecular targets of omega 3 and conjugated linoleic Fatty acids - "micromanaging" cellular response., Front Physiol

BIOALLETHRIN SCN1A

Interaction Types & Directionality:

modulator

Interaction Info:

Publications:

Narahashi, 1996, Neuronal ion channels as the target sites of insecticides., Pharmacol. Toxicol.

McCavera SJ et al., 2012, Differential state-dependent modification of inactivation-deficient Nav1.6 sodium channels by the pyrethroid insecticides S-bioallethrin, tefluthrin and deltamethrin., Neurotoxicology

RANOLAZINE SCN1A

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Rayner-Hartley E et al., 2016, Ranolazine: A Contemporary Review., J Am Heart Assoc

Jerling M, 2006, Clinical pharmacokinetics of ranolazine., Clin Pharmacokinet

Saad M et al., 2016, Ranolazine in Cardiac Arrhythmia., Clin Cardiol

PRAMOXINE SCN1A

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Publications:

Fozzard HA et al., 2011, The sodium channel as a target for local anesthetic drugs., Front Pharmacol
CARBETAPENTANE SCN1A

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Leung YM et al., 2013, The use of carbetapentane for spinal anesthesia and use-dependent block of sodium currents., Eur J Pharmacol
NITRAZEPAM SCN1A

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

Publications:

McLean et al., 1988, Benzodiazepines, but not beta carbolines, limit high frequency repetitive firing of action potentials of spinal cord neurons in cell culture., J. Pharmacol. Exp. Ther.
SAFINAMIDE SCN1A

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

Publications:

LEVETIRACETAM SCN1A

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Bertok S et al., 2017, The association of SCN1A p.Thr1067Ala polymorphism with epilepsy risk and the response to antiepileptic drugs in Slovenian children and adolescents with epilepsy., Seizure

Ma CL et al., 2014, Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy., Pharmacogenomics

Haerian BS et al., 2013, SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis., Pharmacogenomics

CLOBAZAM SCN1A

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Bertok S et al., 2017, The association of SCN1A p.Thr1067Ala polymorphism with epilepsy risk and the response to antiepileptic drugs in Slovenian children and adolescents with epilepsy., Seizure

Ma CL et al., 2014, Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy., Pharmacogenomics

Haerian BS et al., 2013, SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis., Pharmacogenomics

ETHOSUXIMIDE SCN1A

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Bertok S et al., 2017, The association of SCN1A p.Thr1067Ala polymorphism with epilepsy risk and the response to antiepileptic drugs in Slovenian children and adolescents with epilepsy., Seizure

Ma CL et al., 2014, Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy., Pharmacogenomics

Haerian BS et al., 2013, SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis., Pharmacogenomics

Ensembl: ENSG00000144285
- Version: 101_38
Alternate Names:

SCN1A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
GuideToPharmacologyGenes: 578
- Version: 4-March-2015
Alternate Names:

sodium channel, voltage-gated, type I, alpha subunit HUGO Gene Name

10585 HUGO Gene ID

SCN1A Gene Symbol

Gene Info:

GuideToPharmacology Gene Category Name Voltage-gated sodium channels

GuideToPharmacology Gene Category ID 82

GuideToPharmacology Gene Type vgic

Gene Categories:

TRANSPORTER, ION CHANNEL

Publications:
TdgClinicalTrial: P35498
- Version: January-2014
Alternate Names:

SCN1A Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:1.A.1.10.7

Publications:
TEND: P35498
- Version: 01-August-2011
Alternate Names:

SCN1A Gene Symbol

SCN1A_HUMAN Uniprot Id

ENSG00000144285 Ensembl Gene Id

Gene Info:

Target Subclass Voltage_gated_ion_channels

Target Main Class Transporters

Target Subclass Channels

Publications:

RussLampel: ENSG00000144285

Version: 26-July-2011

Alternate Names:

SODIUM CHANNEL PROTEIN TYPE I ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.1) (SODIUM CHANNEL PROTEIN, BRAIN I ALPHA SUBUNIT). [SOURCE:UNIPROT/SWISSPROT;ACC:P35498] Description

ENSG00000144285 Ensembl Gene Id

SCN1A Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

BaderLabGenes: SCN1A
- Version: February-2014
Alternate Names:

6323 Entrez Gene ID

Gene Info:

Initial Gene Query Nav1.1

Counted Citations from 1950-2000 398

Gene Categories:

ION CHANNEL

Publications:
HopkinsGroom: P35498
- Version: 11-September-2012
Alternate Names:

SCN1A Uniprot Gene Name

SCN1A_HUMAN Uniprot Id

ENSG00000144285 Ensembl Gene Id

Gene Info:

Interpro Short Name Ion_trans_dom

Interpro Acc IPR005821

Human Readable Name ION CHANNEL

Gene Categories:

ION CHANNEL, DRUGGABLE GENOME

Publications:

PharmGKB: SCN1A

Version: 18-August-2020

Alternate Names:

PA301 PharmGKB ID

Gene Info:

Publications:

Kumari R et al., 2011, Pharmacogenomic association study on the role of drug metabolizing, drug transporters and drug target gene polymorphisms in drug-resistant epilepsy in a north Indian population., Indian J Hum Genet

Haerian BS et al., 2013, SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis., Pharmacogenomics

Ma CL et al., 2014, Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy., Pharmacogenomics

DrugBank: BE0004901

Version: 5.1.7

Alternate Names:

SCN1A DrugBank Gene Name

P35498 UniProt Accession

6323 Entrez Gene Id

Gene Info:

Publications:

Saad M et al., 2016, Ranolazine in Cardiac Arrhythmia., Clin Cardiol

Jerling M, 2006, Clinical pharmacokinetics of ranolazine., Clin Pharmacokinet

Rayner-Hartley E et al., 2016, Ranolazine: A Contemporary Review., J Am Heart Assoc

DrugBank: BE0009738

Version: 5.1.7

Alternate Names:

SCN1A DrugBank Gene Name

P35498 UniProt Accession

6323 Entrez Gene Id

Gene Info:

Publications:

Coppola et al., 2002, Topiramate as add-on drug in severe myoclonic epilepsy in infancy: an Italian multicenter open trial., Epilepsy Res.

Nieto Barrera et al., [Severe myoclonic epilepsy in infancy (Dravet's syndrome). Its nosological characteristics and therapeutic aspects]., Rev Neurol

Ceulemans et al., 2004, Severe myoclonic epilepsy in infancy: toward an optimal treatment., J. Child Neurol.

DrugBank: BE0000141

Version: 5.1.7

Alternate Names:

SCN1A DrugBank Gene Name

P35498 UniProt Accession

6323 Entrez Gene Id

Gene Info:

Publications:

Leppik, 2004, Zonisamide: chemistry, mechanism of action, and pharmacokinetics., Seizure

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Kothare et al., 2008, Zonisamide: review of pharmacology, clinical efficacy, tolerability, and safety., Expert Opin Drug Metab Toxicol

HingoraniCasas: ENSG00000144285
- Version: 31-May-2017
Alternate Names:

ENSG00000144285 Gene Symbol

SCN1A Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: NAC1
- Version: chembl_23
Alternate Names:

SCN1 GENE_SYMBOL

SCN1A GENE_SYMBOL

Sodium channel protein type 1 subunit alpha UNIPROT

Gene Info:

Publications:
GuideToPharmacologyInteractions: ENSG00000144285
- Version: 20-July-2020
Alternate Names:

Na<sub>v</sub>1.1 GuideToPharmacology Name

P35498 UniProtKB ID

Gene Info:

Publications:
Pharos: SCN1A
- Version: 03-September-2020
Alternate Names:

Sodium channel protein type 1 subunit alpha Gene Name

P35498 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:

Novel drug target	Established target
Trial Name	tetrodotoxin,Tectin, Tetrodin
Specific Action of the Ligand	Pore blocker

Mechanism of Interaction	Sodium channel alpha subunit blocker
Direct Interaction	yes

Direct Interaction?	False
Endogenous Drug?	False
Specific Action of the Ligand	Activation

Trial Name	zonisamide,Zonegran, Trerief
Trial Name	OREX-003, olanzapine plus zonisamide SR
Novel drug target	Established target

sodium channel, voltage-gated, type I, alpha subunit	HUGO Gene Name
10585	HUGO Gene ID
SCN1A	Gene Symbol

SODIUM CHANNEL PROTEIN TYPE I ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.1) (SODIUM CHANNEL PROTEIN, BRAIN I ALPHA SUBUNIT). [SOURCE:UNIPROT/SWISSPROT;ACC:P35498]	Description
ENSG00000144285	Ensembl Gene Id
SCN1A	Display Id

SCN1A	Uniprot Gene Name
SCN1A_HUMAN	Uniprot Id
ENSG00000144285	Ensembl Gene Id

SCN1A	DrugBank Gene Name
P35498	UniProt Accession
6323	Entrez Gene Id

SCN1	GENE_SYMBOL
SCN1A	GENE_SYMBOL
Sodium channel protein type 1 subunit alpha	UNIPROT

Sodium channel protein type 1 subunit alpha	Gene Name
P35498	UniProt ID

SCN1A Gene Record

SCN1A 6323 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Novel drug target Established target Trial Name tetrodotoxin,Tectin, Tetrodin Specific Action of the Ligand Pore blocker

Publications: Sage et al., 2007, Na(v)1.7 and Na(v)1.3 are the only tetrodotoxin-sensitive sodium channels expressed by the adult guinea pig enteric nervous system., J. Comp. Neurol.

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Publications:

Interaction Types & Directionality: activator (activating)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Activation

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Pore blocker

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Publications:

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name tetrodotoxin,Tectin, Tetrodin

Specific Action of the Ligand Pore blocker

Publications:

Sage et al., 2007, Na(v)1.7 and Na(v)1.3 are the only tetrodotoxin-sensitive sodium channels expressed by the adult guinea pig enteric nervous system., J. Comp. Neurol.

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Activation

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Pore blocker

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes