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SCN1A Gene Record

  • Summary
  • Interactions
  • Claims
  • SCN1A 6323 Druggable Genome

    Alternate Names:

    6323
    SODIUM VOLTAGE-GATED CHANNEL ALPHA SUBUNIT 1
    SCN1A
    EIEE6
    FEB3
    FEB3A
    FHM3
    GEFSP2
    HBSCI
    NAC1
    Nav1.1
    SCN1
    SMEI
    182389
    10585
    ENSG00000144285
    OTTHUMG00000044173
    SCN1A_HUMAN
    P35498
    578
    Na<sub>v</sub>1.1
    Sodium channel protein brain I subunit alpha
    Voltage-gated sodium channel subunit alpha Nav1.1
    Sodium channel protein type I subunit alpha
    Sodium channel protein type 1 subunit alpha
    PA301
    BE0004901
    NP_008851|NP_001159435|NP_001159436
    NM_006920|NM_001165963|NM_001165964|NM_001202435
    SODIUM CHANNEL PROTEIN TYPE I ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.1) (SODIUM CHANNEL PROTEIN, BRAIN I ALPHA SUBUNIT). [SOURCE:UNIPROT/SWISSPROT;ACC:P35498]
    BE0000141
    BE0009738

    Gene Info:

    Initial Gene Query Nav1.1
    Counted Citations from 1950-2000 398
    Target Class Transporters
    Target Subclass TC:1.A.1.10.7
    Interpro Short Name Ion_trans_dom
    Interpro Acc IPR005821
    Human Readable Name ION CHANNEL
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Type Domain
    Interpro Name Ion transport domain
    Target Subclass Voltage_gated_ion_channels
    Target Main Class Transporters
    Target Subclass Channels
    Transmembrane Helix Count 24
    Target Subclass SodiumChannels
    GuideToPharmacology Gene Category Name Voltage-gated sodium channels
    GuideToPharmacology Gene Category ID 82
    Gene Biotype PROTEIN_CODING
    (10 More Sources)

    Gene Categories: Category Details

    ION CHANNEL
    DRUGGABLE GENOME

    Publications:

    Haerian BS et al., 2013, SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis., Pharmacogenomics
    Kumari R et al., 2011, Pharmacogenomic association study on the role of drug metabolizing, drug transporters and drug target gene polymorphisms in drug-resistant epilepsy in a north Indian population., Indian J Hum Genet
    Bertok S et al., 2017, The association of SCN1A p.Thr1067Ala polymorphism with epilepsy risk and the response to antiepileptic drugs in Slovenian children and adolescents with epilepsy., Seizure
    Ma CL et al., 2014, Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy., Pharmacogenomics
    Ceulemans et al., 2004, "Severe myoclonic epilepsy in infancy". Relevance for the clinician of severe epilepsy starting in infancy., Acta Neurol Belg
    Ceulemans et al., 2004, Severe myoclonic epilepsy in infancy: toward an optimal treatment., J. Child Neurol.
    Coppola et al., 2002, Topiramate as add-on drug in severe myoclonic epilepsy in infancy: an Italian multicenter open trial., Epilepsy Res.
    Korff et al., 2007, Dravet syndrome (severe myoclonic epilepsy in infancy): a retrospective study of 16 patients., J. Child Neurol.
    Nieto Barrera et al., [Severe myoclonic epilepsy in infancy (Dravet's syndrome). Its nosological characteristics and therapeutic aspects]., Rev Neurol
    Zaccara et al., 2009, Long-term safety and effectiveness of zonisamide in the treatment of epilepsy: a review of the literature., Neuropsychiatr Dis Treat
    Schulze-Bonhage, 2010, Zonisamide in the treatment of epilepsy., Expert Opin Pharmacother
    Sonsalla et al., 2010, The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance., Exp. Neurol.
    Leppik, 2004, Zonisamide: chemistry, mechanism of action, and pharmacokinetics., Seizure
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Janszky, 2009, [Role of zonisamid in treating epilepsy, Parkinson disorders and other neurological diseases]., Ideggyogy Sz
    Sobieszek et al., Zonisamide: a new antiepileptic drug., Pol J Pharmacol
    Kothare et al., 2008, Zonisamide: review of pharmacology, clinical efficacy, tolerability, and safety., Expert Opin Drug Metab Toxicol
    Tate et al., 2006, A common polymorphism in the SCN1A gene associates with phenytoin serum levels at maintenance dose., Pharmacogenet. Genomics
    Tate et al., 2005, Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin., Proc. Natl. Acad. Sci. U.S.A.
    Mantegazza et al., 2010, Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders., Lancet Neurol
    Ragsdale et al., 1996, Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels., Proc. Natl. Acad. Sci. U.S.A.
    Aizawa et al., 2010, Effects of phenazopyridine on rat bladder primary afferent activity, and comparison with lidocaine and acetaminophen., Neurourol. Urodyn.
    Sage et al., 2007, Na(v)1.7 and Na(v)1.3 are the only tetrodotoxin-sensitive sodium channels expressed by the adult guinea pig enteric nervous system., J. Comp. Neurol.
    Wong et al., 1986, Conformational analysis of clinically active anticonvulsant drugs., J. Med. Chem.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    McLean et al., 1988, Benzodiazepines, but not beta carbolines, limit high frequency repetitive firing of action potentials of spinal cord neurons in cell culture., J. Pharmacol. Exp. Ther.
    Breckenridge et al., 2009, Evidence for a separate mechanism of toxicity for the Type I and the Type II pyrethroid insecticides., Neurotoxicology
    Liu et al., 2009, Permethrin resistance and target site insensitivity in the mosquito Culex quinquefasciatus in Alabama., J. Med. Entomol.
    McMahon et al., 2003, In vitro assays for repellents and deterrents for ticks: differing effects of products when tested with attractant or arrestment stimuli., Med. Vet. Entomol.
    Chang et al., 2009, A novel amino acid substitution in a voltage-gated sodium channel is associated with knockdown resistance to permethrin in Aedes aegypti., Insect Biochem. Mol. Biol.
    Cao et al., 2011, Mechanisms of pyrethroid insecticide-induced stimulation of calcium influx in neocortical neurons., J. Pharmacol. Exp. Ther.
    Gammaitoni AR et al., 2013, Heated lidocaine/tetracaine patch for treatment of patellar tendinopathy pain., J Pain Res
    Fozzard HA et al., 2011, The sodium channel as a target for local anesthetic drugs., Front Pharmacol
    Zhou BT et al., 2012, Effects of SCN1A and GABA receptor genetic polymorphisms on carbamazepine tolerability and efficacy in Chinese patients with partial seizures: 2-year longitudinal clinical follow-up., CNS Neurosci Ther
    Shorvon S, 2000, Oxcarbazepine: a review., Seizure
    Thomas AM et al., 2018, Old Friends With New Faces: Are Sodium Channel Blockers the Future of Adjunct Pain Medication Management?, J Pain
    Schmidt D et al., 2000, Oxcarbazepine for Treatment of Partial Epilepsy: A Review and Recommendations for Clinical Use., Epilepsy Behav
    Daci A et al., 2015, Polymorphic Variants of SCN1A and EPHX1 Influence Plasma Carbamazepine Concentration, Metabolism and Pharmacoresistance in a Population of Kosovar Albanian Epileptic Patients., PLoS One
    Schlachter K et al., 2009, A splice site variant in the sodium channel gene SCN1A confers risk of febrile seizures., Neurology
    Lipkind et al., 2010, Molecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore., Mol. Pharmacol.
    Zhou BT et al., 2012, Comprehensive analysis of the association of SCN1A gene polymorphisms with the retention rate of carbamazepine following monotherapy for new-onset focal seizures in the Chinese Han population., Clin Exp Pharmacol Physiol
    Hung CC et al., 2012, Association of polymorphisms in EPHX1, UGT2B7, ABCB1, ABCC2, SCN1A and SCN2A genes with carbamazepine therapy optimization., Pharmacogenomics
    Yang et al., 2002, Inhibition of Na(+) current by imipramine and related compounds: different binding kinetics as an inactivation stabilizer and as an open channel blocker., Mol. Pharmacol.
    Ma CL et al., 2015, Association between PK/PD-involved gene polymorphisms and carbamazepine-individualized therapy., Pharmacogenomics
    Rogawski et al., 2004, The neurobiology of antiepileptic drugs., Nat. Rev. Neurosci.
    Yang et al., 2010, Lidocaine, carbamazepine, and imipramine have partially overlapping binding sites and additive inhibitory effect on neuronal Na+ channels., Anesthesiology
    Manna I et al., 2011, A functional polymorphism in the SCN1A gene does not influence antiepileptic drug responsiveness in Italian patients with focal epilepsy., Epilepsia
    Lipkind et al., 2005, Molecular modeling of local anesthetic drug binding by voltage-gated sodium channels., Mol. Pharmacol.
    Jerling M, 2006, Clinical pharmacokinetics of ranolazine., Clin Pharmacokinet
    Saad M et al., 2016, Ranolazine in Cardiac Arrhythmia., Clin Cardiol
    Rayner-Hartley E et al., 2016, Ranolazine: A Contemporary Review., J Am Heart Assoc
    Crumb WJ Jr et al., 1990, Characterization of cocaine-induced block of cardiac sodium channels., Biophys J
    Wright et al., 1999, State-dependent cocaine block of sodium channel isoforms, chimeras, and channels coexpressed with the beta1 subunit., Biophys. J.
    Zona C et al., 2010, Brivaracetam (ucb 34714) inhibits Na(+) current in rat cortical neurons in culture., Epilepsy Res
    Visioli F et al., 2012, Molecular targets of omega 3 and conjugated linoleic Fatty acids - "micromanaging" cellular response., Front Physiol
    Leung YM et al., 2013, The use of carbetapentane for spinal anesthesia and use-dependent block of sodium currents., Eur J Pharmacol
    Butterworth JF 4th et al., 1990, Molecular mechanisms of local anesthesia: a review., Anesthesiology
    Cantisani C et al., 2013, Topical promethazine side effects: our experience and review of the literature., Biomed Res Int
    Tanaka H et al., 1992, Blockade of Na+ current by promethazine in guinea-pig ventricular myocytes., Br J Pharmacol
    McCavera SJ et al., 2012, Differential state-dependent modification of inactivation-deficient Nav1.6 sodium channels by the pyrethroid insecticides S-bioallethrin, tefluthrin and deltamethrin., Neurotoxicology
    Narahashi, 1996, Neuronal ion channels as the target sites of insecticides., Pharmacol. Toxicol.
    Tan TW et al., 2017, Effectiveness of amylmetacresol and 2,4-dichlorobenzyl alcohol throat lozenges in patients with acute sore throat due to upper respiratory tract infection: a systematic review protocol., JBI Database System Rev Implement Rep
  • AMYLOCAINE   SCN1A

    Interaction Score: 2.27

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:

    PMIDs:
    22053156 2157353


    Sources:
    DrugBank

  • DICHLOROBENZYL ALCOHOL   SCN1A

    Interaction Score: 1.51

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    28398972


    Sources:
    DrugBank

  • PRAMOXINE   SCN1A

    Interaction Score: 1.51

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:

    PMIDs:
    22053156


    Sources:
    DrugBank

  • PHENAZOPYRIDINE   SCN1A

    Interaction Score: 1.14

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    8799190 20976818


    Sources:
    DrugBank

  • ETHOSUXIMIDE   SCN1A

    Interaction Score: 0.76

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23859570 21747585 28753467 25155934


    Sources:
    PharmGKB

  • PERMETHRIN   SCN1A

    Interaction Score: 0.76

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19766671 19960691 14651650 19171193 20881019


    Sources:
    DrugBank

  • PHENACEMIDE   SCN1A

    Interaction Score: 0.61

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    3959032 11752352 17139284 17016423


    Sources:
    TEND TdgClinicalTrial DrugBank ChemblInteractions

  • LEVETIRACETAM   SCN1A

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23859570 21747585 28753467 25155934


    Sources:
    PharmGKB

  • PROPOXYCAINE   SCN1A

    Interaction Score: 0.5

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:

    PMIDs:
    22053156


    Sources:
    DrugBank

  • BIOALLETHRIN   SCN1A

    Interaction Score: 0.45

    Interaction Types & Directionality:
    modulator

    Interaction Info:

    PMIDs:
    22465659 8841090


    Sources:
    DrugBank

  • OXCARBAZEPINE   SCN1A

    Interaction Score: 0.45

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    23859570 21747585 22591328 10845729 28842369 28753467 12737829 25155934 26555147


    Sources:
    PharmGKB DrugBank ChemblInteractions

  • BRIVARACETAM   SCN1A

    Interaction Score: 0.38

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19914041


    Sources:
    DrugBank

  • TETRODOTOXIN   SCN1A

    Interaction Score: 0.34

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name tetrodotoxin,Tectin, Tetrodin
    Specific Action of the Ligand Pore blocker

    PMIDs:
    17663442


    Sources:
    TdgClinicalTrial DrugBank GuideToPharmacology

  • CARBAMAZEPINE   SCN1A

    Interaction Score: 0.28

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    23859570 21747585 22591328 19289736 20643904 22292851 28753467 22188362 12391287 26314341 15208697 25155934 26555147 20526191 21561445


    Sources:
    PharmGKB DrugBank ChemblInteractions

  • RANOLAZINE   SCN1A

    Interaction Score: 0.25

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    16640453 26459200 26979079


    Sources:
    DrugBank

  • ZONISAMIDE   SCN1A

    Interaction Score: 0.25

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name zonisamide,Zonegran, Trerief
    Trial Name OREX-003, olanzapine plus zonisamide SR
    Novel drug target Established target

    PMIDs:
    19557119 20001433 19948168 15511691 11752352 20025128 14704463 18433351


    Sources:
    TEND TdgClinicalTrial DrugBank ChemblInteractions

  • TETRACAINE   SCN1A

    Interaction Score: 0.23

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    23888118 22053156


    Sources:
    DrugBank ChemblInteractions

  • CARBETAPENTANE   SCN1A

    Interaction Score: 0.22

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    23872380


    Sources:
    DrugBank

  • SAXITOXIN   SCN1A

    Interaction Score: 0.19

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Pore blocker

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • VERATRIDINE   SCN1A

    Interaction Score: 0.19

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Activation

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CLOBAZAM   SCN1A

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23859570 21747585 28753467 25155934


    Sources:
    PharmGKB

  • FISH OIL TRIGLYCERIDES   SCN1A

    Interaction Score: 0.15

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    22393325


    Sources:
    DrugBank

  • TOPIRAMATE   SCN1A

    Interaction Score: 0.15

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes
    Trial Name topiramate controlled release,Trokesa

    PMIDs:
    15508261 15526956 11948006 17621480 12861512


    Sources:
    TEND TdgClinicalTrial DrugBank ChemblInteractions

  • LAMOTRIGINE   SCN1A

    Interaction Score: 0.15

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    23859570 21747585 28753467 16174788 25155934


    Sources:
    PharmGKB DrugBank ChemblInteractions

  • NITRAZEPAM   SCN1A

    Interaction Score: 0.14

    Interaction Types & Directionality:
    other/unknown

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    2450203


    Sources:
    TEND TdgClinicalTrial DrugBank

  • PHENYTOIN   SCN1A

    Interaction Score: 0.14

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    17001291 15805193 20298965


    Sources:
    TEND PharmGKB TdgClinicalTrial DrugBank ChemblInteractions

  • PROMETHAZINE   SCN1A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    24350243 1327391


    Sources:
    DrugBank

  • COCAINE   SCN1A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    2155033 9876137


    Sources:
    DrugBank

  • PROPOXYCAINE HYDROCHLORIDE   SCN1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROCAINAMIDE HYDROCHLORIDE   SCN1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • QUINIDINE SULFATE   SCN1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • QUINIDINE POLYGALACTURONATE   SCN1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TETRACAINE HYDROCHLORIDE   SCN1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • EVENAMIDE   SCN1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FOSPHENYTOIN SODIUM   SCN1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ETIDOCAINE HYDROCHLORIDE   SCN1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LIDOCAINE HYDROCHLORIDE   SCN1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROPARACAINE HYDROCHLORIDE   SCN1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROCAINE HYDROCHLORIDE   SCN1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INDECAINIDE HYDROCHLORIDE   SCN1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MERETHOXYLLINE PROCAINE   SCN1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TOCAINIDE HYDROCHLORIDE   SCN1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • HEXYLCAINE HYDROCHLORIDE   SCN1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MEXILETINE HYDROCHLORIDE   SCN1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MEPIVACAINE HYDROCHLORIDE   SCN1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • QUINIDINE GLUCONATE   SCN1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ESLICARBAZEPINE ACETATE   SCN1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ARTICAINE HYDROCHLORIDE   SCN1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ROPIVACAINE HYDROCHLORIDE   SCN1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHLOROPROCAINE HYDROCHLORIDE   SCN1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PHENYTOIN SODIUM   SCN1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NKTR-171   SCN1A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRILOCAINE   SCN1A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ESLICARBAZEPINE   SCN1A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ETHOTOIN   SCN1A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DISOPYRAMIDE PHOSPHATE   SCN1A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BENOXINATE HYDROCHLORIDE   SCN1A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRILOCAINE HYDROCHLORIDE   SCN1A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ERLOSAMIDE   SCN1A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MORICIZINE HYDROCHLORIDE   SCN1A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RUFINAMIDE   SCN1A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MEPHENYTOIN   SCN1A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • IRAMPANEL   SCN1A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROPAFENONE HYDROCHLORIDE   SCN1A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SAFINAMIDE   SCN1A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Safinamide
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • DYCLONINE HYDROCHLORIDE   SCN1A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PHENAZOPYRIDINE HYDROCHLORIDE   SCN1A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DRONEDARONE HYDROCHLORIDE   SCN1A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LIDOCAINE   SCN1A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RALFINAMIDE   SCN1A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ORPHENADRINE HYDROCHLORIDE   SCN1A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ORPHENADRINE CITRATE   SCN1A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RILUZOLE   SCN1A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRIMIDONE   SCN1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NERISPIRDINE   SCN1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000144285

    • Version: 101_38

    Alternate Names:
    SCN1A Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P35498

    • Version: January-2014

    Alternate Names:
    SCN1A Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass TC:1.A.1.10.7

    Publications:

  • TEND: P35498

    • Version: 01-August-2011

    Alternate Names:
    SCN1A Gene Symbol
    SCN1A_HUMAN Uniprot Id
    ENSG00000144285 Ensembl Gene Id

    Gene Info:
    Target Subclass Voltage_gated_ion_channels
    Target Main Class Transporters
    Target Subclass Channels

    Publications:

  • RussLampel: ENSG00000144285

    • Version: 26-July-2011

    Alternate Names:
    SODIUM CHANNEL PROTEIN TYPE I ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.1) (SODIUM CHANNEL PROTEIN, BRAIN I ALPHA SUBUNIT). [SOURCE:UNIPROT/SWISSPROT;ACC:P35498] Description
    ENSG00000144285 Ensembl Gene Id
    SCN1A Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • BaderLabGenes: SCN1A

    • Version: February-2014

    Alternate Names:
    6323 Entrez Gene ID

    Gene Info:
    Initial Gene Query Nav1.1
    Counted Citations from 1950-2000 398

    Gene Categories:
    ION CHANNEL

    Publications:

  • HopkinsGroom: P35498

    • Version: 11-September-2012

    Alternate Names:
    SCN1A Uniprot Gene Name
    SCN1A_HUMAN Uniprot Id
    ENSG00000144285 Ensembl Gene Id

    Gene Info:
    Interpro Short Name Ion_trans_dom
    Interpro Acc IPR005821
    Human Readable Name ION CHANNEL

    Gene Categories:
    ION CHANNEL, DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 6323

    • Version: 29-September-2020

    Alternate Names:
    10585 HUGO Gene ID
    10585 HUGO Gene Symbol
    sodium voltage-gated channel alpha subunit 1 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Voltage-gated sodium channels
    GuideToPharmacology Gene Category ID 82

    Gene Categories:
    ION CHANNEL

    Publications:

  • PharmGKB: SCN1A

    • Version: 18-August-2020

    Alternate Names:
    PA301 PharmGKB ID

    Gene Info:

    Publications:
    Haerian BS et al., 2013, SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis., Pharmacogenomics
    Kumari R et al., 2011, Pharmacogenomic association study on the role of drug metabolizing, drug transporters and drug target gene polymorphisms in drug-resistant epilepsy in a north Indian population., Indian J Hum Genet
    Bertok S et al., 2017, The association of SCN1A p.Thr1067Ala polymorphism with epilepsy risk and the response to antiepileptic drugs in Slovenian children and adolescents with epilepsy., Seizure

  • DrugBank: BE0000141

    • Version: 5.1.7

    Alternate Names:
    SCN1A DrugBank Gene Name
    P35498 UniProt Accession
    6323 Entrez Gene Id

    Gene Info:

    Publications:
    Zaccara et al., 2009, Long-term safety and effectiveness of zonisamide in the treatment of epilepsy: a review of the literature., Neuropsychiatr Dis Treat
    Schulze-Bonhage, 2010, Zonisamide in the treatment of epilepsy., Expert Opin Pharmacother
    Sonsalla et al., 2010, The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance., Exp. Neurol.

  • DrugBank: BE0004901

    • Version: 5.1.7

    Alternate Names:
    SCN1A DrugBank Gene Name
    P35498 UniProt Accession
    6323 Entrez Gene Id

    Gene Info:

    Publications:
    Farber et al., 2002, Antiepileptic drugs and agents that inhibit voltage-gated sodium channels prevent NMDA antagonist neurotoxicity., Mol. Psychiatry
    Shorvon S, 2000, Oxcarbazepine: a review., Seizure
    Thomas AM et al., 2018, Old Friends With New Faces: Are Sodium Channel Blockers the Future of Adjunct Pain Medication Management?, J Pain

  • DrugBank: BE0009738

    • Version: 5.1.7

    Alternate Names:
    SCN1A DrugBank Gene Name
    P35498 UniProt Accession
    6323 Entrez Gene Id

    Gene Info:

    Publications:
    Ceulemans et al., 2004, Severe myoclonic epilepsy in infancy: toward an optimal treatment., J. Child Neurol.
    Coppola et al., 2002, Topiramate as add-on drug in severe myoclonic epilepsy in infancy: an Italian multicenter open trial., Epilepsy Res.
    Nieto Barrera et al., [Severe myoclonic epilepsy in infancy (Dravet's syndrome). Its nosological characteristics and therapeutic aspects]., Rev Neurol

  • HingoraniCasas: ENSG00000144285

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000144285 Gene Symbol
    SCN1A Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: NAC1

    • Version: chembl_23

    Alternate Names:
    SCN1 GENE_SYMBOL
    SCN1A GENE_SYMBOL
    Sodium channel protein type 1 subunit alpha UNIPROT

    Gene Info:

    Publications:

  • Pharos: SCN1A

    • Version: 03-September-2020

    Alternate Names:
    Sodium channel protein type 1 subunit alpha Gene Name
    P35498 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21