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SCN10A Gene Record

  • Summary
  • Interactions
  • Claims
  • SCN10A 6336 Druggable Genome

    Alternate Names:

    6336
    SODIUM VOLTAGE-GATED CHANNEL ALPHA SUBUNIT 10
    SCN10A
    FEPS2
    Nav1.8
    PN3
    SNS
    hPN3
    604427
    10582
    ENSG00000185313
    OTTHUMG00000048245
    Q9Y5Y9
    SCNAA_HUMAN
    SODIUM CHANNEL PROTEIN TYPE 10 SUBUNIT ALPHA
    VOLTAGE-GATED SODIUM CHANNEL SUBUNIT ALPHA NAV1.8
    SODIUM CHANNEL PROTEIN TYPE X SUBUNIT ALPHA
    PERIPHERAL NERVE SODIUM CHANNEL 3
    585
    Na<sub>v</sub>1.8
    NP_006505
    NM_006514
    SODIUM CHANNEL PROTEIN TYPE X ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.8) (PERIPHERAL NERVE SODIUM CHANNEL 3) (HPN3). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9Y5Y9]
    BE0000177
    PA35000
    Voltage-gated sodium channel alpha Nav1.8
    T43739

    Gene Info:

    GuideToPharmacology Gene Category Name Voltage-gated sodium channels
    GuideToPharmacology Gene Category ID 82
    Target Main Class Transporters
    Transmembrane Helix Count 23
    Target Subclass Voltage_gated_ion_channels
    Target Subclass SodiumChannels
    Target Subclass Channels
    Target Class Transporters
    Target Subclass TC:1.A.1.10
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Ion_trans_dom
    Interpro Acc IPR005821
    Uniprot Status Swiss-Prot
    Interpro Name Ion transport domain
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name ION CHANNEL
    Initial Gene Query Nav1.8
    Counted Citations from 1950-2000 298
    Gene Biotype PROTEIN_CODING
    (9 More Sources)

    Gene Categories: Category Details

    ION CHANNEL
    DRUGGABLE GENOME

    Publications:

    Roghani et al., Evaluating the efficacy of commonly used topical anesthetics., Pediatr Dent
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Tella et al., 1998, Monoamine transporter and sodium channel mechanisms in the rapid pressor response to cocaine., Pharmacol. Biochem. Behav.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Sheets et al., 2010, Sodium channel molecular conformations and antiarrhythmic drug affinity., Trends Cardiovasc. Med.
    Hung et al., 2009, Intrathecal oxybuprocaine and proxymetacaine produced potent and long-lasting spinal anesthesia in rats., Neurosci. Lett.
    Hanck et al., 2009, Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity., Circ. Res.
    Ahern et al., 2008, Electrostatic contributions of aromatic residues in the local anesthetic receptor of voltage-gated sodium channels., Circ. Res.
    Lipkind et al., 2005, Molecular modeling of local anesthetic drug binding by voltage-gated sodium channels., Mol. Pharmacol.
    Liu et al., 2000, The effects of ropivacaine on sodium currents in dorsal horn neurons of neonatal rats., Anesth. Analg.
    Louro et al., 1998, Carboxyl groups at the membrane interface as molecular targets for local anesthetics., Biophys. Chem.
    Ryan et al., 1996, Structural effects of neutral and anionic lipids on the nicotinic acetylcholine receptor. An infrared difference spectroscopy study., J. Biol. Chem.
    Karoly et al., 2010, Fast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental study., PLoS Comput. Biol.
    Ekberg et al., 2006, muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits., Proc. Natl. Acad. Sci. U.S.A.
    Muroi et al., 2009, Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel., J. Gen. Physiol.
    Chevrier P et al., 2004, Differential modulation of Nav1.7 and Nav1.8 peripheral nerve sodium channels by the local anesthetic lidocaine., Br J Pharmacol
    Leffler et al., 2010, Block of sensory neuronal Na+ channels by the secreolytic ambroxol is associated with an interaction with local anesthetic binding sites., Eur. J. Pharmacol.
    He YJ et al., 2016, Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial., Pharmacogenomics J
    Wong et al., 1993, On the mechanisms of potentiation of local anesthetics by bicarbonate buffer: drug structure-activity studies on isolated peripheral nerve., Anesth. Analg.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Ueta et al., In vitro antagonism of recombinant ligand-gated ion-channel receptors by stereospecific enantiomers of bupivacaine., Reg Anesth Pain Med
    Vladimirov et al., 2000, Potency of bupivacaine stereoisomers tested in vitro and in vivo: biochemical, electrophysiological, and neurobehavioral studies., Anesthesiology
    Bräu et al., 2000, Block of neuronal tetrodotoxin-resistant Na+ currents by stereoisomers of piperidine local anesthetics., Anesth. Analg.
    Katalymov, 1995, [The effect of inhibitors of sodium permeability (novocaine and tetrodotoxin) on the trace depolarization of myelinated nerve fibers]., Fiziol Zh Im I M Sechenova
    Bräu et al., 1998, Fundamental properties of local anesthetics: half-maximal blocking concentrations for tonic block of Na+ and K+ channels in peripheral nerve., Anesth. Analg.
    Creveling et al., 1990, Procaine isothiocyanate: an irreversible inhibitor of the specific binding of [3H]batrachotoxinin-A benzoate to sodium channels., Neurochem. Res.
    Pubill et al., 1999, Assessment of the adrenergic effects of orphenadrine in rat vas deferens., J. Pharm. Pharmacol.
  • BENZOCAINE   SCN10A

    Interaction Score: 2.95

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    19661462 17967784 17139284 16174788 17016423


    Sources:
    TEND TdgClinicalTrial DrugBank

  • PROPARACAINE   SCN10A

    Interaction Score: 2.58

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17139284 9476974 17016423


    Sources:
    TEND TdgClinicalTrial TTD DrugBank

  • HEXYLCAINE   SCN10A

    Interaction Score: 2.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    15148257 17139284 17016423


    Sources:
    TEND TdgClinicalTrial DrugBank

  • LEVOBUPIVACAINE   SCN10A

    Interaction Score: 1.97

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    16418020 10969308 17139284 11094008 17016423


    Sources:
    TEND TdgClinicalTrial DrugBank

  • BENOXINATE   SCN10A

    Interaction Score: 1.48

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    19429093 17139284 17016423


    Sources:
    TEND TdgClinicalTrial DrugBank

  • ROPIVACAINE   SCN10A

    Interaction Score: 1.03

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name ropivacaine HCl,Naropin
    Novel drug target Established target

    PMIDs:
    10781449 17139284 17016423


    Sources:
    TEND TdgClinicalTrial TTD DrugBank

  • CHLOROPROCAINE   SCN10A

    Interaction Score: 0.89

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    8418714 17139284 17016423


    Sources:
    TEND TdgClinicalTrial DrugBank

  • DSP-2230   SCN10A

    Interaction Score: 0.74

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel protein type X alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    TTD ChemblInteractions

  • PF-04531083   SCN10A

    Interaction Score: 0.74

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel protein type X alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DIBUCAINE   SCN10A

    Interaction Score: 0.74

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    9742684 8798723 17139284 17016423


    Sources:
    TEND TdgClinicalTrial DrugBank

  • MEPIVACAINE   SCN10A

    Interaction Score: 0.63

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name APF 112, mepivacaine sustained-release
    Novel drug target Established target

    PMIDs:
    20044988 17139284 17016423


    Sources:
    TEND TdgClinicalTrial DrugBank

  • DYCLONINE   SCN10A

    Interaction Score: 0.57

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    10355012 17139284 9476974 17016423


    Sources:
    TEND TdgClinicalTrial DrugBank

  • PROCAINE   SCN10A

    Interaction Score: 0.45

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    8581044 9768788 2167458 17139284 17016423


    Sources:
    TEND TdgClinicalTrial DrugBank

  • BUPIVACAINE   SCN10A

    Interaction Score: 0.4

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name Durect
    Trial Name DUR-843,Eladur, Transdur-Bupivacaine
    Trial Name DepoBupivacaine, bupivacaine,Exparel

    PMIDs:
    20685573 17139284 17016423


    Sources:
    TEND TdgClinicalTrial TTD DrugBank

  • RILPIVIRINE   SCN10A

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • LIDOCAINE   SCN10A

    Interaction Score: 0.29

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name ALGRX 3268,Zingo
    Novel drug target Established target
    Trial Name lidocaine hydrochloride, piroxicam, AK1015,Akten

    PMIDs:
    20585544 17077153 19088384


    Sources:
    TEND TdgClinicalTrial DrugBank ChemblInteractions

  • ORPHENADRINE   SCN10A

    Interaction Score: 0.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    10344632


    Sources:
    DrugBank

  • ERLOSAMIDE   SCN10A

    Interaction Score: 0.18

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    10592235


    Sources:
    DrugBank ChemblInteractions

  • CONATUMUMAB   SCN10A

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • DIBUCAINE HYDROCHLORIDE   SCN10A

    Interaction Score: 0.15

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel protein type X alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TIAPRIDE   SCN10A

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • COCAINE   SCN10A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    17139284 17016423


    Sources:
    TEND TdgClinicalTrial

  • TETRACAINE   SCN10A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    TTD ChemblInteractions

  • AFACIFENACIN   SCN10A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel protein type X alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TETRODOTOXIN   SCN10A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name tetrodotoxin,Tectin, Tetrodin
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • TETRACAINE HYDROCHLORIDE   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROCAINE HYDROCHLORIDE   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NKTR-171   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PHENACEMIDE   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • QUINIDINE SULFATE   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROCAINAMIDE HYDROCHLORIDE   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INDECAINIDE HYDROCHLORIDE   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • QUINIDINE POLYGALACTURONATE   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ETIDOCAINE HYDROCHLORIDE   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ESLICARBAZEPINE ACETATE   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHLOROPROCAINE HYDROCHLORIDE   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LIDOCAINE HYDROCHLORIDE   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MEPIVACAINE HYDROCHLORIDE   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROPARACAINE HYDROCHLORIDE   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • EVENAMIDE   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TOCAINIDE HYDROCHLORIDE   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MEXILETINE HYDROCHLORIDE   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PHENYTOIN SODIUM   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROPOXYCAINE HYDROCHLORIDE   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MERETHOXYLLINE PROCAINE   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • QUINIDINE GLUCONATE   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ROPIVACAINE HYDROCHLORIDE   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • HEXYLCAINE HYDROCHLORIDE   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FOSPHENYTOIN SODIUM   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ARTICAINE HYDROCHLORIDE   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BENOXINATE HYDROCHLORIDE   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRILOCAINE   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRILOCAINE HYDROCHLORIDE   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ESLICARBAZEPINE   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DISOPYRAMIDE PHOSPHATE   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ETHOTOIN   SCN10A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MORICIZINE HYDROCHLORIDE   SCN10A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RUFINAMIDE   SCN10A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MEPHENYTOIN   SCN10A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • IRAMPANEL   SCN10A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PROPAFENONE HYDROCHLORIDE   SCN10A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PHENAZOPYRIDINE HYDROCHLORIDE   SCN10A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DRONEDARONE HYDROCHLORIDE   SCN10A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DYCLONINE HYDROCHLORIDE   SCN10A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RALFINAMIDE   SCN10A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • OXCARBAZEPINE   SCN10A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ORPHENADRINE HYDROCHLORIDE   SCN10A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ORPHENADRINE CITRATE   SCN10A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RILUZOLE   SCN10A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PRIMIDONE   SCN10A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ZONISAMIDE   SCN10A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CARBOPLATIN   SCN10A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26194361


    Sources:
    PharmGKB

  • LAMOTRIGINE   SCN10A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sodium channel alpha subunit blocker

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PHENYTOIN   SCN10A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TOPIRAMATE   SCN10A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CARBAMAZEPINE   SCN10A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NERISPIRDINE   SCN10A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium channel alpha subunit blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000185313

    • Version: 101_38

    Alternate Names:
    SCN10A Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: Q9Y5Y9

    • Version: 01-August-2011

    Alternate Names:
    6336 Entrez Gene Id
    SCNAA_HUMAN Uniprot Id
    SCN10A Gene Symbol

    Gene Info:
    Target Main Class Transporters
    Transmembrane Helix Count 23
    Target Subclass Voltage_gated_ion_channels

    Publications:

  • TdgClinicalTrial: Q9Y5Y9

    • Version: January-2014

    Alternate Names:
    SCN10A Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass TC:1.A.1.10

    Publications:

  • HopkinsGroom: Q9Y5Y9

    • Version: 11-September-2012

    Alternate Names:
    SCNAA_HUMAN Uniprot Id
    SODIUM CHANNEL PROTEIN TYPE 10 SUBUNIT ALPHA Uniprot Protein Name
    SCN10A Uniprot Gene Name

    Gene Info:
    Interpro Short Name Ion_trans_dom
    Interpro Acc IPR005821
    Uniprot Status Swiss-Prot

    Gene Categories:
    ION CHANNEL, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000185313

    • Version: 26-July-2011

    Alternate Names:
    SODIUM CHANNEL PROTEIN TYPE X ALPHA SUBUNIT (VOLTAGE-GATED SODIUM CHANNEL ALPHA SUBUNIT NAV1.8) (PERIPHERAL NERVE SODIUM CHANNEL 3) (HPN3). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9Y5Y9] Description
    SCN10A Display Id
    ENSG00000185313 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • BaderLabGenes: SCN10A

    • Version: February-2014

    Alternate Names:
    6336 Entrez Gene ID

    Gene Info:
    Initial Gene Query Nav1.8
    Counted Citations from 1950-2000 298

    Gene Categories:
    ION CHANNEL

    Publications:

  • GuideToPharmacology: 6336

    • Version: 29-September-2020

    Alternate Names:
    10582 HUGO Gene ID
    10582 HUGO Gene Symbol
    sodium voltage-gated channel alpha subunit 10 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Voltage-gated sodium channels
    GuideToPharmacology Gene Category ID 82

    Gene Categories:
    ION CHANNEL

    Publications:

  • PharmGKB: SCN10A

    • Version: 18-August-2020

    Alternate Names:
    PA35000 PharmGKB ID

    Gene Info:

    Publications:
    He YJ et al., 2016, Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial., Pharmacogenomics J

  • DrugBank: BE0000177

    • Version: 5.1.7

    Alternate Names:
    SCN10A DrugBank Gene Name
    Q9Y5Y9 UniProt Accession
    6336 Entrez Gene Id

    Gene Info:

    Publications:
    Sheets et al., 2010, Sodium channel molecular conformations and antiarrhythmic drug affinity., Trends Cardiovasc. Med.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

  • TTD: Voltage-gated sodium channel alpha Nav1.8

    • Version: 2020.06.01

    Alternate Names:
    SCN10A TTD Gene Abbreviation
    T43739 TTD Target ID

    Gene Info:

    Publications:
    Shields SD et al., 2015, Oral administration of PF-01247324, a subtype-selective Nav1.8 blocker, reverses cerebellar deficits in a mouse model of multiple sclerosis., PLoS One

  • HingoraniCasas: ENSG00000185313

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000185313 Gene Symbol
    SCN10A Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: SCN10A

    • Version: chembl_23

    Alternate Names:
    SCN10A GENE_SYMBOL
    Sodium channel protein type 10 subunit alpha UNIPROT
    Peripheral nerve sodium channel 3 UNIPROT

    Gene Info:

    Publications:

  • Pharos: SCN10A

    • Version: 03-September-2020

    Alternate Names:
    Sodium channel protein type 10 subunit alpha Gene Name
    Q9Y5Y9 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21