• Interaction Score: 6.54

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

  • Interaction Score: 4.91

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 4.91

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Triapine
    Novel drug target Novel Target

    PMIDs:
    None found


  • Interaction Score: 4.91

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 2.29

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

  • Interaction Score: 1.64

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 1.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor
    Details of the Assay for Interaction Inhibition of growth of K562 cells

    PMIDs:
    None found


  • Interaction Score: 1.05

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor
    Direct Interaction yes
    Details of the Assay for Interaction Dissolved in 1% DMSO, <i>in vitro</i> assay using reconstituted RRM1/RRM2 holoenzyme

    PMIDs:
    None found


  • Interaction Score: 0.82

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.7

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.25

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24024897


    Sources:
    PharmGKB

  • Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition