DGIdb - RRM1 Gene Record

RRM1 6240 Druggable Genome

Alternate Names:

6240
RIBONUCLEOTIDE REDUCTASE CATALYTIC SUBUNIT M1
RRM1
R1
RIR1
RR1
180410
10451
ENSG00000167325
OTTHUMG00000133361
5051
Ribonucleotide reductase large subunit
Ribonucleoside-diphosphate reductase large subunit
Ribonucleoside-diphosphate reductase subunit M1
PA298
RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT (EC 1.17.4.1) (RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE M1 SUBUNIT) (RIBONUCLEOTIDE REDUCTASE LARGE CHAIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P23921]
P23921
RIR1_HUMAN

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Target Class	Enzymes
Target Subclass	EC:1.17.4.1
Uniprot Evidence	1: Evidence at protein level
Interpro Name	Ribonucleotide reductase large subunit, C-terminal
Interpro Acc	IPR000788
Interpro Type	Domain
Uniprot Status	Swiss-Prot
Interpro Short Name	Ribncl_red_lg_C
Target Subclass	1.17.4.1
Target Main Class	Enzymes
Gene Biotype	PROTEIN_CODING

(11 More Sources)

Gene Categories: Category Details

DNA REPAIR
DRUGGABLE GENOME
ENZYME

Publications:

2004, Clofarabine., Drugs R D
Kantarjian et al., 2007, Clofarabine: past, present, and future., Leuk. Lymphoma
Harned et al., 2008, Treating refractory leukemias in childhood, role of clofarabine., Ther Clin Risk Manag
Pession et al., 2010, Use of clofarabine for acute childhood leukemia., Biologics
Zhenchuk et al., 2009, Mechanisms of anti-cancer action and pharmacology of clofarabine., Biochem. Pharmacol.
Lech-Maranda et al., 2009, Clofarabine as a novel nucleoside analogue approved to treat patients with haematological malignancies: mechanism of action and clinical activity., Mini Rev Med Chem
Musto et al., 2008, Clofarabine: in search of combinations for the treatment of patients with high-risk acute myeloid leukemia., Cancer
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Robak et al., 2009, Current status of older and new purine nucleoside analogues in the treatment of lymphoproliferative diseases., Molecules
Rosell et al., 2003, Targeted therapy in combination with gemcitabine in non-small cell lung cancer., Semin. Oncol.
Nie et al., 2013, The tailored chemotherapy based on RRM1 immunohistochemical expression in patients with advanced non-small cell lung cancer., Cancer Biomark
Ryu JS et al., 2011, Differential effect of polymorphisms of CMPK1 and RRM1 on survival in advanced non-small cell lung cancer patients treated with gemcitabine or taxane/cisplatinum., J Thorac Oncol
Rosell R et al., 2004, Ribonucleotide reductase messenger RNA expression and survival in gemcitabine/cisplatin-treated advanced non-small cell lung cancer patients., Clin Cancer Res
Sampat et al., 2009, Clofarabine: emerging role in leukemias., Expert Opin Investig Drugs
Takahashi et al., 1999, Antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) adenine, a novel deoxyadenosine analog, against human colon tumor xenografts by oral administration., Cancer Chemother. Pharmacol.
Kline et al., 2005, Clofarabine in the treatment of acute myeloid leukaemia and acute lymphoblastic leukaemia: a review., Expert Opin Pharmacother
Cao X et al., 2013, RRM1 and RRM2 pharmacogenetics: association with phenotypes in HapMap cell lines and acute myeloid leukemia patients., Pharmacogenomics
Jiang et al., 2010, Two distinct mechanisms of inactivation of the class Ic ribonucleotide reductase from Chlamydia trachomatis by hydroxyurea: implications for the protein gating of intersubunit electron transfer., Biochemistry
Zhou et al., 2003, The human ribonucleotide reductase subunit hRRM2 complements p53R2 in response to UV-induced DNA repair in cells with mutant p53., Cancer Res.
Davies et al., 2009, Hydroxyurea induces hydroxyl radical-mediated cell death in Escherichia coli., Mol. Cell
Culligan et al., 2004, ATR regulates a G2-phase cell-cycle checkpoint in Arabidopsis thaliana., Plant Cell
Dong et al., 2014, Response to first-line chemotherapy in patients with non-small cell lung cancer according to RRM1 expression., PLoS ONE
Vilmar et al., 2013, Predictive impact of RRM1 protein expression on vinorelbine efficacy in NSCLC patients randomly assigned in a chemotherapy phase III trial., Ann. Oncol.
Labroli MA et al., 2014, The identification of novel 5'-amino gemcitabine analogs as potent RRM1 inhibitors., Bioorg Med Chem
Kwon et al., 2006, Ribonucleotide reductase M1 (RRM1) 2464G>A polymorphism shows an association with gemcitabine chemosensitivity in cancer cell lines., Pharmacogenet. Genomics
Smid et al., 2006, Micro-array analysis of resistance for gemcitabine results in increased expression of ribonucleotide reductase subunits., Nucleosides Nucleotides Nucleic Acids
Bepler et al., 2006, RRM1 modulated in vitro and in vivo efficacy of gemcitabine and platinum in non-small-cell lung cancer., J. Clin. Oncol.
Cerqueira et al., 2007, Understanding ribonucleotide reductase inactivation by gemcitabine., Chemistry
Rosell et al., 2006, Pharmacogenomics and gemcitabine., Ann. Oncol.
Nakahira et al., 2007, Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer., Int. J. Cancer
Akita et al., 2009, Significance of RRM1 and ERCC1 expression in resectable pancreatic adenocarcinoma., Oncogene
Rosell R et al., 2004, Gene expression as a predictive marker of outcome in stage IIB-IIIA-IIIB non-small cell lung cancer after induction gemcitabine-based chemotherapy followed by resectional surgery., Clin Cancer Res
Skierski JS et al., 1999, Effect of FMdC on the cell cycle of some leukemia cell lines., Cytometry

CLOFARABINE RRM1

Interaction Score: 5.89

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Clofarabine

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

PMIDs:
15230627 17852710 18728851 20631817 19576186 19519505 18780321 17016423 17139284

Sources:
TdgClinicalTrial ChemblInteractions TEND
TEZACITABINE RRM1

Interaction Score: 2.94

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

Direct Interaction yes

PMIDs:
10547615

Sources:
ChemblInteractions
HYDROXYUREA RRM1

Interaction Score: 2.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

Trial Name -

PMIDs:
20462199 14583450 20005847 15075397

Sources:
TdgClinicalTrial ChemblInteractions TEND
CLADRIBINE RRM1

Interaction Score: 2.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19715446 17852710 19576186 9923554 16316309 24024897

Sources:
PharmGKB
GALLIUM NITRATE RRM1

Interaction Score: 1.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FLUDARABINE RRM1

Interaction Score: 1.39

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name fludarabine phosphate,Fludara

Novel drug target Established target

PMIDs:
19519505 17016423 17139284 19325518

Sources:
TdgClinicalTrial TEND
GEMCITABINE RRM1

Interaction Score: 0.98

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name gemcitabine HCl,Gemzar

Novel drug target Established target

PMIDs:
24588962 16708051 17065054 16966686 17636467 16807441 17131328 23038758 24647522 19543324 24595080 14977831 15217961

Sources:
DTC ClearityFoundationBiomarkers TdgClinicalTrial ClearityFoundationClinicalTrial CIViC
FLUDARABINE PHOSPHATE RRM1

Interaction Score: 0.74

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
GEMCITABINE HYDROCHLORIDE RRM1

Interaction Score: 0.63

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VINORELBINE RRM1

Interaction Score: 0.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23038758 24647522

Sources:
CIViC
CISPLATIN RRM1

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12917817 24595080 21642870 14977831

Sources:
NCI CIViC PharmGKB
CYTARABINE RRM1

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24024897

Sources:
PharmGKB
DOCETAXEL RRM1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24647522

Sources:
CIViC
PACLITAXEL RRM1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23038758

Sources:
CIViC

Ensembl: ENSG00000167325
- Version: 101_38
Alternate Names:

RRM1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P23921
- Version: 11-September-2012
Alternate Names:

ENSG00000167325 Ensembl Gene Id

RIR1_HUMAN Uniprot Id

RRM1 Uniprot Gene Name

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Interpro Name Ribonucleotide reductase large subunit, C-terminal

Interpro Acc IPR000788

Gene Categories:

DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000167325

Version: 26-July-2011

Alternate Names:

RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT (EC 1.17.4.1) (RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE M1 SUBUNIT) (RIBONUCLEOTIDE REDUCTASE LARGE CHAIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P23921] Description

ENSG00000167325 Ensembl Gene Id

RRM1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TEND: P23921
- Version: 01-August-2011
Alternate Names:

6240 Entrez Gene Id

ENSG00000167325 Ensembl Gene Id

P23921 Uniprot Accession

Gene Info:

Target Subclass 1.17.4.1

Target Main Class Enzymes

Publications:
TdgClinicalTrial: P23921
- Version: January-2014
Alternate Names:

RRM1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.17.4.1

Publications:

PharmGKB: RRM1

Version: 18-August-2020

Alternate Names:

PA298 PharmGKB ID

Gene Info:

Publications:

Ryu JS et al., 2011, Differential effect of polymorphisms of CMPK1 and RRM1 on survival in advanced non-small cell lung cancer patients treated with gemcitabine or taxane/cisplatinum., J Thorac Oncol

Cao X et al., 2013, RRM1 and RRM2 pharmacogenetics: association with phenotypes in HapMap cell lines and acute myeloid leukemia patients., Pharmacogenomics

Soo RA et al., 2009, Distribution of gemcitabine pathway genotypes in ethnic Asians and their association with outcome in non-small cell lung cancer patients., Lung Cancer

CIViC: RRM1

Version: 14-September-2020

Alternate Names:

6240 Entrez Gene ID

5051 CIViC Gene ID

Gene Info:

Publications:

Rosell R et al., 2004, Gene expression as a predictive marker of outcome in stage IIB-IIIA-IIIB non-small cell lung cancer after induction gemcitabine-based chemotherapy followed by resectional surgery., Clin Cancer Res

Vilmar et al., 2013, Predictive impact of RRM1 protein expression on vinorelbine efficacy in NSCLC patients randomly assigned in a chemotherapy phase III trial., Ann. Oncol.

Dong et al., 2014, Response to first-line chemotherapy in patients with non-small cell lung cancer according to RRM1 expression., PLoS ONE

NCI: RRM1
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Rosell et al., 2003, Targeted therapy in combination with gemcitabine in non-small cell lung cancer., Semin. Oncol.
DTC: RRM1
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Labroli MA et al., 2014, The identification of novel 5'-amino gemcitabine analogs as potent RRM1 inhibitors., Bioorg Med Chem
HingoraniCasas: ENSG00000167325
- Version: 31-May-2017
Alternate Names:

ENSG00000167325 Gene Symbol

RRM1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: RR1
- Version: chembl_23
Alternate Names:

RR1 GENE_SYMBOL

RRM1 GENE_SYMBOL

Ribonucleoside-diphosphate reductase large subunit UNIPROT

Gene Info:

Publications:
GO: RRM1
- Version: 01-February-2022
Alternate Names:

RR1 GO Gene Synonym

Gene Info:

Gene Categories:

DNA REPAIR

Publications:
Pharos: RRM1
- Version: 01-February-2022
Alternate Names:

Ribonucleoside-diphosphate reductase large subunit Gene Name

P23921 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
ClearityFoundationBiomarkers: RRM1
- Version: 26-July-2013
Alternate Names:

Gene Info:

Publications:
ClearityFoundationClinicalTrial: RRM1
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:

Novel drug target	Established target
Trial Name	Clofarabine
Mechanism of Interaction	Ribonucleoside-diphosphate reductase RR1 inhibitor

Mechanism of Interaction	Ribonucleoside-diphosphate reductase RR1 inhibitor
Direct Interaction	yes

Trial Name	fludarabine phosphate,Fludara
Novel drug target	Established target

Trial Name	gemcitabine HCl,Gemzar
Novel drug target	Established target

ENSG00000167325	Ensembl Gene Id
RIR1_HUMAN	Uniprot Id
RRM1	Uniprot Gene Name

RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT (EC 1.17.4.1) (RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE M1 SUBUNIT) (RIBONUCLEOTIDE REDUCTASE LARGE CHAIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P23921]	Description
ENSG00000167325	Ensembl Gene Id
RRM1	Display Id

6240	Entrez Gene Id
ENSG00000167325	Ensembl Gene Id
P23921	Uniprot Accession

RR1	GENE_SYMBOL
RRM1	GENE_SYMBOL
Ribonucleoside-diphosphate reductase large subunit	UNIPROT

Ribonucleoside-diphosphate reductase large subunit	Gene Name
P23921	UniProt ID

RRM1 Gene Record

RRM1 6240 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name Clofarabine Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

PMIDs: 15230627 17852710 18728851 20631817 19576186 19519505 18780321 17016423 17139284

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor Direct Interaction yes

PMIDs: 10547615

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor Trial Name -

PMIDs: 20462199 14583450 20005847 15075397

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19715446 17852710 19576186 9923554 16316309 24024897

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name fludarabine phosphate,Fludara Novel drug target Established target

PMIDs: 19519505 17016423 17139284 19325518

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name gemcitabine HCl,Gemzar Novel drug target Established target

PMIDs: 24588962 16708051 17065054 16966686 17636467 16807441 17131328 23038758 24647522 19543324 24595080 14977831 15217961

Sources: DTC ClearityFoundationBiomarkers TdgClinicalTrial ClearityFoundationClinicalTrial CIViC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23038758 24647522

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12917817 24595080 21642870 14977831

Sources: NCI CIViC PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24024897

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24647522

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23038758

Sources: CIViC

Ensembl: ENSG00000167325

Alternate Names: RRM1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: P23921

Alternate Names: ENSG00000167325 Ensembl Gene Id RIR1_HUMAN Uniprot Id RRM1 Uniprot Gene Name

Gene Info: Uniprot Evidence 1: Evidence at protein level Interpro Name Ribonucleotide reductase large subunit, C-terminal Interpro Acc IPR000788

Gene Categories: DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000167325

Alternate Names: RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT (EC 1.17.4.1) (RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE M1 SUBUNIT) (RIBONUCLEOTIDE REDUCTASE LARGE CHAIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P23921] Description ENSG00000167325 Ensembl Gene Id RRM1 Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TEND: P23921

Alternate Names: 6240 Entrez Gene Id ENSG00000167325 Ensembl Gene Id P23921 Uniprot Accession

Gene Info: Target Subclass 1.17.4.1 Target Main Class Enzymes

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Clofarabine

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

PMIDs:
15230627 17852710 18728851 20631817 19576186 19519505 18780321 17016423 17139284

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

Direct Interaction yes

PMIDs:
10547615

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

Trial Name -

PMIDs:
20462199 14583450 20005847 15075397

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19715446 17852710 19576186 9923554 16316309 24024897

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name fludarabine phosphate,Fludara

Novel drug target Established target

PMIDs:
19519505 17016423 17139284 19325518

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name gemcitabine HCl,Gemzar

Novel drug target Established target

PMIDs:
24588962 16708051 17065054 16966686 17636467 16807441 17131328 23038758 24647522 19543324 24595080 14977831 15217961

Sources:
DTC ClearityFoundationBiomarkers TdgClinicalTrial ClearityFoundationClinicalTrial CIViC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
23038758 24647522

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
12917817 24595080 21642870 14977831

Sources:
NCI CIViC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24024897

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24647522

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
23038758

Sources:
CIViC

Alternate Names:

RRM1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000167325 Ensembl Gene Id

RIR1_HUMAN Uniprot Id

RRM1 Uniprot Gene Name

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Interpro Name Ribonucleotide reductase large subunit, C-terminal

Interpro Acc IPR000788

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT (EC 1.17.4.1) (RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE M1 SUBUNIT) (RIBONUCLEOTIDE REDUCTASE LARGE CHAIN). [SOURCE:UNIPROT/SWISSPROT;ACC:P23921] Description

ENSG00000167325 Ensembl Gene Id

RRM1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

6240 Entrez Gene Id

ENSG00000167325 Ensembl Gene Id

P23921 Uniprot Accession

Gene Info:

Target Subclass 1.17.4.1

Target Main Class Enzymes

Alternate Names:

RRM1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.17.4.1

Alternate Names:

PA298 PharmGKB ID

Alternate Names:

6240 Entrez Gene ID

5051 CIViC Gene ID

Publications:

Rosell et al., 2003, Targeted therapy in combination with gemcitabine in non-small cell lung cancer., Semin. Oncol.

Publications:

Labroli MA et al., 2014, The identification of novel 5'-amino gemcitabine analogs as potent RRM1 inhibitors., Bioorg Med Chem

Alternate Names:

ENSG00000167325 Gene Symbol

RRM1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

RR1 GENE_SYMBOL

RRM1 GENE_SYMBOL

Ribonucleoside-diphosphate reductase large subunit UNIPROT

Alternate Names:

RR1 GO Gene Synonym

Gene Categories:

DNA REPAIR

Alternate Names:

Ribonucleoside-diphosphate reductase large subunit Gene Name

P23921 UniProt ID

Gene Categories:

ENZYME