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RPS6KA1 Gene Record

  • Summary
  • Interactions
  • Claims
  • RPS6KA1 6195 Druggable Genome

    Alternate Names:

    6195
    RIBOSOMAL PROTEIN S6 KINASE A1
    RPS6KA1
    HU-1
    MAPKAPK1A
    RSK
    RSK1
    p90Rsk
    601684
    10430
    ENSG00000117676
    OTTHUMG00000004003
    Q15418
    KS6A1_HUMAN
    RIBOSOMAL PROTEIN S6 KINASE ALPHA-1
    RIBOSOMAL PROTEIN S6 KINASE ALPHA 1 (EC 2.7.1.37) (S6K-ALPHA 1) (90 KDA RIBOSOMAL PROTEIN S6 KINASE 1) (P90-RSK 1) (RIBOSOMAL S6 KINASE 1) (RSK-1) (PP90RSK1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q15418]
    T83202
    MAPKAPK1

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Acc IPR002290
    Human Readable Name KINASE
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Domain
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    TRANSCRIPTION FACTOR

    Publications:

    Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
    Goodfellow VS et al., 2013, Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3., J Med Chem
    Li M et al., 2014, Synthesis and Structure-Activity Relationship Study of 5a-Carbasugar Analogues of SL0101., ACS Med Chem Lett
    Li Q et al., 2010, Discovery of 3-(2-aminoethyl)-5-(3-phenyl-propylidene)-thiazolidine-2,4-dione as a dual inhibitor of the Raf/MEK/ERK and the PI3K/Akt signaling pathways., Bioorg Med Chem Lett
  • CHEMBL240954   RPS6KA1

    Interaction Score: 12.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25589938


    Sources:
    DTC

  • CHEMBL573107   RPS6KA1

    Interaction Score: 3.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CEP-1347   RPS6KA1

    Interaction Score: 2.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24044867


    Sources:
    DTC

  • CI-1040   RPS6KA1

    Interaction Score: 1.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20580230


    Sources:
    DTC

  • HESPERADIN   RPS6KA1

    Interaction Score: 0.31

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19035792


    Sources:
    DTC

  • Ensembl: ENSG00000117676

    • Version: 101_38

    Alternate Names:
    RPS6KA1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: Q15418

    • Version: 11-September-2012

    Alternate Names:
    6195 Entrez Gene Id
    Q15418 Uniprot Accession
    ENSG00000117676 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Acc IPR002290

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000117676

    • Version: 26-July-2011

    Alternate Names:
    RPS6KA1 Display Id
    RIBOSOMAL PROTEIN S6 KINASE ALPHA 1 (EC 2.7.1.37) (S6K-ALPHA 1) (90 KDA RIBOSOMAL PROTEIN S6 KINASE 1) (P90-RSK 1) (RIBOSOMAL S6 KINASE 1) (RSK-1) (PP90RSK1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q15418] Description
    ENSG00000117676 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • DTC: RPS6KA1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Goodfellow VS et al., 2013, Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3., J Med Chem
    Li M et al., 2014, Synthesis and Structure-Activity Relationship Study of 5a-Carbasugar Analogues of SL0101., ACS Med Chem Lett
    Li Q et al., 2010, Discovery of 3-(2-aminoethyl)-5-(3-phenyl-propylidene)-thiazolidine-2,4-dione as a dual inhibitor of the Raf/MEK/ERK and the PI3K/Akt signaling pathways., Bioorg Med Chem Lett

  • HingoraniCasas: ENSG00000117676

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000117676 Gene Symbol
    RPS6KA1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: RPS6KA1

    • Version: 01-February-2022

    Alternate Names:
    MAPKAPK1A GO Gene Synonym
    RSK1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE

    Publications:

  • dGene: RPS6KA1

    • Version: 27-Jun-2013

    Alternate Names:
    6195 Gene ID
    HU-1 dGene Synonym
    MAPKAPK1A dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • TTD: Ribosomal protein S6 kinase alpha-1

    • Version: 2020.06.01

    Alternate Names:
    RSK1 TTD Gene Abbreviation
    T83202 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: RPS6KA1

    • Version: 01-February-2022

    Alternate Names:
    Ribosomal protein S6 kinase alpha-1 Gene Name
    Q15418 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, TRANSCRIPTION FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21