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ROS1 6098 Druggable GenomeClinically ActionableDrug Resistance
Alternate Names:
6098 ROS PROTO-ONCOGENE 1, RECEPTOR TYROSINE KINASE ROS1 MCF3 ROS c-ros-1 165020 10261 ENSG00000047936 OTTHUMG00000016188 4941 1840 P08922 NP_002935 NM_002944 c-ros oncogene 1, receptor tyrosine kinase ROS1_HUMAN PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS PRECURSOR (EC 2.7.1.112) (C-ROS-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P08922] PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS PA34633 Reactive oxygen species T20796 Proto-oncogene c-Ros T69128 BE0009534 Gene Info:
CancerCommons Reported Gene Name ALK, ROS Initial Gene Query ROS Counted Citations from 1950-2000 4377 GuideToPharmacology Gene Category Name Type XVII RTKs: ROS receptors GuideToPharmacology Gene Category ID 796 Human Readable Name DRUGGABLE GENOME Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain Interpro Acc IPR001245 Uniprot Status Swiss-Prot Human Readable Name KINASE Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom Uniprot Evidence 1: Evidence at protein level Interpro Type Domain Gene Biotype PROTEIN_CODING Gene Categories: Category Details
CELL SURFACE KINASE TYROSINE KINASE DRUG RESISTANCE DRUGGABLE GENOME CLINICALLY ACTIONABLE ENZYME TRANSCRIPTION FACTOR Publications:
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Interaction Score: 2.43
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Interaction Score: 2.37
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Clinical Status case report Pathway activation Variant Effect gain-of-function -
Interaction Score: 1.89
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Interaction Score: 0.95
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Details of Interaction IC<sub>50</sub> for ROS1<sup>G2032R</sup> is 0.5 nM, and for ROS1<sup>D2033N</sup> is 0.2 nM Endogenous Drug? False -
Interaction Score: 0.95
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Interaction Score: 0.83
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Interaction Score: 0.63
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Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Reported Cancer Type Lung -
Interaction Score: 0.38
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Interaction Score: 0.38
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Interaction Score: 0.32
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Indication/Tumor Type pancreatic cancer Response Type predicted – sensitive Indication/Tumor Type non-small cell lung carcinoma -
Interaction Score: 0.21
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False -
Interaction Score: 0.05
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Interaction Score: 0.04
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Interaction Score: 0.03
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Interaction Score: 0.02
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Interaction Score: 0.02
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Interaction Score: 0.02
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Interaction Score: 0.01
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- Version: 101_38
Alternate Names:
ROS1 Ensembl Gene Name Gene Info:
Gene Biotype PROTEIN_CODING Publications:
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- Version: February-2014
Alternate Names:
6098 Entrez Gene ID Gene Info:
Initial Gene Query ROS Counted Citations from 1950-2000 4377 Gene Categories:
KINASE Publications:
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- Version: 11-September-2012
Alternate Names:
6098 Entrez Gene Id ROS1 Uniprot Gene Name ENSG00000047936 Ensembl Gene Id Gene Info:
Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain Interpro Acc IPR001245 Uniprot Status Swiss-Prot Gene Categories:
KINASE, DRUGGABLE GENOME Publications:
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- Version: 26-July-2011
Alternate Names:
ENSG00000047936 Ensembl Gene Id ROS1 Display Id PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS PRECURSOR (EC 2.7.1.112) (C-ROS-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P08922] Description Gene Info:
Human Readable Name DRUGGABLE GENOME Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: 25-July-2013
Alternate Names:
6098 Entrez Gene ID Gene Info:
CancerCommons Reported Gene Name ALK, ROS Publications:
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- Version: 29-September-2020
Alternate Names:
10261 HUGO Gene ID 10261 HUGO Gene Symbol ROS proto-oncogene 1, receptor tyrosine kinase HUGO Gene Name Gene Info:
GuideToPharmacology Gene Category Name Type XVII RTKs: ROS receptors GuideToPharmacology Gene Category ID 796 Publications:
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Alternate Names:
6098 CKB Entrez Id ROS1 CKB Gene Synonym c-ros-1 CKB Gene Synonym Gene Info:
Publications:
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Alternate Names:
6098 Entrez Gene ID 4941 CIViC Gene ID Gene Info:
Gene Categories:
DRUG RESISTANCE, CLINICALLY ACTIONABLE Publications:
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Alternate Names:
ROS1 DrugBank Gene Name P08922 UniProt Accession 6098 Entrez Gene Id Gene Info:
Publications:
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Alternate Names:
Gene Info:
Publications:
-
Alternate Names:
Gene Info:
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- Version: 31-May-2017
Alternate Names:
ENSG00000047936 Gene Symbol ROS1 Ensembl Id Gene Info:
Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: 20-Jun-2017
Alternate Names:
6098 Entrez Gene Id ROS1 MyCancerGenome Gene Symbol ROS1 MyCancerGenome Reported Gene Name Gene Info:
Publications:
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Alternate Names:
ROS1 Gene Symbol Gene Info:
Publications:
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Alternate Names:
6098 OncoKB Entrez Id MCF3 OncoKB Gene Synonym ROS OncoKB Gene Synonym Gene Info:
Publications:
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Alternate Names:
PA34633 PharmGKB ID Gene Info:
Publications:
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- Version: 19.3
Alternate Names:
ENSG00000047936 Ensembl Gene ID c-ros-1 Human Protein Atlas Gene Synonym MCF3 Human Protein Atlas Gene Synonym Gene Info:
Gene Categories:
ENZYME Publications:
-
Alternate Names:
Proto-oncogene tyrosine-protein kinase ROS Gene Name P08922 UniProt ID Gene Info:
Gene Categories:
KINASE, TRANSCRIPTION FACTOR Publications:
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Alternate Names:
MCF3 GO Gene Synonym ROS GO Gene Synonym Gene Info:
Gene Categories:
CELL SURFACE, TYROSINE KINASE Publications:
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Alternate Names:
ROS1 Gene Symbol Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
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Alternate Names:
6098 Gene ID MCF3 dGene Synonym ROS dGene Synonym Gene Info:
Gene Categories:
KINASE, TYROSINE KINASE Publications:
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- Version: 2020.06.01
Alternate Names:
ROS TTD Gene Abbreviation T20796 TTD Target ID Gene Info:
Publications:
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- Version: 2020.06.01
Alternate Names:
ROS1 TTD Gene Abbreviation T69128 TTD Target ID Gene Info:
Publications:
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- Version: 30-February-2014
Alternate Names:
Gene Info:
Publications:
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Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
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- Version: 03-September-2020
Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
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- Version: 04-September-2020
Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
-
Alternate Names:
Gene Info:
Publications:
-
Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications: