DGIdb - RIPK2 Gene Record

RIPK2 8767 Druggable Genome

Alternate Names:

8767
RECEPTOR INTERACTING SERINE/THREONINE KINASE 2
RIPK2
CARD3
CARDIAK
CCK
GIG30
RICK
RIP2
603455
10020
ENSG00000104312
OTTHUMG00000163809
2190
O43353
NP_003812
NM_003821
UNQ277/PRO314/PRO34092
RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2 (EC 2.7.1.37) (RIP-LIKE INTERACTING CLARP KINASE) (RECEPTOR-INTERACTING PROTEIN 2) (RIP-2) (CARD-CONTAINING INTERLEUKIN-1 BETA CONVERTING ENZYME ASSOCIATED KINASE) (CARD-CONTAINING IL-1 BETA ICE-KINAS
Receptor-interacting serine/threonine-protein kinase 2
BE0009532

Gene Info:

GuideToPharmacology Gene Category Name	Receptor interacting protein kinase (RIPK) family
GuideToPharmacology Gene Category ID	613
Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
ENZYME

Publications:

Degterev A et al., 2008, Identification of RIP1 kinase as a specific cellular target of necrostatins., Nat Chem Biol
Selig R et al., 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors., J Med Chem
Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect

PD-169316 RIPK2

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18408713

Sources:
DTC
SB-202190 RIPK2

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22951114

Sources:
DTC
PONATINIB RIPK2

Interaction Score: 0.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of recombinant RIPK2 in an <i>in vitro</i> ADP-Glo assay (Promega).

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
FOSTAMATINIB RIPK2

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
26516587

Sources:
DrugBank

Ensembl: ENSG00000104312
- Version: 101_38
Alternate Names:

RIPK2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000104312

Version: 26-July-2011

Alternate Names:

ENSG00000104312 Ensembl Gene Id

RIPK2 Display Id

RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2 (EC 2.7.1.37) (RIP-LIKE INTERACTING CLARP KINASE) (RECEPTOR-INTERACTING PROTEIN 2) (RIP-2) (CARD-CONTAINING INTERLEUKIN-1 BETA CONVERTING ENZYME ASSOCIATED KINASE) (CARD-CONTAINING IL-1 BETA ICE-KINAS Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

GuideToPharmacology: 8767
- Version: 29-September-2020
Alternate Names:

10020 HUGO Gene ID

10020 HUGO Gene Symbol

receptor interacting serine/threonine kinase 2 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Receptor interacting protein kinase (RIPK) family

GuideToPharmacology Gene Category ID 613

Gene Categories:

ENZYME

Publications:
DrugBank: BE0009532
- Version: 5.1.7
Alternate Names:

RIPK2 DrugBank Gene Name

O43353 UniProt Accession

8767 Entrez Gene Id

Gene Info:

Publications:

Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect

DTC: RIPK2

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Degterev A et al., 2008, Identification of RIP1 kinase as a specific cellular target of necrostatins., Nat Chem Biol

Selig R et al., 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors., J Med Chem

HingoraniCasas: ENSG00000104312
- Version: 31-May-2017
Alternate Names:

ENSG00000104312 Gene Symbol

RIPK2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: RIPK2
- Version: 03-September-2020
Alternate Names:

Receptor-interacting serine/threonine-protein kinase 2 Gene Name

O43353 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
GO: RIPK2
- Version: 05-September-2020
Alternate Names:

CARDIAK GO Gene Synonym

RICK GO Gene Synonym

RIP2 GO Gene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE

Publications:
dGene: RIPK2
- Version: 27-Jun-2013
Alternate Names:

8767 Gene ID

CARD3 dGene Synonym

CARDIAK dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:

Details of the Assay for Interaction	Inhibition of recombinant RIPK2 in an <i>in vitro</i> ADP-Glo assay (Promega).
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

ENSG00000104312	Ensembl Gene Id
RIPK2	Display Id
RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2 (EC 2.7.1.37) (RIP-LIKE INTERACTING CLARP KINASE) (RECEPTOR-INTERACTING PROTEIN 2) (RIP-2) (CARD-CONTAINING INTERLEUKIN-1 BETA CONVERTING ENZYME ASSOCIATED KINASE) (CARD-CONTAINING IL-1 BETA ICE-KINAS	Description

10020	HUGO Gene ID
10020	HUGO Gene Symbol
receptor interacting serine/threonine kinase 2	HUGO Gene Name

RIPK2	DrugBank Gene Name
O43353	UniProt Accession
8767	Entrez Gene Id

Receptor-interacting serine/threonine-protein kinase 2	Gene Name
O43353	UniProt ID

CARDIAK	GO Gene Synonym
RICK	GO Gene Synonym
RIP2	GO Gene Synonym

RIPK2 Gene Record

RIPK2 8767 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

PD-169316 RIPK2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18408713

Sources: DTC

SB-202190 RIPK2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22951114

Sources: DTC

PONATINIB RIPK2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction Inhibition of recombinant RIPK2 in an <i>in vitro</i> ADP-Glo assay (Promega). Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

FOSTAMATINIB RIPK2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 26516587

Sources: DrugBank

Ensembl: ENSG00000104312

Alternate Names: RIPK2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000104312

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

GuideToPharmacology: 8767

Alternate Names: 10020 HUGO Gene ID 10020 HUGO Gene Symbol receptor interacting serine/threonine kinase 2 HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name Receptor interacting protein kinase (RIPK) family GuideToPharmacology Gene Category ID 613

Gene Categories: ENZYME

Publications:

DrugBank: BE0009532

Alternate Names: RIPK2 DrugBank Gene Name O43353 UniProt Accession 8767 Entrez Gene Id

Gene Info:

Publications: Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect

DTC: RIPK2

Alternate Names:

Gene Info:

Publications: Degterev A et al., 2008, Identification of RIP1 kinase as a specific cellular target of necrostatins., Nat Chem Biol Selig R et al., 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors., J Med Chem

HingoraniCasas: ENSG00000104312

Alternate Names: ENSG00000104312 Gene Symbol RIPK2 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

Pharos: RIPK2

Alternate Names: Receptor-interacting serine/threonine-protein kinase 2 Gene Name O43353 UniProt ID

Gene Info:

Gene Categories: KINASE

Publications:

GO: RIPK2

Alternate Names: CARDIAK GO Gene Synonym RICK GO Gene Synonym RIP2 GO Gene Synonym

Gene Info:

Gene Categories: SERINE THREONINE KINASE

Publications:

dGene: RIPK2

Alternate Names: 8767 Gene ID CARD3 dGene Synonym CARDIAK dGene Synonym

Gene Info:

Gene Categories: KINASE, SERINE THREONINE KINASE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
18408713

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22951114

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of recombinant RIPK2 in an <i>in vitro</i> ADP-Glo assay (Promega).

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
26516587

Sources:
DrugBank

Alternate Names:

RIPK2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

10020 HUGO Gene ID

10020 HUGO Gene Symbol

receptor interacting serine/threonine kinase 2 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Receptor interacting protein kinase (RIPK) family

GuideToPharmacology Gene Category ID 613

Gene Categories:

ENZYME

Alternate Names:

RIPK2 DrugBank Gene Name

O43353 UniProt Accession

8767 Entrez Gene Id

Publications:

Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect

Publications:

Degterev A et al., 2008, Identification of RIP1 kinase as a specific cellular target of necrostatins., Nat Chem Biol

Selig R et al., 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors., J Med Chem

Alternate Names:

ENSG00000104312 Gene Symbol

RIPK2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

Receptor-interacting serine/threonine-protein kinase 2 Gene Name

O43353 UniProt ID

Gene Categories:

KINASE

Alternate Names:

CARDIAK GO Gene Synonym

RICK GO Gene Synonym

RIP2 GO Gene Synonym

Gene Categories:

SERINE THREONINE KINASE

Alternate Names:

8767 Gene ID

CARD3 dGene Synonym

CARDIAK dGene Synonym

Gene Categories:

KINASE, SERINE THREONINE KINASE