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REN Gene Record

  • Summary
  • Interactions
  • Claims
  • REN 5972 Druggable Genome

    Alternate Names:

    5972
    RENIN
    REN
    HNFJ2
    179820
    9958
    ENSG00000143839
    OTTHUMG00000036059
    BE0000270
    P00797
    PA297
    RENI_HUMAN
    Angiotensinogenase
    RENIN PRECURSOR (EC 3.4.23.15) (ANGIOTENSINOGENASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P00797]
    2413
    NP_000528
    NM_000537
    Angiotensinogenase renin
    T61622

    Gene Info:

    Human Readable Name PROTEASE
    Human Readable Name DRUGGABLE GENOME
    Target Class Enzymes
    Target Subclass EC:3.4.23.15
    Target Subclass 3.4.23.15
    Target Main Class Enzymes
    GuideToPharmacology Gene Category Name A1: Pepsin
    GuideToPharmacology Gene Category ID 726
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Peptidase_aspartic_AS
    Interpro Type Active_site
    Interpro Acc IPR001969
    Interpro Name Peptidase aspartic, active site
    Gene Biotype PROTEIN_CODING
    (10 More Sources)

    Gene Categories: Category Details

    PROTEASE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Nussberger et al., 2002, Angiotensin II suppression in humans by the orally active renin inhibitor Aliskiren (SPP100): comparison with enalapril., Hypertension
    Gradman et al., 2006, New drugs for hypertension: what do they offer?, Curr. Hypertens. Rep.
    Ménard et al., 2006, Conformational changes in prorenin during renin inhibition in vitro and in vivo., J. Hypertens.
    Wal P et al., 2011, Aliskiren: An orally active renin inhibitor., J Pharm Bioallied Sci
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Wood et al., 2003, Structure-based design of aliskiren, a novel orally effective renin inhibitor., Biochem. Biophys. Res. Commun.
    Azizi et al., 2006, Renin inhibition with aliskiren: where are we now, and where are we going?, J. Hypertens.
    Geese WJ et al., 2008, Genetic and gene expression studies implicate renin and endothelin-1 in edema caused by peroxisome proliferator-activated receptor gamma agonists., Pharmacogenet Genomics
    Kiowski et al., 1994, Angiotensinergic versus nonangiotensinergic hemodynamic effects of converting enzyme inhibition in patients with chronic heart failure. Assessment by acute renin and converting enzyme inhibition., Circulation
    Hilgers et al., 1994, Vascular renin in the guinea pig. Suppression by the renin inhibitor remikiren., Hypertension
    Clozel et al., 1993, Comparative effects of three different potent renin inhibitors in primates., Hypertension
    van Paassen et al., 1999, Pretreatment renal vascular tone predicts the effect of specific renin inhibition on natriuresis in essential hypertension., Eur. J. Clin. Invest.
    MacFadyen et al., 1995, Responses to an orally active renin inhibitor, remikiren (Ro 42-5892), after controlled salt depletion in humans., J. Cardiovasc. Pharmacol.
    Paulis L et al., 2015, New developments in the pharmacological treatment of hypertension: dead-end or a glimmer at the horizon?, Curr Hypertens Rep
    Glassman et al., 1990, Clinical pharmacology of enalkiren, a novel, dipeptide renin inhibitor., J. Cardiovasc. Pharmacol.
    Te Riet L et al., 2015, Hypertension: renin-angiotensin-aldosterone system alterations., Circ Res
    Werning C, 1976, The effect of minoxidil on blood pressure and plasma renin activity in patients with essential and renal hypertension., Klin Wochenschr
  • REMIKIREN   REN

    Interaction Score: 33.41

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    7994817 8206619 8319997 10583449 11752352 7769797


    Sources:
    TEND TdgClinicalTrial TTD DrugBank

  • ALISKIREN   REN

    Interaction Score: 20.05

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    11799102 16965731 16467656 21687346 11752352 12927775 16508564


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • 3-METHYLBUTANOL   REN

    Interaction Score: 13.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL1231778   REN

    Interaction Score: 13.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • ENALKIREN   REN

    Interaction Score: 10.02

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    1705633 11752352


    Sources:
    DrugBank

  • VTP-27999   REN

    Interaction Score: 10.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name VTP-27999
    Novel drug target Established target

    PMIDs:
    25893478


    Sources:
    TdgClinicalTrial TTD

  • CHEMBL240355   REN

    Interaction Score: 6.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL400431   REN

    Interaction Score: 6.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • DIMETHYLFORMAMIDE   REN

    Interaction Score: 4.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL230153   REN

    Interaction Score: 3.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • IMARIKIREN HYDROCHLORIDE   REN

    Interaction Score: 3.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TERLAKIREN   REN

    Interaction Score: 3.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ALISKIREN FUMARATE   REN

    Interaction Score: 3.34

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Renin inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • 1.ALPHA.-HYDROXYVITAMIN D5   REN

    Interaction Score: 1.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • MURAGLITAZAR   REN

    Interaction Score: 1.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18794727


    Sources:
    PharmGKB

  • LISINOPRIL   REN

    Interaction Score: 0.84

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    25767283


    Sources:
    DrugBank

  • MINOXIDIL   REN

    Interaction Score: 0.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    790007


    Sources:
    DrugBank

  • Ensembl: ENSG00000143839

    • Version: 101_38

    Alternate Names:
    REN Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P00797

    • Version: January-2014

    Alternate Names:
    REN Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.4.23.15

    Publications:

  • TEND: P00797

    • Version: 01-August-2011

    Alternate Names:
    REN Gene Symbol
    P00797 Uniprot Accession
    5972 Entrez Gene Id

    Gene Info:
    Target Subclass 3.4.23.15
    Target Main Class Enzymes

    Publications:

  • RussLampel: ENSG00000143839

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000143839 Ensembl Gene Id
    RENIN PRECURSOR (EC 3.4.23.15) (ANGIOTENSINOGENASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P00797] Description
    REN Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P00797

    • Version: 11-September-2012

    Alternate Names:
    REN Uniprot Gene Name
    RENI_HUMAN Uniprot Id
    5972 Entrez Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    PROTEASE, DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 5972

    • Version: 29-September-2020

    Alternate Names:
    9958 HUGO Gene ID
    9958 HUGO Gene Symbol
    renin HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name A1: Pepsin
    GuideToPharmacology Gene Category ID 726

    Gene Categories:
    ENZYME

    Publications:

  • PharmGKB: REN

    • Version: 18-August-2020

    Alternate Names:
    PA297 PharmGKB ID

    Gene Info:

    Publications:
    Geese WJ et al., 2008, Genetic and gene expression studies implicate renin and endothelin-1 in edema caused by peroxisome proliferator-activated receptor gamma agonists., Pharmacogenet Genomics

  • DrugBank: BE0000270

    • Version: 5.1.7

    Alternate Names:
    REN DrugBank Gene Name
    P00797 UniProt Accession
    5972 Entrez Gene Id

    Gene Info:

    Publications:
    Kiowski et al., 1994, Angiotensinergic versus nonangiotensinergic hemodynamic effects of converting enzyme inhibition in patients with chronic heart failure. Assessment by acute renin and converting enzyme inhibition., Circulation
    Hilgers et al., 1994, Vascular renin in the guinea pig. Suppression by the renin inhibitor remikiren., Hypertension
    Clozel et al., 1993, Comparative effects of three different potent renin inhibitors in primates., Hypertension

  • TTD: Angiotensinogenase renin

    • Version: 2020.06.01

    Alternate Names:
    REN TTD Gene Abbreviation
    T61622 TTD Target ID

    Gene Info:

    Publications:
    Paulis L et al., 2015, New developments in the pharmacological treatment of hypertension: dead-end or a glimmer at the horizon?, Curr Hypertens Rep

  • HingoraniCasas: ENSG00000143839

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000143839 Gene Symbol
    REN Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: REN

    • Version: chembl_23

    Alternate Names:
    REN GENE_SYMBOL
    Renin UNIPROT
    Angiotensinogenase UNIPROT

    Gene Info:

    Publications:

  • Pharos: REN

    • Version: 03-September-2020

    Alternate Names:
    Renin Gene Name
    P00797 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • dGene: REN

    • Version: 27-Jun-2013

    Alternate Names:
    5972 Gene ID
    HNFJ2 dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • GO: REN

    • Version: 05-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21