DGIdb - REN Gene Record

REN 5972 Druggable GenomeDrug Resistance

Alternate Names:

5972
RENIN
REN
HNFJ2
179820
9958
ENSG00000143839
OTTHUMG00000036059
BE0000270
P00797
PA297
RENI_HUMAN
Angiotensinogenase
RENIN PRECURSOR (EC 3.4.23.15) (ANGIOTENSINOGENASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P00797]
2413
NP_000528
NM_000537
Angiotensinogenase renin
T61622

Gene Info:

Human Readable Name	PROTEASE
Human Readable Name	DRUGGABLE GENOME
Target Class	Enzymes
Target Subclass	EC:3.4.23.15
Target Subclass	3.4.23.15
Target Main Class	Enzymes
GuideToPharmacology Gene Category Name	A1: Pepsin
GuideToPharmacology Gene Category ID	726
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	Peptidase_aspartic_AS
Interpro Type	Active_site
Interpro Acc	IPR001969
Interpro Name	Peptidase aspartic, active site
Gene Biotype	PROTEIN_CODING

(10 More Sources)

Gene Categories: Category Details

DRUG RESISTANCE
PROTEASE
DRUGGABLE GENOME
ENZYME

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Ménard et al., 2006, Conformational changes in prorenin during renin inhibition in vitro and in vivo., J. Hypertens.
Gradman et al., 2006, New drugs for hypertension: what do they offer?, Curr. Hypertens. Rep.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Azizi et al., 2006, Renin inhibition with aliskiren: where are we now, and where are we going?, J. Hypertens.
Wood et al., 2003, Structure-based design of aliskiren, a novel orally effective renin inhibitor., Biochem. Biophys. Res. Commun.
Nussberger et al., 2002, Angiotensin II suppression in humans by the orally active renin inhibitor Aliskiren (SPP100): comparison with enalapril., Hypertension
Wal P et al., 2011, Aliskiren: An orally active renin inhibitor., J Pharm Bioallied Sci
Geese WJ et al., 2008, Genetic and gene expression studies implicate renin and endothelin-1 in edema caused by peroxisome proliferator-activated receptor gamma agonists., Pharmacogenet Genomics
Kiowski et al., 1994, Angiotensinergic versus nonangiotensinergic hemodynamic effects of converting enzyme inhibition in patients with chronic heart failure. Assessment by acute renin and converting enzyme inhibition., Circulation
van Paassen et al., 1999, Pretreatment renal vascular tone predicts the effect of specific renin inhibition on natriuresis in essential hypertension., Eur. J. Clin. Invest.
MacFadyen et al., 1995, Responses to an orally active renin inhibitor, remikiren (Ro 42-5892), after controlled salt depletion in humans., J. Cardiovasc. Pharmacol.
Clozel et al., 1993, Comparative effects of three different potent renin inhibitors in primates., Hypertension
Hilgers et al., 1994, Vascular renin in the guinea pig. Suppression by the renin inhibitor remikiren., Hypertension
Paulis L et al., 2015, New developments in the pharmacological treatment of hypertension: dead-end or a glimmer at the horizon?, Curr Hypertens Rep
Glassman et al., 1990, Clinical pharmacology of enalkiren, a novel, dipeptide renin inhibitor., J. Cardiovasc. Pharmacol.
Te Riet L et al., 2015, Hypertension: renin-angiotensin-aldosterone system alterations., Circ Res
Werning C, 1976, The effect of minoxidil on blood pressure and plasma renin activity in patients with essential and renal hypertension., Klin Wochenschr

ALISKIREN FUMARATE REN

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Renin inhibitor

Publications:

ALISKIREN REN

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

Publications:

Ménard et al., 2006, Conformational changes in prorenin during renin inhibition in vitro and in vivo., J. Hypertens.

Gradman et al., 2006, New drugs for hypertension: what do they offer?, Curr. Hypertens. Rep.

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

REMIKIREN REN

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Publications:

Kiowski et al., 1994, Angiotensinergic versus nonangiotensinergic hemodynamic effects of converting enzyme inhibition in patients with chronic heart failure. Assessment by acute renin and converting enzyme inhibition., Circulation

van Paassen et al., 1999, Pretreatment renal vascular tone predicts the effect of specific renin inhibition on natriuresis in essential hypertension., Eur. J. Clin. Invest.

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

ENALKIREN REN

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Glassman et al., 1990, Clinical pharmacology of enalkiren, a novel, dipeptide renin inhibitor., J. Cardiovasc. Pharmacol.

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

LISINOPRIL REN

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Te Riet L et al., 2015, Hypertension: renin-angiotensin-aldosterone system alterations., Circ Res
VTP-27999 REN

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name VTP-27999

Novel drug target Established target

Publications:

Paulis L et al., 2015, New developments in the pharmacological treatment of hypertension: dead-end or a glimmer at the horizon?, Curr Hypertens Rep

DIMETHYLFORMAMIDE REN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

MURAGLITAZAR REN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Geese WJ et al., 2008, Genetic and gene expression studies implicate renin and endothelin-1 in edema caused by peroxisome proliferator-activated receptor gamma agonists., Pharmacogenet Genomics

MINOXIDIL REN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Werning C, 1976, The effect of minoxidil on blood pressure and plasma renin activity in patients with essential and renal hypertension., Klin Wochenschr
CHEMBL400431 REN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
CHEMBL240355 REN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
CHEMBL230153 REN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

CHEMBL1231778 REN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

3-METHYLBUTANOL REN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

TERLAKIREN REN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
IMARIKIREN HYDROCHLORIDE REN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
1.ALPHA.-HYDROXYVITAMIN D5 REN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ensembl: ENSG00000143839
- Version: 101_38
Alternate Names:

REN Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P00797
- Version: January-2014
Alternate Names:

REN Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.23.15

Publications:
TEND: P00797
- Version: 01-August-2011
Alternate Names:

REN Gene Symbol

P00797 Uniprot Accession

5972 Entrez Gene Id

Gene Info:

Target Subclass 3.4.23.15

Target Main Class Enzymes

Publications:
RussLampel: ENSG00000143839
- Version: 26-July-2011
Alternate Names:

ENSG00000143839 Ensembl Gene Id

RENIN PRECURSOR (EC 3.4.23.15) (ANGIOTENSINOGENASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P00797] Description

REN Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: P00797
- Version: 11-September-2012
Alternate Names:

REN Uniprot Gene Name

RENI_HUMAN Uniprot Id

5972 Entrez Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Uniprot Status Swiss-Prot

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

PROTEASE, DRUGGABLE GENOME

Publications:
GuideToPharmacology: 5972
- Version: 29-September-2020
Alternate Names:

9958 HUGO Gene ID

9958 HUGO Gene Symbol

renin HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name A1: Pepsin

GuideToPharmacology Gene Category ID 726

Gene Categories:

ENZYME

Publications:

PharmGKB: REN

Version: 18-August-2020

Alternate Names:

PA297 PharmGKB ID

Gene Info:

Publications:

Geese WJ et al., 2008, Genetic and gene expression studies implicate renin and endothelin-1 in edema caused by peroxisome proliferator-activated receptor gamma agonists., Pharmacogenet Genomics

DrugBank: BE0000270

Version: 5.1.7

Alternate Names:

REN DrugBank Gene Name

P00797 UniProt Accession

5972 Entrez Gene Id

Gene Info:

Publications:

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

MacFadyen et al., 1995, Responses to an orally active renin inhibitor, remikiren (Ro 42-5892), after controlled salt depletion in humans., J. Cardiovasc. Pharmacol.

Clozel et al., 1993, Comparative effects of three different potent renin inhibitors in primates., Hypertension

TTD: Angiotensinogenase renin
- Version: 2020.06.01
Alternate Names:

REN TTD Gene Abbreviation

T61622 TTD Target ID

Gene Info:

Publications:

Paulis L et al., 2015, New developments in the pharmacological treatment of hypertension: dead-end or a glimmer at the horizon?, Curr Hypertens Rep
HingoraniCasas: ENSG00000143839
- Version: 31-May-2017
Alternate Names:

ENSG00000143839 Gene Symbol

REN Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: REN
- Version: chembl_23
Alternate Names:

REN GENE_SYMBOL

Renin UNIPROT

Angiotensinogenase UNIPROT

Gene Info:

Publications:
Pharos: REN
- Version: 03-September-2020
Alternate Names:

Renin Gene Name

P00797 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
dGene: REN
- Version: 27-Jun-2013
Alternate Names:

5972 Gene ID

HNFJ2 dGene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:
GO: REN
- Version: 05-September-2020
Alternate Names:

Gene Info:

Gene Categories:

PROTEASE

Publications:

Direct Interaction	yes
Mechanism of Interaction	Renin inhibitor

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	True

ENSG00000143839	Ensembl Gene Id
RENIN PRECURSOR (EC 3.4.23.15) (ANGIOTENSINOGENASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P00797]	Description
REN	Display Id

REN	DrugBank Gene Name
P00797	UniProt Accession
5972	Entrez Gene Id

REN Gene Record

REN 5972 Druggable GenomeDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Renin inhibitor

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

Publications: Ménard et al., 2006, Conformational changes in prorenin during renin inhibition in vitro and in vivo., J. Hypertens. Gradman et al., 2006, New drugs for hypertension: what do they offer?, Curr. Hypertens. Rep. Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications: Glassman et al., 1990, Clinical pharmacology of enalkiren, a novel, dipeptide renin inhibitor., J. Cardiovasc. Pharmacol. Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications: Te Riet L et al., 2015, Hypertension: renin-angiotensin-aldosterone system alterations., Circ Res

Interaction Types & Directionality: n/a

Interaction Info: Trial Name VTP-27999 Novel drug target Established target

Publications: Paulis L et al., 2015, New developments in the pharmacological treatment of hypertension: dead-end or a glimmer at the horizon?, Curr Hypertens Rep

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res. Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Geese WJ et al., 2008, Genetic and gene expression studies implicate renin and endothelin-1 in edema caused by peroxisome proliferator-activated receptor gamma agonists., Pharmacogenet Genomics

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Werning C, 1976, The effect of minoxidil on blood pressure and plasma renin activity in patients with essential and renal hypertension., Klin Wochenschr

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Ensembl: ENSG00000143839

Alternate Names: REN Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P00797

Alternate Names: REN Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:3.4.23.15

Publications:

TEND: P00797

Alternate Names: REN Gene Symbol P00797 Uniprot Accession 5972 Entrez Gene Id

Gene Info: Target Subclass 3.4.23.15 Target Main Class Enzymes

Publications:

RussLampel: ENSG00000143839

Alternate Names: ENSG00000143839 Ensembl Gene Id RENIN PRECURSOR (EC 3.4.23.15) (ANGIOTENSINOGENASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P00797] Description REN Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: P00797

Alternate Names: REN Uniprot Gene Name RENI_HUMAN Uniprot Id 5972 Entrez Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME Uniprot Status Swiss-Prot Uniprot Evidence 1: Evidence at protein level

Gene Categories: PROTEASE, DRUGGABLE GENOME

Publications:

GuideToPharmacology: 5972

Alternate Names: 9958 HUGO Gene ID 9958 HUGO Gene Symbol renin HUGO Gene Name

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Renin inhibitor

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Interaction Types & Directionality:

inhibitor (inhibitory)

Publications:

Glassman et al., 1990, Clinical pharmacology of enalkiren, a novel, dipeptide renin inhibitor., J. Cardiovasc. Pharmacol.

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Interaction Types & Directionality:

inhibitor (inhibitory)

Publications:

Te Riet L et al., 2015, Hypertension: renin-angiotensin-aldosterone system alterations., Circ Res

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name VTP-27999

Novel drug target Established target

Publications:

Paulis L et al., 2015, New developments in the pharmacological treatment of hypertension: dead-end or a glimmer at the horizon?, Curr Hypertens Rep

Interaction Types & Directionality:

n/a

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Interaction Types & Directionality:

n/a

Publications:

Geese WJ et al., 2008, Genetic and gene expression studies implicate renin and endothelin-1 in edema caused by peroxisome proliferator-activated receptor gamma agonists., Pharmacogenet Genomics

Interaction Types & Directionality:

n/a

Publications:

Werning C, 1976, The effect of minoxidil on blood pressure and plasma renin activity in patients with essential and renal hypertension., Klin Wochenschr

Interaction Types & Directionality:

n/a

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types & Directionality:

n/a

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types & Directionality:

n/a

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types & Directionality:

n/a

Publications:

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types & Directionality:

n/a

Publications:

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Alternate Names:

REN Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

REN Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.23.15

Alternate Names:

REN Gene Symbol

P00797 Uniprot Accession

5972 Entrez Gene Id

Gene Info:

Target Subclass 3.4.23.15

Target Main Class Enzymes

Alternate Names:

ENSG00000143839 Ensembl Gene Id

RENIN PRECURSOR (EC 3.4.23.15) (ANGIOTENSINOGENASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P00797] Description

REN Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

REN Uniprot Gene Name

RENI_HUMAN Uniprot Id

5972 Entrez Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Uniprot Status Swiss-Prot

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

PROTEASE, DRUGGABLE GENOME

Alternate Names:

9958 HUGO Gene ID

9958 HUGO Gene Symbol

renin HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name A1: Pepsin

GuideToPharmacology Gene Category ID 726

Gene Categories:

ENZYME

Alternate Names:

PA297 PharmGKB ID

Publications:

Geese WJ et al., 2008, Genetic and gene expression studies implicate renin and endothelin-1 in edema caused by peroxisome proliferator-activated receptor gamma agonists., Pharmacogenet Genomics

Alternate Names:

REN DrugBank Gene Name

P00797 UniProt Accession

5972 Entrez Gene Id

Alternate Names:

REN TTD Gene Abbreviation

T61622 TTD Target ID

Publications:

Paulis L et al., 2015, New developments in the pharmacological treatment of hypertension: dead-end or a glimmer at the horizon?, Curr Hypertens Rep

Alternate Names:

ENSG00000143839 Gene Symbol

REN Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

REN GENE_SYMBOL

Renin UNIPROT

Angiotensinogenase UNIPROT

Alternate Names:

Renin Gene Name

P00797 UniProt ID

Gene Categories:

ENZYME

Alternate Names:

5972 Gene ID

HNFJ2 dGene Synonym

Gene Categories:

PROTEASE

Gene Categories:

PROTEASE