• Interaction Score: 0.93

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type T-cell adult acute lymphocytic leukemia
    Response Type resistant
    Approval Status Preclinical - Cell culture

  • Interaction Score: 0.82

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type lung small cell carcinoma
    Response Type resistant
    Approval Status Preclinical - Cell line xenograft

    PMIDs:
    26826116


    Sources:
    JAX-CKB

  • Interaction Score: 0.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type lung small cell carcinoma
    Response Type predicted – resistant
    Approval Status Clinical Study

    PMIDs:
    28285684


    Sources:
    JAX-CKB

  • Interaction Score: 0.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Drug family CDK4/6 inhibitor
    Alteration RB1:over
    Indication/Tumor Type glioblastoma multiforme

  • Interaction Score: 0.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type retinoblastoma
    Response Type sensitive
    Approval Status Preclinical - Cell line xenograft


    Sources:
    JAX-CKB

  • Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Evidence Type Actionable
    Approval Status Preclinical - Cell line xenograft
    Response Type sensitive

    PMIDs:
    26826116


    Sources:
    JAX-CKB

  • Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21417417


    Sources:
    DTC

  • Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Evidence Type Actionable
    Approval Status Preclinical - Cell culture
    Response Type decreased response

    PMIDs:
    28151717


    Sources:
    JAX-CKB

  • Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type skin cancer
    Response Type sensitive
    Approval Status Preclinical

    PMIDs:
    25261369


    Sources:
    JAX-CKB

  • Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Ribociclib + Prednisolone
    Indication/Tumor Type T-cell adult acute lymphocytic leukemia
    Response Type sensitive

    PMIDs:
    28151717


    Sources:
    JAX-CKB

  • Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type retinoblastoma
    Response Type sensitive
    Approval Status Preclinical


    Sources:
    JAX-CKB

  • Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Palbociclib + GDC-0941
    Indication/Tumor Type triple-receptor negative breast cancer
    Response Type no benefit

    PMIDs:
    27020857


    Sources:
    JAX-CKB

  • Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type retinoblastoma
    Response Type sensitive
    Approval Status Preclinical - Cell culture


    Sources:
    JAX-CKB

  • Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25002028


    Sources:
    CIViC

  • Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Ribociclib + Mercaptopurine
    Indication/Tumor Type T-cell adult acute lymphocytic leukemia
    Response Type decreased response

    PMIDs:
    28151717


    Sources:
    JAX-CKB

  • Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Ribociclib + Everolimus
    Indication/Tumor Type T-cell adult acute lymphocytic leukemia
    Response Type sensitive

    PMIDs:
    28151717


    Sources:
    JAX-CKB

  • Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Evidence Type Actionable
    Approval Status Preclinical - Cell culture
    Response Type decreased response

    PMIDs:
    27488531


    Sources:
    JAX-CKB

  • Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Ribociclib + Dexamethasone
    Indication/Tumor Type T-cell adult acute lymphocytic leukemia
    Response Type sensitive

    PMIDs:
    28151717


    Sources:
    JAX-CKB

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Ribociclib + Bortezomib
    Indication/Tumor Type T-cell adult acute lymphocytic leukemia
    Response Type sensitive

    PMIDs:
    28151717


    Sources:
    JAX-CKB

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Ribociclib + Methotrexate
    Indication/Tumor Type T-cell adult acute lymphocytic leukemia
    Response Type decreased response

    PMIDs:
    28151717


    Sources:
    JAX-CKB

  • Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type retinoblastoma
    Response Type sensitive
    Approval Status Preclinical

    PMIDs:
    22237022


    Sources:
    JAX-CKB

  • Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Drug family Chemotherapy
    Alteration RB1:.
    Alteration RB1:del

    PMIDs:
    None found


    Sources:
    CGI