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RARA Gene Record

  • Summary
  • Interactions
  • Claims
  • RARA 5914 Druggable GenomeClinically Actionable

    Alternate Names:

    5914
    RETINOIC ACID RECEPTOR ALPHA
    RARA
    NR1B1
    RAR
    180240
    9864
    ENSG00000131759
    OTTHUMG00000133328
    Nuclear receptor subfamily 1 group B member 1
    RAR-alpha
    P10276
    RARA_HUMAN
    590
    NP_001138773|NP_001019980
    NM_001145302
    Retinoic acid receptor-α
    RETINOIC ACID RECEPTOR ALPHA (RAR-ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P10276]
    PA34225
    BE0000663
    T94085

    Gene Info:

    Target Class Receptors
    Target Subclass Nuclear receptor
    GuideToPharmacology Gene Category Name 1B. Retinoic acid receptors
    GuideToPharmacology Gene Category ID 85
    Human Readable Name DRUGGABLE GENOME
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Uniprot Status Swiss-Prot
    Human Readable Name NUCLEAR HORMONE RECEPTOR
    Interpro Acc IPR000536
    Interpro Short Name Nucl_hrmn_rcpt_lig-bd_core
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Initial Gene Query NR1B1
    Counted Citations from 1950-2000 2172
    Target Main Class Receptors
    Gene Biotype PROTEIN_CODING
    (17 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    TRANSCRIPTION FACTOR BINDING
    NUCLEAR HORMONE RECEPTOR
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE

    Publications:

    Baumann et al., 2005, Open-label pilot study of alitretinoin gel 0.1% in the treatment of photoaging., Cutis
    Ritter et al., 2006, Inhibition of retinoic acid receptor signaling by Ski in acute myeloid leukemia., Leukemia
    Cheng et al., 2008, Alitretinoin: a comprehensive review., Expert Opin Investig Drugs
    Schrage et al., 2006, Macrophages and neurons are targets of retinoic acid signaling after spinal cord contusion injury., Eur. J. Neurosci.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Rasooly et al., 2005, Retinoid x receptor agonists increase bcl2a1 expression and decrease apoptosis of naive T lymphocytes., J. Immunol.
    Pathirana C et al., 1994, Identification of an activator of the retinoid X receptor., J Nat Prod
    Milliano et al., 2005, Rat hepatic stellate cells become retinoid unresponsive during activation., Hepatol. Res.
    Nakashima K et al., 2015, Xanthones from the roots of Maclura cochinchinensis var. gerontogea and their retinoic acid receptor-α agonistic activity., Bioorg Med Chem Lett
    Ghyselinck NB et al., 2019, Retinoic acid signaling pathways., Development
    Piérard GE et al., 2009, Spotlight on adapalene., Expert Opin Drug Metab Toxicol
    Shroot et al., 1998, A new concept of drug delivery for acne., Dermatology (Basel)
    Shroot et al., 1997, Pharmacology and chemistry of adapalene., J. Am. Acad. Dermatol.
    Griffiths et al., 1998, Adapalene 0.1% gel and adapalene 0.1% cream stimulate retinoic acid receptor mediated gene transcription without significant irritative effects in the skin of healthy human volunteers., Br. J. Dermatol.
    Kim et al., 2000, The role of specific retinoid receptors in sebocyte growth and differentiation in culture., J. Invest. Dermatol.
    Michel et al., 1998, Pharmacology of adapalene., Br. J. Dermatol.
    Pergolizzi et al., 1999, Role of retinoic acid receptor overexpression in sensitivity to fenretinide and tumorigenicity of human ovarian carcinoma cells., Int. J. Cancer
    Grillier et al., 1997, Alterations of differentiation, clonal proliferation, cell cycle progression and bcl-2 expression in RAR alpha-altered sublines of HL-60., Leukemia
    Jimi et al., 2007, RARalpha is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells., Int. J. Oncol.
    Sanda et al., 2005, Antimyeloma effects of a novel synthetic retinoid Am80 (Tamibarotene) through inhibition of angiogenesis., Leukemia
    Miwako et al., 2007, Tamibarotene., Drugs Today
    2004, Tamibarotene: AM 80, retinobenzoic acid, Tamibaro., Drugs R D
    Tanabe H et al., 2014, Retinoic acid receptor agonist activity of naturally occurring diterpenes., Bioorg Med Chem
    Dahl et al., 2000, Inhaled isotretinoin (13-cis retinoic acid) is an effective lung cancer chemopreventive agent in A/J mice at low doses: a pilot study., Clin. Cancer Res.
    Vu-Dac et al., 1998, Retinoids increase human apo C-III expression at the transcriptional level via the retinoid X receptor. Contribution to the hypertriglyceridemic action of retinoids., J. Clin. Invest.
    Taylor et al., Altered gene expression in murine branchial arches following in utero exposure to retinoic acid., J. Craniofac. Genet. Dev. Biol.
    Zouboulis, 2006, Isotretinoin revisited: pluripotent effects on human sebaceous gland cells., J. Invest. Dermatol.
    Yen et al., 2004, A retinoic acid receptor beta/gamma-selective prodrug (tazarotene) plus a retinoid X receptor ligand induces extracellular signal-regulated kinase activation, retinoblastoma hypophosphorylation, G0 arrest, and cell differentiation., Mol. Pharmacol.
    Nagpal et al., 2000, Recent developments in receptor-selective retinoids., Curr. Pharm. Des.
    Meder et al., 2003, Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23., FEBS Lett.
    Chandraratna, 1996, Tazarotene--first of a new generation of receptor-selective retinoids., Br. J. Dermatol.
    Wang et al., 2001, 1,25-dihydroxyvitamin D3 and retonic acid analogues induce differentiation in breast cancer cells with function- and cell-specific additive effects., Breast Cancer Res. Treat.
    Kim H et al., 2008, Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative., Bioorg Med Chem
    Grummer et al., 1995, Postnatal rat lung retinoic acid receptor (RAR) mRNA expression and effects of dexamethasone on RAR beta mRNA., Pediatr. Pulmonol.
    Ben-Dor et al., 2001, Effects of acyclo-retinoic acid and lycopene on activation of the retinoic acid receptor and proliferation of mammary cancer cells., Arch. Biochem. Biophys.
    Kiefer et al., 2005, Differential regulation of estrogen receptor alpha, glucocorticoid receptor and retinoic acid receptor alpha transcriptional activity by melatonin is mediated via different G proteins., J. Pineal Res.
    Mou et al., 2004, RXR-induced TNF-alpha suppression is reversed by morphine in activated U937 cells., J. Neuroimmunol.
    Orfanos et al., 1997, Current use and future potential role of retinoids in dermatology., Drugs
    Saurat, 1999, Retinoids and psoriasis: novel issues in retinoid pharmacology and implications for psoriasis treatment., J. Am. Acad. Dermatol.
    Tippmann et al., 2009, Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin., FASEB J.
    Tian et al., 1997, The isolation and characterization of purified heterocomplexes of recombinant retinoic acid receptor and retinoid X receptor ligand binding domains., Biochemistry
    Vollberg TM Sr et al., 1992, Retinoic acid receptors as regulators of human epidermal keratinocyte differentiation., Mol Endocrinol
    Harnish et al., 1990, Induction of beta-retinoic acid receptor mRNA by teratogenic doses of retinoids in murine fetuses., Differentiation
    Billoni et al., 1997, Expression of retinoid nuclear receptor superfamily members in human hair follicles and its implication in hair growth., Acta Derm. Venereol.
    Zitnik et al., 1994, Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts., J. Immunol.
    Stromskaya et al., 1998, Influence of exogenous RAR alpha gene on MDR1 expression and P-glycoprotein function in human and rodent cell lines., Br. J. Cancer
    Dvorák et al., 2007, Expression, protein stability and transcriptional activity of retinoic acid receptors are affected by microtubules interfering agents and all-trans-retinoic acid in primary rat hepatocytes., Mol. Cell. Endocrinol.
    Lorenzo P et al., 2008, Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids., J Med Chem
    Chen et al., 1999, Combination of all-trans retinoic acid with butyric acid and its prodrugs markedly enhancing differentiation of human acute promyelocytic leukemia NB4 cells., Chin. Med. J.
    Aubert J et al., 2018, Nonclinical and human pharmacology of the potent and selective topical retinoic acid receptor-γ agonist trifarotene., Br J Dermatol
    Seale et al., 1996, Quantification of PML-RAR alpha transcripts in acute promyelocytic leukaemia: explanation for the lack of sensitivity of RT-PCR for the detection of minimal residual disease and induction of the leukaemia-specific mRNA by alpha interferon., Br. J. Haematol.
    Brtko et al., 1997, Nuclear all-trans retinoic acid receptors in liver of rats with diet-induced insulin resistance., Ann. N. Y. Acad. Sci.
    Alvarez S et al., 2008, New retinoid chemotypes: 9-cis-retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists., Bioorg Med Chem
  • TAMIBAROTENE   RARA

    Interaction Score: 4.58

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    17611697 15843826 17925887 15563242 11752352


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • NRX195183   RARA

    Interaction Score: 3.66

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoic acid receptor alpha agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    TTD ChemblInteractions

  • GERONTOXANTHONE B   RARA

    Interaction Score: 3.66

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25838141


    Sources:
    DTC

  • GERONTOXANTHONE A   RARA

    Interaction Score: 3.66

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25838141


    Sources:
    DTC

  • TAZAROTENE   RARA

    Interaction Score: 2.52

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoic acid receptor agonist
    Direct Interaction yes
    Trial Name tazarotene,Tazorac

    PMIDs:
    16144296 15383624 10828316 14675762 9035701 11519864


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

  • ADAPALENE   RARA

    Interaction Score: 2.2

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Mechanism of Interaction Retinoic acid receptor agonist

    PMIDs:
    31273085 19929446 9557255 9204085 9990415 10651997 9990413


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

  • ALITRETINOIN   RARA

    Interaction Score: 1.99

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    16144296 16424870 18321241 16420438 11752352 16339527 7807131 16253547


    Sources:
    TEND DTC DrugBank GuideToPharmacology ChemblInteractions

  • TRIFAROTENE   RARA

    Interaction Score: 1.83

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Details of the Assay for Interaction In a reported assay measuring activation mediated by agonist binding to the RARα ligand-binding domain.
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

    PMIDs:
    29974453


    Sources:
    DrugBank GuideToPharmacology

  • PIMARIC ACID   RARA

    Interaction Score: 1.83

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24799257


    Sources:
    DTC

  • ETRETINATE   RARA

    Interaction Score: 1.83

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Retinoid receptor agonist

    PMIDs:
    1965892 9074840 10459139 9298126 8301142


    Sources:
    DrugBank ChemblInteractions

  • RETINYLRETINOATE   RARA

    Interaction Score: 1.83

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18511283


    Sources:
    DTC

  • ISOTRETINOIN   RARA

    Interaction Score: 1.5

    Interaction Types & Directionality:
    agonist (activating)
    other/unknown

    Interaction Info:
    Mechanism of Interaction Retinoic acid receptor agonist
    Direct Interaction yes
    Trial Name CIP-isotretinoin

    PMIDs:
    10955779 9691099 7601910 9204085 16983322


    Sources:
    TEND TdgClinicalTrial DrugBank ChemblInteractions

  • CHEMBL472172   RARA

    Interaction Score: 1.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18702457


    Sources:
    DTC

  • ABIETIC ACID   RARA

    Interaction Score: 1.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24799257


    Sources:
    DTC

  • TRIBUTYRIN   RARA

    Interaction Score: 0.92

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11593538


    Sources:
    NCI

  • ACITRETIN   RARA

    Interaction Score: 0.86

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Retinoid receptor agonist

    PMIDs:
    9074840 10459139 19144697 9153406


    Sources:
    TEND TdgClinicalTrial DrugBank ChemblInteractions

  • IRX4310   RARA

    Interaction Score: 0.61

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Retinoic acid receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GERONTOXANTHONE H   RARA

    Interaction Score: 0.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25838141


    Sources:
    DTC

  • DIMETHYL SULFOXIDE   RARA

    Interaction Score: 0.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9067579


    Sources:
    NCI

  • LYCOPENE   RARA

    Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11437362


    Sources:
    NCI

  • TRETINOIN   RARA

    Interaction Score: 0.37

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Retinoic acid receptor agonist
    Specific Action of the Ligand Agonist

    PMIDs:
    25838141 18511283 1318502


    Sources:
    DTC FDA PharmGKB DrugBank GuideToPharmacology ChemblInteractions

  • MOFAROTENE   RARA

    Interaction Score: 0.31

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Retinoid receptor modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHEMBL275311   RARA

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18951029


    Sources:
    DTC

  • RETINOL   RARA

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18511283


    Sources:
    DTC

  • NALOXONE   RARA

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14741437


    Sources:
    NCI

  • FENRETINIDE   RARA

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name fenretinide, RT-101
    Novel drug target Established target

    PMIDs:
    10328240


    Sources:
    NCI TdgClinicalTrial

  • COLCHICINE   RARA

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9667638 17291686


    Sources:
    NCI

  • MELATONIN   RARA

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15813899


    Sources:
    NCI

  • CETUXIMAB   RARA

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8857944


    Sources:
    NCI

  • INSULIN   RARA

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9329777


    Sources:
    NCI

  • DEXAMETHASONE   RARA

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8606853


    Sources:
    NCI

  • Ensembl: ENSG00000131759

    • Version: 101_38

    Alternate Names:
    RARA Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • BaderLabGenes: RARA

    • Version: February-2014

    Alternate Names:
    5914 Entrez Gene ID

    Gene Info:
    Initial Gene Query NR1B1
    Counted Citations from 1950-2000 2172

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • TEND: P10276

    • Version: 01-August-2011

    Alternate Names:
    P10276 Uniprot Accession
    RARA Gene Symbol
    5914 Entrez Gene Id

    Gene Info:
    Target Subclass Nuclear receptor
    Target Main Class Receptors

    Publications:

  • RussLampel: ENSG00000131759

    • Version: 26-July-2011

    Alternate Names:
    RARA Display Id
    RETINOIC ACID RECEPTOR ALPHA (RAR-ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P10276] Description
    ENSG00000131759 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P10276

    • Version: 11-September-2012

    Alternate Names:
    5914 Entrez Gene Id
    RARA_HUMAN Uniprot Id
    ENSG00000131759 Ensembl Gene Id

    Gene Info:
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Uniprot Status Swiss-Prot
    Human Readable Name NUCLEAR HORMONE RECEPTOR

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P10276

    • Version: January-2014

    Alternate Names:
    RARA Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Nuclear receptor

    Publications:

  • GuideToPharmacology: 5914

    • Version: 29-September-2020

    Alternate Names:
    9864 HUGO Gene ID
    9864 HUGO Gene Symbol
    retinoic acid receptor alpha HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name 1B. Retinoic acid receptors
    GuideToPharmacology Gene Category ID 85

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • DrugBank: BE0000663

    • Version: 5.1.7

    Alternate Names:
    RARA DrugBank Gene Name
    P10276 UniProt Accession
    5914 Entrez Gene Id

    Gene Info:

    Publications:
    Ghyselinck NB et al., 2019, Retinoic acid signaling pathways., Development
    Piérard GE et al., 2009, Spotlight on adapalene., Expert Opin Drug Metab Toxicol
    Shroot et al., 1997, Pharmacology and chemistry of adapalene., J. Am. Acad. Dermatol.

  • NCI: RARA

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Grillier et al., 1997, Alterations of differentiation, clonal proliferation, cell cycle progression and bcl-2 expression in RAR alpha-altered sublines of HL-60., Leukemia
    Chen et al., 1999, Combination of all-trans retinoic acid with butyric acid and its prodrugs markedly enhancing differentiation of human acute promyelocytic leukemia NB4 cells., Chin. Med. J.
    Fitzgerald et al., 1997, Retinoic acid receptor alpha expression correlates with retinoid-induced growth inhibition of human breast cancer cells regardless of estrogen receptor status., Cancer Res.

  • DTC: RARA

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Pathirana C et al., 1994, Identification of an activator of the retinoid X receptor., J Nat Prod
    Nakashima K et al., 2015, Xanthones from the roots of Maclura cochinchinensis var. gerontogea and their retinoic acid receptor-α agonistic activity., Bioorg Med Chem Lett
    Alvarez S et al., 2008, New retinoid chemotypes: 9-cis-retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists., Bioorg Med Chem

  • HingoraniCasas: ENSG00000131759

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000131759 Gene Symbol
    RARA Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: NR1B1

    • Version: chembl_23

    Alternate Names:
    NR1B1 GENE_SYMBOL
    RARA GENE_SYMBOL
    Retinoic acid receptor alpha UNIPROT

    Gene Info:

    Publications:

  • PharmGKB: RARA

    • Version: 18-August-2020

    Alternate Names:
    PA34225 PharmGKB ID

    Gene Info:

    Publications:

  • GO: RARA

    • Version: 05-September-2020

    Alternate Names:
    NR1B1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, TRANSCRIPTION FACTOR BINDING, NUCLEAR HORMONE RECEPTOR

    Publications:

  • Tempus: RARA

    • Version: 11-November-2018

    Alternate Names:
    RARA Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • dGene: RARA

    • Version: 27-Jun-2013

    Alternate Names:
    5914 Gene ID
    NR1B1 dGene Synonym
    RAR dGene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • TTD: Retinoic acid receptor alpha

    • Version: 2020.06.01

    Alternate Names:
    RARA TTD Gene Abbreviation
    T94085 TTD Target ID

    Gene Info:

    Publications:

  • MskImpact: RARA

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: RARA

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: RARA

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FDA: RARA

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21