DGIdb - RARA Gene Record

RARA 5914 Druggable GenomeClinically Actionable

Alternate Names:

5914
RETINOIC ACID RECEPTOR ALPHA
RARA
NR1B1
RAR
180240
9864
ENSG00000131759
OTTHUMG00000133328
Nuclear receptor subfamily 1 group B member 1
RAR-alpha
P10276
RARA_HUMAN
590
NP_001138773\|NP_001019980
NM_001145302
Retinoic acid receptor-α
retinoic acid receptor, alpha
RETINOIC ACID RECEPTOR ALPHA (RAR-ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P10276]
PA34225
TTDS00073
RAR ALPHA
BE0000663
T94085

Gene Info:

Source Reported Gene Name	RARA
Target Class	Receptors
Target Subclass	Nuclear receptor
GuideToPharmacology Gene Category Name	1B. Retinoic acid receptors
GuideToPharmacology Gene Category ID	85
GuideToPharmacology Gene Type	nhr
Human Readable Name	DRUGGABLE GENOME
Is VIP	false
Has Variant Annotation	false
Interpro Name	Nuclear hormone receptor, ligand-binding, core
Uniprot Status	Swiss-Prot
Human Readable Name	NUCLEAR HORMONE RECEPTOR
Interpro Acc	IPR000536
Interpro Short Name	Nucl_hrmn_rcpt_lig-bd_core
Interpro Type	Domain
Uniprot Evidence	1: Evidence at protein level
Initial Gene Query	NR1B1
Counted Citations from 1950-2000	2172
Target Main Class	Receptors
Gene Biotype	PROTEIN_CODING

(18 More Sources)

Gene Categories: Category Details

CELL SURFACE
TUMOR SUPPRESSOR
TRANSCRIPTION FACTOR BINDING
NUCLEAR HORMONE RECEPTOR
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Pathirana C et al., 1994, Identification of an activator of the retinoid X receptor., J Nat Prod
Cheng et al., 2008, Alitretinoin: a comprehensive review., Expert Opin Investig Drugs
Ritter et al., 2006, Inhibition of retinoic acid receptor signaling by Ski in acute myeloid leukemia., Leukemia
Schrage et al., 2006, Macrophages and neurons are targets of retinoic acid signaling after spinal cord contusion injury., Eur. J. Neurosci.
Baumann et al., 2005, Open-label pilot study of alitretinoin gel 0.1% in the treatment of photoaging., Cutis
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Milliano et al., 2005, Rat hepatic stellate cells become retinoid unresponsive during activation., Hepatol. Res.
Rasooly et al., 2005, Retinoid x receptor agonists increase bcl2a1 expression and decrease apoptosis of naive T lymphocytes., J. Immunol.
Nakashima K et al., 2015, Xanthones from the roots of Maclura cochinchinensis var. gerontogea and their retinoic acid receptor-α agonistic activity., Bioorg Med Chem Lett
Shroot et al., 1998, A new concept of drug delivery for acne., Dermatology (Basel)
Michel et al., 1998, Pharmacology of adapalene., Br. J. Dermatol.
Kim et al., 2000, The role of specific retinoid receptors in sebocyte growth and differentiation in culture., J. Invest. Dermatol.
Griffiths et al., 1998, Adapalene 0.1% gel and adapalene 0.1% cream stimulate retinoic acid receptor mediated gene transcription without significant irritative effects in the skin of healthy human volunteers., Br. J. Dermatol.
Shroot et al., 1997, Pharmacology and chemistry of adapalene., J. Am. Acad. Dermatol.
Piérard GE et al., 2009, Spotlight on adapalene., Expert Opin Drug Metab Toxicol
Ghyselinck NB et al., 2019, Retinoic acid signaling pathways., Development
Pergolizzi et al., 1999, Role of retinoic acid receptor overexpression in sensitivity to fenretinide and tumorigenicity of human ovarian carcinoma cells., Int. J. Cancer
Grillier et al., 1997, Alterations of differentiation, clonal proliferation, cell cycle progression and bcl-2 expression in RAR alpha-altered sublines of HL-60., Leukemia
Miwako et al., 2007, Tamibarotene., Drugs Today
Sanda et al., 2005, Antimyeloma effects of a novel synthetic retinoid Am80 (Tamibarotene) through inhibition of angiogenesis., Leukemia
Jimi et al., 2007, RARalpha is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells., Int. J. Oncol.
2004, Tamibarotene: AM 80, retinobenzoic acid, Tamibaro., Drugs R D
Tanabe H et al., 2014, Retinoic acid receptor agonist activity of naturally occurring diterpenes., Bioorg Med Chem
Taylor et al., Altered gene expression in murine branchial arches following in utero exposure to retinoic acid., J. Craniofac. Genet. Dev. Biol.
Dahl et al., 2000, Inhaled isotretinoin (13-cis retinoic acid) is an effective lung cancer chemopreventive agent in A/J mice at low doses: a pilot study., Clin. Cancer Res.
Zouboulis, 2006, Isotretinoin revisited: pluripotent effects on human sebaceous gland cells., J. Invest. Dermatol.
Vu-Dac et al., 1998, Retinoids increase human apo C-III expression at the transcriptional level via the retinoid X receptor. Contribution to the hypertriglyceridemic action of retinoids., J. Clin. Invest.
Wang et al., 2001, 1,25-dihydroxyvitamin D3 and retonic acid analogues induce differentiation in breast cancer cells with function- and cell-specific additive effects., Breast Cancer Res. Treat.
Nagpal et al., 2000, Recent developments in receptor-selective retinoids., Curr. Pharm. Des.
Chandraratna, 1996, Tazarotene--first of a new generation of receptor-selective retinoids., Br. J. Dermatol.
Yen et al., 2004, A retinoic acid receptor beta/gamma-selective prodrug (tazarotene) plus a retinoid X receptor ligand induces extracellular signal-regulated kinase activation, retinoblastoma hypophosphorylation, G0 arrest, and cell differentiation., Mol. Pharmacol.
Meder et al., 2003, Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23., FEBS Lett.
Kim H et al., 2008, Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative., Bioorg Med Chem
Grummer et al., 1995, Postnatal rat lung retinoic acid receptor (RAR) mRNA expression and effects of dexamethasone on RAR beta mRNA., Pediatr. Pulmonol.
Ben-Dor et al., 2001, Effects of acyclo-retinoic acid and lycopene on activation of the retinoic acid receptor and proliferation of mammary cancer cells., Arch. Biochem. Biophys.
Kiefer et al., 2005, Differential regulation of estrogen receptor alpha, glucocorticoid receptor and retinoic acid receptor alpha transcriptional activity by melatonin is mediated via different G proteins., J. Pineal Res.
Mou et al., 2004, RXR-induced TNF-alpha suppression is reversed by morphine in activated U937 cells., J. Neuroimmunol.
Saurat, 1999, Retinoids and psoriasis: novel issues in retinoid pharmacology and implications for psoriasis treatment., J. Am. Acad. Dermatol.
Tippmann et al., 2009, Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin., FASEB J.
Tian et al., 1997, The isolation and characterization of purified heterocomplexes of recombinant retinoic acid receptor and retinoid X receptor ligand binding domains., Biochemistry
Orfanos et al., 1997, Current use and future potential role of retinoids in dermatology., Drugs
Vollberg TM Sr et al., 1992, Retinoic acid receptors as regulators of human epidermal keratinocyte differentiation., Mol Endocrinol
Harnish et al., 1990, Induction of beta-retinoic acid receptor mRNA by teratogenic doses of retinoids in murine fetuses., Differentiation
Zitnik et al., 1994, Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts., J. Immunol.
Billoni et al., 1997, Expression of retinoid nuclear receptor superfamily members in human hair follicles and its implication in hair growth., Acta Derm. Venereol.
Stromskaya et al., 1998, Influence of exogenous RAR alpha gene on MDR1 expression and P-glycoprotein function in human and rodent cell lines., Br. J. Cancer
Dvorák et al., 2007, Expression, protein stability and transcriptional activity of retinoic acid receptors are affected by microtubules interfering agents and all-trans-retinoic acid in primary rat hepatocytes., Mol. Cell. Endocrinol.
Lorenzo P et al., 2008, Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids., J Med Chem
Chen et al., 1999, Combination of all-trans retinoic acid with butyric acid and its prodrugs markedly enhancing differentiation of human acute promyelocytic leukemia NB4 cells., Chin. Med. J.
Aubert J et al., 2018, Nonclinical and human pharmacology of the potent and selective topical retinoic acid receptor-γ agonist trifarotene., Br J Dermatol
Seale et al., 1996, Quantification of PML-RAR alpha transcripts in acute promyelocytic leukaemia: explanation for the lack of sensitivity of RT-PCR for the detection of minimal residual disease and induction of the leukaemia-specific mRNA by alpha interferon., Br. J. Haematol.
Brtko et al., 1997, Nuclear all-trans retinoic acid receptors in liver of rats with diet-induced insulin resistance., Ann. N. Y. Acad. Sci.
Alvarez S et al., 2008, New retinoid chemotypes: 9-cis-retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists., Bioorg Med Chem

TRETINOIN RARA

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Retinoic acid receptor agonist

Specific Action of the Ligand Agonist

Publications:

Nakashima K et al., 2015, Xanthones from the roots of Maclura cochinchinensis var. gerontogea and their retinoic acid receptor-α agonistic activity., Bioorg Med Chem Lett

Kim H et al., 2008, Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative., Bioorg Med Chem

Vollberg TM Sr et al., 1992, Retinoic acid receptors as regulators of human epidermal keratinocyte differentiation., Mol Endocrinol

TRIFAROTENE RARA

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Details of the Assay for Interaction In a reported assay measuring activation mediated by agonist binding to the RARα ligand-binding domain.

Specific Action of the Ligand Agonist

Endogenous Drug? False

Publications:

Aubert J et al., 2018, Nonclinical and human pharmacology of the potent and selective topical retinoic acid receptor-γ agonist trifarotene., Br J Dermatol

IRX4310 RARA

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Retinoic acid receptor antagonist

Direct Interaction yes

Publications:
NRX195183 RARA

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoic acid receptor alpha agonist

Direct Interaction yes

Publications:
MOFAROTENE RARA

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Retinoid receptor modulator

Direct Interaction yes

Publications:

ALITRETINOIN RARA

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? True

Publications:

Pathirana C et al., 1994, Identification of an activator of the retinoid X receptor., J Nat Prod

Cheng et al., 2008, Alitretinoin: a comprehensive review., Expert Opin Investig Drugs

Ritter et al., 2006, Inhibition of retinoic acid receptor signaling by Ski in acute myeloid leukemia., Leukemia

ADAPALENE RARA

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Retinoic acid receptor agonist

Publications:

Shroot et al., 1998, A new concept of drug delivery for acne., Dermatology (Basel)

Michel et al., 1998, Pharmacology of adapalene., Br. J. Dermatol.

Kim et al., 2000, The role of specific retinoid receptors in sebocyte growth and differentiation in culture., J. Invest. Dermatol.

TAMIBAROTENE RARA

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? True

Publications:

Miwako et al., 2007, Tamibarotene., Drugs Today

Sanda et al., 2005, Antimyeloma effects of a novel synthetic retinoid Am80 (Tamibarotene) through inhibition of angiogenesis., Leukemia

Jimi et al., 2007, RARalpha is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells., Int. J. Oncol.

ISOTRETINOIN RARA

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoic acid receptor agonist

Direct Interaction yes

Trial Name CIP-isotretinoin

Publications:

Shroot et al., 1997, Pharmacology and chemistry of adapalene., J. Am. Acad. Dermatol.

Taylor et al., Altered gene expression in murine branchial arches following in utero exposure to retinoic acid., J. Craniofac. Genet. Dev. Biol.

Dahl et al., 2000, Inhaled isotretinoin (13-cis retinoic acid) is an effective lung cancer chemopreventive agent in A/J mice at low doses: a pilot study., Clin. Cancer Res.

TAZAROTENE RARA

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoic acid receptor agonist

Direct Interaction yes

Trial Name tazarotene,Tazorac

Publications:

Wang et al., 2001, 1,25-dihydroxyvitamin D3 and retonic acid analogues induce differentiation in breast cancer cells with function- and cell-specific additive effects., Breast Cancer Res. Treat.

Nagpal et al., 2000, Recent developments in receptor-selective retinoids., Curr. Pharm. Des.

Chandraratna, 1996, Tazarotene--first of a new generation of receptor-selective retinoids., Br. J. Dermatol.

ACITRETIN RARA

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Retinoid receptor agonist

Publications:

Saurat, 1999, Retinoids and psoriasis: novel issues in retinoid pharmacology and implications for psoriasis treatment., J. Am. Acad. Dermatol.

Tippmann et al., 2009, Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin., FASEB J.

Tian et al., 1997, The isolation and characterization of purified heterocomplexes of recombinant retinoic acid receptor and retinoid X receptor ligand binding domains., Biochemistry

ETRETINATE RARA

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Retinoid receptor agonist

Publications:

Harnish et al., 1990, Induction of beta-retinoic acid receptor mRNA by teratogenic doses of retinoids in murine fetuses., Differentiation

Saurat, 1999, Retinoids and psoriasis: novel issues in retinoid pharmacology and implications for psoriasis treatment., J. Am. Acad. Dermatol.

Zitnik et al., 1994, Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts., J. Immunol.

FENRETINIDE RARA

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name fenretinide, RT-101

Novel drug target Established target

Publications:

Pergolizzi et al., 1999, Role of retinoic acid receptor overexpression in sensitivity to fenretinide and tumorigenicity of human ovarian carcinoma cells., Int. J. Cancer
GERONTOXANTHONE A RARA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Nakashima K et al., 2015, Xanthones from the roots of Maclura cochinchinensis var. gerontogea and their retinoic acid receptor-α agonistic activity., Bioorg Med Chem Lett
DIMETHYL SULFOXIDE RARA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Grillier et al., 1997, Alterations of differentiation, clonal proliferation, cell cycle progression and bcl-2 expression in RAR alpha-altered sublines of HL-60., Leukemia
ABIETIC ACID RARA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Tanabe H et al., 2014, Retinoic acid receptor agonist activity of naturally occurring diterpenes., Bioorg Med Chem
RETINOL RARA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Kim H et al., 2008, Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative., Bioorg Med Chem
RETINYLRETINOATE RARA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Kim H et al., 2008, Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative., Bioorg Med Chem
DEXAMETHASONE RARA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Grummer et al., 1995, Postnatal rat lung retinoic acid receptor (RAR) mRNA expression and effects of dexamethasone on RAR beta mRNA., Pediatr. Pulmonol.
LYCOPENE RARA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ben-Dor et al., 2001, Effects of acyclo-retinoic acid and lycopene on activation of the retinoic acid receptor and proliferation of mammary cancer cells., Arch. Biochem. Biophys.

MELATONIN RARA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Kiefer et al., 2005, Differential regulation of estrogen receptor alpha, glucocorticoid receptor and retinoic acid receptor alpha transcriptional activity by melatonin is mediated via different G proteins., J. Pineal Res.

GERONTOXANTHONE H RARA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Nakashima K et al., 2015, Xanthones from the roots of Maclura cochinchinensis var. gerontogea and their retinoic acid receptor-α agonistic activity., Bioorg Med Chem Lett
NALOXONE RARA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Mou et al., 2004, RXR-induced TNF-alpha suppression is reversed by morphine in activated U937 cells., J. Neuroimmunol.
GERONTOXANTHONE B RARA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Nakashima K et al., 2015, Xanthones from the roots of Maclura cochinchinensis var. gerontogea and their retinoic acid receptor-α agonistic activity., Bioorg Med Chem Lett

COLCHICINE RARA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Stromskaya et al., 1998, Influence of exogenous RAR alpha gene on MDR1 expression and P-glycoprotein function in human and rodent cell lines., Br. J. Cancer

Dvorák et al., 2007, Expression, protein stability and transcriptional activity of retinoic acid receptors are affected by microtubules interfering agents and all-trans-retinoic acid in primary rat hepatocytes., Mol. Cell. Endocrinol.

chembl:CHEMBL472172 RARA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Lorenzo P et al., 2008, Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids., J Med Chem
PIMARIC ACID RARA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Tanabe H et al., 2014, Retinoic acid receptor agonist activity of naturally occurring diterpenes., Bioorg Med Chem
TRIBUTYRIN RARA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Chen et al., 1999, Combination of all-trans retinoic acid with butyric acid and its prodrugs markedly enhancing differentiation of human acute promyelocytic leukemia NB4 cells., Chin. Med. J.

CETUXIMAB RARA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Seale et al., 1996, Quantification of PML-RAR alpha transcripts in acute promyelocytic leukaemia: explanation for the lack of sensitivity of RT-PCR for the detection of minimal residual disease and induction of the leukaemia-specific mRNA by alpha interferon., Br. J. Haematol.

INSULIN RARA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Brtko et al., 1997, Nuclear all-trans retinoic acid receptors in liver of rats with diet-induced insulin resistance., Ann. N. Y. Acad. Sci.
chembl:CHEMBL275311 RARA

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Alvarez S et al., 2008, New retinoid chemotypes: 9-cis-retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists., Bioorg Med Chem

Ensembl: ENSG00000131759
- Version: 101_38
Alternate Names:

RARA Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
BaderLabGenes: RARA
- Version: February-2014
Alternate Names:

5914 Entrez Gene ID

Gene Info:

Initial Gene Query NR1B1

Counted Citations from 1950-2000 2172

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
TEND: P10276
- Version: 01-August-2011
Alternate Names:

P10276 Uniprot Accession

RARA Gene Symbol

5914 Entrez Gene Id

Gene Info:

Target Subclass Nuclear receptor

Target Main Class Receptors

Publications:
GuideToPharmacologyGenes: 590
- Version: 4-March-2015
Alternate Names:

retinoic acid receptor, alpha HUGO Gene Name

9864 HUGO Gene ID

RARA Gene Symbol

Gene Info:

GuideToPharmacology Gene Category Name 1B. Retinoic acid receptors

GuideToPharmacology Gene Category ID 85

GuideToPharmacology Gene Type nhr

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
RussLampel: ENSG00000131759
- Version: 26-July-2011
Alternate Names:

RARA Display Id

RETINOIC ACID RECEPTOR ALPHA (RAR-ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P10276] Description

ENSG00000131759 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: P10276
- Version: 11-September-2012
Alternate Names:

5914 Entrez Gene Id

RARA_HUMAN Uniprot Id

ENSG00000131759 Ensembl Gene Id

Gene Info:

Interpro Name Nuclear hormone receptor, ligand-binding, core

Uniprot Status Swiss-Prot

Human Readable Name NUCLEAR HORMONE RECEPTOR

Gene Categories:

NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P10276
- Version: January-2014
Alternate Names:

RARA Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Nuclear receptor

Publications:

DrugBank: BE0000663

Version: 5.1.7

Alternate Names:

RARA DrugBank Gene Name

P10276 UniProt Accession

5914 Entrez Gene Id

Gene Info:

Publications:

Ghyselinck NB et al., 2019, Retinoic acid signaling pathways., Development

Kim et al., 2000, The role of specific retinoid receptors in sebocyte growth and differentiation in culture., J. Invest. Dermatol.

Shroot et al., 1997, Pharmacology and chemistry of adapalene., J. Am. Acad. Dermatol.

NCI: RARA

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Grillier et al., 1997, Alterations of differentiation, clonal proliferation, cell cycle progression and bcl-2 expression in RAR alpha-altered sublines of HL-60., Leukemia

Chen et al., 1999, Combination of all-trans retinoic acid with butyric acid and its prodrugs markedly enhancing differentiation of human acute promyelocytic leukemia NB4 cells., Chin. Med. J.

Fitzgerald et al., 1997, Retinoic acid receptor alpha expression correlates with retinoid-induced growth inhibition of human breast cancer cells regardless of estrogen receptor status., Cancer Res.

DTC: RARA

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Pathirana C et al., 1994, Identification of an activator of the retinoid X receptor., J Nat Prod

Nakashima K et al., 2015, Xanthones from the roots of Maclura cochinchinensis var. gerontogea and their retinoic acid receptor-α agonistic activity., Bioorg Med Chem Lett

Alvarez S et al., 2008, New retinoid chemotypes: 9-cis-retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists., Bioorg Med Chem

HingoraniCasas: ENSG00000131759
- Version: 31-May-2017
Alternate Names:

ENSG00000131759 Gene Symbol

RARA Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: NR1B1
- Version: chembl_23
Alternate Names:

NR1B1 GENE_SYMBOL

RARA GENE_SYMBOL

Retinoic acid receptor alpha UNIPROT

Gene Info:

Publications:
GuideToPharmacologyInteractions: ENSG00000131759
- Version: 20-July-2020
Alternate Names:

Retinoic acid receptor-α GuideToPharmacology Name

P10276 UniProtKB ID

Gene Info:

Publications:
PharmGKB: RARA
- Version: 18-August-2020
Alternate Names:

PA34225 PharmGKB ID

Gene Info:

Publications:
TTD: Retinoic acid receptor alpha
- Version: 2020.06.01
Alternate Names:

RARA TTD Gene Abbreviation

T94085 TTD Target ID

Gene Info:

Publications:
GO: RARA
- Version: 05-September-2020
Alternate Names:

NR1B1 GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR BINDING

Publications:
Tempus: RARA
- Version: 11-November-2018
Alternate Names:

RARA Gene Symbol

Gene Info:

Publications:
dGene: RARA
- Version: 27-Jun-2013
Alternate Names:

5914 Gene ID

NR1B1 dGene Synonym

RAR dGene Synonym

Gene Info:

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Publications:
MskImpact: RARA
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: RARA
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: RARA
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FDA: RARA
- Version: 04-September-2020
Alternate Names:

Gene Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Retinoic acid receptor agonist
Specific Action of the Ligand	Agonist

Details of the Assay for Interaction	In a reported assay measuring activation mediated by agonist binding to the RARα ligand-binding domain.
Specific Action of the Ligand	Agonist
Endogenous Drug?	False

Mechanism of Interaction	Retinoic acid receptor antagonist
Direct Interaction	yes

Mechanism of Interaction	Retinoic acid receptor alpha agonist
Direct Interaction	yes

Mechanism of Interaction	Retinoid receptor modulator
Direct Interaction	yes

Novel drug target	Established target
Trial Name	-
Mechanism of Interaction	Retinoic acid receptor agonist

Direct Interaction	yes
Mechanism of Interaction	Retinoid receptor agonist

Trial Name	fenretinide, RT-101
Novel drug target	Established target

retinoic acid receptor, alpha	HUGO Gene Name
9864	HUGO Gene ID
RARA	Gene Symbol

RARA	Display Id
RETINOIC ACID RECEPTOR ALPHA (RAR-ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P10276]	Description
ENSG00000131759	Ensembl Gene Id

5914	Entrez Gene Id
RARA_HUMAN	Uniprot Id
ENSG00000131759	Ensembl Gene Id

RARA	DrugBank Gene Name
P10276	UniProt Accession
5914	Entrez Gene Id

NR1B1	GENE_SYMBOL
RARA	GENE_SYMBOL
Retinoic acid receptor alpha	UNIPROT

Retinoic acid receptor-α	GuideToPharmacology Name
P10276	UniProtKB ID

RARA Gene Record

RARA 5914 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Retinoic acid receptor agonist Specific Action of the Ligand Agonist

Interaction Types & Directionality: agonist (activating)

Interaction Info: Details of the Assay for Interaction In a reported assay measuring activation mediated by agonist binding to the RAR&alpha; ligand-binding domain. Specific Action of the Ligand Agonist Endogenous Drug? False

Publications: Aubert J et al., 2018, Nonclinical and human pharmacology of the potent and selective topical retinoic acid receptor-γ agonist trifarotene., Br J Dermatol

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Retinoic acid receptor antagonist Direct Interaction yes

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Retinoic acid receptor alpha agonist Direct Interaction yes

Publications:

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Retinoid receptor modulator Direct Interaction yes

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False Direct Interaction? True

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name - Mechanism of Interaction Retinoic acid receptor agonist

Publications: Shroot et al., 1998, A new concept of drug delivery for acne., Dermatology (Basel) Michel et al., 1998, Pharmacology of adapalene., Br. J. Dermatol. Kim et al., 2000, The role of specific retinoid receptors in sebocyte growth and differentiation in culture., J. Invest. Dermatol.

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False Direct Interaction? True

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Retinoic acid receptor agonist Direct Interaction yes Trial Name CIP-isotretinoin

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Retinoic acid receptor agonist Direct Interaction yes Trial Name tazarotene,Tazorac

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Retinoid receptor agonist

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Retinoid receptor agonist

Interaction Types & Directionality: n/a

Interaction Info: Trial Name fenretinide, RT-101 Novel drug target Established target

Publications: Pergolizzi et al., 1999, Role of retinoic acid receptor overexpression in sensitivity to fenretinide and tumorigenicity of human ovarian carcinoma cells., Int. J. Cancer

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Nakashima K et al., 2015, Xanthones from the roots of Maclura cochinchinensis var. gerontogea and their retinoic acid receptor-α agonistic activity., Bioorg Med Chem Lett

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Grillier et al., 1997, Alterations of differentiation, clonal proliferation, cell cycle progression and bcl-2 expression in RAR alpha-altered sublines of HL-60., Leukemia

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Tanabe H et al., 2014, Retinoic acid receptor agonist activity of naturally occurring diterpenes., Bioorg Med Chem

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Kim H et al., 2008, Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative., Bioorg Med Chem

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Kim H et al., 2008, Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative., Bioorg Med Chem

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Grummer et al., 1995, Postnatal rat lung retinoic acid receptor (RAR) mRNA expression and effects of dexamethasone on RAR beta mRNA., Pediatr. Pulmonol.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Ben-Dor et al., 2001, Effects of acyclo-retinoic acid and lycopene on activation of the retinoic acid receptor and proliferation of mammary cancer cells., Arch. Biochem. Biophys.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Kiefer et al., 2005, Differential regulation of estrogen receptor alpha, glucocorticoid receptor and retinoic acid receptor alpha transcriptional activity by melatonin is mediated via different G proteins., J. Pineal Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Nakashima K et al., 2015, Xanthones from the roots of Maclura cochinchinensis var. gerontogea and their retinoic acid receptor-α agonistic activity., Bioorg Med Chem Lett

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Mou et al., 2004, RXR-induced TNF-alpha suppression is reversed by morphine in activated U937 cells., J. Neuroimmunol.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Nakashima K et al., 2015, Xanthones from the roots of Maclura cochinchinensis var. gerontogea and their retinoic acid receptor-α agonistic activity., Bioorg Med Chem Lett

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Lorenzo P et al., 2008, Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids., J Med Chem

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Tanabe H et al., 2014, Retinoic acid receptor agonist activity of naturally occurring diterpenes., Bioorg Med Chem

Interaction Types & Directionality: n/a

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Retinoic acid receptor agonist

Specific Action of the Ligand Agonist

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Details of the Assay for Interaction In a reported assay measuring activation mediated by agonist binding to the RARα ligand-binding domain.

Specific Action of the Ligand Agonist

Endogenous Drug? False

Publications:

Aubert J et al., 2018, Nonclinical and human pharmacology of the potent and selective topical retinoic acid receptor-γ agonist trifarotene., Br J Dermatol

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Retinoic acid receptor antagonist

Direct Interaction yes

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoic acid receptor alpha agonist

Direct Interaction yes

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Retinoid receptor modulator

Direct Interaction yes

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? True

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Retinoic acid receptor agonist

Publications:

Shroot et al., 1998, A new concept of drug delivery for acne., Dermatology (Basel)

Michel et al., 1998, Pharmacology of adapalene., Br. J. Dermatol.

Kim et al., 2000, The role of specific retinoid receptors in sebocyte growth and differentiation in culture., J. Invest. Dermatol.

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? True

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoic acid receptor agonist

Direct Interaction yes

Trial Name CIP-isotretinoin

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoic acid receptor agonist

Direct Interaction yes

Trial Name tazarotene,Tazorac

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Retinoid receptor agonist

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Retinoid receptor agonist

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name fenretinide, RT-101

Novel drug target Established target

Publications:

Pergolizzi et al., 1999, Role of retinoic acid receptor overexpression in sensitivity to fenretinide and tumorigenicity of human ovarian carcinoma cells., Int. J. Cancer

Interaction Types & Directionality:

n/a

Publications:

Nakashima K et al., 2015, Xanthones from the roots of Maclura cochinchinensis var. gerontogea and their retinoic acid receptor-α agonistic activity., Bioorg Med Chem Lett

Interaction Types & Directionality:

n/a

Publications:

Grillier et al., 1997, Alterations of differentiation, clonal proliferation, cell cycle progression and bcl-2 expression in RAR alpha-altered sublines of HL-60., Leukemia

Interaction Types & Directionality:

n/a

Publications:

Tanabe H et al., 2014, Retinoic acid receptor agonist activity of naturally occurring diterpenes., Bioorg Med Chem

Interaction Types & Directionality:

n/a

Publications:

Kim H et al., 2008, Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative., Bioorg Med Chem

Interaction Types & Directionality:

n/a

Publications:

Kim H et al., 2008, Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative., Bioorg Med Chem

Interaction Types & Directionality:

n/a

Publications:

Grummer et al., 1995, Postnatal rat lung retinoic acid receptor (RAR) mRNA expression and effects of dexamethasone on RAR beta mRNA., Pediatr. Pulmonol.

Interaction Types & Directionality:

n/a

Publications:

Ben-Dor et al., 2001, Effects of acyclo-retinoic acid and lycopene on activation of the retinoic acid receptor and proliferation of mammary cancer cells., Arch. Biochem. Biophys.

Interaction Types & Directionality:

n/a

Publications:

Kiefer et al., 2005, Differential regulation of estrogen receptor alpha, glucocorticoid receptor and retinoic acid receptor alpha transcriptional activity by melatonin is mediated via different G proteins., J. Pineal Res.

Interaction Types & Directionality:

n/a

Publications:

Nakashima K et al., 2015, Xanthones from the roots of Maclura cochinchinensis var. gerontogea and their retinoic acid receptor-α agonistic activity., Bioorg Med Chem Lett

Interaction Types & Directionality:

n/a

Publications:

Mou et al., 2004, RXR-induced TNF-alpha suppression is reversed by morphine in activated U937 cells., J. Neuroimmunol.

Interaction Types & Directionality:

n/a

Publications:

Nakashima K et al., 2015, Xanthones from the roots of Maclura cochinchinensis var. gerontogea and their retinoic acid receptor-α agonistic activity., Bioorg Med Chem Lett

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

Lorenzo P et al., 2008, Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids., J Med Chem

Interaction Types & Directionality:

n/a

Publications:

Tanabe H et al., 2014, Retinoic acid receptor agonist activity of naturally occurring diterpenes., Bioorg Med Chem

Interaction Types & Directionality:

n/a

Publications:

Chen et al., 1999, Combination of all-trans retinoic acid with butyric acid and its prodrugs markedly enhancing differentiation of human acute promyelocytic leukemia NB4 cells., Chin. Med. J.

Interaction Types & Directionality:

n/a

Publications:

Seale et al., 1996, Quantification of PML-RAR alpha transcripts in acute promyelocytic leukaemia: explanation for the lack of sensitivity of RT-PCR for the detection of minimal residual disease and induction of the leukaemia-specific mRNA by alpha interferon., Br. J. Haematol.

Interaction Types & Directionality:

n/a

Publications:

Brtko et al., 1997, Nuclear all-trans retinoic acid receptors in liver of rats with diet-induced insulin resistance., Ann. N. Y. Acad. Sci.

Interaction Types & Directionality:

n/a

Publications:

Alvarez S et al., 2008, New retinoid chemotypes: 9-cis-retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists., Bioorg Med Chem

Alternate Names:

RARA Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

5914 Entrez Gene ID

Gene Info:

Initial Gene Query NR1B1

Counted Citations from 1950-2000 2172

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Alternate Names:

P10276 Uniprot Accession

RARA Gene Symbol

5914 Entrez Gene Id

Gene Info:

Target Subclass Nuclear receptor

Target Main Class Receptors

Alternate Names:

retinoic acid receptor, alpha HUGO Gene Name

9864 HUGO Gene ID

RARA Gene Symbol

Gene Info:

GuideToPharmacology Gene Category Name 1B. Retinoic acid receptors

GuideToPharmacology Gene Category ID 85

GuideToPharmacology Gene Type nhr

Gene Categories:

NUCLEAR HORMONE RECEPTOR

Alternate Names:

RARA Display Id

RETINOIC ACID RECEPTOR ALPHA (RAR-ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P10276] Description

ENSG00000131759 Ensembl Gene Id