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RARA Gene Record

  • Summary
  • Interactions
  • Claims
  • RARA 5914 Druggable GenomeClinically Actionable

    Alternate Names:

    5914
    RETINOIC ACID RECEPTOR ALPHA
    RARA
    NR1B1
    RAR
    180240
    9864
    ENSG00000131759
    OTTHUMG00000133328
    Nuclear receptor subfamily 1 group B member 1
    RAR-alpha
    P10276
    RARA_HUMAN
    RETINOIC ACID RECEPTOR ALPHA (RAR-ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P10276]
    PA34225
    T94085
    RARalpha

    Gene Info:

    Target Class Receptors
    Target Subclass Nuclear receptor
    Human Readable Name DRUGGABLE GENOME
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Uniprot Status Swiss-Prot
    Human Readable Name NUCLEAR HORMONE RECEPTOR
    Interpro Acc IPR000536
    Interpro Short Name Nucl_hrmn_rcpt_lig-bd_core
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Initial Gene Query NR1B1
    Counted Citations from 1950-2000 2172
    Target Main Class Receptors
    Gene Biotype PROTEIN_CODING
    (15 More Sources)

    Gene Categories: Category Details

    TRANSCRIPTION FACTOR COMPLEX
    CELL SURFACE
    NUCLEAR HORMONE RECEPTOR
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE

    Publications:

    Pathirana C et al., 1994, Identification of an activator of the retinoid X receptor., J Nat Prod
    Cheng et al., 2008, Alitretinoin: a comprehensive review., Expert Opin Investig Drugs
    Ritter et al., 2006, Inhibition of retinoic acid receptor signaling by Ski in acute myeloid leukemia., Leukemia
    Schrage et al., 2006, Macrophages and neurons are targets of retinoic acid signaling after spinal cord contusion injury., Eur. J. Neurosci.
    Baumann et al., 2005, Open-label pilot study of alitretinoin gel 0.1% in the treatment of photoaging., Cutis
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Milliano et al., 2005, Rat hepatic stellate cells become retinoid unresponsive during activation., Hepatol. Res.
    Rasooly et al., 2005, Retinoid x receptor agonists increase bcl2a1 expression and decrease apoptosis of naive T lymphocytes., J. Immunol.
    Nakashima K et al., 2015, Xanthones from the roots of Maclura cochinchinensis var. gerontogea and their retinoic acid receptor-α agonistic activity., Bioorg Med Chem Lett
    Shroot et al., 1998, A new concept of drug delivery for acne., Dermatology (Basel)
    Michel et al., 1998, Pharmacology of adapalene., Br. J. Dermatol.
    Kim et al., 2000, The role of specific retinoid receptors in sebocyte growth and differentiation in culture., J. Invest. Dermatol.
    Griffiths et al., 1998, Adapalene 0.1% gel and adapalene 0.1% cream stimulate retinoic acid receptor mediated gene transcription without significant irritative effects in the skin of healthy human volunteers., Br. J. Dermatol.
    Shroot et al., 1997, Pharmacology and chemistry of adapalene., J. Am. Acad. Dermatol.
    Piérard GE et al., 2009, Spotlight on adapalene., Expert Opin Drug Metab Toxicol
    Ghyselinck NB et al., 2019, Retinoic acid signaling pathways., Development
    Pergolizzi et al., 1999, Role of retinoic acid receptor overexpression in sensitivity to fenretinide and tumorigenicity of human ovarian carcinoma cells., Int. J. Cancer
    Grillier et al., 1997, Alterations of differentiation, clonal proliferation, cell cycle progression and bcl-2 expression in RAR alpha-altered sublines of HL-60., Leukemia
    Miwako et al., 2007, Tamibarotene., Drugs Today
    Sanda et al., 2005, Antimyeloma effects of a novel synthetic retinoid Am80 (Tamibarotene) through inhibition of angiogenesis., Leukemia
    Jimi et al., 2007, RARalpha is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells., Int. J. Oncol.
    2004, Tamibarotene: AM 80, retinobenzoic acid, Tamibaro., Drugs R D
    Tanabe H et al., 2014, Retinoic acid receptor agonist activity of naturally occurring diterpenes., Bioorg Med Chem
    Taylor et al., Altered gene expression in murine branchial arches following in utero exposure to retinoic acid., J. Craniofac. Genet. Dev. Biol.
    Dahl et al., 2000, Inhaled isotretinoin (13-cis retinoic acid) is an effective lung cancer chemopreventive agent in A/J mice at low doses: a pilot study., Clin. Cancer Res.
    Zouboulis, 2006, Isotretinoin revisited: pluripotent effects on human sebaceous gland cells., J. Invest. Dermatol.
    Vu-Dac et al., 1998, Retinoids increase human apo C-III expression at the transcriptional level via the retinoid X receptor. Contribution to the hypertriglyceridemic action of retinoids., J. Clin. Invest.
    Wang et al., 2001, 1,25-dihydroxyvitamin D3 and retonic acid analogues induce differentiation in breast cancer cells with function- and cell-specific additive effects., Breast Cancer Res. Treat.
    Nagpal et al., 2000, Recent developments in receptor-selective retinoids., Curr. Pharm. Des.
    Chandraratna, 1996, Tazarotene--first of a new generation of receptor-selective retinoids., Br. J. Dermatol.
    Yen et al., 2004, A retinoic acid receptor beta/gamma-selective prodrug (tazarotene) plus a retinoid X receptor ligand induces extracellular signal-regulated kinase activation, retinoblastoma hypophosphorylation, G0 arrest, and cell differentiation., Mol. Pharmacol.
    Meder et al., 2003, Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23., FEBS Lett.
    Kim H et al., 2008, Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative., Bioorg Med Chem
    Grummer et al., 1995, Postnatal rat lung retinoic acid receptor (RAR) mRNA expression and effects of dexamethasone on RAR beta mRNA., Pediatr. Pulmonol.
    Ben-Dor et al., 2001, Effects of acyclo-retinoic acid and lycopene on activation of the retinoic acid receptor and proliferation of mammary cancer cells., Arch. Biochem. Biophys.
    Kiefer et al., 2005, Differential regulation of estrogen receptor alpha, glucocorticoid receptor and retinoic acid receptor alpha transcriptional activity by melatonin is mediated via different G proteins., J. Pineal Res.
    Mou et al., 2004, RXR-induced TNF-alpha suppression is reversed by morphine in activated U937 cells., J. Neuroimmunol.
    Saurat, 1999, Retinoids and psoriasis: novel issues in retinoid pharmacology and implications for psoriasis treatment., J. Am. Acad. Dermatol.
    Tippmann et al., 2009, Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin., FASEB J.
    Tian et al., 1997, The isolation and characterization of purified heterocomplexes of recombinant retinoic acid receptor and retinoid X receptor ligand binding domains., Biochemistry
    Orfanos et al., 1997, Current use and future potential role of retinoids in dermatology., Drugs
    Vollberg TM Sr et al., 1992, Retinoic acid receptors as regulators of human epidermal keratinocyte differentiation., Mol Endocrinol
    Harnish et al., 1990, Induction of beta-retinoic acid receptor mRNA by teratogenic doses of retinoids in murine fetuses., Differentiation
    Zitnik et al., 1994, Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts., J. Immunol.
    Billoni et al., 1997, Expression of retinoid nuclear receptor superfamily members in human hair follicles and its implication in hair growth., Acta Derm. Venereol.
    Stromskaya et al., 1998, Influence of exogenous RAR alpha gene on MDR1 expression and P-glycoprotein function in human and rodent cell lines., Br. J. Cancer
    Dvorák et al., 2007, Expression, protein stability and transcriptional activity of retinoic acid receptors are affected by microtubules interfering agents and all-trans-retinoic acid in primary rat hepatocytes., Mol. Cell. Endocrinol.
    Lorenzo P et al., 2008, Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids., J Med Chem
    Chen et al., 1999, Combination of all-trans retinoic acid with butyric acid and its prodrugs markedly enhancing differentiation of human acute promyelocytic leukemia NB4 cells., Chin. Med. J.
    Seale et al., 1996, Quantification of PML-RAR alpha transcripts in acute promyelocytic leukaemia: explanation for the lack of sensitivity of RT-PCR for the detection of minimal residual disease and induction of the leukaemia-specific mRNA by alpha interferon., Br. J. Haematol.
    Brtko et al., 1997, Nuclear all-trans retinoic acid receptors in liver of rats with diet-induced insulin resistance., Ann. N. Y. Acad. Sci.
    Alvarez S et al., 2008, New retinoid chemotypes: 9-cis-retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists., Bioorg Med Chem
  • TAMIBAROTENE   RARA

    Interaction Score: 5.5

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name Tamibarotene, Z-208, INNO-507
    Novel drug target Established target

    PMIDs:
    17925887 15843826 17611697 15563242 11752352


    Sources:
    TdgClinicalTrial TEND TTD

  • NRX195183   RARA

    Interaction Score: 4.12

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoic acid receptor alpha agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • GERONTOXANTHONE B   RARA

    Interaction Score: 4.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25838141


    Sources:
    DTC

  • GERONTOXANTHONE A   RARA

    Interaction Score: 4.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25838141


    Sources:
    DTC

  • ADAPALENE   RARA

    Interaction Score: 2.94

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Mechanism of Interaction Retinoic acid receptor agonist

    PMIDs:
    9557255 9990413 10651997 9990415 9204085 19929446 31273085


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • ALITRETINOIN   RARA

    Interaction Score: 2.83

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoid receptor agonist
    Direct Interaction yes

    PMIDs:
    7807131 18321241 16424870 16420438 16144296 11752352 16253547 16339527


    Sources:
    DTC ChemblInteractions TEND

  • TAZAROTENE   RARA

    Interaction Score: 2.32

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoic acid receptor agonist
    Direct Interaction yes
    Trial Name tazarotene,Tazorac

    PMIDs:
    11519864 10828316 9035701 16144296 15383624 14675762


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • PIMARIC ACID   RARA

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24799257


    Sources:
    DTC

  • RETINYLRETINOATE   RARA

    Interaction Score: 2.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18511283


    Sources:
    DTC

  • ETRETINATE   RARA

    Interaction Score: 1.77

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Retinoid receptor agonist

    PMIDs:
    1965892 10459139 8301142 9074840 9298126


    Sources:
    ChemblInteractions

  • ISOTRETINOIN   RARA

    Interaction Score: 1.5

    Interaction Types & Directionality:
    agonist (activating)
    other/unknown

    Interaction Info:
    Mechanism of Interaction Retinoic acid receptor agonist
    Direct Interaction yes
    Trial Name CIP-isotretinoin

    PMIDs:
    9204085 7601910 10955779 16983322 9691099


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • CHEMBL472172   RARA

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18702457


    Sources:
    DTC

  • ABIETIC ACID   RARA

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24799257


    Sources:
    DTC

  • TRIBUTYRIN   RARA

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11593538


    Sources:
    NCI

  • ACITRETIN   RARA

    Interaction Score: 0.9

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Retinoid receptor agonist

    PMIDs:
    10459139 19144697 9153406 9074840


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • IRX4310   RARA

    Interaction Score: 0.69

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Retinoic acid receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GERONTOXANTHONE H   RARA

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25838141


    Sources:
    DTC

  • DIMETHYL SULFOXIDE   RARA

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9067579


    Sources:
    NCI

  • LYCOPENE   RARA

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11437362


    Sources:
    NCI

  • TRETINOIN   RARA

    Interaction Score: 0.5

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Retinoic acid receptor agonist
    Fusion protein PML:RARA

    PMIDs:
    25838141 18511283 1318502


    Sources:
    DTC ChemblInteractions PharmGKB FDA

  • NALOXONE   RARA

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14741437


    Sources:
    NCI

  • MOFAROTENE   RARA

    Interaction Score: 0.34

    Interaction Types & Directionality:
    modulator

    Interaction Info:
    Mechanism of Interaction Retinoid receptor modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RETINOL   RARA

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18511283


    Sources:
    DTC

  • CHEMBL275311   RARA

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18951029


    Sources:
    DTC

  • FENRETINIDE   RARA

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name fenretinide, RT-101
    Novel drug target Established target

    PMIDs:
    10328240


    Sources:
    TdgClinicalTrial NCI

  • MELATONIN   RARA

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15813899


    Sources:
    NCI

  • COLCHICINE   RARA

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9667638 17291686


    Sources:
    NCI

  • CETUXIMAB   RARA

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8857944


    Sources:
    NCI

  • INSULIN   RARA

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9329777


    Sources:
    NCI

  • DEXAMETHASONE   RARA

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8606853


    Sources:
    NCI

  • Ensembl: ENSG00000131759

    • Version: 101_38

    Alternate Names:
    RARA Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • BaderLabGenes: RARA

    • Version: February-2014

    Alternate Names:
    5914 Entrez Gene ID

    Gene Info:
    Initial Gene Query NR1B1
    Counted Citations from 1950-2000 2172

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • TEND: P10276

    • Version: 01-August-2011

    Alternate Names:
    P10276 Uniprot Accession
    RARA Gene Symbol
    5914 Entrez Gene Id

    Gene Info:
    Target Subclass Nuclear receptor
    Target Main Class Receptors

    Publications:

  • RussLampel: ENSG00000131759

    • Version: 26-July-2011

    Alternate Names:
    RARA Display Id
    RETINOIC ACID RECEPTOR ALPHA (RAR-ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P10276] Description
    ENSG00000131759 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P10276

    • Version: 11-September-2012

    Alternate Names:
    5914 Entrez Gene Id
    RARA_HUMAN Uniprot Id
    ENSG00000131759 Ensembl Gene Id

    Gene Info:
    Interpro Name Nuclear hormone receptor, ligand-binding, core
    Uniprot Status Swiss-Prot
    Human Readable Name NUCLEAR HORMONE RECEPTOR

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P10276

    • Version: January-2014

    Alternate Names:
    RARA Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Nuclear receptor

    Publications:

  • NCI: RARA

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Grillier et al., 1997, Alterations of differentiation, clonal proliferation, cell cycle progression and bcl-2 expression in RAR alpha-altered sublines of HL-60., Leukemia
    Chen et al., 1999, Combination of all-trans retinoic acid with butyric acid and its prodrugs markedly enhancing differentiation of human acute promyelocytic leukemia NB4 cells., Chin. Med. J.
    Fitzgerald et al., 1997, Retinoic acid receptor alpha expression correlates with retinoid-induced growth inhibition of human breast cancer cells regardless of estrogen receptor status., Cancer Res.

  • DTC: RARA

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Pathirana C et al., 1994, Identification of an activator of the retinoid X receptor., J Nat Prod
    Nakashima K et al., 2015, Xanthones from the roots of Maclura cochinchinensis var. gerontogea and their retinoic acid receptor-α agonistic activity., Bioorg Med Chem Lett
    Alvarez S et al., 2008, New retinoid chemotypes: 9-cis-retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists., Bioorg Med Chem

  • HingoraniCasas: ENSG00000131759

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000131759 Gene Symbol
    RARA Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: NR1B1

    • Version: chembl_23

    Alternate Names:
    NR1B1 GENE_SYMBOL
    RARA GENE_SYMBOL
    Retinoic acid receptor alpha UNIPROT

    Gene Info:

    Publications:

  • PharmGKB: RARA

    • Version: 18-August-2020

    Alternate Names:
    PA34225 PharmGKB ID

    Gene Info:

    Publications:

  • GO: RARA

    • Version: 01-February-2022

    Alternate Names:
    NR1B1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR COMPLEX, CELL SURFACE, NUCLEAR HORMONE RECEPTOR

    Publications:

  • Tempus: RARA

    • Version: 11-November-2018

    Alternate Names:
    RARA Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • dGene: RARA

    • Version: 27-Jun-2013

    Alternate Names:
    5914 Gene ID
    NR1B1 dGene Synonym
    RAR dGene Synonym

    Gene Info:

    Gene Categories:
    NUCLEAR HORMONE RECEPTOR

    Publications:

  • TTD: Retinoic acid receptor alpha

    • Version: 2020.06.01

    Alternate Names:
    RARA TTD Gene Abbreviation
    T94085 TTD Target ID

    Gene Info:

    Publications:

  • MskImpact: RARA

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: RARA

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: RARA

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FDA: RARA

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21