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RAF1 5894 Druggable GenomeClinically Actionable
Alternate Names:
5894 RAF-1 PROTO-ONCOGENE, SERINE/THREONINE KINASE RAF1 CMD1NN CRAF NS5 Raf-1 c-Raf 164760 9829 ENSG00000132155 OTTHUMG00000129789 P04049 RAF1_HUMAN RAF Proto-oncogene c-RAF RAF proto-oncogene serine/threonine-protein kinase RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.37) (RAF- 1) (C-RAF) (CRAF). [SOURCE:UNIPROT/SWISSPROT;ACC:P04049] PA34183 T23673 4767 Gene Info:
Target Main Class Enzymes Target Subclass 2.7.11.1 Human Readable Name DRUGGABLE GENOME Target Class Enzymes Target Subclass EC:2.7.11.1 Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom Human Readable Name KINASE Interpro Type Domain Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain Uniprot Evidence 1: Evidence at protein level Interpro Acc IPR001245 Uniprot Status Swiss-Prot Gene Biotype PROTEIN_CODING Gene Categories: Category Details
KINASE SERINE THREONINE KINASE DRUGGABLE GENOME CLINICALLY ACTIONABLE Publications:
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Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Serine/threonine-protein kinase RAF inhibitor Direct Interaction yes -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Serine/threonine-protein kinase RAF inhibitor Direct Interaction yes -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Serine/threonine-protein kinase RAF inhibitor Direct Interaction yes -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase RAF inhibitor -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction RAF serine/threonine protein kinase inhibitor Direct Interaction yes -
Interaction Types & Directionality:
n/a Interaction Info:
Novel drug target Established target Trial Name CHIR-265 -
Interaction Score: 0.7
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Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Trial Name Nexavar Novel drug target Established target -
Interaction Score: 0.54
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Serine/threonine-protein kinase RAF inhibitor Direct Interaction yes -
Interaction Score: 0.41
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
-
Interaction Score: 0.35
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase RAF inhibitor -
Interaction Score: 0.2
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Serine/threonine-protein kinase RAF inhibitor Direct Interaction yes -
Interaction Score: 0.15
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Interaction Score: 0.08
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Interaction Score: 0.08
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Interaction Score: 0.07
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- Version: 101_38
Alternate Names:
RAF1 Ensembl Gene Name Gene Info:
Gene Biotype PROTEIN_CODING Publications:
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- Version: 26-July-2011
Alternate Names:
ENSG00000132155 Ensembl Gene Id RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.37) (RAF- 1) (C-RAF) (CRAF). [SOURCE:UNIPROT/SWISSPROT;ACC:P04049] Description RAF1 Display Id Gene Info:
Human Readable Name DRUGGABLE GENOME Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: 11-September-2012
Alternate Names:
P04049 Uniprot Accession RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE Uniprot Protein Name 5894 Entrez Gene Id Gene Info:
Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom Human Readable Name KINASE Human Readable Name DRUGGABLE GENOME Gene Categories:
KINASE, DRUGGABLE GENOME Publications:
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- Version: January-2014
Alternate Names:
RAF1 Gene Symbol Gene Info:
Target Class Enzymes Target Subclass EC:2.7.11.1 Publications:
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Alternate Names:
5894 Entrez Gene Id P04049 Uniprot Accession RAF1_HUMAN Uniprot Id Gene Info:
Target Main Class Enzymes Target Subclass 2.7.11.1 Publications:
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Alternate Names:
PA34183 PharmGKB ID Gene Info:
Publications:
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Alternate Names:
5894 Entrez Gene ID 4767 CIViC Gene ID Gene Info:
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- Version: 31-May-2017
Alternate Names:
ENSG00000132155 Gene Symbol RAF1 Ensembl Id Gene Info:
Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: 20-Jun-2017
Alternate Names:
5894 Entrez Gene Id RAF1 MyCancerGenome Gene Symbol RAF MyCancerGenome Reported Gene Name Gene Info:
Publications:
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Alternate Names:
RAF-1 Gene Symbol Gene Info:
Publications:
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Alternate Names:
C-RAF Gene Symbol Gene Info:
Publications:
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- Version: chembl_23
Alternate Names:
RAF GENE_SYMBOL RAF1 GENE_SYMBOL RAF proto-oncogene serine/threonine-protein kinase UNIPROT Gene Info:
Publications:
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Alternate Names:
5894 OncoKB Entrez Id NS5 OncoKB Gene Synonym c-Raf OncoKB Gene Synonym Gene Info:
Publications:
-
Alternate Names:
RAF GO Gene Synonym Gene Info:
Gene Categories:
SERINE THREONINE KINASE Publications:
-
Alternate Names:
RAF1 Gene Symbol Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
-
Alternate Names:
5894 Gene ID CRAF dGene Synonym NS5 dGene Synonym Gene Info:
Gene Categories:
KINASE, SERINE THREONINE KINASE Publications:
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- Version: 2020.06.01
Alternate Names:
c-RAF TTD Gene Abbreviation T23673 TTD Target ID Gene Info:
Publications:
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Alternate Names:
RAF proto-oncogene serine/threonine-protein kinase Gene Name P04049 UniProt ID Gene Info:
Gene Categories:
KINASE Publications:
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- Version: 30-February-2014
Alternate Names:
Gene Info:
Publications:
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- Version: 30-February-2014
Alternate Names:
Gene Info:
Publications:
-
Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
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- Version: 03-September-2020
Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
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- Version: 04-September-2020
Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
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Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications: