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RAF1 Gene Record

  • Summary
  • Interactions
  • Claims
  • RAF1 5894 Druggable GenomeClinically Actionable

    Alternate Names:

    5894
    RAF-1 PROTO-ONCOGENE, SERINE/THREONINE KINASE
    RAF1
    CMD1NN
    CRAF
    NS5
    Raf-1
    c-Raf
    164760
    9829
    ENSG00000132155
    OTTHUMG00000129789
    P04049
    RAF1_HUMAN
    RAF
    Proto-oncogene c-RAF
    RAF proto-oncogene serine/threonine-protein kinase
    RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.37) (RAF- 1) (C-RAF) (CRAF). [SOURCE:UNIPROT/SWISSPROT;ACC:P04049]
    PA34183
    T23673
    4767

    Gene Info:

    Target Main Class Enzymes
    Target Subclass 2.7.11.1
    Human Readable Name DRUGGABLE GENOME
    Target Class Enzymes
    Target Subclass EC:2.7.11.1
    Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom
    Human Readable Name KINASE
    Interpro Type Domain
    Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR001245
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    (20 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE

    Publications:

    Gong L et al., 2017, PharmGKB summary: sorafenib pathways., Pharmacogenet Genomics
    Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics
    Lu et al., 2010, Sorafenib induces growth inhibition and apoptosis of human chondrosarcoma cells by blocking the RAF/ERK/MEK pathway., J Surg Oncol
    Gridelli et al., 2007, Sorafenib and sunitinib in the treatment of advanced non-small cell lung cancer., Oncologist
    Huether et al., 2007, Sorafenib alone or as combination therapy for growth control of cholangiocarcinoma., Biochem. Pharmacol.
    Adnane et al., 2006, Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature., Meth. Enzymol.
    Wilhelm et al., 2008, Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling., Mol. Cancer Ther.
    Cascone et al., 2007, Combined targeted therapies in non-small cell lung cancer: a winner strategy?, Curr Opin Oncol
    Gollob et al., 2006, Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway., Semin. Oncol.
    Smalley et al., 2009, CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations., Oncogene
    Li Y et al., 2011, Genetic variations in multiple drug action pathways and survival in advanced stage non-small cell lung cancer treated with chemotherapy., Clin Cancer Res
    McEvoy CR et al., 2019, Profound MEK inhibitor response in a cutaneous melanoma harboring a GOLGA4-RAF1 fusion., J Clin Invest
  • RG-7376   RAF1

    Interaction Score: 3.25

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase RAF inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • XL-281   RAF1

    Interaction Score: 2.17

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase RAF inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    MyCancerGenome ChemblInteractions

  • LGX-806   RAF1

    Interaction Score: 1.63

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase RAF inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ARQ-736   RAF1

    Interaction Score: 1.63

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serine/threonine-protein kinase RAF inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MLN-2480   RAF1

    Interaction Score: 1.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction RAF serine/threonine protein kinase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RAF-265   RAF1

    Interaction Score: 0.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name CHIR-265

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • COBIMETINIB   RAF1

    Interaction Score: 0.7

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30835257


    Sources:
    CIViC OncoKB

  • SEMAPIMOD   RAF1

    Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • SORAFENIB   RAF1

    Interaction Score: 0.6

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name Nexavar
    Novel drug target Established target

    PMIDs:
    28362716 20124951 20812347 17296815 17266941 16757355 18852116 17272980 16890795 18794803


    Sources:
    MyCancerGenome TdgClinicalTrial TEND MyCancerGenomeClinicalTrial PharmGKB

  • LY-3009120   RAF1

    Interaction Score: 0.54

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase RAF inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ENCORAFENIB   RAF1

    Interaction Score: 0.41

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    MyCancerGenome

  • REGORAFENIB   RAF1

    Interaction Score: 0.35

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serine/threonine-protein kinase RAF inhibitor

    PMIDs:
    None found


    Sources:
    MyCancerGenome ChemblInteractions MyCancerGenomeClinicalTrial

  • SORAFENIB TOSYLATE   RAF1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serine/threonine-protein kinase RAF inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TRAMETINIB   RAF1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30835257


    Sources:
    CIViC

  • DOCETAXEL   RAF1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21636554


    Sources:
    PharmGKB

  • CARBOPLATIN   RAF1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21636554


    Sources:
    PharmGKB

  • GEMCITABINE   RAF1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21636554


    Sources:
    PharmGKB

  • PACLITAXEL   RAF1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21636554


    Sources:
    PharmGKB

  • CISPLATIN   RAF1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21636554


    Sources:
    PharmGKB

  • Ensembl: ENSG00000132155

    • Version: 101_38

    Alternate Names:
    RAF1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000132155

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000132155 Ensembl Gene Id
    RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.37) (RAF- 1) (C-RAF) (CRAF). [SOURCE:UNIPROT/SWISSPROT;ACC:P04049] Description
    RAF1 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P04049

    • Version: 11-September-2012

    Alternate Names:
    P04049 Uniprot Accession
    RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE Uniprot Protein Name
    5894 Entrez Gene Id

    Gene Info:
    Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom
    Human Readable Name KINASE
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P04049

    • Version: January-2014

    Alternate Names:
    RAF1 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.1

    Publications:

  • TEND: P04049

    • Version: 01-August-2011

    Alternate Names:
    5894 Entrez Gene Id
    P04049 Uniprot Accession
    RAF1_HUMAN Uniprot Id

    Gene Info:
    Target Main Class Enzymes
    Target Subclass 2.7.11.1

    Publications:

  • PharmGKB: RAF1

    • Version: 18-August-2020

    Alternate Names:
    PA34183 PharmGKB ID

    Gene Info:

    Publications:
    Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics
    Gong L et al., 2017, PharmGKB summary: sorafenib pathways., Pharmacogenet Genomics
    Li Y et al., 2011, Genetic variations in multiple drug action pathways and survival in advanced stage non-small cell lung cancer treated with chemotherapy., Clin Cancer Res

  • CIViC: RAF1

    • Version: 14-September-2020

    Alternate Names:
    5894 Entrez Gene ID
    4767 CIViC Gene ID

    Gene Info:

    Publications:
    McEvoy CR et al., 2019, Profound MEK inhibitor response in a cutaneous melanoma harboring a GOLGA4-RAF1 fusion., J Clin Invest

  • HingoraniCasas: ENSG00000132155

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000132155 Gene Symbol
    RAF1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • MyCancerGenome: RAF1

    • Version: 20-Jun-2017

    Alternate Names:
    5894 Entrez Gene Id
    RAF1 MyCancerGenome Gene Symbol
    RAF MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

  • TALC: RAF-1

    • Version: 12-May-2016

    Alternate Names:
    RAF-1 Gene Symbol

    Gene Info:

    Publications:

  • TALC: C-RAF

    • Version: 12-May-2016

    Alternate Names:
    C-RAF Gene Symbol

    Gene Info:

    Publications:

  • ChemblInteractions: RAF

    • Version: chembl_23

    Alternate Names:
    RAF GENE_SYMBOL
    RAF1 GENE_SYMBOL
    RAF proto-oncogene serine/threonine-protein kinase UNIPROT

    Gene Info:

    Publications:

  • OncoKB: RAF1

    • Version: 23-July-2020

    Alternate Names:
    5894 OncoKB Entrez Id
    NS5 OncoKB Gene Synonym
    c-Raf OncoKB Gene Synonym

    Gene Info:

    Publications:

  • GO: RAF1

    • Version: 01-February-2022

    Alternate Names:
    RAF GO Gene Synonym

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE

    Publications:

  • Tempus: RAF1

    • Version: 11-November-2018

    Alternate Names:
    RAF1 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • dGene: RAF1

    • Version: 27-Jun-2013

    Alternate Names:
    5894 Gene ID
    CRAF dGene Synonym
    NS5 dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • TTD: Proto-oncogene c-RAF

    • Version: 2020.06.01

    Alternate Names:
    c-RAF TTD Gene Abbreviation
    T23673 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: RAF1

    • Version: 01-February-2022

    Alternate Names:
    RAF proto-oncogene serine/threonine-protein kinase Gene Name
    P04049 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • MyCancerGenomeClinicalTrial: RAF-1

    • Version: 30-February-2014

    Alternate Names:

    Gene Info:

    Publications:

  • MyCancerGenomeClinicalTrial: RAF1

    • Version: 30-February-2014

    Alternate Names:

    Gene Info:

    Publications:

  • MskImpact: RAF1

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: RAF1

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: RAF1

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Oncomine: RAF1

    • Version: v3

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21