DGIdb - PYGL Gene Record

PYGL 5836 Druggable Genome

Alternate Names:

5836
GLYCOGEN PHOSPHORYLASE L
PYGL
GSD6
613741
9725
ENSG00000100504
OTTHUMG00000166596
P06737
GLYCOGEN PHOSPHORYLASE, LIVER FORM (EC 2.4.1.1). [SOURCE:UNIPROT/SWISSPROT;ACC:P06737]
PYGL_HUMAN
GLYCOGEN PHOSPHORYLASE, LIVER FORM
BE0000007
PA34068

Gene Info:

Target Class	Enzymes
Target Subclass	EC:2.4.1.1
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	Glyco_trans_35
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR000811
Interpro Type	Family
Uniprot Status	Swiss-Prot
Interpro Name	Glycosyl transferase, family 35
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Yang JJ et al., 2012, Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia., Blood
Oikonomakos NG et al., 2005, Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs., Protein Sci
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Kaiser A et al., 2001, The cyclin-dependent kinase (CDK) inhibitor flavopiridol inhibits glycogen phosphorylase., Arch Biochem Biophys
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Beauchamp et al., 2007, High frequency of missense mutations in glycogen storage disease type VI., J. Inherit. Metab. Dis.

CHEMBL335954 PYGL

Interaction Score: 16.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL434025 PYGL

Interaction Score: 12.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
URIC ACID PYGL

Interaction Score: 12.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
CHEMBL198408 PYGL

Interaction Score: 8.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL1231099 PYGL

Interaction Score: 8.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL335315 PYGL

Interaction Score: 6.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
ADENOSINE PHOSPHATE PYGL

Interaction Score: 1.35

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
15987904 17139284 17016423

Sources:
DrugBank
DEXFOSFOSERINE PYGL

Interaction Score: 0.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
DEXTROSE PYGL

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
ASPARAGINASE PYGL

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23007406

Sources:
PharmGKB
ALVOCIDIB PYGL

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11368340

Sources:
DrugBank
PYRIDOXAL PHOSPHATE PYGL

Interaction Score: 0.16

Interaction Types & Directionality:

cofactor (activating)

Interaction Info:

PMIDs:
17705025

Sources:
DrugBank
DEXAMETHASONE PYGL

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23007406

Sources:
PharmGKB
METHOTREXATE PYGL

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23007406

Sources:
PharmGKB

Ensembl: ENSG00000100504
- Version: 101_38
Alternate Names:

PYGL Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P06737
- Version: January-2014
Alternate Names:

PYGL Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.4.1.1

Publications:
RussLampel: ENSG00000100504
- Version: 26-July-2011
Alternate Names:

ENSG00000100504 Ensembl Gene Id

GLYCOGEN PHOSPHORYLASE, LIVER FORM (EC 2.4.1.1). [SOURCE:UNIPROT/SWISSPROT;ACC:P06737] Description

PYGL Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: P06737
- Version: 11-September-2012
Alternate Names:

5836 Entrez Gene Id

ENSG00000100504 Ensembl Gene Id

P06737 Uniprot Accession

Gene Info:

Interpro Short Name Glyco_trans_35

Uniprot Evidence 1: Evidence at protein level

Interpro Acc IPR000811

Gene Categories:

DRUGGABLE GENOME

Publications:
PharmGKB: PYGL
- Version: 18-August-2020
Alternate Names:

PA34068 PharmGKB ID

Gene Info:

Publications:

Yang JJ et al., 2012, Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia., Blood

DrugBank: BE0000007

Version: 5.1.7

Alternate Names:

Gene Info:

Publications:

Beauchamp et al., 2007, High frequency of missense mutations in glycogen storage disease type VI., J. Inherit. Metab. Dis.

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

HingoraniCasas: ENSG00000100504
- Version: 31-May-2017
Alternate Names:

ENSG00000100504 Gene Symbol

PYGL Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: PYGL
- Version: 19.3
Alternate Names:

ENSG00000100504 Ensembl Gene ID

Glycogen phosphorylase L Human Protein Atlas Gene Description

P06737 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
Pharos: PYGL
- Version: 03-September-2020
Alternate Names:

Glycogen phosphorylase, liver form Gene Name

P06737 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

ENSG00000100504	Ensembl Gene Id
GLYCOGEN PHOSPHORYLASE, LIVER FORM (EC 2.4.1.1). [SOURCE:UNIPROT/SWISSPROT;ACC:P06737]	Description
PYGL	Display Id

5836	Entrez Gene Id
ENSG00000100504	Ensembl Gene Id
P06737	Uniprot Accession

PYGL Gene Record

PYGL 5836 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: activator (activating)

Interaction Info:

PMIDs: 15987904 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23007406

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11368340

Sources: DrugBank

Interaction Types & Directionality: cofactor (activating)

Interaction Info:

PMIDs: 17705025

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23007406

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23007406

Sources: PharmGKB

Ensembl: ENSG00000100504

Alternate Names: PYGL Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P06737

Alternate Names: PYGL Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:2.4.1.1

Publications:

RussLampel: ENSG00000100504

Alternate Names: ENSG00000100504 Ensembl Gene Id GLYCOGEN PHOSPHORYLASE, LIVER FORM (EC 2.4.1.1). [SOURCE:UNIPROT/SWISSPROT;ACC:P06737] Description PYGL Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: P06737

Alternate Names: 5836 Entrez Gene Id ENSG00000100504 Ensembl Gene Id P06737 Uniprot Accession

Gene Info: Interpro Short Name Glyco_trans_35 Uniprot Evidence 1: Evidence at protein level Interpro Acc IPR000811

Gene Categories: DRUGGABLE GENOME

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

activator (activating)

PMIDs:
15987904 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
23007406

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
11368340

Sources:
DrugBank

Interaction Types & Directionality:

cofactor (activating)

PMIDs:
17705025

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
23007406

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23007406

Sources:
PharmGKB

Alternate Names:

PYGL Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PYGL Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.4.1.1

Alternate Names:

ENSG00000100504 Ensembl Gene Id

GLYCOGEN PHOSPHORYLASE, LIVER FORM (EC 2.4.1.1). [SOURCE:UNIPROT/SWISSPROT;ACC:P06737] Description

PYGL Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

5836 Entrez Gene Id

ENSG00000100504 Ensembl Gene Id

P06737 Uniprot Accession

Gene Info:

Interpro Short Name Glyco_trans_35

Uniprot Evidence 1: Evidence at protein level

Interpro Acc IPR000811

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PA34068 PharmGKB ID

Publications:

Yang JJ et al., 2012, Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia., Blood

Alternate Names:

ENSG00000100504 Gene Symbol

PYGL Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000100504 Ensembl Gene ID

Glycogen phosphorylase L Human Protein Atlas Gene Description

P06737 UniProt ID

Gene Categories:

ENZYME

Alternate Names:

Glycogen phosphorylase, liver form Gene Name

P06737 UniProt ID

Gene Categories:

ENZYME