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PYGL Gene Record

  • Summary
  • Interactions
  • Claims
  • PYGL 5836 Druggable Genome

    Alternate Names:

    5836
    GLYCOGEN PHOSPHORYLASE L
    PYGL
    GSD6
    613741
    9725
    ENSG00000100504
    OTTHUMG00000166596
    P06737
    GLYCOGEN PHOSPHORYLASE, LIVER FORM (EC 2.4.1.1). [SOURCE:UNIPROT/SWISSPROT;ACC:P06737]
    PYGL_HUMAN
    GLYCOGEN PHOSPHORYLASE, LIVER FORM
    BE0000007
    PA34068

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:2.4.1.1
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Glyco_trans_35
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR000811
    Interpro Type Family
    Uniprot Status Swiss-Prot
    Interpro Name Glycosyl transferase, family 35
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Yang JJ et al., 2012, Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia., Blood
    Oikonomakos NG et al., 2005, Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs., Protein Sci
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Kaiser A et al., 2001, The cyclin-dependent kinase (CDK) inhibitor flavopiridol inhibits glycogen phosphorylase., Arch Biochem Biophys
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Beauchamp et al., 2007, High frequency of missense mutations in glycogen storage disease type VI., J. Inherit. Metab. Dis.
  • CHEMBL335954   PYGL

    Interaction Score: 16.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL434025   PYGL

    Interaction Score: 12.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17139284 17016423


    Sources:
    DrugBank

  • URIC ACID   PYGL

    Interaction Score: 12.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17139284 17016423


    Sources:
    DrugBank

  • CHEMBL198408   PYGL

    Interaction Score: 8.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1231099   PYGL

    Interaction Score: 8.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL335315   PYGL

    Interaction Score: 6.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17139284 17016423


    Sources:
    DrugBank

  • ADENOSINE PHOSPHATE   PYGL

    Interaction Score: 1.35

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    15987904 17139284 17016423


    Sources:
    DrugBank

  • DEXFOSFOSERINE   PYGL

    Interaction Score: 0.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17139284 17016423


    Sources:
    DrugBank

  • DEXTROSE   PYGL

    Interaction Score: 0.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17139284 17016423


    Sources:
    DrugBank

  • ASPARAGINASE   PYGL

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23007406


    Sources:
    PharmGKB

  • ALVOCIDIB   PYGL

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11368340


    Sources:
    DrugBank

  • PYRIDOXAL PHOSPHATE   PYGL

    Interaction Score: 0.16

    Interaction Types & Directionality:
    cofactor (activating)

    Interaction Info:

    PMIDs:
    17705025


    Sources:
    DrugBank

  • DEXAMETHASONE   PYGL

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23007406


    Sources:
    PharmGKB

  • METHOTREXATE   PYGL

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23007406


    Sources:
    PharmGKB

  • Ensembl: ENSG00000100504

    • Version: 101_38

    Alternate Names:
    PYGL Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P06737

    • Version: January-2014

    Alternate Names:
    PYGL Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.4.1.1

    Publications:

  • RussLampel: ENSG00000100504

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000100504 Ensembl Gene Id
    GLYCOGEN PHOSPHORYLASE, LIVER FORM (EC 2.4.1.1). [SOURCE:UNIPROT/SWISSPROT;ACC:P06737] Description
    PYGL Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P06737

    • Version: 11-September-2012

    Alternate Names:
    5836 Entrez Gene Id
    ENSG00000100504 Ensembl Gene Id
    P06737 Uniprot Accession

    Gene Info:
    Interpro Short Name Glyco_trans_35
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR000811

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: PYGL

    • Version: 18-August-2020

    Alternate Names:
    PA34068 PharmGKB ID

    Gene Info:

    Publications:
    Yang JJ et al., 2012, Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia., Blood

  • DrugBank: BE0000007

    • Version: 5.1.7

    Alternate Names:

    Gene Info:

    Publications:
    Beauchamp et al., 2007, High frequency of missense mutations in glycogen storage disease type VI., J. Inherit. Metab. Dis.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

  • HingoraniCasas: ENSG00000100504

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000100504 Gene Symbol
    PYGL Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: PYGL

    • Version: 19.3

    Alternate Names:
    ENSG00000100504 Ensembl Gene ID
    Glycogen phosphorylase L Human Protein Atlas Gene Description
    P06737 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • Pharos: PYGL

    • Version: 03-September-2020

    Alternate Names:
    Glycogen phosphorylase, liver form Gene Name
    P06737 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21