DGIdb - PTPRC Gene Record

PTPRC 5788 Druggable GenomeClinically Actionable

Alternate Names:

5788
PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE C
PTPRC
B220
CD45
CD45R
GP180
L-CA
LCA
LY5
T200
151460
9666
ENSG00000081237
OTTHUMG00000035702
P08575
RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
PTPRC_HUMAN
LEUKOCYTE COMMON ANTIGEN PRECURSOR (EC 3.1.3.48) (L-CA) (CD45 ANTIGEN) (T200). [SOURCE:UNIPROT/SWISSPROT;ACC:P08575]
PA34011
Leukocyte common antigen
T43115
protein tyrosine phosphatase receptor type C

Gene Info:

Human Readable Name	PROTEIN PHOSPHATASE
Uniprot Status	Swiss-Prot
Interpro Type	Domain
Interpro Acc	IPR000387
Interpro Name	Protein-tyrosine/Dual-specificity phosphatase
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	Tyr/Dual-specificity_Pase
Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

PROTEIN PHOSPHATASE
CELL SURFACE
TUMOR SUPPRESSOR
KINASE
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Tjernberg A et al., 2004, Mechanism of action of pyridazine analogues on protein tyrosine phosphatase 1B (PTP1B)., Bioorg Med Chem Lett
Ammersbach et al., The effect of glucocorticoids on canine lymphocyte marker expression and apoptosis., J. Vet. Intern. Med.
Broxmeyer et al., 1991, CD45 cell surface antigens are linked to stimulation of early human myeloid progenitor cells by interleukin 3 (IL-3), granulocyte/macrophage colony-stimulating factor (GM-CSF), a GM-CSF/IL-3 fusion protein, and mast cell growth factor (a c-kit ligand)., J. Exp. Med.
Pappas DA et al., 2013, Association of rheumatoid arthritis risk alleles with response to anti-TNF biologics: results from the CORRONA registry and meta-analysis., Inflammation
Cui J et al., 2010, Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy., Arthritis Rheum
Thorson MK et al., 2014, Inhibition of the lymphoid tyrosine phosphatase: the effect of zinc(II) ions and chelating ligand fragments on enzymatic activity., Bioorg Med Chem Lett
Kakiuchi et al., 2004, Flow cytometric analyses on lineage-specific cell surface antigens of rat bone marrow to seek potential myelotoxic biomarkers: status after repeated dose of 5-fluorouracil., J Toxicol Sci
Smith et al., 2000, Periovulatory human oocytes, cumulus cells, and ovarian leukocytes express type 1 but not type 2 11beta-hydroxysteroid dehydrogenase RNA., Fertil. Steril.
Wahab et al., 1999, The distribution of endometrial leukocytes and their proliferation markers in trimegestone-treated postmenopausal women compared to the endometrium of the natural cycle: a dose-ranging study., Hum. Reprod.

HYDROGEN PEROXIDE PTPRC

Interaction Score: 10.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15012988

Sources:
DTC
APAMISTAMAB IODINE I-131 PTPRC

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL204543 PTPRC

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24997687

Sources:
DTC
ALENDRONIC ACID PTPRC

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15012988

Sources:
DTC
ADALIMUMAB PTPRC

Interaction Score: 0.91

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23007924 20309874

Sources:
PharmGKB
ETANERCEPT PTPRC

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23007924 20309874

Sources:
PharmGKB
INFLIXIMAB PTPRC

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23007924 20309874

Sources:
PharmGKB
EPOETIN BETA PTPRC

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1713254

Sources:
NCI
ESTRADIOL PTPRC

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10325261

Sources:
NCI
PREDNISONE PTPRC

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17063711

Sources:
NCI
HYDROCORTISONE PTPRC

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10731548

Sources:
NCI
FLUOROURACIL PTPRC

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15206578

Sources:
NCI

Ensembl: ENSG00000081237
- Version: 101_38
Alternate Names:

PTPRC Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000081237
- Version: 26-July-2011
Alternate Names:

ENSG00000081237 Ensembl Gene Id

LEUKOCYTE COMMON ANTIGEN PRECURSOR (EC 3.1.3.48) (L-CA) (CD45 ANTIGEN) (T200). [SOURCE:UNIPROT/SWISSPROT;ACC:P08575] Description

PTPRC Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: P08575
- Version: 11-September-2012
Alternate Names:

P08575 Uniprot Accession

5788 Entrez Gene Id

PTPRC_HUMAN Uniprot Id

Gene Info:

Human Readable Name PROTEIN PHOSPHATASE

Uniprot Status Swiss-Prot

Interpro Type Domain

Gene Categories:

PROTEIN PHOSPHATASE, DRUGGABLE GENOME

Publications:

PharmGKB: PTPRC

Version: 18-August-2020

Alternate Names:

PA34011 PharmGKB ID

Gene Info:

Publications:

Cui J et al., 2010, Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy., Arthritis Rheum

Pappas DA et al., 2013, Association of rheumatoid arthritis risk alleles with response to anti-TNF biologics: results from the CORRONA registry and meta-analysis., Inflammation

NCI: PTPRC

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Rider et al., 2003, Oxidative inactivation of CD45 protein tyrosine phosphatase may contribute to T lymphocyte dysfunction in the elderly., Mech. Ageing Dev.

Broxmeyer et al., 1991, CD45 cell surface antigens are linked to stimulation of early human myeloid progenitor cells by interleukin 3 (IL-3), granulocyte/macrophage colony-stimulating factor (GM-CSF), a GM-CSF/IL-3 fusion protein, and mast cell growth factor (a c-kit ligand)., J. Exp. Med.

Coombe et al., 1994, Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic progenitor cells to stromal cell elements via recognition of stromal heparan sulfate., Blood

DTC: PTPRC

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Tjernberg A et al., 2004, Mechanism of action of pyridazine analogues on protein tyrosine phosphatase 1B (PTP1B)., Bioorg Med Chem Lett

Thorson MK et al., 2014, Inhibition of the lymphoid tyrosine phosphatase: the effect of zinc(II) ions and chelating ligand fragments on enzymatic activity., Bioorg Med Chem Lett

HingoraniCasas: ENSG00000081237
- Version: 31-May-2017
Alternate Names:

ENSG00000081237 Gene Symbol

PTPRC Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: PTPRC
- Version: 01-February-2022
Alternate Names:

CD45 GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, TUMOR SUPPRESSOR, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
dGene: PTPRC
- Version: 27-Jun-2013
Alternate Names:

5788 Gene ID

B220 dGene Synonym

CD45 dGene Synonym

Gene Info:

Gene Categories:

PROTEIN PHOSPHATASE

Publications:
TTD: Leukocyte common antigen
- Version: 2020.06.01
Alternate Names:

PTPRC TTD Gene Abbreviation

T43115 TTD Target ID

Gene Info:

Publications:
Pharos: PTPRC
- Version: 01-February-2022
Alternate Names:

Receptor-type tyrosine-protein phosphatase C Gene Name

P08575 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
CarisMolecularIntelligence: PTPRC
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

ENSG00000081237	Ensembl Gene Id
LEUKOCYTE COMMON ANTIGEN PRECURSOR (EC 3.1.3.48) (L-CA) (CD45 ANTIGEN) (T200). [SOURCE:UNIPROT/SWISSPROT;ACC:P08575]	Description
PTPRC	Display Id

P08575	Uniprot Accession
5788	Entrez Gene Id
PTPRC_HUMAN	Uniprot Id

Receptor-type tyrosine-protein phosphatase C	Gene Name
P08575	UniProt ID

PTPRC Gene Record

PTPRC 5788 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15012988

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24997687

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15012988

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23007924 20309874

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23007924 20309874

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23007924 20309874

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1713254

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10325261

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17063711

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10731548

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15206578

Sources: NCI

Ensembl: ENSG00000081237

Alternate Names: PTPRC Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000081237

Alternate Names: ENSG00000081237 Ensembl Gene Id LEUKOCYTE COMMON ANTIGEN PRECURSOR (EC 3.1.3.48) (L-CA) (CD45 ANTIGEN) (T200). [SOURCE:UNIPROT/SWISSPROT;ACC:P08575] Description PTPRC Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: P08575

Alternate Names: P08575 Uniprot Accession 5788 Entrez Gene Id PTPRC_HUMAN Uniprot Id

Gene Info: Human Readable Name PROTEIN PHOSPHATASE Uniprot Status Swiss-Prot Interpro Type Domain

Gene Categories: PROTEIN PHOSPHATASE, DRUGGABLE GENOME

Publications:

PharmGKB: PTPRC

Alternate Names: PA34011 PharmGKB ID

Gene Info:

NCI: PTPRC

Alternate Names:

Gene Info:

DTC: PTPRC

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000081237

Alternate Names: ENSG00000081237 Gene Symbol PTPRC Ensembl Id

Gene Info:

Interaction Types & Directionality:

n/a

PMIDs:
15012988

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
24997687

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
15012988

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23007924 20309874

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23007924 20309874

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23007924 20309874

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
1713254

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10325261

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17063711

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10731548

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15206578

Sources:
NCI

Alternate Names:

PTPRC Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000081237 Ensembl Gene Id

LEUKOCYTE COMMON ANTIGEN PRECURSOR (EC 3.1.3.48) (L-CA) (CD45 ANTIGEN) (T200). [SOURCE:UNIPROT/SWISSPROT;ACC:P08575] Description

PTPRC Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

P08575 Uniprot Accession

5788 Entrez Gene Id

PTPRC_HUMAN Uniprot Id

Gene Info:

Human Readable Name PROTEIN PHOSPHATASE

Uniprot Status Swiss-Prot

Interpro Type Domain

Gene Categories:

PROTEIN PHOSPHATASE, DRUGGABLE GENOME

Alternate Names:

PA34011 PharmGKB ID

Alternate Names:

ENSG00000081237 Gene Symbol

PTPRC Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CD45 GO Gene Synonym

Gene Categories:

CELL SURFACE, TUMOR SUPPRESSOR, EXTERNAL SIDE OF PLASMA MEMBRANE

Alternate Names:

5788 Gene ID

B220 dGene Synonym

CD45 dGene Synonym

Gene Categories:

PROTEIN PHOSPHATASE

Alternate Names:

PTPRC TTD Gene Abbreviation

T43115 TTD Target ID

Alternate Names:

Receptor-type tyrosine-protein phosphatase C Gene Name

P08575 UniProt ID

Gene Categories:

KINASE

Gene Categories:

CLINICALLY ACTIONABLE