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PTPRC Gene Record

  • Summary
  • Interactions
  • Claims
  • PTPRC 5788 Druggable GenomeClinically Actionable

    Alternate Names:

    5788
    PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE C
    PTPRC
    B220
    CD45
    CD45R
    GP180
    L-CA
    LCA
    LY5
    T200
    151460
    9666
    ENSG00000081237
    OTTHUMG00000035702
    P08575
    RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
    PTPRC_HUMAN
    LEUKOCYTE COMMON ANTIGEN PRECURSOR (EC 3.1.3.48) (L-CA) (CD45 ANTIGEN) (T200). [SOURCE:UNIPROT/SWISSPROT;ACC:P08575]
    1852
    RTP Type C
    PA34011
    Leukocyte common antigen
    T43115
    protein tyrosine phosphatase receptor type C

    Gene Info:

    Human Readable Name PROTEIN PHOSPHATASE
    Uniprot Status Swiss-Prot
    Interpro Type Domain
    Interpro Acc IPR000387
    Interpro Name Protein-tyrosine/Dual-specificity phosphatase
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Tyr/Dual-specificity_Pase
    Human Readable Name DRUGGABLE GENOME
    GuideToPharmacology Gene Category ID 333
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name Receptor tyrosine phosphatase (RTP) family
    (9 More Sources)

    Gene Categories: Category Details

    PROTEIN PHOSPHATASE
    CELL SURFACE
    TUMOR SUPPRESSOR
    KINASE
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE

    Publications:

    Tjernberg A et al., 2004, Mechanism of action of pyridazine analogues on protein tyrosine phosphatase 1B (PTP1B)., Bioorg Med Chem Lett
    Ammersbach et al., The effect of glucocorticoids on canine lymphocyte marker expression and apoptosis., J. Vet. Intern. Med.
    Broxmeyer et al., 1991, CD45 cell surface antigens are linked to stimulation of early human myeloid progenitor cells by interleukin 3 (IL-3), granulocyte/macrophage colony-stimulating factor (GM-CSF), a GM-CSF/IL-3 fusion protein, and mast cell growth factor (a c-kit ligand)., J. Exp. Med.
    Cui J et al., 2010, Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy., Arthritis Rheum
    Pappas DA et al., 2013, Association of rheumatoid arthritis risk alleles with response to anti-TNF biologics: results from the CORRONA registry and meta-analysis., Inflammation
    Thorson MK et al., 2014, Inhibition of the lymphoid tyrosine phosphatase: the effect of zinc(II) ions and chelating ligand fragments on enzymatic activity., Bioorg Med Chem Lett
    Kakiuchi et al., 2004, Flow cytometric analyses on lineage-specific cell surface antigens of rat bone marrow to seek potential myelotoxic biomarkers: status after repeated dose of 5-fluorouracil., J Toxicol Sci
    Smith et al., 2000, Periovulatory human oocytes, cumulus cells, and ovarian leukocytes express type 1 but not type 2 11beta-hydroxysteroid dehydrogenase RNA., Fertil. Steril.
    Wahab et al., 1999, The distribution of endometrial leukocytes and their proliferation markers in trimegestone-treated postmenopausal women compared to the endometrium of the natural cycle: a dose-ranging study., Hum. Reprod.
  • HYDROGEN PEROXIDE   PTPRC

    Interaction Score: 9.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15012988


    Sources:
    DTC

  • APAMISTAMAB IODINE I-131   PTPRC

    Interaction Score: 4.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CHEMBL204543   PTPRC

    Interaction Score: 4.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24997687


    Sources:
    DTC

  • ALENDRONIC ACID   PTPRC

    Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15012988


    Sources:
    DTC

  • ADALIMUMAB   PTPRC

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20309874 23007924


    Sources:
    PharmGKB

  • INFLIXIMAB   PTPRC

    Interaction Score: 0.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20309874 23007924


    Sources:
    PharmGKB

  • EPOETIN BETA   PTPRC

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1713254


    Sources:
    NCI

  • ETANERCEPT   PTPRC

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20309874 23007924


    Sources:
    PharmGKB

  • PREDNISONE   PTPRC

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17063711


    Sources:
    NCI

  • ESTRADIOL   PTPRC

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10325261


    Sources:
    NCI

  • HYDROCORTISONE   PTPRC

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10731548


    Sources:
    NCI

  • FLUOROURACIL   PTPRC

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15206578


    Sources:
    NCI

  • Ensembl: ENSG00000081237

    • Version: 101_38

    Alternate Names:
    PTPRC Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000081237

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000081237 Ensembl Gene Id
    LEUKOCYTE COMMON ANTIGEN PRECURSOR (EC 3.1.3.48) (L-CA) (CD45 ANTIGEN) (T200). [SOURCE:UNIPROT/SWISSPROT;ACC:P08575] Description
    PTPRC Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P08575

    • Version: 11-September-2012

    Alternate Names:
    P08575 Uniprot Accession
    5788 Entrez Gene Id
    PTPRC_HUMAN Uniprot Id

    Gene Info:
    Human Readable Name PROTEIN PHOSPHATASE
    Uniprot Status Swiss-Prot
    Interpro Type Domain

    Gene Categories:
    PROTEIN PHOSPHATASE, DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 5788

    • Version: 29-September-2020

    Alternate Names:
    9666 HUGO Gene ID
    9666 HUGO Gene Symbol
    protein tyrosine phosphatase receptor type C HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Receptor tyrosine phosphatase (RTP) family
    GuideToPharmacology Gene Category ID 333

    Publications:

  • PharmGKB: PTPRC

    • Version: 18-August-2020

    Alternate Names:
    PA34011 PharmGKB ID

    Gene Info:

    Publications:
    Cui J et al., 2010, Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy., Arthritis Rheum
    Pappas DA et al., 2013, Association of rheumatoid arthritis risk alleles with response to anti-TNF biologics: results from the CORRONA registry and meta-analysis., Inflammation

  • NCI: PTPRC

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Rider et al., 2003, Oxidative inactivation of CD45 protein tyrosine phosphatase may contribute to T lymphocyte dysfunction in the elderly., Mech. Ageing Dev.
    Broxmeyer et al., 1991, CD45 cell surface antigens are linked to stimulation of early human myeloid progenitor cells by interleukin 3 (IL-3), granulocyte/macrophage colony-stimulating factor (GM-CSF), a GM-CSF/IL-3 fusion protein, and mast cell growth factor (a c-kit ligand)., J. Exp. Med.
    Coombe et al., 1994, Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic progenitor cells to stromal cell elements via recognition of stromal heparan sulfate., Blood

  • DTC: PTPRC

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Tjernberg A et al., 2004, Mechanism of action of pyridazine analogues on protein tyrosine phosphatase 1B (PTP1B)., Bioorg Med Chem Lett
    Thorson MK et al., 2014, Inhibition of the lymphoid tyrosine phosphatase: the effect of zinc(II) ions and chelating ligand fragments on enzymatic activity., Bioorg Med Chem Lett

  • HingoraniCasas: ENSG00000081237

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000081237 Gene Symbol
    PTPRC Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: PTPRC

    • Version: 03-September-2020

    Alternate Names:
    Receptor-type tyrosine-protein phosphatase C Gene Name
    P08575 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • GO: PTPRC

    • Version: 05-September-2020

    Alternate Names:
    CD45 GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, TUMOR SUPPRESSOR, EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • dGene: PTPRC

    • Version: 27-Jun-2013

    Alternate Names:
    5788 Gene ID
    B220 dGene Synonym
    CD45 dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEIN PHOSPHATASE

    Publications:

  • TTD: Leukocyte common antigen

    • Version: 2020.06.01

    Alternate Names:
    PTPRC TTD Gene Abbreviation
    T43115 TTD Target ID

    Gene Info:

    Publications:

  • CarisMolecularIntelligence: PTPRC

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21