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PTPN1 Gene Record

  • Summary
  • Interactions
  • Claims
  • PTPN1 5770 Druggable Genome

    Alternate Names:

    5770
    PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1
    PTPN1
    PTP1B
    176885
    9642
    ENSG00000196396
    OTTHUMG00000032729
    P18031
    PTN1_HUMAN
    PROTEIN-TYROSINE PHOSPHATASE 1B
    TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 1 (EC 3.1.3.48) (PROTEIN-TYROSINE PHOSPHATASE 1B) (PTP-1B). [SOURCE:UNIPROT/SWISSPROT;ACC:P18031]
    TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1
    protein tyrosine phosphatase non-receptor type 1
    T16347

    Gene Info:

    Target Main Class Enzymes
    Target Subclass 3.1.3
    Transmembrane Helix Count 1
    Target Class Enzymes
    Target Subclass EC:3.1.3
    Human Readable Name PROTEIN PHOSPHATASE
    Human Readable Name DRUGGABLE GENOME
    Interpro Name Protein-tyrosine/Dual-specificity phosphatase
    Interpro Acc IPR000387
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Tyr/Dual-specificity_Pase
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    PROTEIN PHOSPHATASE
    KINASE
    DRUGGABLE GENOME

    Publications:

    Ramírez-Espinosa JJ et al., 2011, Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP-1B: in vitro, in silico, and in vivo approaches., Eur J Med Chem
    Lewis SM et al., 2015, Inactivation of protein tyrosine phosphatases by dietary isothiocyanates., Bioorg Med Chem Lett
    Li W et al., 2013, Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors., Bioorg Med Chem Lett
    Cui Y et al., 2012, New diterpene furanoids from the Antarctic lichen Huea sp., Bioorg Med Chem Lett
    Li S et al., 2010, Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities., Bioorg Med Chem Lett
    Seely et al., 1996, Protein tyrosine phosphatase 1B interacts with the activated insulin receptor., Diabetes
    Kawaguchi M et al., 2011, Development of a highly selective fluorescence probe for alkaline phosphatase., Bioorg Med Chem Lett
    Bhattacharya S et al., 2008, Oxidative inactivation of protein tyrosine phosphatase 1B by organic hydroperoxides., Bioorg Med Chem Lett
    Kate AS et al., 2008, Lipidyl pseudopteranes A-F: isolation, biomimetic synthesis, and PTP1B inhibitory activity of a new class of pseudopteranoids from the Gorgonian Pseudopterogorgia acerosa., J Nat Prod
    Xie J et al., 2011, Pyrrolo[2,3-c]azepine derivatives: a new class of potent protein tyrosine phosphatase 1B inhibitors., Bioorg Med Chem Lett
    Bhattacharyya S et al., 2010, Inactivation of protein tyrosine phosphatases by oltipraz and other cancer chemopreventive 1,2-dithiole-3-thiones., Bioorg Med Chem
    Thorson MK et al., 2014, Inhibition of the lymphoid tyrosine phosphatase: the effect of zinc(II) ions and chelating ligand fragments on enzymatic activity., Bioorg Med Chem Lett
    Seo C et al., 2009, Protein tyrosine phosphatase 1B inhibitory effects of depsidone and pseudodepsidone metabolites from the Antarctic lichen Stereocaulon alpinum., Bioorg Med Chem Lett
  • ISOBAVACHALCONE   PTPN1

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24047800


    Sources:
    DTC

  • LIPIDYL PSEUDOPTERANE D   PTPN1

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19061360


    Sources:
    DTC

  • ALDISIN   PTPN1

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21696953


    Sources:
    DTC

  • CHEMBL458855   PTPN1

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18595691


    Sources:
    DTC

  • LIPIDYL PSEUDOPTERANE A   PTPN1

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19061360


    Sources:
    DTC

  • CHEMBL1162414   PTPN1

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18595691


    Sources:
    DTC

  • MOROLIC ACID   PTPN1

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21453996


    Sources:
    DTC

  • LICOAGRONE   PTPN1

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24047800


    Sources:
    DTC

  • FLUORESCEIN DIPHOSPHATE   PTPN1

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21482108


    Sources:
    DTC

  • GLISOFLAVONE   PTPN1

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20724155


    Sources:
    DTC

  • CHEMBL2207339   PTPN1

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23141910


    Sources:
    DTC

  • LICOAGRODIN   PTPN1

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24047800


    Sources:
    DTC

  • MORONIC ACID   PTPN1

    Interaction Score: 2.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21453996


    Sources:
    DTC

  • CHEMBL204543   PTPN1

    Interaction Score: 2.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24997687


    Sources:
    DTC

  • TRODUSQUEMINE   PTPN1

    Interaction Score: 2.58

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name trodusquemine, MSI-1436
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD

  • TILUDRONIC ACID   PTPN1

    Interaction Score: 2.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TEND

  • ALLYL ISOTHIOCYANATE   PTPN1

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26338358


    Sources:
    DTC

  • OLEANOLIC_ACID   PTPN1

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21453996


    Sources:
    DTC

  • OLTIPRAZ   PTPN1

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20655236


    Sources:
    DTC

  • ANETHOLTRITHION   PTPN1

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20655236


    Sources:
    DTC

  • DITHIOLETHIONE   PTPN1

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20655236


    Sources:
    DTC

  • URSOLIC ACID   PTPN1

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21453996


    Sources:
    DTC

  • LOBARIC ACID   PTPN1

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19362837


    Sources:
    DTC

  • INSULIN   PTPN1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8826975


    Sources:
    NCI

  • Ensembl: ENSG00000196396

    • Version: 101_38

    Alternate Names:
    PTPN1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P18031

    • Version: January-2014

    Alternate Names:
    PTPN1 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.1.3

    Publications:

  • RussLampel: ENSG00000196396

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000196396 Ensembl Gene Id
    PTPN1 Display Id
    TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 1 (EC 3.1.3.48) (PROTEIN-TYROSINE PHOSPHATASE 1B) (PTP-1B). [SOURCE:UNIPROT/SWISSPROT;ACC:P18031] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TEND: P18031

    • Version: 01-August-2011

    Alternate Names:
    5770 Entrez Gene Id
    P18031 Uniprot Accession
    ENSG00000196396 Ensembl Gene Id

    Gene Info:
    Target Main Class Enzymes
    Target Subclass 3.1.3
    Transmembrane Helix Count 1

    Publications:

  • HopkinsGroom: P18031

    • Version: 11-September-2012

    Alternate Names:
    5770 Entrez Gene Id
    TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1 Uniprot Protein Name
    PTN1_HUMAN Uniprot Id

    Gene Info:
    Human Readable Name PROTEIN PHOSPHATASE
    Interpro Name Protein-tyrosine/Dual-specificity phosphatase
    Interpro Acc IPR000387

    Gene Categories:
    PROTEIN PHOSPHATASE, DRUGGABLE GENOME

    Publications:

  • NCI: PTPN1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Seely et al., 1996, Protein tyrosine phosphatase 1B interacts with the activated insulin receptor., Diabetes

  • DTC: PTPN1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Lewis SM et al., 2015, Inactivation of protein tyrosine phosphatases by dietary isothiocyanates., Bioorg Med Chem Lett
    Li S et al., 2010, Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities., Bioorg Med Chem Lett
    Bhattacharya S et al., 2008, Oxidative inactivation of protein tyrosine phosphatase 1B by organic hydroperoxides., Bioorg Med Chem Lett

  • HingoraniCasas: ENSG00000196396

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000196396 Gene Symbol
    PTPN1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • dGene: PTPN1

    • Version: 27-Jun-2013

    Alternate Names:
    5770 Gene ID
    PTP1B dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEIN PHOSPHATASE

    Publications:

  • TTD: Protein-tyrosine phosphatase 1B

    • Version: 2020.06.01

    Alternate Names:
    PTP1B TTD Gene Abbreviation
    T16347 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: PTPN1

    • Version: 01-February-2022

    Alternate Names:
    Tyrosine-protein phosphatase non-receptor type 1 Gene Name
    P18031 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21