• PTK2B 2185 Druggable GenomeDrug Resistance

    Alternate Names:

    2185
    PROTEIN TYROSINE KINASE 2 BETA
    PTK2B
    CADTK
    CAKB
    FADK2
    FAK2
    PKB
    PTK
    PYK2
    RAFTK
    601212
    9612
    ENSG00000120899
    OTTHUMG00000102082
    Q14289
    FAK2_HUMAN
    PROTEIN-TYROSINE KINASE 2-BETA
    PROTEIN TYROSINE KINASE 2 BETA (EC 2.7.1.112) (FOCAL ADHESION KINASE 2) (FADK 2) (PROLINE-RICH TYROSINE KINASE 2) (CELL ADHESION KINASE BETA) (CAK BETA) (CALCIUM-DEPENDENT TYROSINE KINASE) (CADTK) (RELATED ADHESION FOCAL TYROSINE KINASE). [SOURCE:UNIPROT/
    2181
    NM_004103
    NP_004094
    TYROSINE-PROTEIN KINASE
    FADK 2
    CAK-beta
    Related adhesion focal tyrosine kinase
    Proline-rich tyrosine kinase 2
    Focal adhesion kinase 2
    Cell adhesion kinase beta
    Calcium-regulated non-receptor proline-rich tyrosine kinase
    Calcium-dependent tyrosine kinase
    T43415

    Gene Info:

    Uniprot Status Swiss-Prot
    Human Readable Name KINASE
    Interpro Type Domain
    Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom
    Interpro Acc IPR001245
    GuideToPharmacology Gene Category Name Fak family
    GuideToPharmacology Gene Category ID 574
    CancerCommons Reported Gene Name FAK, PYK2
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    KINASE
    ION CHANNEL
    TYROSINE KINASE
    DRUG RESISTANCE
    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME
    ENZYME
  • Interaction Score: 1.68

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Protein tyrosine kinase 2 beta inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 1.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 1.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 0.42

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19035792


    Sources:
    DTC

  • Interaction Score: 0.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

    • Version: 101_38

    Alternate Names:
    PTK2B Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    PROTEIN-TYROSINE KINASE 2-BETA Uniprot Protein Name
    FAK2_HUMAN Uniprot Id
    ENSG00000120899 Ensembl Gene Id

    Gene Info:
    Uniprot Status Swiss-Prot
    Human Readable Name KINASE
    Interpro Type Domain

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    PTK2B Display Id
    PROTEIN TYROSINE KINASE 2 BETA (EC 2.7.1.112) (FOCAL ADHESION KINASE 2) (FADK 2) (PROLINE-RICH TYROSINE KINASE 2) (CELL ADHESION KINASE BETA) (CAK BETA) (CALCIUM-DEPENDENT TYROSINE KINASE) (CADTK) (RELATED ADHESION FOCAL TYROSINE KINASE). [SOURCE:UNIPROT/ Description
    ENSG00000120899 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 25-July-2013

    Alternate Names:
    2185 Entrez Gene ID

    Gene Info:
    CancerCommons Reported Gene Name FAK, PYK2

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    9612 HUGO Gene ID
    9612 HUGO Gene Symbol
    protein tyrosine kinase 2 beta HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Fak family
    GuideToPharmacology Gene Category ID 574

    Gene Categories:
    ENZYME

    Publications:

    • Version: 02-September-2020
    • Version: 31-May-2017

    Alternate Names:
    ENSG00000120899 Gene Symbol
    PTK2B Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    PYK2 GENE_SYMBOL
    RAFTK GENE_SYMBOL
    PTK2B GENE_SYMBOL

    Gene Info:

    Publications:

    • Version: 27-Jun-2013

    Alternate Names:
    2185 Gene ID
    CADTK dGene Synonym
    CAKB dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, TYROSINE KINASE

    Publications:

    • Version: 2020.06.01

    Alternate Names:
    PTK TTD Gene Abbreviation
    T43415 TTD Target ID

    Gene Info:

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    FAK2 GO Gene Synonym
    PYK2 GO Gene Synonym
    RAFTK GO Gene Synonym

    Gene Info:

    Gene Categories:
    TYROSINE KINASE, DRUG RESISTANCE

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Protein-tyrosine kinase 2-beta Gene Name
    Q14289 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, ION CHANNEL, G PROTEIN COUPLED RECEPTOR

    Publications: