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PTGER4 Gene Record

  • Summary
  • Interactions
  • Claims
  • PTGER4 5734 Druggable Genome

    Alternate Names:

    5734
    PROSTAGLANDIN E RECEPTOR 4
    PTGER4
    EP4
    EP4R
    601586
    9596
    ENSG00000171522
    OTTHUMG00000094769
    P35408
    PE2R4_HUMAN
    PROSTAGLANDIN E2 RECEPTOR EP4 SUBTYPE
    343
    EP<sub>4</sub> receptor
    NM_000958
    NP_000949
    PROSTAGLANDIN E2 RECEPTOR, EP4 SUBTYPE (PROSTANOID EP4 RECEPTOR) (PGE RECEPTOR, EP4 SUBTYPE). [SOURCE:UNIPROT/SWISSPROT;ACC:P35408]
    BE0003522
    PA289
    Prostaglandin E2 receptor EP4
    T18876

    Gene Info:

    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name GPCR, rhodopsin-like, 7TM
    Uniprot Status Swiss-Prot
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Interpro Type Family
    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR000276
    GuideToPharmacology Gene Category Name Prostanoid receptors
    GuideToPharmacology Gene Category ID 58
    Transmembrane Helix Count 7
    Target Main Class Receptors
    Gene Biotype PROTEIN_CODING
    (10 More Sources)

    Gene Categories: Category Details

    KINASE
    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Sugimoto et al., 2007, Prostaglandin E receptors., J. Biol. Chem.
    Wise, 2006, Lack of interaction between prostaglandin E2 receptor subtypes in regulating adenylyl cyclase activity in cultured rat dorsal root ganglion cells., Eur. J. Pharmacol.
    Baryawno et al., 2008, Tumor-growth-promoting cyclooxygenase-2 prostaglandin E2 pathway provides medulloblastoma therapeutic targets., Neuro-oncology
    Tamiji et al., 2010, Prostaglandin E(2) and misoprostol induce neurite retraction in Neuro-2a cells., Biochem. Biophys. Res. Commun.
    Legler et al., 2010, Prostaglandin E2 at new glance: novel insights in functional diversity offer therapeutic chances., Int. J. Biochem. Cell Biol.
    Finnegan DF et al., 2015, Novel tail and head group prostamide probes., Bioorg Med Chem Lett
    Schmitz et al., 2007, Prostaglandin E2 receptor expression in fetal baboon lung at 0.7 gestation after betamethasone exposure., Pediatr. Res.
    Nasrallah et al., 2007, Renal prostaglandin E2 receptor (EP) expression profile is altered in streptozotocin and B6-Ins2Akita type I diabetic mice., Am. J. Physiol. Renal Physiol.
    Li et al., 2008, Misoprostol, an anti-ulcer agent and PGE2 receptor agonist, protects against cerebral ischemia., Neurosci. Lett.
    Nakae et al., 2005, Functional role of prostacyclin receptor in rat dorsal root ganglion neurons., Neurosci. Lett.
    Crider et al., Pharmacology of functional endogenous IP prostanoid receptors in NCB-20 cells: comparison with binding data from human platelets., Prostaglandins Leukot. Essent. Fatty Acids
    Guan et al., 2002, Cloning and expression of the rabbit prostaglandin EP2 receptor., BMC Pharmacol.
    Kiriyama et al., 1997, Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells., Br. J. Pharmacol.
    Nataraj et al., 2001, Receptors for prostaglandin E(2) that regulate cellular immune responses in the mouse., J. Clin. Invest.
    Abran et al., 1997, Characterization and regulation of prostaglandin E2 receptor and receptor-coupled functions in the choroidal vasculature of the pig during development., Circ. Res.
    Woodward DF et al., 2011, International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress., Pharmacol Rev
    Kirkby Shaw K et al., 2015, Grapiprant: an EP4 prostaglandin receptor antagonist and novel therapy for pain and inflammation., Vet Med Sci
    Kraus S et al., 2013, Impact of genetic polymorphisms on adenoma recurrence and toxicity in a COX2 inhibitor (celecoxib) trial: results from a pilot study., Pharmacogenet Genomics
  • GRAPIPRANT   PTGER4

    Interaction Score: 11.36

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    21752876 29067176


    Sources:
    DrugBank GuideToPharmacology

  • MISOPROSTOL   PTGER4

    Interaction Score: 3.31

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    18472336 16039053 11993717 12097143 9313928 11602631


    Sources:
    DrugBank

  • CHEMBL597997   PTGER4

    Interaction Score: 2.84

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CR-6086   PTGER4

    Interaction Score: 2.84

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • DINOPROSTONE   PTGER4

    Interaction Score: 2.4

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Specific Action of the Ligand Full agonist

    PMIDs:
    17329241 16545798 18715952 20599704 19788928 25701254


    Sources:
    TEND DTC TdgClinicalTrial DrugBank GuideToPharmacology

  • EVATANEPAG   PTGER4

    Interaction Score: 1.42

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • BERAPROST   PTGER4

    Interaction Score: 0.95

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • LIMAPROST   PTGER4

    Interaction Score: 0.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • ENPROSTIL   PTGER4

    Interaction Score: 0.71

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CICAPROST   PTGER4

    Interaction Score: 0.71

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Full agonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • BETAMETHASONE   PTGER4

    Interaction Score: 0.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17515865


    Sources:
    NCI

  • EPOPROSTENOL   PTGER4

    Interaction Score: 0.57

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? True

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • BUTAPROST   PTGER4

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CARBACYCLIN   PTGER4

    Interaction Score: 0.36

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • TREPROSTINIL   PTGER4

    Interaction Score: 0.32

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ILOPROST   PTGER4

    Interaction Score: 0.19

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ALPROSTADIL   PTGER4

    Interaction Score: 0.18

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? True
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • IBUPROFEN   PTGER4

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9118476


    Sources:
    NCI

  • STREPTOZOCIN   PTGER4

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16954344


    Sources:
    NCI

  • CELECOXIB   PTGER4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23778325


    Sources:
    PharmGKB

  • Ensembl: ENSG00000171522

    • Version: 101_38

    Alternate Names:
    PTGER4 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P35408

    • Version: 01-August-2011

    Alternate Names:
    PE2R4_HUMAN Uniprot Id
    5734 Entrez Gene Id
    PTGER4 Gene Symbol

    Gene Info:
    Target Subclass GPCR
    Target Subclass Rhodopsin
    Transmembrane Helix Count 7

    Publications:

  • TdgClinicalTrial: P35408

    • Version: January-2014

    Alternate Names:
    PTGER4 Gene Symbol

    Gene Info:
    Target Subclass GPCR
    Target Subclass Rhodopsin
    Target Class Receptors

    Publications:

  • RussLampel: ENSG00000171522

    • Version: 26-July-2011

    Alternate Names:
    PTGER4 Display Id
    PROSTAGLANDIN E2 RECEPTOR, EP4 SUBTYPE (PROSTANOID EP4 RECEPTOR) (PGE RECEPTOR, EP4 SUBTYPE). [SOURCE:UNIPROT/SWISSPROT;ACC:P35408] Description
    ENSG00000171522 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P35408

    • Version: 11-September-2012

    Alternate Names:
    PROSTAGLANDIN E2 RECEPTOR EP4 SUBTYPE Uniprot Protein Name
    ENSG00000171522 Ensembl Gene Id
    PTGER4 Uniprot Gene Name

    Gene Info:
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name GPCR, rhodopsin-like, 7TM
    Uniprot Status Swiss-Prot

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 5734

    • Version: 29-September-2020

    Alternate Names:
    9596 HUGO Gene ID
    9596 HUGO Gene Symbol
    prostaglandin E receptor 4 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Prostanoid receptors
    GuideToPharmacology Gene Category ID 58

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • PharmGKB: PTGER4

    • Version: 18-August-2020

    Alternate Names:
    PA289 PharmGKB ID

    Gene Info:

    Publications:
    Kraus S et al., 2013, Impact of genetic polymorphisms on adenoma recurrence and toxicity in a COX2 inhibitor (celecoxib) trial: results from a pilot study., Pharmacogenet Genomics

  • DrugBank: BE0003522

    • Version: 5.1.7

    Alternate Names:
    PTGER4 DrugBank Gene Name
    P35408 UniProt Accession
    5734 Entrez Gene Id

    Gene Info:

    Publications:
    Li et al., 2008, Misoprostol, an anti-ulcer agent and PGE2 receptor agonist, protects against cerebral ischemia., Neurosci. Lett.
    Nakae et al., 2005, Functional role of prostacyclin receptor in rat dorsal root ganglion neurons., Neurosci. Lett.
    Crider et al., Pharmacology of functional endogenous IP prostanoid receptors in NCB-20 cells: comparison with binding data from human platelets., Prostaglandins Leukot. Essent. Fatty Acids

  • TTD: Prostaglandin E2 receptor EP4

    • Version: 2020.06.01

    Alternate Names:
    PTGER4 TTD Gene Abbreviation
    T18876 TTD Target ID

    Gene Info:

    Publications:
    Maubach et al., 2009, BGC20-1531, a novel, potent and selective prostanoid EP receptor antagonist: a putative new treatment for migraine headache., Br. J. Pharmacol.

  • NCI: PTGER4

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Abran et al., 1997, Characterization and regulation of prostaglandin E2 receptor and receptor-coupled functions in the choroidal vasculature of the pig during development., Circ. Res.
    Schmitz et al., 2007, Prostaglandin E2 receptor expression in fetal baboon lung at 0.7 gestation after betamethasone exposure., Pediatr. Res.
    Nasrallah et al., 2007, Renal prostaglandin E2 receptor (EP) expression profile is altered in streptozotocin and B6-Ins2Akita type I diabetic mice., Am. J. Physiol. Renal Physiol.

  • DTC: PTGER4

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Finnegan DF et al., 2015, Novel tail and head group prostamide probes., Bioorg Med Chem Lett

  • HingoraniCasas: ENSG00000171522

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000171522 Gene Symbol
    PTGER4 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: PTGER4

    • Version: 03-September-2020

    Alternate Names:
    Prostaglandin E2 receptor EP4 subtype Gene Name
    P35408 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • dGene: PTGER4

    • Version: 27-Jun-2013

    Alternate Names:
    5734 Gene ID
    EP4 dGene Synonym
    EP4R dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21