• Interaction Score: 5.26

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name bimatoprost, AGN 192024,Lumigan
    Novel drug target Established target

  • Interaction Score: 4.73

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    28439968 7834185


    Sources:
    DrugBank

  • Interaction Score: 4.73

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Prostanoid EP3 receptor agonist
    Direct Interaction yes

  • Interaction Score: 3.16

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Details of Interaction EP<sub>3</sub>-II isoform
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 2.67

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Prostaglandin E2 receptor agonist
    Direct Interaction yes
    Details of Interaction EP<sub>3</sub>-II & -III isoforms

  • Interaction Score: 1.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 1.05

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 1.05

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Details of Interaction EP<sub>3</sub>-III isoform
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 1.05

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Details of Interaction EP<sub>3</sub>-III isoform

    PMIDs:
    None found


  • Interaction Score: 0.79

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • Interaction Score: 0.79

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Details of Interaction EP<sub>3</sub>-III isoform
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.79

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Details of Interaction EP<sub>3</sub>-III isoform

    PMIDs:
    None found


  • Interaction Score: 0.63

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Details of Interaction EP<sub>3</sub>-III isoform
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 0.39

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Details of Interaction EP<sub>3</sub>-III isoform
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.35

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? False
    Details of Interaction EP<sub>3</sub>-I isoform
    Specific Action of the Ligand Full agonist

    PMIDs:
    None found


  • Interaction Score: 0.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Details of Interaction EP<sub>3</sub>-III isoform
    Endogenous Drug? False
    Details of Interaction EP<sub>3</sub>-I isoform

    PMIDs:
    None found


  • Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17496729


    Sources:
    PharmGKB