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PSMD2 Gene Record

  • Summary
  • Interactions
  • Claims
  • PSMD2 5708

    Alternate Names:

    5708
    PROTEASOME 26S SUBUNIT, NON-ATPASE 2
    PSMD2
    P97
    RPN1
    S2
    TRAP2
    606223
    9559
    ENSG00000175166
    OTTHUMG00000156796
    Q13200
    26S proteasome regulatory subunit RPN1
    Tumor necrosis factor type 1 receptor-associated protein 2
    Protein 55.11
    26S proteasome subunit p97
    26S proteasome non-ATPase regulatory subunit 2
    26S proteasome regulatory subunit S2
    PSMD2_HUMAN
    Proteasome
    PROTEASOME 26S SUBUNIT UBIQUITIN RECEPTOR, NON-ATPASE 2

    Gene Info:

    Target Class Miscellaneous
    Target Subclass Enzyme regulator
    Target Main Class Other
    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    Publications:

    Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem
  • CARFILZOMIB   PSMD2

    Interaction Score: 1.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction 26S proteosome inhibitor
    Direct Interaction yes

    PMIDs:
    24524217


    Sources:
    DTC MyCancerGenome ChemblInteractions

  • BORTEZOMIB   PSMD2

    Interaction Score: 1.03

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction 26S proteosome inhibitor
    Trial Name Velcade

    PMIDs:
    24524217


    Sources:
    DTC MyCancerGenome TdgClinicalTrial ChemblInteractions TEND

  • IXAZOMIB CITRATE   PSMD2

    Interaction Score: 0.81

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction 26S proteosome inhibitor
    Direct Interaction yes
    Trial Name MLN-9708

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • OPROZOMIB   PSMD2

    Interaction Score: 0.79

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction 26S proteosome inhibitor
    Direct Interaction yes
    Trial Name ONX 0912

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • Ensembl: ENSG00000175166

    • Version: 101_38

    Alternate Names:
    PSMD2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: Q13200

    • Version: 01-August-2011

    Alternate Names:
    5708 Entrez Gene Id
    Q13200 Uniprot Accession
    ENSG00000175166 Ensembl Gene Id

    Gene Info:
    Target Subclass Enzyme regulator
    Target Main Class Other

    Publications:

  • TdgClinicalTrial: Q13200

    • Version: January-2014

    Alternate Names:
    PSMD2 Gene Symbol

    Gene Info:
    Target Class Miscellaneous
    Target Subclass Enzyme regulator

    Publications:

  • DTC: PSMD2

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem

  • MyCancerGenome: PSMD2

    • Version: 20-Jun-2017

    Alternate Names:
    5708 Entrez Gene Id
    PSMD2 MyCancerGenome Gene Symbol
    Proteasome MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

  • ChemblInteractions: TRAP2

    • Version: chembl_23

    Alternate Names:
    TRAP2 GENE_SYMBOL
    PSMD2 GENE_SYMBOL
    26S proteasome non-ATPase regulatory subunit 2 UNIPROT

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21