DGIdb - PSMD2 Gene Record

PSMD2 5708

Alternate Names:

5708
PROTEASOME 26S SUBUNIT, NON-ATPASE 2
PSMD2
P97
RPN1
S2
TRAP2
606223
9559
ENSG00000175166
OTTHUMG00000156796
Q13200
26S proteasome regulatory subunit RPN1
Tumor necrosis factor type 1 receptor-associated protein 2
Protein 55.11
26S proteasome subunit p97
26S proteasome non-ATPase regulatory subunit 2
26S proteasome regulatory subunit S2
PSMD2_HUMAN
Proteasome
PROTEASOME 26S SUBUNIT UBIQUITIN RECEPTOR, NON-ATPASE 2

Gene Info:

Target Class	Miscellaneous
Target Subclass	Enzyme regulator
Target Main Class	Other
Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

Publications:

Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem

CARFILZOMIB PSMD2

Interaction Score: 1.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
BORTEZOMIB PSMD2

Interaction Score: 1.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 26S proteosome inhibitor

Trial Name Velcade

PMIDs:
24524217

Sources:
DTC MyCancerGenome TdgClinicalTrial ChemblInteractions TEND
IXAZOMIB CITRATE PSMD2

Interaction Score: 0.84

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

Trial Name MLN-9708

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
OPROZOMIB PSMD2

Interaction Score: 0.82

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

Trial Name ONX 0912

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Ensembl: ENSG00000175166
- Version: 101_38
Alternate Names:

PSMD2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: Q13200
- Version: 01-August-2011
Alternate Names:

5708 Entrez Gene Id

Q13200 Uniprot Accession

ENSG00000175166 Ensembl Gene Id

Gene Info:

Target Subclass Enzyme regulator

Target Main Class Other

Publications:
TdgClinicalTrial: Q13200
- Version: January-2014
Alternate Names:

PSMD2 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Enzyme regulator

Publications:

DTC: PSMD2

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem

MyCancerGenome: PSMD2
- Version: 20-Jun-2017
Alternate Names:

5708 Entrez Gene Id

PSMD2 MyCancerGenome Gene Symbol

Proteasome MyCancerGenome Reported Gene Name

Gene Info:

Publications:
ChemblInteractions: TRAP2
- Version: chembl_23
Alternate Names:

TRAP2 GENE_SYMBOL

PSMD2 GENE_SYMBOL

26S proteasome non-ATPase regulatory subunit 2 UNIPROT

Gene Info:

Publications:

Mechanism of Interaction	26S proteosome inhibitor
Direct Interaction	yes

5708	Entrez Gene Id
Q13200	Uniprot Accession
ENSG00000175166	Ensembl Gene Id

TRAP2	GENE_SYMBOL
PSMD2	GENE_SYMBOL
26S proteasome non-ATPase regulatory subunit 2	UNIPROT

PSMD2 Gene Record

PSMD2 5708

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

CARFILZOMIB PSMD2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes

PMIDs: 24524217

Sources: DTC MyCancerGenome ChemblInteractions

BORTEZOMIB PSMD2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction 26S proteosome inhibitor Trial Name Velcade

PMIDs: 24524217

Sources: DTC MyCancerGenome TdgClinicalTrial ChemblInteractions TEND

IXAZOMIB CITRATE PSMD2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes Trial Name MLN-9708

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

OPROZOMIB PSMD2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes Trial Name ONX 0912

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Ensembl: ENSG00000175166

Alternate Names: PSMD2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TEND: Q13200

Alternate Names: 5708 Entrez Gene Id Q13200 Uniprot Accession ENSG00000175166 Ensembl Gene Id

Gene Info: Target Subclass Enzyme regulator Target Main Class Other

Publications:

TdgClinicalTrial: Q13200

Alternate Names: PSMD2 Gene Symbol

Gene Info: Target Class Miscellaneous Target Subclass Enzyme regulator

Publications:

DTC: PSMD2

Alternate Names:

Gene Info:

Publications: Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem

MyCancerGenome: PSMD2

Alternate Names: 5708 Entrez Gene Id PSMD2 MyCancerGenome Gene Symbol Proteasome MyCancerGenome Reported Gene Name

Gene Info:

Publications:

ChemblInteractions: TRAP2

Alternate Names: TRAP2 GENE_SYMBOL PSMD2 GENE_SYMBOL 26S proteasome non-ATPase regulatory subunit 2 UNIPROT

Gene Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 26S proteosome inhibitor

Trial Name Velcade

PMIDs:
24524217

Sources:
DTC MyCancerGenome TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

Trial Name MLN-9708

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

Trial Name ONX 0912

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Alternate Names:

PSMD2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

5708 Entrez Gene Id

Q13200 Uniprot Accession

ENSG00000175166 Ensembl Gene Id

Gene Info:

Target Subclass Enzyme regulator

Target Main Class Other

Alternate Names:

PSMD2 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Enzyme regulator

Publications:

Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem

Alternate Names:

5708 Entrez Gene Id

PSMD2 MyCancerGenome Gene Symbol

Proteasome MyCancerGenome Reported Gene Name

Alternate Names:

TRAP2 GENE_SYMBOL

PSMD2 GENE_SYMBOL

26S proteasome non-ATPase regulatory subunit 2 UNIPROT