• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

PSMD1 Gene Record

  • Summary
  • Interactions
  • Claims
  • PSMD1 5707

    Alternate Names:

    5707
    PROTEASOME 26S SUBUNIT, NON-ATPASE 1
    PSMD1
    P112
    Rpn2
    S1
    9554
    ENSG00000173692
    OTTHUMG00000133223
    Proteasome
    Q99460
    PSMD1_HUMAN
    26S proteasome subunit p112
    26S proteasome non-ATPase regulatory subunit 1
    26S proteasome regulatory subunit RPN2
    26S proteasome regulatory subunit S1

    Gene Info:

    Target Main Class Other
    Target Subclass Enzyme regulator
    Target Class Miscellaneous
    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    Publications:

    Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem
  • CARFILZOMIB   PSMD1

    Interaction Score: 1.0

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction 26S proteosome inhibitor
    Direct Interaction yes

    PMIDs:
    24524217


    Sources:
    DTC MyCancerGenome ChemblInteractions

  • BORTEZOMIB   PSMD1

    Interaction Score: 0.95

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction 26S proteosome inhibitor
    Direct Interaction yes
    Trial Name Velcade

    PMIDs:
    24524217


    Sources:
    TEND DTC TdgClinicalTrial MyCancerGenome ChemblInteractions

  • IXAZOMIB CITRATE   PSMD1

    Interaction Score: 0.75

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name MLN-9708
    Novel drug target Established target
    Mechanism of Interaction 26S proteosome inhibitor

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • OPROZOMIB   PSMD1

    Interaction Score: 0.73

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name ONX 0912
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • Ensembl: ENSG00000173692

    • Version: 101_38

    Alternate Names:
    PSMD1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: Q99460

    • Version: 01-August-2011

    Alternate Names:
    PSMD1_HUMAN Uniprot Id
    PSMD1 Gene Symbol
    5707 Entrez Gene Id

    Gene Info:
    Target Main Class Other
    Target Subclass Enzyme regulator

    Publications:

  • TdgClinicalTrial: Q99460

    • Version: January-2014

    Alternate Names:
    PSMD1 Gene Symbol

    Gene Info:
    Target Class Miscellaneous
    Target Subclass Enzyme regulator

    Publications:

  • DTC: PSMD1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem

  • MyCancerGenome: PSMD1

    • Version: 20-Jun-2017

    Alternate Names:
    5707 Entrez Gene Id
    PSMD1 MyCancerGenome Gene Symbol
    Proteasome MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

  • ChemblInteractions: PSMD1

    • Version: chembl_23

    Alternate Names:
    PSMD1 GENE_SYMBOL
    26S proteasome non-ATPase regulatory subunit 1 UNIPROT
    26S proteasome regulatory subunit RPN2 UNIPROT

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21