DGIdb - PSMD1 Gene Record

PSMD1 5707

Alternate Names:

5707
PROTEASOME 26S SUBUNIT, NON-ATPASE 1
PSMD1
P112
Rpn2
S1
9554
ENSG00000173692
OTTHUMG00000133223
Proteasome
Q99460
PSMD1_HUMAN
26S proteasome subunit p112
26S proteasome non-ATPase regulatory subunit 1
26S proteasome regulatory subunit RPN2
26S proteasome regulatory subunit S1

Gene Info:

Target Main Class	Other
Target Subclass	Enzyme regulator
Target Class	Miscellaneous
Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

Publications:

Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem

CARFILZOMIB PSMD1

Interaction Score: 1.0

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
BORTEZOMIB PSMD1

Interaction Score: 0.95

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

Trial Name Velcade

PMIDs:
24524217

Sources:
TEND DTC TdgClinicalTrial MyCancerGenome ChemblInteractions
IXAZOMIB CITRATE PSMD1

Interaction Score: 0.75

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MLN-9708

Novel drug target Established target

Mechanism of Interaction 26S proteosome inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
OPROZOMIB PSMD1

Interaction Score: 0.73

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name ONX 0912

Direct Interaction yes

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Ensembl: ENSG00000173692
- Version: 101_38
Alternate Names:

PSMD1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: Q99460
- Version: 01-August-2011
Alternate Names:

PSMD1_HUMAN Uniprot Id

PSMD1 Gene Symbol

5707 Entrez Gene Id

Gene Info:

Target Main Class Other

Target Subclass Enzyme regulator

Publications:
TdgClinicalTrial: Q99460
- Version: January-2014
Alternate Names:

PSMD1 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Enzyme regulator

Publications:

DTC: PSMD1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem

MyCancerGenome: PSMD1
- Version: 20-Jun-2017
Alternate Names:

5707 Entrez Gene Id

PSMD1 MyCancerGenome Gene Symbol

Proteasome MyCancerGenome Reported Gene Name

Gene Info:

Publications:
ChemblInteractions: PSMD1
- Version: chembl_23
Alternate Names:

PSMD1 GENE_SYMBOL

26S proteasome non-ATPase regulatory subunit 1 UNIPROT

26S proteasome regulatory subunit RPN2 UNIPROT

Gene Info:

Publications:

Mechanism of Interaction	26S proteosome inhibitor
Direct Interaction	yes

Trial Name	MLN-9708
Novel drug target	Established target
Mechanism of Interaction	26S proteosome inhibitor

5707	Entrez Gene Id
PSMD1	MyCancerGenome Gene Symbol
Proteasome	MyCancerGenome Reported Gene Name

PSMD1	GENE_SYMBOL
26S proteasome non-ATPase regulatory subunit 1	UNIPROT
26S proteasome regulatory subunit RPN2	UNIPROT

PSMD1 Gene Record

PSMD1 5707

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

CARFILZOMIB PSMD1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes

PMIDs: 24524217

Sources: DTC MyCancerGenome ChemblInteractions

BORTEZOMIB PSMD1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes Trial Name Velcade

PMIDs: 24524217

Sources: TEND DTC TdgClinicalTrial MyCancerGenome ChemblInteractions

IXAZOMIB CITRATE PSMD1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name MLN-9708 Novel drug target Established target Mechanism of Interaction 26S proteosome inhibitor

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

OPROZOMIB PSMD1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name ONX 0912 Direct Interaction yes

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Ensembl: ENSG00000173692

Alternate Names: PSMD1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TEND: Q99460

Alternate Names: PSMD1_HUMAN Uniprot Id PSMD1 Gene Symbol 5707 Entrez Gene Id

Gene Info: Target Main Class Other Target Subclass Enzyme regulator

Publications:

TdgClinicalTrial: Q99460

Alternate Names: PSMD1 Gene Symbol

Gene Info: Target Class Miscellaneous Target Subclass Enzyme regulator

Publications:

DTC: PSMD1

Alternate Names:

Gene Info:

Publications: Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem

MyCancerGenome: PSMD1

Alternate Names: 5707 Entrez Gene Id PSMD1 MyCancerGenome Gene Symbol Proteasome MyCancerGenome Reported Gene Name

Gene Info:

Publications:

ChemblInteractions: PSMD1

Alternate Names: PSMD1 GENE_SYMBOL 26S proteasome non-ATPase regulatory subunit 1 UNIPROT 26S proteasome regulatory subunit RPN2 UNIPROT

Gene Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

Trial Name Velcade

PMIDs:
24524217

Sources:
TEND DTC TdgClinicalTrial MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MLN-9708

Novel drug target Established target

Mechanism of Interaction 26S proteosome inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name ONX 0912

Direct Interaction yes

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Alternate Names:

PSMD1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PSMD1_HUMAN Uniprot Id

PSMD1 Gene Symbol

5707 Entrez Gene Id

Gene Info:

Target Main Class Other

Target Subclass Enzyme regulator

Alternate Names:

PSMD1 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Enzyme regulator

Publications:

Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem

Alternate Names:

5707 Entrez Gene Id

PSMD1 MyCancerGenome Gene Symbol

Proteasome MyCancerGenome Reported Gene Name

Alternate Names:

PSMD1 GENE_SYMBOL

26S proteasome non-ATPase regulatory subunit 1 UNIPROT

26S proteasome regulatory subunit RPN2 UNIPROT