DGIdb - PSMB1 Gene Record

PSMB1 5689 Druggable Genome

Alternate Names:

5689
PROTEASOME SUBUNIT BETA 1
PSMB1
HC5
PMSB1
PSC5
602017
9537
ENSG00000008018
OTTHUMG00000016087
BE0002347
P20618
Proteasome subunit beta type-1
Macropain subunit C5
Multicatalytic endopeptidase complex subunit C5
Proteasome component C5
Proteasome gamma chain
PSB1_HUMAN
2404
NM_002793
NP_002784
Proteasome
proteasome 20S subunit beta 1

Gene Info:

Target Subclass	3.4.25.1
Target Main Class	Enzymes
GuideToPharmacology Gene Category Name	T1: Proteasome
GuideToPharmacology Gene Category ID	752
Target Class	Enzymes
Target Subclass	EC:3.4.25.1
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

PROTEASE
DRUGGABLE GENOME
ENZYME

Publications:

Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem
Hasegawa M et al., 2014, A novel tamoxifen derivative, ridaifen-F, is a nonpeptidic small-molecule proteasome inhibitor., Eur J Med Chem
Hasegawa M et al., 2008, Affinity labeling of the proteasome by a belactosin A derived inhibitor., Bioorg Med Chem Lett
Kuhn et al., 2007, Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma., Blood

MG-132 PSMB1

Interaction Score: 4.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24321833 18801655

Sources:
DTC
CARFILZOMIB PSMB1

Interaction Score: 1.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

Trial Name Carfilzomib

PMIDs:
17591945 24524217

Sources:
DTC TdgClinicalTrial DrugBank MyCancerGenome ChemblInteractions
BORTEZOMIB PSMB1

Interaction Score: 0.74

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Velcade

Direct Interaction yes

PMIDs:
24524217

Sources:
TEND DTC TdgClinicalTrial DrugBank MyCancerGenome ChemblInteractions
IXAZOMIB CITRATE PSMB1

Interaction Score: 0.5

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MLN-9708

Novel drug target Established target

Mechanism of Interaction 26S proteosome inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
OPROZOMIB PSMB1

Interaction Score: 0.49

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 26S proteosome inhibitor

Trial Name ONX 0912

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
MARIZOMIB PSMB1

Interaction Score: 0.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 20S Proteasome inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000008018
- Version: 101_38
Alternate Names:

PSMB1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P20618
- Version: January-2014
Alternate Names:

PSMB1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.25.1

Publications:
TEND: P20618
- Version: 01-August-2011
Alternate Names:

P20618 Uniprot Accession

5689 Entrez Gene Id

PSMB1 Gene Symbol

Gene Info:

Target Subclass 3.4.25.1

Target Main Class Enzymes

Publications:
GuideToPharmacology: 5689
- Version: 29-September-2020
Alternate Names:

9537 HUGO Gene ID

9537 HUGO Gene Symbol

proteasome 20S subunit beta 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name T1: Proteasome

GuideToPharmacology Gene Category ID 752

Gene Categories:

ENZYME

Publications:

DrugBank: BE0002347

Version: 5.1.7

Alternate Names:

PSMB1 DrugBank Gene Name

P20618 UniProt Accession

5689 Entrez Gene Id

Gene Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Kuhn et al., 2007, Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma., Blood

DTC: PSMB1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Hasegawa M et al., 2014, A novel tamoxifen derivative, ridaifen-F, is a nonpeptidic small-molecule proteasome inhibitor., Eur J Med Chem

Hasegawa M et al., 2008, Affinity labeling of the proteasome by a belactosin A derived inhibitor., Bioorg Med Chem Lett

Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem

HingoraniCasas: ENSG00000008018
- Version: 31-May-2017
Alternate Names:

ENSG00000008018 Gene Symbol

PSMB1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: PSC5
- Version: chembl_23
Alternate Names:

PSC5 GENE_SYMBOL

PSMB1 GENE_SYMBOL

Proteasome subunit beta type-1 UNIPROT

Gene Info:

Publications:
MyCancerGenome: PSMB1
- Version: 20-Jun-2017
Alternate Names:

5689 Entrez Gene Id

PSMB1 MyCancerGenome Gene Symbol

Proteasome MyCancerGenome Reported Gene Name

Gene Info:

Publications:
dGene: PSMB1
- Version: 27-Jun-2013
Alternate Names:

5689 Gene ID

HC5 dGene Synonym

PMSB1 dGene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:

Mechanism of Interaction	26S proteosome inhibitor
Direct Interaction	yes
Trial Name	Carfilzomib

Novel drug target	Established target
Trial Name	Velcade
Direct Interaction	yes

Trial Name	MLN-9708
Novel drug target	Established target
Mechanism of Interaction	26S proteosome inhibitor

Mechanism of Interaction	20S Proteasome inhibitor
Direct Interaction	yes

9537	HUGO Gene ID
9537	HUGO Gene Symbol
proteasome 20S subunit beta 1	HUGO Gene Name

PSMB1	DrugBank Gene Name
P20618	UniProt Accession
5689	Entrez Gene Id

PSC5	GENE_SYMBOL
PSMB1	GENE_SYMBOL
Proteasome subunit beta type-1	UNIPROT

PSMB1 Gene Record

PSMB1 5689 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

MG-132 PSMB1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24321833 18801655

Sources: DTC

CARFILZOMIB PSMB1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes Trial Name Carfilzomib

PMIDs: 17591945 24524217

Sources: DTC TdgClinicalTrial DrugBank MyCancerGenome ChemblInteractions

BORTEZOMIB PSMB1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name Velcade Direct Interaction yes

PMIDs: 24524217

Sources: TEND DTC TdgClinicalTrial DrugBank MyCancerGenome ChemblInteractions

IXAZOMIB CITRATE PSMB1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name MLN-9708 Novel drug target Established target Mechanism of Interaction 26S proteosome inhibitor

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

OPROZOMIB PSMB1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction 26S proteosome inhibitor Trial Name ONX 0912

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

MARIZOMIB PSMB1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 20S Proteasome inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000008018

Alternate Names: PSMB1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P20618

Alternate Names: PSMB1 Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:3.4.25.1

Publications:

TEND: P20618

Alternate Names: P20618 Uniprot Accession 5689 Entrez Gene Id PSMB1 Gene Symbol

Gene Info: Target Subclass 3.4.25.1 Target Main Class Enzymes

Publications:

GuideToPharmacology: 5689

Alternate Names: 9537 HUGO Gene ID 9537 HUGO Gene Symbol proteasome 20S subunit beta 1 HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name T1: Proteasome GuideToPharmacology Gene Category ID 752

Gene Categories: ENZYME

Publications:

DrugBank: BE0002347

Alternate Names: PSMB1 DrugBank Gene Name P20618 UniProt Accession 5689 Entrez Gene Id

Gene Info:

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res. Kuhn et al., 2007, Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma., Blood

DTC: PSMB1

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000008018

Alternate Names: ENSG00000008018 Gene Symbol PSMB1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: PSC5

Alternate Names: PSC5 GENE_SYMBOL PSMB1 GENE_SYMBOL Proteasome subunit beta type-1 UNIPROT

Gene Info:

Publications:

MyCancerGenome: PSMB1

Alternate Names: 5689 Entrez Gene Id PSMB1 MyCancerGenome Gene Symbol Proteasome MyCancerGenome Reported Gene Name

Gene Info:

Publications:

dGene: PSMB1

Alternate Names: 5689 Gene ID HC5 dGene Synonym PMSB1 dGene Synonym

Gene Info:

Gene Categories: PROTEASE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
24321833 18801655

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

Trial Name Carfilzomib

PMIDs:
17591945 24524217

Sources:
DTC TdgClinicalTrial DrugBank MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Velcade

Direct Interaction yes

PMIDs:
24524217

Sources:
TEND DTC TdgClinicalTrial DrugBank MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MLN-9708

Novel drug target Established target

Mechanism of Interaction 26S proteosome inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 26S proteosome inhibitor

Trial Name ONX 0912

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 20S Proteasome inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

PSMB1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PSMB1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.25.1

Alternate Names:

P20618 Uniprot Accession

5689 Entrez Gene Id

PSMB1 Gene Symbol

Gene Info:

Target Subclass 3.4.25.1

Target Main Class Enzymes

Alternate Names:

9537 HUGO Gene ID

9537 HUGO Gene Symbol

proteasome 20S subunit beta 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name T1: Proteasome

GuideToPharmacology Gene Category ID 752

Gene Categories:

ENZYME

Alternate Names:

PSMB1 DrugBank Gene Name

P20618 UniProt Accession

5689 Entrez Gene Id

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Kuhn et al., 2007, Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma., Blood

Alternate Names:

ENSG00000008018 Gene Symbol

PSMB1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PSC5 GENE_SYMBOL

PSMB1 GENE_SYMBOL

Proteasome subunit beta type-1 UNIPROT

Alternate Names:

5689 Entrez Gene Id

PSMB1 MyCancerGenome Gene Symbol

Proteasome MyCancerGenome Reported Gene Name

Alternate Names:

5689 Gene ID

HC5 dGene Synonym

PMSB1 dGene Synonym

Gene Categories:

PROTEASE