• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

PSMB1 Gene Record

  • Summary
  • Interactions
  • Claims
  • PSMB1 5689 Druggable Genome

    Alternate Names:

    5689
    PROTEASOME SUBUNIT BETA 1
    PSMB1
    HC5
    PMSB1
    PSC5
    602017
    9537
    ENSG00000008018
    OTTHUMG00000016087
    P20618
    Proteasome subunit beta type-1
    Macropain subunit C5
    Multicatalytic endopeptidase complex subunit C5
    Proteasome component C5
    Proteasome gamma chain
    PSB1_HUMAN
    Proteasome
    proteasome 20S subunit beta 1

    Gene Info:

    Target Subclass 3.4.25.1
    Target Main Class Enzymes
    Target Class Enzymes
    Target Subclass EC:3.4.25.1
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    PROTEASE
    DRUGGABLE GENOME

    Publications:

    Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem
    Hasegawa M et al., 2008, Affinity labeling of the proteasome by a belactosin A derived inhibitor., Bioorg Med Chem Lett
    Hasegawa M et al., 2014, A novel tamoxifen derivative, ridaifen-F, is a nonpeptidic small-molecule proteasome inhibitor., Eur J Med Chem
    Kuhn et al., 2007, Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma., Blood
  • MG-132   PSMB1

    Interaction Score: 5.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18801655 24321833


    Sources:
    DTC

  • CARFILZOMIB   PSMB1

    Interaction Score: 1.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction 26S proteosome inhibitor
    Direct Interaction yes
    Trial Name Carfilzomib

    PMIDs:
    24524217 17591945


    Sources:
    DTC MyCancerGenome TdgClinicalTrial ChemblInteractions

  • BORTEZOMIB   PSMB1

    Interaction Score: 0.69

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name Velcade
    Direct Interaction yes

    PMIDs:
    24524217


    Sources:
    DTC MyCancerGenome TdgClinicalTrial ChemblInteractions TEND

  • IXAZOMIB CITRATE   PSMB1

    Interaction Score: 0.54

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name MLN-9708
    Novel drug target Established target
    Mechanism of Interaction 26S proteosome inhibitor

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • OPROZOMIB   PSMB1

    Interaction Score: 0.53

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction 26S proteosome inhibitor
    Trial Name ONX 0912

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • MARIZOMIB   PSMB1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction 20S Proteasome inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000008018

    • Version: 101_38

    Alternate Names:
    PSMB1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P20618

    • Version: January-2014

    Alternate Names:
    PSMB1 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.4.25.1

    Publications:

  • TEND: P20618

    • Version: 01-August-2011

    Alternate Names:
    P20618 Uniprot Accession
    5689 Entrez Gene Id
    PSMB1 Gene Symbol

    Gene Info:
    Target Subclass 3.4.25.1
    Target Main Class Enzymes

    Publications:

  • DTC: PSMB1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Hasegawa M et al., 2014, A novel tamoxifen derivative, ridaifen-F, is a nonpeptidic small-molecule proteasome inhibitor., Eur J Med Chem
    Hasegawa M et al., 2008, Affinity labeling of the proteasome by a belactosin A derived inhibitor., Bioorg Med Chem Lett
    Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem

  • HingoraniCasas: ENSG00000008018

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000008018 Gene Symbol
    PSMB1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: PSC5

    • Version: chembl_23

    Alternate Names:
    PSC5 GENE_SYMBOL
    PSMB1 GENE_SYMBOL
    Proteasome subunit beta type-1 UNIPROT

    Gene Info:

    Publications:

  • MyCancerGenome: PSMB1

    • Version: 20-Jun-2017

    Alternate Names:
    5689 Entrez Gene Id
    PSMB1 MyCancerGenome Gene Symbol
    Proteasome MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

  • GO: PSMB1

    • Version: 01-February-2022

    Alternate Names:
    PSC5 GO Gene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • dGene: PSMB1

    • Version: 27-Jun-2013

    Alternate Names:
    5689 Gene ID
    HC5 dGene Synonym
    PMSB1 dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21