DGIdb - PSMB1 Gene Record

PSMB1 5689 Druggable Genome

Alternate Names:

5689
PROTEASOME SUBUNIT BETA 1
PSMB1
HC5
PMSB1
PSC5
602017
9537
ENSG00000008018
OTTHUMG00000016087
P20618
Proteasome subunit beta type-1
Macropain subunit C5
Multicatalytic endopeptidase complex subunit C5
Proteasome component C5
Proteasome gamma chain
PSB1_HUMAN
Proteasome
proteasome 20S subunit beta 1

Gene Info:

Target Subclass	3.4.25.1
Target Main Class	Enzymes
Target Class	Enzymes
Target Subclass	EC:3.4.25.1
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

PROTEASE
DRUGGABLE GENOME

Publications:

Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem
Hasegawa M et al., 2008, Affinity labeling of the proteasome by a belactosin A derived inhibitor., Bioorg Med Chem Lett
Hasegawa M et al., 2014, A novel tamoxifen derivative, ridaifen-F, is a nonpeptidic small-molecule proteasome inhibitor., Eur J Med Chem
Kuhn et al., 2007, Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma., Blood

MG-132 PSMB1

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18801655 24321833

Sources:
DTC
CARFILZOMIB PSMB1

Interaction Score: 1.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

Trial Name Carfilzomib

PMIDs:
24524217 17591945

Sources:
DTC MyCancerGenome TdgClinicalTrial ChemblInteractions
BORTEZOMIB PSMB1

Interaction Score: 0.69

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Velcade

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome TdgClinicalTrial ChemblInteractions TEND
IXAZOMIB CITRATE PSMB1

Interaction Score: 0.54

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MLN-9708

Novel drug target Established target

Mechanism of Interaction 26S proteosome inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
OPROZOMIB PSMB1

Interaction Score: 0.53

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 26S proteosome inhibitor

Trial Name ONX 0912

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
MARIZOMIB PSMB1

Interaction Score: 0.52

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 20S Proteasome inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000008018
- Version: 101_38
Alternate Names:

PSMB1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P20618
- Version: January-2014
Alternate Names:

PSMB1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.25.1

Publications:
TEND: P20618
- Version: 01-August-2011
Alternate Names:

P20618 Uniprot Accession

5689 Entrez Gene Id

PSMB1 Gene Symbol

Gene Info:

Target Subclass 3.4.25.1

Target Main Class Enzymes

Publications:

DTC: PSMB1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Hasegawa M et al., 2014, A novel tamoxifen derivative, ridaifen-F, is a nonpeptidic small-molecule proteasome inhibitor., Eur J Med Chem

Hasegawa M et al., 2008, Affinity labeling of the proteasome by a belactosin A derived inhibitor., Bioorg Med Chem Lett

Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem

HingoraniCasas: ENSG00000008018
- Version: 31-May-2017
Alternate Names:

ENSG00000008018 Gene Symbol

PSMB1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: PSC5
- Version: chembl_23
Alternate Names:

PSC5 GENE_SYMBOL

PSMB1 GENE_SYMBOL

Proteasome subunit beta type-1 UNIPROT

Gene Info:

Publications:
MyCancerGenome: PSMB1
- Version: 20-Jun-2017
Alternate Names:

5689 Entrez Gene Id

PSMB1 MyCancerGenome Gene Symbol

Proteasome MyCancerGenome Reported Gene Name

Gene Info:

Publications:
GO: PSMB1
- Version: 01-February-2022
Alternate Names:

PSC5 GO Gene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:
dGene: PSMB1
- Version: 27-Jun-2013
Alternate Names:

5689 Gene ID

HC5 dGene Synonym

PMSB1 dGene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:

Mechanism of Interaction	26S proteosome inhibitor
Direct Interaction	yes
Trial Name	Carfilzomib

Novel drug target	Established target
Trial Name	Velcade
Direct Interaction	yes

Trial Name	MLN-9708
Novel drug target	Established target
Mechanism of Interaction	26S proteosome inhibitor

Mechanism of Interaction	20S Proteasome inhibitor
Direct Interaction	yes

PSC5	GENE_SYMBOL
PSMB1	GENE_SYMBOL
Proteasome subunit beta type-1	UNIPROT

5689	Entrez Gene Id
PSMB1	MyCancerGenome Gene Symbol
Proteasome	MyCancerGenome Reported Gene Name

PSMB1 Gene Record

PSMB1 5689 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

MG-132 PSMB1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18801655 24321833

Sources: DTC

CARFILZOMIB PSMB1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes Trial Name Carfilzomib

PMIDs: 24524217 17591945

Sources: DTC MyCancerGenome TdgClinicalTrial ChemblInteractions

BORTEZOMIB PSMB1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name Velcade Direct Interaction yes

PMIDs: 24524217

Sources: DTC MyCancerGenome TdgClinicalTrial ChemblInteractions TEND

IXAZOMIB CITRATE PSMB1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name MLN-9708 Novel drug target Established target Mechanism of Interaction 26S proteosome inhibitor

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

OPROZOMIB PSMB1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction 26S proteosome inhibitor Trial Name ONX 0912

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

MARIZOMIB PSMB1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 20S Proteasome inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000008018

Alternate Names: PSMB1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P20618

Alternate Names: PSMB1 Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:3.4.25.1

Publications:

TEND: P20618

Alternate Names: P20618 Uniprot Accession 5689 Entrez Gene Id PSMB1 Gene Symbol

Gene Info: Target Subclass 3.4.25.1 Target Main Class Enzymes

Publications:

DTC: PSMB1

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000008018

Alternate Names: ENSG00000008018 Gene Symbol PSMB1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: PSC5

Alternate Names: PSC5 GENE_SYMBOL PSMB1 GENE_SYMBOL Proteasome subunit beta type-1 UNIPROT

Gene Info:

Publications:

MyCancerGenome: PSMB1

Alternate Names: 5689 Entrez Gene Id PSMB1 MyCancerGenome Gene Symbol Proteasome MyCancerGenome Reported Gene Name

Gene Info:

Publications:

GO: PSMB1

Alternate Names: PSC5 GO Gene Synonym

Gene Info:

Gene Categories: PROTEASE

Publications:

dGene: PSMB1

Alternate Names: 5689 Gene ID HC5 dGene Synonym PMSB1 dGene Synonym

Gene Info:

Gene Categories: PROTEASE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
18801655 24321833

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

Trial Name Carfilzomib

PMIDs:
24524217 17591945

Sources:
DTC MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Velcade

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MLN-9708

Novel drug target Established target

Mechanism of Interaction 26S proteosome inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 26S proteosome inhibitor

Trial Name ONX 0912

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 20S Proteasome inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

PSMB1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PSMB1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.25.1

Alternate Names:

P20618 Uniprot Accession

5689 Entrez Gene Id

PSMB1 Gene Symbol

Gene Info:

Target Subclass 3.4.25.1

Target Main Class Enzymes

Alternate Names:

ENSG00000008018 Gene Symbol

PSMB1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PSC5 GENE_SYMBOL

PSMB1 GENE_SYMBOL

Proteasome subunit beta type-1 UNIPROT

Alternate Names:

5689 Entrez Gene Id

PSMB1 MyCancerGenome Gene Symbol

Proteasome MyCancerGenome Reported Gene Name

Alternate Names:

PSC5 GO Gene Synonym

Gene Categories:

PROTEASE

Alternate Names:

5689 Gene ID

HC5 dGene Synonym

PMSB1 dGene Synonym

Gene Categories:

PROTEASE