DGIdb - PSMA4 Gene Record

PSMA4 5685 Druggable Genome

Alternate Names:

5685
PROTEASOME SUBUNIT ALPHA 4
PSMA4
HC9
HsT17706
PSC9
176846
9533
ENSG00000041357
OTTHUMG00000143859
Proteasome subunit L
Proteasome component C9
Multicatalytic endopeptidase complex subunit C9
Macropain subunit C9
Proteasome subunit alpha type-4
Proteasome
PA33878
PROTEASOME 20S SUBUNIT ALPHA 4

Gene Info:

Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

PROTEASE
DRUGGABLE GENOME

Publications:

Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem

COTININE PSMA4

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CARFILZOMIB PSMA4

Interaction Score: 0.72

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 26S proteosome inhibitor

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
MARIZOMIB PSMA4

Interaction Score: 0.52

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 20S Proteasome inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BORTEZOMIB PSMA4

Interaction Score: 0.46

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
IXAZOMIB CITRATE PSMA4

Interaction Score: 0.27

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OPROZOMIB PSMA4

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000041357
- Version: 101_38
Alternate Names:

PSMA4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

DTC: PSMA4

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem

HingoraniCasas: ENSG00000041357
- Version: 31-May-2017
Alternate Names:

ENSG00000041357 Gene Symbol

PSMA4 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
MyCancerGenome: PSMA4
- Version: 20-Jun-2017
Alternate Names:

5685 Entrez Gene Id

PSMA4 MyCancerGenome Gene Symbol

Proteasome MyCancerGenome Reported Gene Name

Gene Info:

Publications:
ChemblInteractions: HC9
- Version: chembl_23
Alternate Names:

PSC9 GENE_SYMBOL

PSMA4 GENE_SYMBOL

Proteasome subunit alpha type-4 UNIPROT

Gene Info:

Publications:
PharmGKB: PSMA4
- Version: 18-August-2020
Alternate Names:

PA33878 PharmGKB ID

Gene Info:

Publications:
dGene: PSMA4
- Version: 27-Jun-2013
Alternate Names:

5685 Gene ID

HC9 dGene Synonym

HsT17706 dGene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:

Direct Interaction	yes
Mechanism of Interaction	26S proteosome inhibitor

Mechanism of Interaction	20S Proteasome inhibitor
Direct Interaction	yes

5685	Entrez Gene Id
PSMA4	MyCancerGenome Gene Symbol
Proteasome	MyCancerGenome Reported Gene Name

PSC9	GENE_SYMBOL
PSMA4	GENE_SYMBOL
Proteasome subunit alpha type-4	UNIPROT

5685	Gene ID
HC9	dGene Synonym
HsT17706	dGene Synonym

PSMA4 Gene Record

PSMA4 5685 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

COTININE PSMA4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

CARFILZOMIB PSMA4

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction 26S proteosome inhibitor

PMIDs: 24524217

Sources: DTC MyCancerGenome ChemblInteractions

MARIZOMIB PSMA4

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 20S Proteasome inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

BORTEZOMIB PSMA4

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes

PMIDs: 24524217

Sources: DTC MyCancerGenome ChemblInteractions

IXAZOMIB CITRATE PSMA4

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

OPROZOMIB PSMA4

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000041357

Alternate Names: PSMA4 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

DTC: PSMA4

Alternate Names:

Gene Info:

Publications: Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem

HingoraniCasas: ENSG00000041357

Alternate Names: ENSG00000041357 Gene Symbol PSMA4 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

MyCancerGenome: PSMA4

Alternate Names: 5685 Entrez Gene Id PSMA4 MyCancerGenome Gene Symbol Proteasome MyCancerGenome Reported Gene Name

Gene Info:

Publications:

ChemblInteractions: HC9

Alternate Names: PSC9 GENE_SYMBOL PSMA4 GENE_SYMBOL Proteasome subunit alpha type-4 UNIPROT

Gene Info:

Publications:

PharmGKB: PSMA4

Alternate Names: PA33878 PharmGKB ID

Gene Info:

Publications:

dGene: PSMA4

Alternate Names: 5685 Gene ID HC9 dGene Synonym HsT17706 dGene Synonym

Gene Info:

Gene Categories: PROTEASE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 26S proteosome inhibitor

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 20S Proteasome inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

PSMA4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem

Alternate Names:

ENSG00000041357 Gene Symbol

PSMA4 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

5685 Entrez Gene Id

PSMA4 MyCancerGenome Gene Symbol

Proteasome MyCancerGenome Reported Gene Name

Alternate Names:

PSC9 GENE_SYMBOL

PSMA4 GENE_SYMBOL

Proteasome subunit alpha type-4 UNIPROT

Alternate Names:

PA33878 PharmGKB ID

Alternate Names:

5685 Gene ID

HC9 dGene Synonym

HsT17706 dGene Synonym

Gene Categories:

PROTEASE