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PSMA3 Gene Record

  • Summary
  • Interactions
  • Claims
  • PSMA3 5684 Druggable Genome

    Alternate Names:

    5684
    PROTEASOME SUBUNIT ALPHA 3
    PSMA3
    HC8
    PSC3
    176843
    9532
    ENSG00000100567
    OTTHUMG00000140319
    Proteasome subunit alpha type-3
    Macropain subunit C8
    Multicatalytic endopeptidase complex subunit C8
    Proteasome component C8
    PSC8
    Proteasome
    P25788
    BE0003912

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    PROTEASE
    DRUGGABLE GENOME

    Publications:

    Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem
    Mi L et al., 2011, Identification of potential protein targets of isothiocyanates by proteomics., Chem Res Toxicol
  • CARFILZOMIB   PSMA3

    Interaction Score: 0.66

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction 26S proteosome inhibitor
    Direct Interaction yes

    PMIDs:
    24524217


    Sources:
    DTC MyCancerGenome ChemblInteractions

  • MARIZOMIB   PSMA3

    Interaction Score: 0.47

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction 20S Proteasome inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BORTEZOMIB   PSMA3

    Interaction Score: 0.42

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction 26S proteosome inhibitor
    Direct Interaction yes

    PMIDs:
    24524217


    Sources:
    DTC MyCancerGenome ChemblInteractions

  • PHENETHYLISOTHIOCYANATE   PSMA3

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21838287


    Sources:
    DrugBank

  • IXAZOMIB CITRATE   PSMA3

    Interaction Score: 0.25

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction 26S proteosome inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • OPROZOMIB   PSMA3

    Interaction Score: 0.24

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction 26S proteosome inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000100567

    • Version: 101_38

    Alternate Names:
    PSMA3 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • DrugBank: BE0003912

    • Version: 5.1.7

    Alternate Names:
    PSMA3 DrugBank Gene Name
    P25788 UniProt Accession
    5684 Entrez Gene Id

    Gene Info:

    Publications:
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Mi L et al., 2011, Identification of potential protein targets of isothiocyanates by proteomics., Chem Res Toxicol

  • DTC: PSMA3

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem

  • MyCancerGenome: PSMA3

    • Version: 20-Jun-2017

    Alternate Names:
    5684 Entrez Gene Id
    PSMA3 MyCancerGenome Gene Symbol
    Proteasome MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000100567

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000100567 Gene Symbol
    PSMA3 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: HC8

    • Version: chembl_23

    Alternate Names:
    PSC8 GENE_SYMBOL
    PSMA3 GENE_SYMBOL
    Proteasome subunit alpha type-3 UNIPROT

    Gene Info:

    Publications:

  • dGene: PSMA3

    • Version: 27-Jun-2013

    Alternate Names:
    5684 Gene ID
    HC8 dGene Synonym
    PSC3 dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21