DGIdb - PSMA3 Gene Record

PSMA3 5684 Druggable Genome

Alternate Names:

5684
PROTEASOME SUBUNIT ALPHA 3
PSMA3
HC8
PSC3
176843
9532
ENSG00000100567
OTTHUMG00000140319
Proteasome subunit alpha type-3
Macropain subunit C8
Multicatalytic endopeptidase complex subunit C8
Proteasome component C8
PSC8
Proteasome
P25788
BE0003912

Gene Info:

Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

PROTEASE
DRUGGABLE GENOME

Publications:

Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem
Mi L et al., 2011, Identification of potential protein targets of isothiocyanates by proteomics., Chem Res Toxicol

CARFILZOMIB PSMA3

Interaction Score: 0.66

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
MARIZOMIB PSMA3

Interaction Score: 0.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 20S Proteasome inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BORTEZOMIB PSMA3

Interaction Score: 0.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions
PHENETHYLISOTHIOCYANATE PSMA3

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21838287

Sources:
DrugBank
IXAZOMIB CITRATE PSMA3

Interaction Score: 0.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OPROZOMIB PSMA3

Interaction Score: 0.24

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 26S proteosome inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000100567
- Version: 101_38
Alternate Names:

PSMA3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
DrugBank: BE0003912
- Version: 5.1.7
Alternate Names:

PSMA3 DrugBank Gene Name

P25788 UniProt Accession

5684 Entrez Gene Id

Gene Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Mi L et al., 2011, Identification of potential protein targets of isothiocyanates by proteomics., Chem Res Toxicol

DTC: PSMA3

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem

MyCancerGenome: PSMA3
- Version: 20-Jun-2017
Alternate Names:

5684 Entrez Gene Id

PSMA3 MyCancerGenome Gene Symbol

Proteasome MyCancerGenome Reported Gene Name

Gene Info:

Publications:
HingoraniCasas: ENSG00000100567
- Version: 31-May-2017
Alternate Names:

ENSG00000100567 Gene Symbol

PSMA3 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: HC8
- Version: chembl_23
Alternate Names:

PSC8 GENE_SYMBOL

PSMA3 GENE_SYMBOL

Proteasome subunit alpha type-3 UNIPROT

Gene Info:

Publications:
dGene: PSMA3
- Version: 27-Jun-2013
Alternate Names:

5684 Gene ID

HC8 dGene Synonym

PSC3 dGene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:

Mechanism of Interaction	26S proteosome inhibitor
Direct Interaction	yes

Mechanism of Interaction	20S Proteasome inhibitor
Direct Interaction	yes

PSMA3	DrugBank Gene Name
P25788	UniProt Accession
5684	Entrez Gene Id

PSC8	GENE_SYMBOL
PSMA3	GENE_SYMBOL
Proteasome subunit alpha type-3	UNIPROT

5684	Gene ID
HC8	dGene Synonym
PSC3	dGene Synonym

PSMA3 Gene Record

PSMA3 5684 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

CARFILZOMIB PSMA3

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes

PMIDs: 24524217

Sources: DTC MyCancerGenome ChemblInteractions

MARIZOMIB PSMA3

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 20S Proteasome inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

BORTEZOMIB PSMA3

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes

PMIDs: 24524217

Sources: DTC MyCancerGenome ChemblInteractions

PHENETHYLISOTHIOCYANATE PSMA3

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21838287

Sources: DrugBank

IXAZOMIB CITRATE PSMA3

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 26S proteosome inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

OPROZOMIB PSMA3

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction 26S proteosome inhibitor

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000100567

Alternate Names: PSMA3 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

DrugBank: BE0003912

Alternate Names: PSMA3 DrugBank Gene Name P25788 UniProt Accession 5684 Entrez Gene Id

Gene Info:

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res. Mi L et al., 2011, Identification of potential protein targets of isothiocyanates by proteomics., Chem Res Toxicol

DTC: PSMA3

Alternate Names:

Gene Info:

Publications: Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem

MyCancerGenome: PSMA3

Alternate Names: 5684 Entrez Gene Id PSMA3 MyCancerGenome Gene Symbol Proteasome MyCancerGenome Reported Gene Name

Gene Info:

Publications:

HingoraniCasas: ENSG00000100567

Alternate Names: ENSG00000100567 Gene Symbol PSMA3 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: HC8

Alternate Names: PSC8 GENE_SYMBOL PSMA3 GENE_SYMBOL Proteasome subunit alpha type-3 UNIPROT

Gene Info:

Publications:

dGene: PSMA3

Alternate Names: 5684 Gene ID HC8 dGene Synonym PSC3 dGene Synonym

Gene Info:

Gene Categories: PROTEASE

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 20S Proteasome inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
24524217

Sources:
DTC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
21838287

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 26S proteosome inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 26S proteosome inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

PSMA3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PSMA3 DrugBank Gene Name

P25788 UniProt Accession

5684 Entrez Gene Id

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Mi L et al., 2011, Identification of potential protein targets of isothiocyanates by proteomics., Chem Res Toxicol

Publications:

Kawamura S et al., 2014, Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates., J Med Chem

Alternate Names:

5684 Entrez Gene Id

PSMA3 MyCancerGenome Gene Symbol

Proteasome MyCancerGenome Reported Gene Name

Alternate Names:

ENSG00000100567 Gene Symbol

PSMA3 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PSC8 GENE_SYMBOL

PSMA3 GENE_SYMBOL

Proteasome subunit alpha type-3 UNIPROT

Alternate Names:

5684 Gene ID

HC8 dGene Synonym

PSC3 dGene Synonym

Gene Categories:

PROTEASE