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PRSS2 Gene Record

  • Summary
  • Interactions
  • Claims
  • PRSS2 5645 Druggable Genome

    Alternate Names:

    5645
    PROTEASE, SERINE 2
    PRSS2
    TRY2
    TRY8
    TRYP2
    601564
    9483
    ENSG00000275896
    OTTHUMG00000158904
    2398
    NP_002761
    NM_002770
    P07478
    TRY2_HUMAN
    TRYPSIN-2
    ENSG00000262739
    BE0004529
    serine protease 2

    Gene Info:

    GuideToPharmacology Gene Category Name S1: Chymotrypsin
    GuideToPharmacology Gene Category ID 751
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME
    Human Readable Name PROTEASE
    Interpro Acc IPR001254
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Interpro Name Peptidase S1/S6, chymotrypsin/Hap
    Interpro Short Name Peptidase_S1_S6
    Target Class Enzymes
    Target Subclass EC:3.4.21.4
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    PROTEASE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett
  • PHENETHYLAMINE   PRSS2

    Interaction Score: 14.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • BENZYLAMINE   PRSS2

    Interaction Score: 14.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL276864   PRSS2

    Interaction Score: 14.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • PHOSPHORYLISOPROPANE   PRSS2

    Interaction Score: 9.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • BENZAMIDINE   PRSS2

    Interaction Score: 2.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CYANOPEPTOLIN SS   PRSS2

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CYANOPEPTOLIN S   PRSS2

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BORTEZOMIB   PRSS2

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20875739


    Sources:
    DTC

  • Ensembl: ENSG00000275896

    • Version: 101_38

    Alternate Names:
    PRSS2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P07478

    • Version: 11-September-2012

    Alternate Names:
    TRY2_HUMAN Uniprot Id
    ENSG00000262739 Ensembl Gene Id
    5645 Entrez Gene Id

    Gene Info:
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME
    Human Readable Name PROTEASE

    Gene Categories:
    PROTEASE, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P07478

    • Version: January-2014

    Alternate Names:
    PRSS2 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.4.21.4

    Publications:

  • GuideToPharmacology: 5645

    • Version: 29-September-2020

    Alternate Names:
    9483 HUGO Gene ID
    9483 HUGO Gene Symbol
    serine protease 2 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name S1: Chymotrypsin
    GuideToPharmacology Gene Category ID 751

    Gene Categories:
    ENZYME

    Publications:

  • DrugBank: BE0004529

    • Version: 5.1.7

    Alternate Names:
    PRSS2 DrugBank Gene Name
    P07478 UniProt Accession
    5645 Entrez Gene Id

    Gene Info:

    Publications:
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

  • DTC: PRSS2

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett

  • Pharos: PRSS2

    • Version: 03-September-2020

    Alternate Names:
    Trypsin-2 Gene Name
    P07478 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • dGene: PRSS2

    • Version: 27-Jun-2013

    Alternate Names:
    5645 Gene ID
    TRY2 dGene Synonym
    TRY8 dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21