DGIdb - PRSS2 Gene Record

PRSS2 5645 Druggable Genome

Alternate Names:

5645
PROTEASE, SERINE 2
PRSS2
TRY2
TRY8
TRYP2
601564
9483
ENSG00000275896
OTTHUMG00000158904
2398
NP_002761
NM_002770
P07478
TRY2_HUMAN
TRYPSIN-2
ENSG00000262739
BE0004529
serine protease 2

Gene Info:

GuideToPharmacology Gene Category Name	S1: Chymotrypsin
GuideToPharmacology Gene Category ID	751
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	DRUGGABLE GENOME
Human Readable Name	PROTEASE
Interpro Acc	IPR001254
Interpro Type	Domain
Uniprot Status	Swiss-Prot
Interpro Name	Peptidase S1/S6, chymotrypsin/Hap
Interpro Short Name	Peptidase_S1_S6
Target Class	Enzymes
Target Subclass	EC:3.4.21.4
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

PROTEASE
DRUGGABLE GENOME
ENZYME

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett

PHENETHYLAMINE PRSS2

Interaction Score: 14.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
BENZYLAMINE PRSS2

Interaction Score: 14.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL276864 PRSS2

Interaction Score: 14.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
PHOSPHORYLISOPROPANE PRSS2

Interaction Score: 9.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
BENZAMIDINE PRSS2

Interaction Score: 2.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CYANOPEPTOLIN SS PRSS2

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYANOPEPTOLIN S PRSS2

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BORTEZOMIB PRSS2

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20875739

Sources:
DTC

Ensembl: ENSG00000275896
- Version: 101_38
Alternate Names:

PRSS2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P07478
- Version: 11-September-2012
Alternate Names:

TRY2_HUMAN Uniprot Id

ENSG00000262739 Ensembl Gene Id

5645 Entrez Gene Id

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Human Readable Name DRUGGABLE GENOME

Human Readable Name PROTEASE

Gene Categories:

PROTEASE, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P07478
- Version: January-2014
Alternate Names:

PRSS2 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.21.4

Publications:
GuideToPharmacology: 5645
- Version: 29-September-2020
Alternate Names:

9483 HUGO Gene ID

9483 HUGO Gene Symbol

serine protease 2 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name S1: Chymotrypsin

GuideToPharmacology Gene Category ID 751

Gene Categories:

ENZYME

Publications:

DrugBank: BE0004529

Version: 5.1.7

Alternate Names:

PRSS2 DrugBank Gene Name

P07478 UniProt Accession

5645 Entrez Gene Id

Gene Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

DTC: PRSS2

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett

Pharos: PRSS2
- Version: 03-September-2020
Alternate Names:

Trypsin-2 Gene Name

P07478 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
dGene: PRSS2
- Version: 27-Jun-2013
Alternate Names:

5645 Gene ID

TRY2 dGene Synonym

TRY8 dGene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:

TRY2_HUMAN	Uniprot Id
ENSG00000262739	Ensembl Gene Id
5645	Entrez Gene Id

9483	HUGO Gene ID
9483	HUGO Gene Symbol
serine protease 2	HUGO Gene Name

PRSS2	DrugBank Gene Name
P07478	UniProt Accession
5645	Entrez Gene Id

PRSS2 Gene Record

PRSS2 5645 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20875739

Sources: DTC

Ensembl: ENSG00000275896

Alternate Names: PRSS2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: P07478

Alternate Names: TRY2_HUMAN Uniprot Id ENSG00000262739 Ensembl Gene Id 5645 Entrez Gene Id

Gene Info: Uniprot Evidence 1: Evidence at protein level Human Readable Name DRUGGABLE GENOME Human Readable Name PROTEASE

Gene Categories: PROTEASE, DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P07478

Alternate Names: PRSS2 Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:3.4.21.4

Publications:

GuideToPharmacology: 5645

Alternate Names: 9483 HUGO Gene ID 9483 HUGO Gene Symbol serine protease 2 HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name S1: Chymotrypsin GuideToPharmacology Gene Category ID 751

Gene Categories: ENZYME

Publications:

DrugBank: BE0004529

Alternate Names: PRSS2 DrugBank Gene Name P07478 UniProt Accession 5645 Entrez Gene Id

Gene Info:

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res. Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

DTC: PRSS2

Alternate Names:

Gene Info:

Publications: Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett

Pharos: PRSS2

Alternate Names: Trypsin-2 Gene Name P07478 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

dGene: PRSS2

Alternate Names: 5645 Gene ID TRY2 dGene Synonym TRY8 dGene Synonym

Gene Info:

Gene Categories: PROTEASE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20875739

Sources:
DTC

Alternate Names:

PRSS2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

TRY2_HUMAN Uniprot Id

ENSG00000262739 Ensembl Gene Id

5645 Entrez Gene Id

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Human Readable Name DRUGGABLE GENOME

Human Readable Name PROTEASE

Gene Categories:

PROTEASE, DRUGGABLE GENOME

Alternate Names:

PRSS2 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.21.4

Alternate Names:

9483 HUGO Gene ID

9483 HUGO Gene Symbol

serine protease 2 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name S1: Chymotrypsin

GuideToPharmacology Gene Category ID 751

Gene Categories:

ENZYME

Alternate Names:

PRSS2 DrugBank Gene Name

P07478 UniProt Accession

5645 Entrez Gene Id

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Publications:

Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett

Alternate Names:

Trypsin-2 Gene Name

P07478 UniProt ID

Gene Categories:

ENZYME

Alternate Names:

5645 Gene ID

TRY2 dGene Synonym

TRY8 dGene Synonym

Gene Categories:

PROTEASE