DGIdb - PRSS1 Gene Record

PRSS1 5644 Druggable Genome

Alternate Names:

5644
PROTEASE, SERINE 1
PRSS1
TRP1
TRY1
TRY4
TRYP1
276000
9475
ENSG00000204983
OTTHUMG00000158923
P07477
ALPHA-TRYPSIN CHAIN 2
TRY1_HUMAN
ENSG00000261473
BE0001739
ENSG00000173636
TRYPSIN I PRECURSOR (EC 3.4.21.4) (CATIONIC TRYPSINOGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P07477]
2397
NM_002769
NP_002760
serine protease 1
Cationic trypsinogen
T27602
Trypsin-1

Gene Info:

Uniprot Status	Swiss-Prot
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	Peptidase_S1_S6
Human Readable Name	PROTEASE
Uniprot Evidence	1: Evidence at protein level
Interpro Type	Domain
Interpro Name	Peptidase S1/S6, chymotrypsin/Hap
Interpro Acc	IPR001254
Target Class	Enzymes
Target Subclass	EC:3.4.21.4
GuideToPharmacology Gene Category Name	S1: Chymotrypsin
GuideToPharmacology Gene Category ID	751
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

PROTEASE
DRUGGABLE GENOME
ENZYME

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Mahdy et al., 2004, Perioperative systemic haemostatic agents., Br J Anaesth
Ramjee MK et al., 2000, The kinetic and structural characterization of the reaction of nafamostat with bovine pancreatic trypsin., Thromb Res
Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Senokuchi et al., 1995, New orally active serine protease inhibitors., J. Med. Chem.
Tamura Y et al., 1977, Synthetic inhibitors of trypsin, plasmin, kallikrein, thrombin, C1r-, and C1 esterase., Biochim Biophys Acta
Costanzo MJ et al., 2003, Potent, small-molecule inhibitors of human mast cell tryptase. Antiasthmatic action of a dipeptide-based transition-state analogue containing a benzothiazole ketone., J Med Chem

CYCLOTHEONAMIDE A PRSS1

Interaction Score: 4.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL62807 PRSS1

Interaction Score: 4.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL270527 PRSS1

Interaction Score: 4.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL369251 PRSS1

Interaction Score: 4.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL1231689 PRSS1

Interaction Score: 4.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL330572 PRSS1

Interaction Score: 4.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL62492 PRSS1

Interaction Score: 4.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL1190476 PRSS1

Interaction Score: 4.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL48046 PRSS1

Interaction Score: 4.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL1161253 PRSS1

Interaction Score: 4.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL104815 PRSS1

Interaction Score: 4.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL343892 PRSS1

Interaction Score: 4.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL12392 PRSS1

Interaction Score: 4.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
4-PHENYL-BUTYLAMINE PRSS1

Interaction Score: 4.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL48608 PRSS1

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL186483 PRSS1

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL1233097 PRSS1

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL164138 PRSS1

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL95097 PRSS1

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL64579 PRSS1

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL64676 PRSS1

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL92277 PRSS1

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
PHENETHYLAMINE PRSS1

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
BENZYLAMINE PRSS1

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL276864 PRSS1

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL49636 PRSS1

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL327715 PRSS1

Interaction Score: 1.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CHEMBL433501 PRSS1

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL303992 PRSS1

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL46148 PRSS1

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL1198650 PRSS1

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL62836 PRSS1

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL1198138 PRSS1

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL1234624 PRSS1

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL256892 PRSS1

Interaction Score: 1.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
12930148

Sources:
DrugBank
PHOSPHORYLISOPROPANE PRSS1

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
ULINASTATIN PRSS1

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CAMOSTAT PRSS1

Interaction Score: 0.95

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
7629790 143965

Sources:
DrugBank GuideToPharmacology
CHEMBL96433 PRSS1

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
BENZAMIDINE PRSS1

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
CYANOPEPTOLIN SS PRSS1

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYANOPEPTOLIN S PRSS1

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIMINAZENE PRSS1

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
APROTININ PRSS1

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15277296

Sources:
DrugBank
NAFAMOSTAT PRSS1

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
10899355

Sources:
DrugBank GuideToPharmacology
DIOTYROSINE PRSS1

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
MELAGATRAN PRSS1

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
BORTEZOMIB PRSS1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20875739

Sources:
DTC TTD

Ensembl: ENSG00000204983
- Version: 101_38
Alternate Names:

PRSS1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P07477
- Version: January-2014
Alternate Names:

PRSS1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.21.4

Publications:
RussLampel: ENSG00000173636
- Version: 26-July-2011
Alternate Names:

ENSG00000173636 Ensembl Gene Id

PRSS1 Display Id

TRYPSIN I PRECURSOR (EC 3.4.21.4) (CATIONIC TRYPSINOGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P07477] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: P07477
- Version: 11-September-2012
Alternate Names:

PRSS1 Uniprot Gene Name

ENSG00000204983 Ensembl Gene Id

P07477 Uniprot Accession

Gene Info:

Uniprot Status Swiss-Prot

Human Readable Name DRUGGABLE GENOME

Interpro Short Name Peptidase_S1_S6

Gene Categories:

PROTEASE, DRUGGABLE GENOME

Publications:
GuideToPharmacology: 5644
- Version: 29-September-2020
Alternate Names:

9475 HUGO Gene ID

9475 HUGO Gene Symbol

serine protease 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name S1: Chymotrypsin

GuideToPharmacology Gene Category ID 751

Gene Categories:

ENZYME

Publications:

DrugBank: BE0001739

Version: 5.1.7

Alternate Names:

PRSS1 DrugBank Gene Name

P07477 UniProt Accession

5644 Entrez Gene Id

Gene Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

DTC: PRSS1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett

HingoraniCasas: ENSG00000204983
- Version: 31-May-2017
Alternate Names:

ENSG00000204983 Gene Symbol

PRSS1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: PRSS1
- Version: 03-September-2020
Alternate Names:

Trypsin-1 Gene Name

P07477 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
Tempus: PRSS1
- Version: 11-November-2018
Alternate Names:

PRSS1 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: PRSS1
- Version: 27-Jun-2013
Alternate Names:

5644 Gene ID

TRP1 dGene Synonym

TRY1 dGene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:
TTD: Cationic trypsinogen
- Version: 2020.06.01
Alternate Names:

PRSS1 TTD Gene Abbreviation

T27602 TTD Target ID

Gene Info:

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	True

ENSG00000173636	Ensembl Gene Id
PRSS1	Display Id
TRYPSIN I PRECURSOR (EC 3.4.21.4) (CATIONIC TRYPSINOGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P07477]	Description

PRSS1	Uniprot Gene Name
ENSG00000204983	Ensembl Gene Id
P07477	Uniprot Accession

9475	HUGO Gene ID
9475	HUGO Gene Symbol
serine protease 1	HUGO Gene Name

PRSS1	DrugBank Gene Name
P07477	UniProt Accession
5644	Entrez Gene Id

PRSS1 Gene Record

PRSS1 5644 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423