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PRSS1 Gene Record

  • Summary
  • Interactions
  • Claims
  • PRSS1 5644 Druggable Genome

    Alternate Names:

    5644
    PROTEASE, SERINE 1
    PRSS1
    TRP1
    TRY1
    TRY4
    TRYP1
    276000
    9475
    ENSG00000204983
    OTTHUMG00000158923
    P07477
    ALPHA-TRYPSIN CHAIN 2
    TRY1_HUMAN
    ENSG00000261473
    BE0001739
    ENSG00000173636
    TRYPSIN I PRECURSOR (EC 3.4.21.4) (CATIONIC TRYPSINOGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P07477]
    2397
    NM_002769
    NP_002760
    serine protease 1
    Cationic trypsinogen
    T27602
    Trypsin-1

    Gene Info:

    Uniprot Status Swiss-Prot
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Peptidase_S1_S6
    Human Readable Name PROTEASE
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Domain
    Interpro Name Peptidase S1/S6, chymotrypsin/Hap
    Interpro Acc IPR001254
    Target Class Enzymes
    Target Subclass EC:3.4.21.4
    GuideToPharmacology Gene Category Name S1: Chymotrypsin
    GuideToPharmacology Gene Category ID 751
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    PROTEASE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Mahdy et al., 2004, Perioperative systemic haemostatic agents., Br J Anaesth
    Ramjee MK et al., 2000, The kinetic and structural characterization of the reaction of nafamostat with bovine pancreatic trypsin., Thromb Res
    Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Senokuchi et al., 1995, New orally active serine protease inhibitors., J. Med. Chem.
    Tamura Y et al., 1977, Synthetic inhibitors of trypsin, plasmin, kallikrein, thrombin, C1r-, and C1 esterase., Biochim Biophys Acta
    Costanzo MJ et al., 2003, Potent, small-molecule inhibitors of human mast cell tryptase. Antiasthmatic action of a dipeptide-based transition-state analogue containing a benzothiazole ketone., J Med Chem
  • CYCLOTHEONAMIDE A   PRSS1

    Interaction Score: 4.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL62807   PRSS1

    Interaction Score: 4.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL270527   PRSS1

    Interaction Score: 4.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL369251   PRSS1

    Interaction Score: 4.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL1231689   PRSS1

    Interaction Score: 4.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL330572   PRSS1

    Interaction Score: 4.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL62492   PRSS1

    Interaction Score: 4.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL1190476   PRSS1

    Interaction Score: 4.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL48046   PRSS1

    Interaction Score: 4.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL1161253   PRSS1

    Interaction Score: 4.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL104815   PRSS1

    Interaction Score: 4.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL343892   PRSS1

    Interaction Score: 4.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL12392   PRSS1

    Interaction Score: 4.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • 4-PHENYL-BUTYLAMINE   PRSS1

    Interaction Score: 4.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL48608   PRSS1

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL186483   PRSS1

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1233097   PRSS1

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL164138   PRSS1

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL95097   PRSS1

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL64579   PRSS1

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL64676   PRSS1

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL92277   PRSS1

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • PHENETHYLAMINE   PRSS1

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • BENZYLAMINE   PRSS1

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL276864   PRSS1

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL49636   PRSS1

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL327715   PRSS1

    Interaction Score: 1.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL433501   PRSS1

    Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL303992   PRSS1

    Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL46148   PRSS1

    Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1198650   PRSS1

    Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL62836   PRSS1

    Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1198138   PRSS1

    Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1234624   PRSS1

    Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL256892   PRSS1

    Interaction Score: 1.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    12930148


    Sources:
    DrugBank

  • PHOSPHORYLISOPROPANE   PRSS1

    Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17139284 17016423


    Sources:
    DrugBank

  • ULINASTATIN   PRSS1

    Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CAMOSTAT   PRSS1

    Interaction Score: 0.95

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    7629790 143965


    Sources:
    DrugBank GuideToPharmacology

  • CHEMBL96433   PRSS1

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • BENZAMIDINE   PRSS1

    Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CYANOPEPTOLIN SS   PRSS1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CYANOPEPTOLIN S   PRSS1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIMINAZENE   PRSS1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • APROTININ   PRSS1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15277296


    Sources:
    DrugBank

  • NAFAMOSTAT   PRSS1

    Interaction Score: 0.22

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    10899355


    Sources:
    DrugBank GuideToPharmacology

  • DIOTYROSINE   PRSS1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • MELAGATRAN   PRSS1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • BORTEZOMIB   PRSS1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20875739


    Sources:
    DTC TTD

  • Ensembl: ENSG00000204983

    • Version: 101_38

    Alternate Names:
    PRSS1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P07477

    • Version: January-2014

    Alternate Names:
    PRSS1 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.4.21.4

    Publications:

  • RussLampel: ENSG00000173636

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000173636 Ensembl Gene Id
    PRSS1 Display Id
    TRYPSIN I PRECURSOR (EC 3.4.21.4) (CATIONIC TRYPSINOGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P07477] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P07477

    • Version: 11-September-2012

    Alternate Names:
    PRSS1 Uniprot Gene Name
    ENSG00000204983 Ensembl Gene Id
    P07477 Uniprot Accession

    Gene Info:
    Uniprot Status Swiss-Prot
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Peptidase_S1_S6

    Gene Categories:
    PROTEASE, DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 5644

    • Version: 29-September-2020

    Alternate Names:
    9475 HUGO Gene ID
    9475 HUGO Gene Symbol
    serine protease 1 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name S1: Chymotrypsin
    GuideToPharmacology Gene Category ID 751

    Gene Categories:
    ENZYME

    Publications:

  • DrugBank: BE0001739

    • Version: 5.1.7

    Alternate Names:
    PRSS1 DrugBank Gene Name
    P07477 UniProt Accession
    5644 Entrez Gene Id

    Gene Info:

    Publications:
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

  • DTC: PRSS1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Blackburn C et al., 2010, Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome., Bioorg Med Chem Lett

  • HingoraniCasas: ENSG00000204983

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000204983 Gene Symbol
    PRSS1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: PRSS1

    • Version: 03-September-2020

    Alternate Names:
    Trypsin-1 Gene Name
    P07477 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • Tempus: PRSS1

    • Version: 11-November-2018

    Alternate Names:
    PRSS1 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • dGene: PRSS1

    • Version: 27-Jun-2013

    Alternate Names:
    5644 Gene ID
    TRP1 dGene Synonym
    TRY1 dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE

    Publications:

  • TTD: Cationic trypsinogen

    • Version: 2020.06.01

    Alternate Names:
    PRSS1 TTD Gene Abbreviation
    T27602 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21