DGIdb - PRL Gene Record

PRL 5617 Druggable Genome

Alternate Names:

5617
PROLACTIN
PRL
GHA1
176760
9445
ENSG00000172179
OTTHUMG00000016111

Gene Info:

Gene Biotype	PROTEIN_CODING

(0 More Sources)

Gene Categories: Category Details

HORMONE ACTIVITY
DRUGGABLE GENOME

Publications:

Krishnamra et al., 1993, Acute effect and mechanism of action of prolactin on the in situ passive calcium absorption in rat., Bone Miner
Coccaro et al., 1990, Buspirone challenge: preliminary evidence for a role for central 5-HT1a receptor function in impulsive aggressive behavior in humans., Psychopharmacol Bull
Oxberry et al., 1984, Down regulation of prolactin receptors in the hamster ovary by the preovulatory gonadotropin surge., Biol. Reprod.
Gräf et al., 1978, The role of the anterior pituitary gland in progestagen-induced proliferative mammary gland changes in the beagle., Arzneimittelforschung
Karanth et al., Effects of azido-3'-deoxy-thymidine on luteinizing hormone, follicle-stimulating hormone and prolactin release by the pituitary-hypothalamus complex., Neuroimmunomodulation
Barni et al., 1987, Acute effects of various chemotherapeutic combinations on hypophyseal and pineal hormone secretions in cancer patients., Tumori
Kabuto et al., 1991, [Effect of calcium channel antagonist (nicardipine) on growth hormone and prolactin secretion in pituitary adenomas]., No To Shinkei
de Greef et al., 1987, Control of prolactin release induced by suckling., Endocrinology
Luerti et al., 1984, Cord blood prolactin and thyroid hormone levels after antenatal administration of betamethasone or ambroxol for prevention of respiratory distress syndrome (RDS)., Biol Res Pregnancy Perinatol
Williams et al., 1994, The regulation of prolactin cells in the rainbow trout (Oncorhynchus mykiss). 1. Possible roles for thyrotropin-releasing hormone (TRH) and oestradiol., Gen. Comp. Endocrinol.
Rillema et al., 1997, Characteristics of the prolactin stimulation of iodide uptake into mouse mammary gland explants., Proc. Soc. Exp. Biol. Med.
Ambrosi et al., 1986, Effects of acute benzodiazepine administration on growth hormone, prolactin and cortisol release after moderate insulin-induced hypoglycemia in normal women., Psychopharmacology (Berl.)
Di Carlo et al., 2005, Effect on prolactin secretion of Echinacea purpurea, hypericum perforatum and Eleutherococcus senticosus., Phytomedicine
White, 1985, Evidence for a role of calmodulin in the regulation of prolactin gene expression., J. Biol. Chem.
Camarillo et al., 1997, Lovastatin inhibits prolactin-induced Nb2 cell mitogenesis and milk product synthesis in mouse mammary gland explants., Proc. Soc. Exp. Biol. Med.
Elangovan et al., 1996, Neurohormonal and behavioral response to methylphenidate in cocaine abstinence., Psychiatry Res
Weizman et al., 1987, Effects of acute and chronic methylphenidate administration on beta-endorphin, growth hormone, prolactin and cortisol in children with attention deficit disorder and hyperactivity., Life Sci.
Morley et al., 1981, The relationship of androgen to the thyrotropin and prolactin responses to thyrotropin-releasing hormone in hypogonadal and normal men., J. Clin. Endocrinol. Metab.
Hall et al., 1984, Serotonin and acetylcholine affect the release of prolactin and growth hormone from pituitary glands of domestic fowl in vitro in the presence of hypothalamic tissue., Acta Endocrinol.
Bonuccelli et al., 1985, Effects of carbamazepine on prolactin secretion in normal subjects and in epileptic subjects., Clin Neuropharmacol
Isojärvi et al., Effects of carbamazepine therapy on serum sex hormone levels in male patients with epilepsy., Epilepsia
Rao et al., 1995, Nuclear translocation of prolactin: collaboration of tyrosine kinase and protein kinase C activation in rat Nb2 node lymphoma cells., J. Cell. Physiol.
Caviezel et al., 1983, The effect of acetylsalicylic acid and diclofenac on stimulated growth hormone and prolactin secretion in humans., Int J Clin Pharmacol Ther Toxicol
Saksena et al., 1982, Antifertility effects of gossypol in male hamsters., Fertil. Steril.
Hoshiai et al., 1982, Gossypol as oral contraceptive for male: trial case report., Tohoku J. Exp. Med.
Chang et al., 1983, [Comparison of changes of serum gonadotropins and steroid hormones in azoospermic men caused by gossypol and other factors]., Shengzhi Yu Biyun
Favaretto et al., 1990, Pituitary-testicular axis in benznidazole-treated rats., Braz. J. Med. Biol. Res.
Laverrière et al., 1989, Thyroliberin and dihydropyridines modulate prolactin gene expression through interacting pathways in GH3 cells., Neuroendocrinology
Kovacs et al., 2007, Temozolomide therapy in a man with an aggressive prolactin-secreting pituitary neoplasm: Morphological findings., Hum. Pathol.
Pontiroli et al., 1981, The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress., J. Clin. Endocrinol. Metab.
Schlienger et al., [Different effects of tricyclic (clomipramine and amitriptyline) and tetracyclic (maprotiline) antidepressors on the release of thyroid stimulating hormone, prolactin and growth hormone to thyrostimulating releasing hormone in patients with psychoaffective disorders (author's transl)]., Acta Psychiatr Belg
Linkowski et al., 1983, Prolactin and growth hormone response to levodopa in affective illness., Neuropsychobiology
Pende et al., 1987, Interaction between morphine, an opioid agonist, and clonidine, an alpha-adrenergic agonist, on the regulation of anterior pituitary hormone secretion in normal male subjects., Biomed. Pharmacother.
Lobo et al., 1982, Clomiphene and dexamethasone in women unresponsive to clomiphene alone., Obstet Gynecol
Serafini et al., 1987, Modulation of prolactin responses to gonadotropin releasing hormone by acute testosterone infusions in normal women., Gynecol. Endocrinol.
Lieberman et al., 1994, Predictors of response to clozapine., J Clin Psychiatry
Viguié et al., 1997, Characterization of the short day-induced decrease in median eminence tyrosine hydroxylase activity in the ewe: temporal relationship to the changes in luteinizing hormone and prolactin secretion and short day-like effect of melatonin., Endocrinology
Gilbeau et al., 1986, Dynorphin effects on plasma concentrations of anterior pituitary hormones in the nonhuman primate., J. Pharmacol. Exp. Ther.

BENZNIDAZOLE PRL

Interaction Score: 1.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2129270

Sources:
NCI
TESTOLACTONE PRL

Interaction Score: 1.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3332537

Sources:
NCI
CLOMIPHENE PRL

Interaction Score: 1.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6214735

Sources:
NCI
FLUOXYMESTERONE PRL

Interaction Score: 1.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6161941

Sources:
NCI
BACITRACIN PRL

Interaction Score: 1.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8194740

Sources:
NCI
ECHINACEA, UNSPECIFIED PRL

Interaction Score: 0.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16194051

Sources:
NCI
MANNITOL PRL

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8148670

Sources:
NCI
BUSPIRONE PRL

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2274641

Sources:
NCI
AMITRIPTYLINE PRL

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6786002 6621850

Sources:
NCI
CLONIDINE PRL

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3663877

Sources:
NCI
BETAMETHASONE PRL

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6548163

Sources:
NCI
NORETHINDRONE PRL

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
580200

Sources:
NCI
NALOXONE PRL

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2875176

Sources:
NCI
PILOCARPINE PRL

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6144226

Sources:
NCI
NICARDIPINE PRL

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1910948

Sources:
NCI
PROMETHAZINE PRL

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7228996

Sources:
NCI
PHENOTHIAZINE PRL

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3918029

Sources:
NCI
PROPYLTHIOURACIL PRL

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9270719

Sources:
NCI
BUPROPION PRL

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3109881

Sources:
NCI
TEMOZOLOMIDE PRL

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17056093

Sources:
NCI
ALTEPLASE PRL

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2482456

Sources:
NCI
DICLOFENAC PRL

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6642786

Sources:
NCI
FLURAZEPAM PRL

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3081931

Sources:
NCI
GOSSYPOL PRL

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7075801 6818716 12339175

Sources:
NCI
MELATONIN PRL

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8977440

Sources:
NCI
METHYLPHENIDATE PRL

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9122287 3035307

Sources:
NCI
CARBAMAZEPINE PRL

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3924400 3191895

Sources:
NCI
ZIDOVUDINE PRL

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9500147

Sources:
NCI
PHENOBARBITAL PRL

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6091795

Sources:
NCI
LOVASTATIN PRL

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9316617

Sources:
NCI
GENISTEIN PRL

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7706371

Sources:
NCI
CLOZAPINE PRL

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7961556

Sources:
NCI
CISPLATIN PRL

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2953096

Sources:
NCI

Ensembl: ENSG00000172179
- Version: 101_38
Alternate Names:

PRL Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

NCI: PRL

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Krishnamra et al., 1993, Acute effect and mechanism of action of prolactin on the in situ passive calcium absorption in rat., Bone Miner

Oxberry et al., 1984, Down regulation of prolactin receptors in the hamster ovary by the preovulatory gonadotropin surge., Biol. Reprod.

Gräf et al., 1978, The role of the anterior pituitary gland in progestagen-induced proliferative mammary gland changes in the beagle., Arzneimittelforschung

HingoraniCasas: ENSG00000172179
- Version: 31-May-2017
Alternate Names:

ENSG00000172179 Gene Symbol

PRL Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: PRL
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

HORMONE ACTIVITY

Publications:

PRL Gene Record

PRL 5617 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2129270

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3332537

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6214735

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6161941

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8194740

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16194051

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8148670

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2274641

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6786002 6621850

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3663877

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6548163

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 580200

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2875176

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6144226

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1910948

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7228996

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3918029

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9270719

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
2129270

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3332537

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6214735

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6161941

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8194740

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16194051

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8148670

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2274641

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6786002 6621850

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3663877

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6548163

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
580200

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2875176

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6144226

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1910948

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7228996

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3918029

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9270719

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3109881

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17056093

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2482456

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6642786

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3081931

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7075801 6818716 12339175

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8977440

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9122287 3035307

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3924400 3191895