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PRL Gene Record

  • Summary
  • Interactions
  • Claims
  • PRL 5617 Druggable Genome

    Alternate Names:

    5617
    PROLACTIN
    PRL
    GHA1
    176760
    9445
    ENSG00000172179
    OTTHUMG00000016111

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (0 More Sources)

    Gene Categories: Category Details

    HORMONE ACTIVITY
    DRUGGABLE GENOME

    Publications:

    Krishnamra et al., 1993, Acute effect and mechanism of action of prolactin on the in situ passive calcium absorption in rat., Bone Miner
    Coccaro et al., 1990, Buspirone challenge: preliminary evidence for a role for central 5-HT1a receptor function in impulsive aggressive behavior in humans., Psychopharmacol Bull
    Oxberry et al., 1984, Down regulation of prolactin receptors in the hamster ovary by the preovulatory gonadotropin surge., Biol. Reprod.
    Gräf et al., 1978, The role of the anterior pituitary gland in progestagen-induced proliferative mammary gland changes in the beagle., Arzneimittelforschung
    Karanth et al., Effects of azido-3'-deoxy-thymidine on luteinizing hormone, follicle-stimulating hormone and prolactin release by the pituitary-hypothalamus complex., Neuroimmunomodulation
    Barni et al., 1987, Acute effects of various chemotherapeutic combinations on hypophyseal and pineal hormone secretions in cancer patients., Tumori
    Kabuto et al., 1991, [Effect of calcium channel antagonist (nicardipine) on growth hormone and prolactin secretion in pituitary adenomas]., No To Shinkei
    de Greef et al., 1987, Control of prolactin release induced by suckling., Endocrinology
    Luerti et al., 1984, Cord blood prolactin and thyroid hormone levels after antenatal administration of betamethasone or ambroxol for prevention of respiratory distress syndrome (RDS)., Biol Res Pregnancy Perinatol
    Williams et al., 1994, The regulation of prolactin cells in the rainbow trout (Oncorhynchus mykiss). 1. Possible roles for thyrotropin-releasing hormone (TRH) and oestradiol., Gen. Comp. Endocrinol.
    Rillema et al., 1997, Characteristics of the prolactin stimulation of iodide uptake into mouse mammary gland explants., Proc. Soc. Exp. Biol. Med.
    Ambrosi et al., 1986, Effects of acute benzodiazepine administration on growth hormone, prolactin and cortisol release after moderate insulin-induced hypoglycemia in normal women., Psychopharmacology (Berl.)
    Di Carlo et al., 2005, Effect on prolactin secretion of Echinacea purpurea, hypericum perforatum and Eleutherococcus senticosus., Phytomedicine
    White, 1985, Evidence for a role of calmodulin in the regulation of prolactin gene expression., J. Biol. Chem.
    Camarillo et al., 1997, Lovastatin inhibits prolactin-induced Nb2 cell mitogenesis and milk product synthesis in mouse mammary gland explants., Proc. Soc. Exp. Biol. Med.
    Elangovan et al., 1996, Neurohormonal and behavioral response to methylphenidate in cocaine abstinence., Psychiatry Res
    Weizman et al., 1987, Effects of acute and chronic methylphenidate administration on beta-endorphin, growth hormone, prolactin and cortisol in children with attention deficit disorder and hyperactivity., Life Sci.
    Morley et al., 1981, The relationship of androgen to the thyrotropin and prolactin responses to thyrotropin-releasing hormone in hypogonadal and normal men., J. Clin. Endocrinol. Metab.
    Hall et al., 1984, Serotonin and acetylcholine affect the release of prolactin and growth hormone from pituitary glands of domestic fowl in vitro in the presence of hypothalamic tissue., Acta Endocrinol.
    Isojärvi et al., Effects of carbamazepine therapy on serum sex hormone levels in male patients with epilepsy., Epilepsia
    Bonuccelli et al., 1985, Effects of carbamazepine on prolactin secretion in normal subjects and in epileptic subjects., Clin Neuropharmacol
    Rao et al., 1995, Nuclear translocation of prolactin: collaboration of tyrosine kinase and protein kinase C activation in rat Nb2 node lymphoma cells., J. Cell. Physiol.
    Caviezel et al., 1983, The effect of acetylsalicylic acid and diclofenac on stimulated growth hormone and prolactin secretion in humans., Int J Clin Pharmacol Ther Toxicol
    Chang et al., 1983, [Comparison of changes of serum gonadotropins and steroid hormones in azoospermic men caused by gossypol and other factors]., Shengzhi Yu Biyun
    Saksena et al., 1982, Antifertility effects of gossypol in male hamsters., Fertil. Steril.
    Hoshiai et al., 1982, Gossypol as oral contraceptive for male: trial case report., Tohoku J. Exp. Med.
    Favaretto et al., 1990, Pituitary-testicular axis in benznidazole-treated rats., Braz. J. Med. Biol. Res.
    Laverrière et al., 1989, Thyroliberin and dihydropyridines modulate prolactin gene expression through interacting pathways in GH3 cells., Neuroendocrinology
    Kovacs et al., 2007, Temozolomide therapy in a man with an aggressive prolactin-secreting pituitary neoplasm: Morphological findings., Hum. Pathol.
    Pontiroli et al., 1981, The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress., J. Clin. Endocrinol. Metab.
    Schlienger et al., [Different effects of tricyclic (clomipramine and amitriptyline) and tetracyclic (maprotiline) antidepressors on the release of thyroid stimulating hormone, prolactin and growth hormone to thyrostimulating releasing hormone in patients with psychoaffective disorders (author's transl)]., Acta Psychiatr Belg
    Linkowski et al., 1983, Prolactin and growth hormone response to levodopa in affective illness., Neuropsychobiology
    Pende et al., 1987, Interaction between morphine, an opioid agonist, and clonidine, an alpha-adrenergic agonist, on the regulation of anterior pituitary hormone secretion in normal male subjects., Biomed. Pharmacother.
    Lobo et al., 1982, Clomiphene and dexamethasone in women unresponsive to clomiphene alone., Obstet Gynecol
    Serafini et al., 1987, Modulation of prolactin responses to gonadotropin releasing hormone by acute testosterone infusions in normal women., Gynecol. Endocrinol.
    Lieberman et al., 1994, Predictors of response to clozapine., J Clin Psychiatry
    Viguié et al., 1997, Characterization of the short day-induced decrease in median eminence tyrosine hydroxylase activity in the ewe: temporal relationship to the changes in luteinizing hormone and prolactin secretion and short day-like effect of melatonin., Endocrinology
    Gilbeau et al., 1986, Dynorphin effects on plasma concentrations of anterior pituitary hormones in the nonhuman primate., J. Pharmacol. Exp. Ther.
  • BENZNIDAZOLE   PRL

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2129270


    Sources:
    NCI

  • TESTOLACTONE   PRL

    Interaction Score: 1.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3332537


    Sources:
    NCI

  • CLOMIPHENE   PRL

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6214735


    Sources:
    NCI

  • ECHINACEA, UNSPECIFIED   PRL

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16194051


    Sources:
    NCI

  • BACITRACIN   PRL

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8194740


    Sources:
    NCI

  • FLUOXYMESTERONE   PRL

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6161941


    Sources:
    NCI

  • MANNITOL   PRL

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8148670


    Sources:
    NCI

  • BETAMETHASONE   PRL

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6548163


    Sources:
    NCI

  • NORETHINDRONE   PRL

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    580200


    Sources:
    NCI

  • BUSPIRONE   PRL

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2274641


    Sources:
    NCI

  • CLONIDINE   PRL

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3663877


    Sources:
    NCI

  • PILOCARPINE   PRL

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6144226


    Sources:
    NCI

  • NALOXONE   PRL

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2875176


    Sources:
    NCI

  • PHENOTHIAZINE   PRL

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3918029


    Sources:
    NCI

  • PROPYLTHIOURACIL   PRL

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9270719


    Sources:
    NCI

  • BUPROPION   PRL

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3109881


    Sources:
    NCI

  • PROMETHAZINE   PRL

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7228996


    Sources:
    NCI

  • TEMOZOLOMIDE   PRL

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17056093


    Sources:
    NCI

  • ALTEPLASE   PRL

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2482456


    Sources:
    NCI

  • FLURAZEPAM   PRL

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3081931


    Sources:
    NCI

  • GOSSYPOL   PRL

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12339175 7075801 6818716


    Sources:
    NCI

  • DICLOFENAC   PRL

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6642786


    Sources:
    NCI

  • AMITRIPTYLINE   PRL

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6786002 6621850


    Sources:
    NCI

  • NICARDIPINE   PRL

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1910948


    Sources:
    NCI

  • METHYLPHENIDATE   PRL

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9122287 3035307


    Sources:
    NCI

  • CARBAMAZEPINE   PRL

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3191895 3924400


    Sources:
    NCI

  • ZIDOVUDINE   PRL

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9500147


    Sources:
    NCI

  • MELATONIN   PRL

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8977440


    Sources:
    NCI

  • PHENOBARBITAL   PRL

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6091795


    Sources:
    NCI

  • LOVASTATIN   PRL

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9316617


    Sources:
    NCI

  • GENISTEIN   PRL

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7706371


    Sources:
    NCI

  • CLOZAPINE   PRL

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7961556


    Sources:
    NCI

  • CISPLATIN   PRL

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2953096


    Sources:
    NCI

  • Ensembl: ENSG00000172179

    • Version: 101_38

    Alternate Names:
    PRL Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • NCI: PRL

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Krishnamra et al., 1993, Acute effect and mechanism of action of prolactin on the in situ passive calcium absorption in rat., Bone Miner
    Oxberry et al., 1984, Down regulation of prolactin receptors in the hamster ovary by the preovulatory gonadotropin surge., Biol. Reprod.
    Gräf et al., 1978, The role of the anterior pituitary gland in progestagen-induced proliferative mammary gland changes in the beagle., Arzneimittelforschung

  • HingoraniCasas: ENSG00000172179

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000172179 Gene Symbol
    PRL Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: PRL

    • Version: 05-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    HORMONE ACTIVITY

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21