• PRKDC 5591 Druggable GenomeClinically Actionable

    Alternate Names:

    5591
    PROTEIN KINASE, DNA-ACTIVATED, CATALYTIC POLYPEPTIDE
    PRKDC
    DNA-PKcs
    DNAPK
    DNPK1
    HYRC
    HYRC1
    IMD26
    XRCC7
    p350
    600899
    9413
    ENSG00000253729
    OTTHUMG00000164239
    P78527
    DNA-dependent protein kinase catalytic subunit
    p460
    DNA-PK catalytic subunit
    PRKDC_HUMAN
    2800
    NP_008835|NP_001075109
    NM_006904|NM_001081640
    ENSG00000121031
    DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT (EC 2.7.1.37) (DNA- PKCS) (DNPK1) (P460). [SOURCE:UNIPROT/SWISSPROT;ACC:P78527]
    protein kinase, DNA-activated, catalytic subunit
    DNA-dependent protein kinase catalytic
    T81735
    DNA-PKC
    DNAPKc

    Gene Info:

    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Interpro Name Phosphatidylinositol 3-/4-kinase, catalytic domain
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name PI3/4_kinase_cat_dom
    Human Readable Name PHOSPHATIDYLINOSITOL 3 KINASE
    Interpro Acc IPR000403
    Uniprot Evidence 1: Evidence at protein level
    GuideToPharmacology Gene Category Name Other PIKK family kinases
    GuideToPharmacology Gene Category ID 598
    Target Class Enzymes
    Target Subclass EC:2.7.11.1
    Gene Biotype PROTEIN_CODING
    (11 More Sources)

    Gene Categories: Category Details

    TRANSCRIPTION FACTOR COMPLEX
    KINASE
    SERINE THREONINE KINASE
    TRANSCRIPTION FACTOR BINDING
    DRUGGABLE GENOME
    PHOSPHATIDYLINOSITOL 3 KINASE
    CLINICALLY ACTIONABLE
    ENZYME
  • Interaction Score: 10.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 10.63

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 5.32

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction DNA-dependent protein kinase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 5.32

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    23855836


  • Interaction Score: 0.53

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    • Version: 101_38

    Alternate Names:
    PRKDC Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000253729 Ensembl Gene Id
    PRKDC_HUMAN Uniprot Id
    DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT Uniprot Protein Name

    Gene Info:
    Uniprot Status Swiss-Prot
    Interpro Name Phosphatidylinositol 3-/4-kinase, catalytic domain
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME, PHOSPHATIDYLINOSITOL 3 KINASE

    Publications:

    • Version: January-2014

    Alternate Names:
    PRKDC Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.1

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT (EC 2.7.1.37) (DNA- PKCS) (DNPK1) (P460). [SOURCE:UNIPROT/SWISSPROT;ACC:P78527] Description
    PRKDC Display Id
    ENSG00000121031 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    9413 HUGO Gene ID
    9413 HUGO Gene Symbol
    protein kinase, DNA-activated, catalytic subunit HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Other PIKK family kinases
    GuideToPharmacology Gene Category ID 598

    Gene Categories:
    ENZYME

    Publications:

    • Version: 02-September-2020
    • Version: 31-May-2017

    Alternate Names:
    ENSG00000253729 Gene Symbol
    PRKDC Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    HYRC1 GENE_SYMBOL
    PRKDC GENE_SYMBOL
    DNA-dependent protein kinase catalytic subunit UNIPROT

    Gene Info:

    Publications:

    • Version: 19.3

    Alternate Names:
    ENSG00000253729 Ensembl Gene ID
    DNA-PKcs Human Protein Atlas Gene Synonym
    DNAPK Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

    • Version: 27-Jun-2013

    Alternate Names:
    5591 Gene ID
    DNA-PKcs dGene Synonym
    DNAPK dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • Alternate Names:
    PRKDC TTD Gene Abbreviation
    T81735 TTD Target ID

    Gene Info:

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    HYRC GO Gene Synonym
    HYRC1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR COMPLEX, SERINE THREONINE KINASE, TRANSCRIPTION FACTOR BINDING

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    DNA-dependent protein kinase catalytic subunit Gene Name
    P78527 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications: