DGIdb - PRKCE Gene Record

PRKCE 5581 Druggable Genome

Alternate Names:

5581
PROTEIN KINASE C EPSILON
PRKCE
PKCE
nPKC-epsilon
176975
9401
ENSG00000171132
OTTHUMG00000128817
Protein kinase C epsilon type
Q02156
PKC
PKC-epsilon
PROTEIN KINASE C, EPSILON TYPE (EC 2.7.1.-) (NPKC-EPSILON). [SOURCE:UNIPROT/SWISSPROT;ACC:Q02156]
KPCE_HUMAN
PA33765
T00895

Gene Info:

Target Class	Enzymes
Target Subclass	EC:2.7.11.13
Initial Gene Query	PKC epsilon
Counted Citations from 1950-2000	1023
Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR002290
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Uniprot Status	Swiss-Prot
Human Readable Name	KINASE
Interpro Type	Domain
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Gene Biotype	PROTEIN_CODING

(10 More Sources)

Gene Categories: Category Details

KINASE
ION CHANNEL
SERINE THREONINE KINASE
DRUGGABLE GENOME
TRANSCRIPTION FACTOR

Publications:

Keck GE et al., 2012, Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity., Bioorg Med Chem Lett
Garcia LC et al., 2014, Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP., Bioorg Med Chem
Mochly-Rosen D et al., 2012, Protein kinase C, an elusive therapeutic target?, Nat Rev Drug Discov

KAI-1678 PRKCE

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name KAI-1678

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
CHEMBL27768 PRKCE

Interaction Score: 2.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24794745

Sources:
DTC
PHORBOL MYRISTATE ACETATE PRKCE

Interaction Score: 2.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22579485

Sources:
DTC
ENZASTAURIN PRKCE

Interaction Score: 0.64

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
MEPROBAMATE PRKCE

Interaction Score: 0.57

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23197040

Sources:
TTD
BRYOSTATIN PRKCE

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Bryostatin

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
GSK-690693 PRKCE

Interaction Score: 0.3

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CEP-2563 PRKCE

Interaction Score: 0.3

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Protein kinase C (PKC) inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
UCN-01 PRKCE

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Protein kinase C (PKC) inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
MIDOSTAURIN PRKCE

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SOTRASTAURIN PRKCE

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
QUERCETIN PRKCE

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome

Ensembl: ENSG00000171132
- Version: 101_38
Alternate Names:

PRKCE Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: Q02156
- Version: 11-September-2012
Alternate Names:

PROTEIN KINASE C EPSILON TYPE Uniprot Protein Name

PRKCE Uniprot Gene Name

5581 Entrez Gene Id

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Interpro Acc IPR002290

Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
BaderLabGenes: PRKCE
- Version: February-2014
Alternate Names:

5581 Entrez Gene ID

Gene Info:

Initial Gene Query PKC epsilon

Counted Citations from 1950-2000 1023

Gene Categories:

KINASE

Publications:
RussLampel: ENSG00000171132
- Version: 26-July-2011
Alternate Names:

PRKCE Display Id

PROTEIN KINASE C, EPSILON TYPE (EC 2.7.1.-) (NPKC-EPSILON). [SOURCE:UNIPROT/SWISSPROT;ACC:Q02156] Description

ENSG00000171132 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: Q02156
- Version: January-2014
Alternate Names:

PRKCE Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.13

Publications:
PharmGKB: PRKCE
- Version: 18-August-2020
Alternate Names:

PA33765 PharmGKB ID

Gene Info:

Publications:

Pu X et al., 2014, Inflammation-related genetic variants predict toxicity following definitive radiotherapy for lung cancer., Clin Pharmacol Ther
TTD: Protein kinase C epsilon
- Version: 2020.06.01
Alternate Names:

PRKCE TTD Gene Abbreviation

T00895 TTD Target ID

Gene Info:

Publications:

Mochly-Rosen D et al., 2012, Protein kinase C, an elusive therapeutic target?, Nat Rev Drug Discov

DTC: PRKCE

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Keck GE et al., 2012, Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity., Bioorg Med Chem Lett

Garcia LC et al., 2014, Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP., Bioorg Med Chem

ChemblInteractions: PKCE
- Version: chembl_23
Alternate Names:

nPKC-epsilon UNIPROT

PKCE GENE_SYMBOL

PRKCE GENE_SYMBOL

Gene Info:

Publications:
HingoraniCasas: ENSG00000171132
- Version: 31-May-2017
Alternate Names:

ENSG00000171132 Gene Symbol

PRKCE Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
MyCancerGenome: PRKCE
- Version: 20-Jun-2017
Alternate Names:

5581 Entrez Gene Id

PRKCE MyCancerGenome Gene Symbol

PKC-epsilon MyCancerGenome Reported Gene Name

Gene Info:

Publications:
GO: PRKCE
- Version: 01-February-2022
Alternate Names:

PKCE GO Gene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE

Publications:
dGene: PRKCE
- Version: 27-Jun-2013
Alternate Names:

5581 Gene ID

PKCE dGene Synonym

nPKC-epsilon dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
Pharos: PRKCE
- Version: 01-February-2022
Alternate Names:

Protein kinase C epsilon type Gene Name

Q02156 UniProt ID

Gene Info:

Gene Categories:

KINASE, ION CHANNEL, TRANSCRIPTION FACTOR

Publications:

Mechanism of Interaction	Protein kinase C (PKC) inhibitor
Direct Interaction	yes

PROTEIN KINASE C EPSILON TYPE	Uniprot Protein Name
PRKCE	Uniprot Gene Name
5581	Entrez Gene Id

PRKCE	Display Id
PROTEIN KINASE C, EPSILON TYPE (EC 2.7.1.-) (NPKC-EPSILON). [SOURCE:UNIPROT/SWISSPROT;ACC:Q02156]	Description
ENSG00000171132	Ensembl Gene Id

Trial Name	KAI-1678
Novel drug target	Established target

Trial Name	Bryostatin
Novel drug target	Established target

PRKCE Gene Record

PRKCE 5581 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Trial Name KAI-1678 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24794745

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22579485

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: MyCancerGenome

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23197040

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Bryostatin Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Protein kinase C (PKC) inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Protein kinase C (PKC) inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Protein kinase C (PKC) inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Protein kinase C (PKC) inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Protein kinase C (PKC) inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: MyCancerGenome

Ensembl: ENSG00000171132

Alternate Names: PRKCE Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: Q02156

Alternate Names: PROTEIN KINASE C EPSILON TYPE Uniprot Protein Name PRKCE Uniprot Gene Name 5581 Entrez Gene Id

Gene Info: Uniprot Evidence 1: Evidence at protein level Interpro Acc IPR002290 Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain

Gene Categories: KINASE, DRUGGABLE GENOME

Publications:

BaderLabGenes: PRKCE

Alternate Names: 5581 Entrez Gene ID

Gene Info: Initial Gene Query PKC epsilon Counted Citations from 1950-2000 1023

Gene Categories: KINASE

Publications:

RussLampel: ENSG00000171132

Alternate Names: PRKCE Display Id PROTEIN KINASE C, EPSILON TYPE (EC 2.7.1.-) (NPKC-EPSILON). [SOURCE:UNIPROT/SWISSPROT;ACC:Q02156] Description ENSG00000171132 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TdgClinicalTrial: Q02156

Alternate Names: PRKCE Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:2.7.11.13

Publications:

PharmGKB: PRKCE

Alternate Names: PA33765 PharmGKB ID

Gene Info:

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name KAI-1678

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
24794745

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22579485

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
MyCancerGenome

Interaction Types & Directionality:

n/a

PMIDs:
23197040

Sources:
TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Bryostatin

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Protein kinase C (PKC) inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Protein kinase C (PKC) inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
MyCancerGenome

Alternate Names:

PRKCE Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PROTEIN KINASE C EPSILON TYPE Uniprot Protein Name

PRKCE Uniprot Gene Name

5581 Entrez Gene Id

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Interpro Acc IPR002290

Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain

Gene Categories:

KINASE, DRUGGABLE GENOME

Alternate Names:

5581 Entrez Gene ID

Gene Info:

Initial Gene Query PKC epsilon

Counted Citations from 1950-2000 1023

Gene Categories:

KINASE

Alternate Names:

PRKCE Display Id

PROTEIN KINASE C, EPSILON TYPE (EC 2.7.1.-) (NPKC-EPSILON). [SOURCE:UNIPROT/SWISSPROT;ACC:Q02156] Description

ENSG00000171132 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PRKCE Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.13

Alternate Names:

PA33765 PharmGKB ID

Publications:

Pu X et al., 2014, Inflammation-related genetic variants predict toxicity following definitive radiotherapy for lung cancer., Clin Pharmacol Ther

Alternate Names:

PRKCE TTD Gene Abbreviation

T00895 TTD Target ID

Publications:

Mochly-Rosen D et al., 2012, Protein kinase C, an elusive therapeutic target?, Nat Rev Drug Discov

Alternate Names:

nPKC-epsilon UNIPROT

PKCE GENE_SYMBOL

PRKCE GENE_SYMBOL

Alternate Names:

ENSG00000171132 Gene Symbol

PRKCE Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

5581 Entrez Gene Id

PRKCE MyCancerGenome Gene Symbol

PKC-epsilon MyCancerGenome Reported Gene Name

Alternate Names:

PKCE GO Gene Synonym

Gene Categories:

SERINE THREONINE KINASE

Alternate Names:

5581 Gene ID

PKCE dGene Synonym

nPKC-epsilon dGene Synonym

Gene Categories:

KINASE, SERINE THREONINE KINASE

Alternate Names:

Protein kinase C epsilon type Gene Name

Q02156 UniProt ID

Gene Categories:

KINASE, ION CHANNEL, TRANSCRIPTION FACTOR