• PRKACA 5566 Druggable GenomeClinically Actionable

    Alternate Names:

    5566
    PROTEIN KINASE CAMP-ACTIVATED CATALYTIC SUBUNIT ALPHA
    PRKACA
    PKACA
    PPNAD4
    601639
    9380
    ENSG00000072062
    OTTHUMG00000182051
    PKA C-alpha
    cAMP-dependent protein kinase catalytic subunit alpha
    P17612
    CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT (EC 2.7.1.37) (PKA C-ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P17612]
    1476
    NP_002721
    NM_002730
    protein kinase, cAMP-dependent, catalytic, alpha subunit
    KAPCA_HUMAN
    PRKCA
    Protein kinase C alpha type
    PKC-A
    PKC-alpha
    PKCA
    CAFD1

    Gene Info:

    Initial Gene Query PKA
    Counted Citations from 1950-2000 10080
    Human Readable Name DRUGGABLE GENOME
    GuideToPharmacology Gene Category ID 284
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Human Readable Name KINASE
    Interpro Acc IPR002290
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name Protein kinase A (PKA) family
    (9 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    ENZYME
  • Interaction Score: 2.03

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    10592235


  • Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.28

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction cAMP-dependent protein kinase (PKA) inhibitor
    Direct Interaction yes
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DTC

  • Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

    • Version: 101_38

    Alternate Names:
    PRKACA Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: February-2014

    Alternate Names:
    5566 Entrez Gene ID

    Gene Info:
    Initial Gene Query PKA
    Counted Citations from 1950-2000 10080

    Gene Categories:
    KINASE

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    PRKACA Display Id
    CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT (EC 2.7.1.37) (PKA C-ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P17612] Description
    ENSG00000072062 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    PRKACA Uniprot Gene Name
    KAPCA_HUMAN Uniprot Id
    5566 Entrez Gene Id

    Gene Info:
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Human Readable Name KINASE
    Interpro Acc IPR002290

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    9380 HUGO Gene ID
    9380 HUGO Gene Symbol
    protein kinase cAMP-activated catalytic subunit alpha HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Protein kinase A (PKA) family
    GuideToPharmacology Gene Category ID 284

    Gene Categories:
    ENZYME

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000072062 Gene Symbol
    PRKACA Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    PKACA GENE_SYMBOL
    PRKACA GENE_SYMBOL
    cAMP-dependent protein kinase catalytic subunit alpha UNIPROT

    Gene Info:

    Publications:

    • Version: 19.3

    Alternate Names:
    ENSG00000072062 Ensembl Gene ID
    PKACa Human Protein Atlas Gene Synonym
    Protein kinase cAMP-activated catalytic subunit alpha Human Protein Atlas Gene Description

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

    • Version: 27-Jun-2013

    Alternate Names:
    5566 Gene ID
    PKACA dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    PKACA GO Gene Synonym

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    cAMP-dependent protein kinase catalytic subunit alpha Gene Name
    P17612 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:

    • Version: v3

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications: